{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T00:40:25Z","timestamp":1785890425534,"version":"3.56.0"},"reference-count":72,"publisher":"American Chemical Society (ACS)","issue":"2","license":[{"start":{"date-parts":[[2026,1,6]],"date-time":"2026-01-06T00:00:00Z","timestamp":1767657600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,1,6]],"date-time":"2026-01-06T00:00:00Z","timestamp":1767657600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,1,6]],"date-time":"2026-01-06T00:00:00Z","timestamp":1767657600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/501100021856","name":"Ministero dell'Universit? e della Ricerca","doi-asserted-by":"publisher","award":["D.M. 1061\/2021 - CUP I59 J21017690008"],"award-info":[{"award-number":["D.M. 1061\/2021 - CUP I59 J21017690008"]}],"id":[{"id":"10.13039\/501100021856","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010661","name":"Horizon 2020 Framework Programme","doi-asserted-by":"publisher","award":["101129751"],"award-info":[{"award-number":["101129751"]}],"id":[{"id":"10.13039\/100010661","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007514","name":"Universit? di Pisa","doi-asserted-by":"publisher","award":["0048740\/2022"],"award-info":[{"award-number":["0048740\/2022"]}],"id":[{"id":"10.13039\/501100007514","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007601","name":"Horizon 2020","doi-asserted-by":"publisher","award":["101004806"],"award-info":[{"award-number":["101004806"]}],"id":[{"id":"10.13039\/501100007601","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biomacromolecules"],"published-print":{"date-parts":[[2026,2,9]]},"DOI":"10.1021\/acs.biomac.5c02245","type":"journal-article","created":{"date-parts":[[2026,1,6]],"date-time":"2026-01-06T13:40:55Z","timestamp":1767706855000},"page":"1612-1624","source":"Crossref","is-referenced-by-count":2,"title":["<i>Candida rugosa<\/i>\n                    Lipase Bioconjugation to Cellulose Nanocrystals with High Immobilization Efficiency: Comparison with Nonspecific Approach"],"prefix":"10.1021","volume":"27","author":[{"given":"Laura","family":"Spagnuolo","sequence":"first","affiliation":[{"name":"Dipartimento di Chimica e Chimica Industriale, Universit\u00e0 di Pisa, via Giuseppe Moruzzi 13, I-56124 Pisa, Italy"},{"name":"Interuniversity Consortium of Chemical Reactivity and Catalysis (CIRCC), Via Celso Ulpiani 27, Bari I-70126 (Italy)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6793-5845","authenticated-orcid":true,"given":"Alessia","family":"Lasorsa","sequence":"additional","affiliation":[{"name":"Zernike Institute for Advanced Materials, University of Groningen, Nijenborgh 3, 9747 AG Groningen, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosarita","family":"D\u2019Orsi","sequence":"additional","affiliation":[{"name":"Dipartimento di Chimica e Chimica Industriale, Universit\u00e0 di Pisa, via Giuseppe Moruzzi 13, I-56124 Pisa, Italy"},{"name":"Interuniversity Consortium of Chemical Reactivity and Catalysis (CIRCC), Via Celso Ulpiani 27, Bari I-70126 (Italy)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Capodieci","sequence":"additional","affiliation":[{"name":"Department for Sustainability (SSPT)-DivisionTechnologies and Materials for Sustainable Manufacturing Industry (TIMAS)-Laboratory Ceramic and Composite Materials for the Manufacturing Industry (MCC) SSPT-TIMAS-MCC","place":["Brindisi, Italy"]},{"name":"Italian National Agency for New Technologies, Energy and Sustainable Economic Development (ENEA)","place":["Brindisi, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3810-5209","authenticated-orcid":true,"given":"Omar","family":"Hassan Omar","sequence":"additional","affiliation":[{"name":"CNR-ICCOM Istituto di Chimica dei Composti Organometallici, Via Orabona 4, I-70126 Bari, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Micheli","sequence":"additional","affiliation":[{"name":"Dipartimento di Scienze e Tecnologie Chimiche, Universit\u00e0 degli Studi di Roma Tor Vergata, via della Ricerca Scientifica, I-00133 Roma, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5390-3321","authenticated-orcid":true,"given":"Patrick