{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T18:29:46Z","timestamp":1787077786468,"version":"build-2736575974"},"reference-count":69,"publisher":"American Chemical Society (ACS)","issue":"10","license":[{"start":{"date-parts":[[2025,9,30]],"date-time":"2025-09-30T00:00:00Z","timestamp":1759190400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,9,30]],"date-time":"2025-09-30T00:00:00Z","timestamp":1759190400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,9,30]],"date-time":"2025-09-30T00:00:00Z","timestamp":1759190400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22205008"],"award-info":[{"award-number":["22205008"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22274003"],"award-info":[{"award-number":["22274003"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003995","name":"Natural Science Foundation of Anhui Province","doi-asserted-by":"publisher","award":["2008085QB76"],"award-info":[{"award-number":["2008085QB76"]}],"id":[{"id":"10.13039\/501100003995","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,10,13]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Polyacrylic acid (PAA)-based hydrogels have been widely used in commercial wound dressings. However, they may trigger a series of adverse reactions within biological organisms due to PAA\u2019s nonbiodegradable nature and the difficulty of metabolism in physiological environments. To overcome this issue, a degradable PAA derivative (PLC) containing acrylic acid, \u03b1-lipoic acid (LA), and 2-(N-3-sulfopropyl-N,N-dimethylammonium)\u00adethyl methacrylate was synthesized by reversible addition\u2013fragmentation chain-transfer (RAFT) polymerization. Then, a multifunctional PLC-based hydrogel (CAPLCT@Chlorella) was developed through a facile mixture of PLC, tannic acid (TA), l-arginine-coupled chitosan (CA), and Chlorella. Chlorella in the hydrogel could constantly generate oxygen (O2) through photosynthesis, relieving hypoxia. CA in the hydrogel endows CAPLCT@Chlorella the release of nitric oxide (NO), which could promote angiogenesis. The hydrogel not only exhibits excellent antibacterial and antibiofilm activities but can also relieve oxidative stress and modulate the inflammatory microenvironment. CAPLCT@Chlorella offers a promising therapeutic option for bacteria-infected wound healing.<\/jats:p>","DOI":"10.1021\/acs.biomac.5c01694","type":"journal-article","created":{"date-parts":[[2025,9,30]],"date-time":"2025-09-30T16:51:13Z","timestamp":1759251073000},"page":"7204-7216","source":"Crossref","is-referenced-by-count":2,"title":["Polyacrylic Acid-Based\n                    <i>Chlorella<\/i>\n                    Loading\nHydrogel Featuring Antibacterial and Microenvironment Remodeling Properties\nfor Expedited Wound Healing"],"prefix":"10.1021","volume":"26","author":[{"given":"Siyuan","family":"Yuan","sequence":"first","affiliation":[{"name":"Anhui Normal University , , ,","place":["Wuhu, P. R. China, 241002"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongjie","family":"Zhang","sequence":"additional","affiliation":[{"name":"Anhui Normal University , , ,","place":["Wuhu, P. R. China, 241002"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5128-0653","authenticated-orcid":true,"given":"Xiaomei","family":"Dai","sequence":"additional","affiliation":[{"name":"Anhui Normal University , , ,","place":["Wuhu, P. R. China, 241002"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuqin","family":"Zou","sequence":"additional","affiliation":[{"name":"Anhui Normal University , , ,","place":["Wuhu, P. R. China, 241002"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Menglin","family":"Huang","sequence":"additional","affiliation":[{"name":"Anhui Normal University , , ,","place":["Wuhu, P. R. China, 241002"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xue","family":"Yang","sequence":"additional","affiliation":[{"name":"Anhui Normal University , , ,","place":["Wuhu, P. R. China, 241002"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongqi","family":"Chen","sequence":"additional","affiliation":[{"name":"Anhui Normal University , , ,","place":["Wuhu, P. R. China, 241002"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3173-1650","authenticated-orcid":true,"given":"Feng","family":"Gao","sequence":"additional","affiliation":[{"name":"Anhui Normal University , , ,","place":["Wuhu, P. R. China, 241002"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2025,9,30]]},"reference":[{"key":"2026081812201642500_cit1","doi-asserted-by":"publisher","first-page":"859","DOI":"10.1111\/exd.13689","article-title":"Recent Evolution of the Human Skin Barrier","volume":"27","author":"Brettmann","year":"2018","journal-title":"Exp. 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Polym."},{"key":"2026081812201642500_cit6","doi-asserted-by":"publisher","first-page":"314","DOI":"10.1038\/nature07039","article-title":"Wound Repair and\nRegeneration","volume":"453","author":"Gurtner","year":"2008","journal-title":"Nature"},{"key":"2026081812201642500_cit7","doi-asserted-by":"publisher","first-page":"941","DOI":"10.1126\/science.1253836","article-title":"Advances in Skin Grafting and Treatment\nof Cutaneous Wounds","volume":"346","author":"Sun","year":"2014","journal-title":"Science"},{"key":"2026081812201642500_cit8","doi-asserted-by":"publisher","first-page":"637","DOI":"10.1016\/S0039-6109(05)70572-7","article-title":"Wound Infection:\nA Failure of Wound Healing Caused by an Imbalance of Bacteria","volume":"77","author":"Robson","year":"1997","journal-title":"Surg. Clin. North Am."},{"key":"2026081812201642500_cit9","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/316235","article-title":"Curbing\nInflammation in Skin Wound\nHealing: A Review","volume":"2015","author":"Rosique","year":"2015","journal-title":"Int. J. Inflammation"},{"key":"2026081812201642500_cit10","doi-asserted-by":"publisher","first-page":"560","DOI":"10.1038\/s41563-020-00844-w","article-title":"Activating\nan Adaptive Immune Response from a Hydrogel Scaffold Imparts Regenerative\nWound Healing","volume":"20","author":"Griffin","year":"2021","journal-title":"Nat. Mater."},{"key":"2026081812201642500_cit11","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1016\/j.bioactmat.2023.07.015","article-title":"Antibacterial Conductive\nSelf-Healing Hydrogel Wound Dressing with Dual Dynamic Bonds Promotes\nInfected wound Healing","volume":"30","author":"Qiao","year":"2023","journal-title":"Bioact. 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