{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T16:46:49Z","timestamp":1789663609121,"version":"4.0.1"},"reference-count":46,"publisher":"American Chemical Society (ACS)","issue":"10","license":[{"start":{"date-parts":[[2025,9,26]],"date-time":"2025-09-26T00:00:00Z","timestamp":1758844800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,9,26]],"date-time":"2025-09-26T00:00:00Z","timestamp":1758844800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,9,26]],"date-time":"2025-09-26T00:00:00Z","timestamp":1758844800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000038","name":"Natural Sciences and Engineering Research Council of Canada","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000038","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000245","name":"Michael Smith Health Research BC","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000245","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004489","name":"Mitacs","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004489","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,10,13]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>We report the design and synthesis of a biodegradable hyperbranched polyether polyketal polyol, containing acid-labile ketal groups with controlled degradation, high water solubility, excellent hemocompatibility, and cell compatibility. For this, we have developed a new AB2-type acid-labile monomer, 2-((4-(2-(oxiran-2-ylmethoxy) ethoxy)\u00adtetrahydro-2H-pyran-4-yl)\u00adoxy)\u00adethan-1-ol (OTPE). The OTPE monomer is copolymerized with glycidol through anionic ring-opening multibranching polymerization generating OTPE-incorporated hyperbranched polyglycerol (A-BioHPG) with varying degradable monomer content. Gel permeation chromatography assisted degradation studies indicated polymer stability at physiological pH, while controlled degradation is observed under acidic pH, and the data support the homogeneous distribution of the OTPE monomer throughout the polymer. The hemocompatibility of A-BioHPG is assessed by blood coagulation, platelet activation, red blood cell lysis and aggregation, and cell compatibility with endothelial cells. Our findings show that A-BioHPG is a promising candidate for use in multitude of biomedical applications, including but not limited to solubility enhancement, drug delivery, tissue engineering, and bioconjugation.<\/jats:p>","DOI":"10.1021\/acs.biomac.5c01458","type":"journal-article","created":{"date-parts":[[2025,9,26]],"date-time":"2025-09-26T06:18:42Z","timestamp":1758867522000},"page":"7108-7124","source":"Crossref","is-referenced-by-count":3,"title":["A\u2011BioHPG:\nA Hydrophilic Biodegradable and Hemocompatible\nHyperbranched\/Dendritic Polyketal Polyglycerol with Tunable Degradation"],"prefix":"10.1021","volume":"26","author":[{"given":"Erfan","family":"Dinjoo","sequence":"first","affiliation":[{"name":"University of British Columbia , , , ,","place":["Vancouver, British Columbia, Canada, V6T 1Z3"]},{"name":"University of British Columbia , , , ,","place":["Vancouver, British Columbia, Canada, V6T 1Z3"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michae\u0308l\nW.","family":"Kulka","sequence":"additional","affiliation":[{"name":"University of British Columbia , , , ,","place":["Vancouver, British Columbia, Canada, V6T 1Z3"]},{"name":"University of British Columbia , , , ,","place":["Vancouver, British Columbia, Canada, V6T 1Z3"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-8116-9914","authenticated-orcid":true,"given":"Peyman","family":"Malek Mohammadi Nouri","sequence":"additional","affiliation":[{"name":"University of British Columbia , , , ,","place":["Vancouver, British Columbia, Canada, V6T 1Z3"]},{"name":"University of British Columbia , , , ,","place":["Vancouver, British Columbia, Canada, V6T 1Z3"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4092-0066","authenticated-orcid":true,"given":"Iren","family":"Constantinescu","sequence":"additional","affiliation":[{"name":"University of British Columbia , , , ,","place":["Vancouver, British Columbia, Canada, V6T 1Z3"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haifeng","family":"Ji","sequence":"additional","affiliation":[{"name":"University of British Columbia , , , ,","place":["Vancouver, British Columbia, Canada, V6T 1Z3"]},{"name":"University of British Columbia , , , ,","place":["Vancouver, British Columbia, Canada, V6T 1Z3"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arshdeep","family":"Gill","sequence":"additional","affiliation":[{"name":"University of British Columbia , , , ,","place":["Vancouver, British Columbia, Canada, V6T 1Z3"]},{"name":"University of British Columbia , , , ,","place":["Vancouver, British Columbia, Canada, V6T 1Z3"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7688-7574","authenticated-orcid":true,"given":"Jayachandran N.","family":"Kizhakkedathu","sequence":"additional","affiliation":[{"name":"University of British Columbia , , , ,","place":["Vancouver, British Columbia, Canada, V6T 1Z3"]},{"name":"University of British Columbia , , , ,","place":["Vancouver, British Columbia, Canada, V6T 1Z3"]},{"name":"University of British Columbia , , , ,","place":["Vancouver, British Columbia, Canada, V6T 1Z3"]},{"name":"University of British Columbia , , , ,","place":["Vancouver, British Columbia, Canada, V6T 1Z3"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2025,9,26]]},"reference":[{"issue":"5","key":"2026081812203965700_cit1","doi-asserted-by":"publisher","first-page":"427","DOI":"10.1002\/pat.3305","article-title":"Biodegradable polymers\ue5f8an\noverview","volume":"25","author":"Doppalapudi","year":"2014","journal-title":"Polym. 