{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T12:07:58Z","timestamp":1789387678716,"version":"build-2803163510"},"reference-count":29,"publisher":"American Chemical Society (ACS)","issue":"9","license":[{"start":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T00:00:00Z","timestamp":1785888000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T00:00:00Z","timestamp":1785888000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T00:00:00Z","timestamp":1785888000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"name":"Office of Science, Office of Basic Energy Sciences, U.S. Department of Energy","award":["DE-AC02-05CH11231"],"award-info":[{"award-number":["DE-AC02-05CH11231"]}]},{"name":"DARPA-SPREE program","award":["HR0011-24-3-0302"],"award-info":[{"award-number":["HR0011-24-3-0302"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,9,14]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The sustainable separation of rare earth elements (REEs) from complex mixtures remains a critical technological challenge. Biomaterials offer a promising route, but their deployment has been hindered by their limited stability and efficiency. Here, we report a robust elastin-based hydrogel incorporating the lanthanide-binding protein, lanmodulin, for efficient and selective REE separation. A fusion protein of elastin-like polypeptide and lanmodulin was synthesized and cross-linked with four-arm polyethylene glycol to form a porous network that enhances REE binding and release in aqueous environments. The protein-cross-linked hydrogel exhibits high internal selectivity for lanthanide ions over multiple regeneration cycles. When implemented as an ion exchange chromatography adsorbent, it enables the selective fractionation of lanthanides from allanite ore, a complex natural source containing abundant REEs and non-REEs. The combination of excellent selectivity and operational stability positions this protein hydrogel as a sustainable platform for eco-friendly REE separation and purification.<\/jats:p>","DOI":"10.1021\/acs.biomac.5c02269","type":"journal-article","created":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T16:02:23Z","timestamp":1785945743000},"page":"5878-5886","source":"Crossref","is-referenced-by-count":0,"title":["Elastin-Based\nHydrogel for Selective Adsorption of\nRare Earth Elements"],"prefix":"10.1021","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-8582-1584","authenticated-orcid":true,"given":"Inseok","family":"Chae","sequence":"first","affiliation":[{"name":"University of California , , , ,","place":["Berkeley, California, United States, 94720"]},{"name":"Lawrence Berkeley National Laboratory , , , ,","place":["Berkeley, California, United States, 94720"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Butaek","family":"Lim","sequence":"additional","affiliation":[{"name":"University of California , , , ,","place":["Berkeley, California, United States, 94720"]},{"name":"Lawrence Berkeley National Laboratory , , , ,","place":["Berkeley, California, United States, 94720"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-6546-9224","authenticated-orcid":true,"given":"Dylan S.","family":"Chang","sequence":"additional","affiliation":[{"name":"University of California , , , ,","place":["Berkeley, California, United States, 94720"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6052-6229","authenticated-orcid":true,"given":"Fiona M.","family":"Doyle","sequence":"additional","affiliation":[{"name":"University of California , , , ,","place":["Berkeley, California, United States, 94720"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0501-8432","authenticated-orcid":true,"given":"Seung-Wuk","family":"Lee","sequence":"additional","affiliation":[{"name":"University of California , , , ,","place":["Berkeley, California, United States, 94720"]},{"name":"Lawrence Berkeley National Laboratory , , , ,","place":["Berkeley, California, United States, 94720"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,8,5]]},"reference":[{"issue":"6426","key":"2026091407062556700_cit1","doi-asserted-by":"publisher","first-page":"489","DOI":"10.1126\/science.aau7628","article-title":"Rare