C. A.","family":"van der Wel","sequence":"additional","affiliation":[{"name":"Zernike Institute for Advanced Materials, University of Groningen, Nijenborgh 3, 9747 AG Groningen, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8527-0920","authenticated-orcid":true,"given":"Alessandra","family":"Operamolla","sequence":"additional","affiliation":[{"name":"Dipartimento di Chimica e Chimica Industriale, Universit\u00e0 di Pisa, via Giuseppe Moruzzi 13, I-56124 Pisa, Italy"},{"name":"Interuniversity Consortium of Chemical Reactivity and Catalysis (CIRCC), Via Celso Ulpiani 27, Bari I-70126 (Italy)"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,1,6]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"crossref","DOI":"10.1007\/978-3-642-17393-6","volume-title":"Biotransformations in Organic Chemistry: A Textbook","author":"Faber K.","year":"2011","edition":"6"},{"key":"ref2\/cit2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ddtec.2012.08.002"},{"key":"ref3\/cit3","doi-asserted-by":"publisher","DOI":"10.1002\/adsc.200700082"},{"key":"ref4\/cit4","doi-asserted-by":"publisher","DOI":"10.1016\/j.nantod.2014.02.005"},{"key":"ref5\/cit5","volume-title":"Nanocellulose: From Nature to High Performance Tailored Materials","author":"Dufresne A.","year":"2018","edition":"2"},{"key":"ref7\/cit7","doi-asserted-by":"publisher","DOI":"10.1039\/DF9511100158"},{"key":"ref8\/cit8","doi-asserted-by":"publisher","DOI":"10.1021\/ie50554a046"},{"key":"ref9\/cit9","doi-asserted-by":"publisher","DOI":"10.1080\/17425247.2016.1182491"},{"key":"ref10\/cit10","doi-asserted-by":"publisher","DOI":"10.1021\/acs.biomac.5b00805"},{"key":"ref11\/cit11","doi-asserted-by":"publisher","DOI":"10.1089\/ind.2014.0024"},{"key":"ref12\/cit12","doi-asserted-by":"publisher","DOI":"10.1021\/acssuschemeng.5b00290"},{"key":"ref13\/cit13","doi-asserted-by":"publisher","DOI":"10.1038\/srep20420"},{"key":"ref14\/cit14","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/j.molcatb.2015.09.007","volume":"122","author":"Kim H.","year":"2015","journal-title":"J. Mol. Catal. B: Enzym."},{"key":"ref15\/cit15","doi-asserted-by":"publisher","DOI":"10.1016\/j.cej.2018.04.026"},{"key":"ref16\/cit16","doi-asserted-by":"publisher","DOI":"10.1021\/acs.biomac.9b00285"},{"key":"ref17\/cit17","doi-asserted-by":"publisher","DOI":"10.1021\/am900331d"},{"key":"ref18\/cit18","doi-asserted-by":"publisher","DOI":"10.1007\/s10570-012-9805-2"},{"key":"ref19\/cit19","doi-asserted-by":"publisher","DOI":"10.3923\/biotech.2008.233.241"},{"key":"ref20\/cit20","doi-asserted-by":"publisher","DOI":"10.1002\/admi.201900437"},{"key":"ref21\/cit21","doi-asserted-by":"publisher","DOI":"10.1002\/chem.202402171"},{"key":"ref22\/cit22","doi-asserted-by":"publisher","DOI":"10.3390\/md22050194"},{"key":"ref23\/cit23","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23179933"},{"key":"ref24\/cit24","doi-asserted-by":"publisher","DOI":"10.1039\/D4GC02904F"},{"key":"ref25\/cit25","doi-asserted-by":"publisher","DOI":"10.1007\/s00449-006-0074-z"},{"key":"ref26\/cit26","doi-asserted-by":"publisher","DOI":"10.1186\/1472-6750-14-27"},{"key":"ref27\/cit27","doi-asserted-by":"publisher","DOI":"10.1039\/C4GC02289K"},{"key":"ref28\/cit28","first-page":"4901","volume":"18","author":"Pellis A.","year":"2016","journal-title":"Green Chem."},{"key":"ref29\/cit29","doi-asserted-by":"publisher","DOI":"10.1016\/j.carbpol.2020.116276"},{"key":"ref30\/cit30","doi-asserted-by":"publisher","DOI":"10.1042\/ETLS20170088"},{"key":"ref31\/cit31","doi-asserted-by":"publisher","DOI":"10.1038\/s43586-020-00002-1"},{"key":"ref32\/cit32","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodhyd.2022.107500"},{"key":"ref33\/cit33","doi-asserted-by":"publisher","DOI":"10.3390\/molecules26165032"},{"key":"ref34\/cit34","doi-asserted-by":"publisher","DOI":"10.1002\/slct.202401511"},{"key":"ref35\/cit35","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.1c15330"},{"key":"ref36\/cit36","doi-asserted-by":"publisher","DOI":"10.1021\/ja045461p"},{"key":"ref37\/cit37","doi-asserted-by":"publisher","DOI":"10.1007\/bf00197809"},{"issue":"5","key":"ref38\/cit38","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1016\/S0149-7634(96)00023-1","volume":"21","author":"Van Rossum D.","year":"1997","journal-title":"Neurosci. Biobehav. Rev."