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The delayed healing process is multifactorial, involving the accumulation of exudate, microbial colonization, and immune dysfunction. Building upon our previous work with the broad-spectrum antimicrobial peptide LKAHR, this study introduces structural modifications via site-specific cysteine conjugation and alkyl chain functionalization. The mechanical properties of gelatin hydrogels were optimized through PEG cross-linking to improve drug delivery capabilities. Three modified antimicrobial peptides (AMPs) were systematically assessed for hemocompatibility, antimicrobial efficacy, and radical scavenging activity, with Cys2-LKAHR-C8 emerging as the top candidate. This optimized peptide demonstrated a 50% enhancement in antimicrobial efficacy compared to native LKAHR, along with potent free radical neutralization capacity. Mechanistically, it exerts hepatoprotective effects through glutathione-mimetic redox regulation. 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