earth elements: Mendeleev\u2019s bane, modern\nmarvels","volume":"363","author":"Cheisson","year":"2019","journal-title":"Science"},{"issue":"7600","key":"2026091407062556700_cit2","doi-asserted-by":"publisher","first-page":"435","DOI":"10.1038\/532435a","article-title":"Seven chemical separations\nto change the world","volume":"532","author":"Sholl","year":"2016","journal-title":"Nature"},{"issue":"44","key":"2026091407062556700_cit3","doi-asserted-by":"publisher","first-page":"40807","DOI":"10.1021\/jacs.5c13850","article-title":"Y-Doped\nCuS Promotes Selective Electroreduction of CO2 to Ethanol","volume":"147","author":"Shen","year":"2025","journal-title":"J. Am. Chem. Soc."},{"key":"2026091407062556700_cit4","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1016\/j.mineng.2013.10.021","article-title":"A critical review on\nsolvent extraction of rare earths from aqueous solutions","volume":"56","author":"Xie","year":"2014","journal-title":"Miner. Eng."},{"issue":"4","key":"2026091407062556700_cit5","doi-asserted-by":"publisher","first-page":"614","DOI":"10.3390\/resources3040614","article-title":"Rare Earth\nElements:\nOverview of Mining, Mineralogy, Uses, Sustainability and Environmental\nImpact","volume":"3","author":"Haque","year":"2014","journal-title":"Resources"},{"issue":"8","key":"2026091407062556700_cit6","doi-asserted-by":"publisher","first-page":"1925","DOI":"10.2113\/econgeo.110.8.1925","article-title":"A Detailed Assessment\nof Global Rare Earth Element Resources: Opportunities and Challenges","volume":"110","author":"Weng","year":"2015","journal-title":"Econ. Geol."},{"issue":"4","key":"2026091407062556700_cit7","doi-asserted-by":"publisher","first-page":"1285","DOI":"10.1016\/j.gsf.2018.12.005","article-title":"Rare earth\nelements: A review of applications, occurrence, exploration, analysis,\nrecycling, and environmental impact","volume":"10","author":"Balaram","year":"2019","journal-title":"Geosci.\nFront."},{"issue":"9","key":"2026091407062556700_cit8","doi-asserted-by":"publisher","first-page":"1496","DOI":"10.1021\/acscentsci.9b00642","article-title":"The Chemistry of Lanthanides in Biology:\nRecent Discoveries,\nEmerging Principles, and Technological Applications","volume":"5","author":"Cotruvo","year":"2019","journal-title":"ACS Cent. Sci."},{"issue":"11","key":"2026091407062556700_cit9","doi-asserted-by":"publisher","first-page":"1776","DOI":"10.1021\/acscentsci.1c01357","article-title":"Unlocking\nthe Lanthanome","volume":"7","author":"Peplow","year":"2021","journal-title":"ACS Cent. Sci."},{"issue":"22","key":"2026091407062556700_cit10","doi-asserted-by":"publisher","first-page":"8315","DOI":"10.1039\/D0CS00653J","article-title":"Biological, biomolecular, and bio-inspired strategies\nfor detection, extraction, and separations of lanthanides and actinides","volume":"49","author":"Mattocks","year":"2020","journal-title":"Chem. Soc. Rev."},{"issue":"1","key":"2026091407062556700_cit11","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamcr.2020.118864","article-title":"The biochemistry\nof lanthanide acquisition, trafficking,\nand utilization","volume":"1868","author":"Featherston","year":"2021","journal-title":"Biochim. Biophys. Acta, Mol.\nCell Res."},{"issue":"5","key":"2026091407062556700_cit12","doi-asserted-by":"publisher","first-page":"2735","DOI":"10.1021\/acs.est.5b06129","article-title":"Bioadsorption of Rare Earth Elements\nthrough Cell Surface Display of Lanthanide Binding Tags","volume":"50","author":"Park","year":"2016","journal-title":"Environ. Sci. Technol."},{"issue":"4","key":"2026091407062556700_cit13","doi-asserted-by":"publisher","first-page":"180","DOI":"10.1021\/acs.estlett.6b00064","article-title":"Rare-Earth Separation\nUsing Bacteria","volume":"3","author":"Bonificio","year":"2016","journal-title":"Environ. Sci. Technol. Lett."},{"issue":"5","key":"2026091407062556700_cit14","doi-asserted-by":"publisher","first-page":"575","DOI":"10.1016\/j.tibtech.2023.10.011","article-title":"Engineering biomaterials for the\nrecovery of rare earth elements","volume":"42","author":"Ye","year":"2024","journal-title":"Trends Biotechnol."