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Ther."},{"issue":"4","key":"2026081812203965700_cit5","doi-asserted-by":"publisher","first-page":"490","DOI":"10.1007\/s11426-014-5086-y","article-title":"Synthetic biodegradable functional polymers for tissue\nengineering:\nA brief review","volume":"57","author":"Guo","year":"2014","journal-title":"Sci. China:Chem."},{"issue":"20","key":"2026081812203965700_cit6","doi-asserted-by":"publisher","first-page":"4854","DOI":"10.3390\/molecules29204854","article-title":"Enhancing\ndrug solubility, bioavailability,\nand targeted therapeutic applications through magnetic nanoparticles","volume":"29","author":"Zhuo","year":"2024","journal-title":"Molecules"},{"key":"2026081812203965700_cit7","doi-asserted-by":"publisher","first-page":"540","DOI":"10.1016\/j.matpr.2022.12.254","article-title":"Biodegradable\nsynthetic polymer in orthopaedic application: A review","volume":"74","author":"Al-Shalawi","year":"2023","journal-title":"Mater. 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Drug Target."},{"key":"2026081812203965700_cit24","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1201\/9780429136405-7","article-title":"Bioconjugation\nof biodegradable poly\u00ad(lactic\/glycolic acid) to protein, peptide, and\nanti-cancer drug: An alternative pathway for achieving controlled\nrelease from micro- and nanoparticles","volume-title":"Polymeric Drugs and Drug Delivery Systems","author":"Park","year":"2019"},{"issue":"25","key":"2026081812203965700_cit25","doi-asserted-by":"publisher","first-page":"6068","DOI":"10.1016\/j.biomaterials.2013.04.043","article-title":"Biodegradable\npolyglycerols with randomly distributed ketal groups as multi-functional\ndrug delivery systems","volume":"34","author":"Shenoi","year":"2013","journal-title":"Biomaterials"},{"issue":"11","key":"2026081812203965700_cit26","doi-asserted-by":"publisher","first-page":"3683","DOI":"10.1021\/acs.biomac.6b01198","article-title":"In vivo\nbiological evaluation of\nhigh molecular weight multifunctional acid-degradable polymeric drug\ncarriers with structurally different ketals","volume":"17","author":"Shenoi","year":"2016","journal-title":"Biomacromolecules"},{"issue":"36","key":"2026081812203965700_cit27","doi-asserted-by":"publisher","first-page":"14945","DOI":"10.1021\/ja305080f","article-title":"Branched multifunctional polyether\npolyketals: Variation\nof ketal group structure enables unprecedented control over polymer\ndegradation in solution and within cells","volume":"134","author":"Shenoi","year":"2012","journal-title":"J.\nAm. Chem. Soc."},{"issue":"13","key":"2026081812203965700_cit28","doi-asserted-by":"publisher","first-page":"4240","DOI":"10.1021\/ma990090w","article-title":"Controlled\nsynthesis of hyperbranched polyglycerols by ring-opening multibranching\npolymerization","volume":"32","author":"Sunder","year":"1999","journal-title":"Macromolecules"},{"issue":"13","key":"2026081812203965700_cit29","doi-asserted-by":"publisher","first-page":"2684","DOI":"10.3390\/polym14132684","article-title":"Polyglycerols\nas multi-functional\nplatforms: Synthesis and biomedical applications","volume":"14","author":"Pouyan","year":"2022","journal-title":"Polymers"},{"issue":"47","key":"2026081812203965700_cit30","doi-asserted-by":"publisher","first-page":"9249","DOI":"10.1039\/C7TB02515G","article-title":"Hyperbranched\npolyglycerols: Recent advances in synthesis, biocompatibility and\nbiomedical applications","volume":"5","author":"Abbina","year":"2017","journal-title":"J. Mater. Chem. 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Bio Mater."},{"issue":"35","key":"2026081812203965700_cit46","doi-asserted-by":"publisher","first-page":"9135","DOI":"10.1016\/j.biomaterials.2012.09.007","article-title":"Influence of architecture of high molecular weight\nlinear and branched polyglycerols on their biocompatibility and biodistribution","volume":"33","author":"Imran\nul-haq","year":"2012","journal-title":"Biomaterials"}],"container-title":["Biomacromolecules"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acs.biomac.5c01458","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/bomaf6\/article-pdf\/26\/10\/7108\/41120039\/bm5c01458.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/pubs.acs.org\/bomaf6\/article-pdf\/26\/10\/7108\/41120039\/bm5c01458.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T18:07:07Z","timestamp":1787076427000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/bomaf6\/article\/26\/10\/7108\/3682295\/A-BioHPG-A-Hydrophilic-Biodegradable-and"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9,26]]},"references-count":46,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2025,9,26]]},"published-print":{"date-parts":[[2025,10,13]]}},"URL":"https:\/\/doi.org\/10.1021\/acs.biomac.5c01458","relation":{},"ISSN":["1525-7797","1526-4602"],"issn-type":[{"value":"1525-7797","type":"print"},{"value":"1526-4602","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,9,26]]}}}