{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T12:33:06Z","timestamp":1786365186460,"version":"build-2736575974"},"reference-count":91,"publisher":"American Chemical Society (ACS)","issue":"8","license":[{"start":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T00:00:00Z","timestamp":1785369600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T00:00:00Z","timestamp":1785369600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T00:00:00Z","timestamp":1785369600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/na","name":"the Iran Science Foundation","doi-asserted-by":"publisher","award":["grant number: 4046737"],"award-info":[{"award-number":["grant number: 4046737"]}],"id":[{"id":"10.13039\/na","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,8,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>A biocompatible, injectable, and self-healing hydrogel was constructed via electrostatic self-assembly of anionic pectin (PEC) and cationic quaternized guar gum (QGG). The optimized PEC\/QGG hydrogel (QPE5, 1:3.5 ratio) exhibited rapid gelation (1.5 min), high yield (95.7%), shear-thinning behavior (viscosity decrease from 430 to 1.7 Pa\u00b7s), and excellent self-healing with \u223c90% recovery of compressive strength. Zeta potential analysis confirmed charge neutralization (+2.9 mV for QPE5), indicating strong electrostatic interactions. The hydrogel displayed pH- and enzyme-responsive degradation, with accelerated disintegration under acidic (pH 5.5) and pectinase-rich conditions. 5-Fluorouracil (5-FU) was loaded with encapsulation efficiency of \u223c72% and loading efficiency of \u223c15% for QPE3 formulation. Drug release was adequately described by kinetic models, with the best-fitting model depending on the release conditions. The hydrogel demonstrated excellent cytocompatibility (&amp;gt;80% cell viability) and hemocompatibility (&amp;lt;2% hemolysis), while enabling selective inhibition of CT-26 colon carcinoma cells (viability reduced to \u223c40% with enzyme-triggered release). This PEC\/QGG platform integrates injectability, self-healing, and colon-specific degradability, offering a promising approach for localized colorectal cancer therapy.<\/jats:p>","DOI":"10.1021\/acs.biomac.5c02480","type":"journal-article","created":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T13:21:24Z","timestamp":1785849684000},"page":"5055-5078","source":"Crossref","is-referenced-by-count":0,"title":["Natural Biopolymer-Based\nInjectable, Self-Healing\nHydrogel via Self-Assembly of Pectin and Quaternized Guar Gum for\nTargeted Treatment of Colon Cancer"],"prefix":"10.1021","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6524-7176","authenticated-orcid":true,"given":"Ali","family":"Rahmatpour","sequence":"first","affiliation":[{"name":"Shahid Beheshti University , , P.O. Box, ,","place":["Tehran, Iran, 1983969411"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melika Emami","family":"Kian","sequence":"additional","affiliation":[{"name":"Shahid Beheshti University , , P.O. Box, ,","place":["Tehran, Iran, 1983969411"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Parvaneh","family":"Soleimani","sequence":"additional","affiliation":[{"name":"Shahid Beheshti University , , P.O. Box, ,","place":["Tehran, Iran, 1983969411"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,7,30]]},"reference":[{"issue":"6","key":"2026081008073731300_cit1","doi-asserted-by":"publisher","first-page":"394","DOI":"10.3322\/caac.21492","article-title":"Global Cancer Statistics 2018: GLOBOCAN Estimates of Incidence and\nMortality Worldwide for 36 Cancers in 185 Countries","volume":"68","author":"Bray","year":"2018","journal-title":"Ca-Cancer J. 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