},{"key":"ref39\/cit39","doi-asserted-by":"publisher","DOI":"10.1007\/s10858-013-9718-x"},{"key":"ref40\/cit40","doi-asserted-by":"publisher","DOI":"10.1039\/C3NR06761K"},{"key":"ref41\/cit41","doi-asserted-by":"publisher","DOI":"10.1039\/C0NR00583E"},{"key":"ref42\/cit42","doi-asserted-by":"publisher","DOI":"10.1177\/004051755902901003"},{"key":"ref43\/cit43","doi-asserted-by":"publisher","DOI":"10.1093\/femsyr\/foac047"},{"key":"ref44\/cit44","doi-asserted-by":"publisher","DOI":"10.1002\/0471140864.ps1701s35"},{"key":"ref45\/cit45","doi-asserted-by":"publisher","DOI":"10.1039\/D3GC03302C"},{"key":"ref46\/cit46","doi-asserted-by":"publisher","DOI":"10.26656\/fr.2017.4(5).060"},{"key":"ref47\/cit47","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcatb.2010.11.004"},{"key":"ref48\/cit48","doi-asserted-by":"publisher","DOI":"10.1139\/W07-017"},{"key":"ref49\/cit49","first-page":"3714","volume":"46","author":"Sayed N.","year":"2011","journal-title":"Appl. Biochem. Biotechnol."},{"key":"ref50\/cit50","doi-asserted-by":"publisher","DOI":"10.1007\/s12010-019-03171-2"},{"key":"ref51\/cit51","doi-asserted-by":"publisher","DOI":"10.1016\/0378-4347(91)80262-B"},{"key":"ref52\/cit52","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(19)68183-4"},{"key":"ref53\/cit53","doi-asserted-by":"publisher","DOI":"10.1093\/clinchem\/38.2.211"},{"key":"ref54\/cit54","doi-asserted-by":"publisher","DOI":"10.22201\/fesz.23958723e.2021.318"},{"key":"ref55\/cit55","doi-asserted-by":"publisher","DOI":"10.1016\/j.ab.2020.113904"},{"key":"ref56\/cit56","doi-asserted-by":"publisher","DOI":"10.1016\/j.biotechadv.2019.04.003"},{"key":"ref57\/cit57","doi-asserted-by":"publisher","DOI":"10.1016\/j.cej.2024.158054"},{"key":"ref59\/cit59","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.9b11707"},{"key":"ref60\/cit60","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymeth.2018.04.015"},{"key":"ref61\/cit61","doi-asserted-by":"publisher","DOI":"10.1007\/BF00816383"},{"key":"ref62\/cit62","doi-asserted-by":"publisher","DOI":"10.1016\/S0926-2040(99)00043-0"},{"key":"ref63\/cit63","doi-asserted-by":"publisher","DOI":"10.1134\/S0965545X16060109"},{"key":"ref64\/cit64","doi-asserted-by":"publisher","DOI":"10.1186\/1754-6834-3-10"},{"key":"ref65\/cit65","doi-asserted-by":"publisher","DOI":"10.1515\/hfsg.1990.44.5.351"},{"key":"ref66\/cit66","doi-asserted-by":"publisher","DOI":"10.1007\/s10570-017-1549-6"},{"key":"ref67\/cit67","doi-asserted-by":"publisher","DOI":"10.1021\/bm801193d"},{"key":"ref68\/cit68","doi-asserted-by":"publisher","DOI":"10.1039\/d0an00714e"},{"key":"ref69\/cit69","doi-asserted-by":"publisher","DOI":"10.1016\/j.carbpol.2022.119258"},{"key":"ref70\/cit70","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2019.126022"},{"key":"ref71\/cit71","doi-asserted-by":"publisher","DOI":"10.1016\/j.cplett.2007.09.041"},{"key":"ref72\/cit72","doi-asserted-by":"publisher","DOI":"10.1039\/c3cs35446f"},{"key":"ref73\/cit73","doi-asserted-by":"publisher","DOI":"10.1016\/j.procbio.2013.08.016"},{"key":"ref74\/cit74","doi-asserted-by":"publisher","DOI":"10.1039\/D4GC05113K"}],"container-title":["Biomacromolecules"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acs.biomac.5c02245","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acs.biomac.5c02245","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,9]],"date-time":"2026-02-09T09:13:08Z","timestamp":1770628388000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/acs.biomac.5c02245"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,6]]},"references-count":72,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,2,9]]}},"alternative-id":["10.1021\/acs.biomac.5c02245"],"URL":"https:\/\/doi.org\/10.1021\/acs.biomac.5c02245","relation":{},"ISSN":["1525-7797","1526-4602"],"issn-type":[{"value":"1525-7797","type":"print"},{"value":"1526-4602","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1,6]]}}}