},{"issue":"2","key":"2026091407062556700_cit15","doi-asserted-by":"publisher","first-page":"120","DOI":"10.1021\/acs.biochem.8b01019","article-title":"Structural Basis for Rare Earth Element Recognition by Methylobacterium\nextorquens Lanmodulin","volume":"58","author":"Cook","year":"2019","journal-title":"Biochemistry"},{"issue":"44","key":"2026091407062556700_cit16","doi-asserted-by":"publisher","first-page":"15056","DOI":"10.1021\/jacs.8b09842","article-title":"Lanmodulin: A Highly\nSelective Lanthanide-Binding Protein\nfrom a Lanthanide-Utilizing Bacterium","volume":"140","author":"Cotruvo","year":"2018","journal-title":"J. Am.\nChem. Soc."},{"issue":"17","key":"2026091407062556700_cit17","doi-asserted-by":"publisher","first-page":"11855","DOI":"10.1021\/acs.inorgchem.0c01303","article-title":"Selective and Efficient Biomacromolecular\nExtraction of Rare-Earth Elements using Lanmodulin","volume":"59","author":"Deblonde","year":"2020","journal-title":"Inorg. Chem."},{"issue":"7963","key":"2026091407062556700_cit18","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1038\/s41586-023-05945-5","article-title":"Enhanced rare-earth separation with\na metal-sensitive lanmodulin dimer","volume":"618","author":"Mattocks","year":"2023","journal-title":"Nature"},{"issue":"22","key":"2026091407062556700_cit19","doi-asserted-by":"publisher","first-page":"13471","DOI":"10.1021\/acs.est.7b02414","article-title":"Recovery\nof Rare Earth Elements from Low-Grade Feedstock Leachates Using Engineered\nBacteria","volume":"51","author":"Park","year":"2017","journal-title":"Environ. Sci. Technol."},{"issue":"15","key":"2026091407062556700_cit20","doi-asserted-by":"publisher","first-page":"3512","DOI":"10.1039\/C8GC01355A","article-title":"Repurposing bacterial\nextracellular matrix for selective and differential abstraction of\nrare earth elements","volume":"20","author":"Tay","year":"2018","journal-title":"Green Chem."},{"issue":"32","key":"2026091407062556700_cit21","doi-asserted-by":"publisher","first-page":"9946","DOI":"10.1021\/acs.nanolett.4c02510","article-title":"Virus-Based Separation\nof Rare Earth Elements","volume":"24","author":"Chae","year":"2024","journal-title":"Nano Lett."},{"key":"2026091407062556700_cit22","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/2405954","article-title":"Role of Recombinant DNA Technology\nto Improve Life","volume":"2016","author":"Khan","year":"2016","journal-title":"Int. J. 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Sci.\nEng."},{"key":"2026091407062556700_cit28","volume-title":"Hydrometallurgical Extraction\nand Reclamation","author":"Jackson","year":"1986"},{"key":"2026091407062556700_cit29","doi-asserted-by":"publisher","first-page":"78","DOI":"10.1016\/j.hydromet.2017.09.011","article-title":"Synergistic\nextraction and separation of rare earths from chloride medium by the\nmixture of HEHAPP and D2EHPA","volume":"174","author":"Kuang","year":"2017","journal-title":"Hydrometallurgy"}],"container-title":["Biomacromolecules"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acs.biomac.5c02269","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/bomaf6\/article-pdf\/27\/9\/5878\/66415511\/acs.biomac.5c02269.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/pubs.acs.org\/bomaf6\/article-pdf\/27\/9\/5878\/66415511\/acs.biomac.5c02269.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T11:29:16Z","timestamp":1789385356000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/bomaf6\/article\/27\/9\/5878\/5246206\/Elastin-Based-Hydrogel-for-Selective-Adsorption-of"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,5]]},"references-count":29,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2026,8,5]]},"published-print":{"date-parts":[[2026,9,14]]}},"URL":"https:\/\/doi.org\/10.1021\/acs.biomac.5c02269","relation":{},"ISSN":["1525-7797","1526-4602"],"issn-type":[{"value":"1525-7797","type":"print"},{"value":"1526-4602","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,5]]}}}