{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T04:24:33Z","timestamp":1782447873850,"version":"3.54.5"},"reference-count":51,"publisher":"American Chemical Society (ACS)","issue":"3","license":[{"start":{"date-parts":[[2026,2,5]],"date-time":"2026-02-05T00:00:00Z","timestamp":1770249600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,2,5]],"date-time":"2026-02-05T00:00:00Z","timestamp":1770249600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,2,5]],"date-time":"2026-02-05T00:00:00Z","timestamp":1770249600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/501100013068","name":"Key Technologies Research and Development Program of Guangzhou Municipality","doi-asserted-by":"publisher","award":["2025B01J3007"],"award-info":[{"award-number":["2025B01J3007"]}],"id":[{"id":"10.13039\/501100013068","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32271374"],"award-info":[{"award-number":["32271374"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003453","name":"Natural Science Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2024A1515012639"],"award-info":[{"award-number":["2024A1515012639"]}],"id":[{"id":"10.13039\/501100003453","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biomacromolecules"],"published-print":{"date-parts":[[2026,3,9]]},"DOI":"10.1021\/acs.biomac.5c02569","type":"journal-article","created":{"date-parts":[[2026,2,5]],"date-time":"2026-02-05T07:03:58Z","timestamp":1770275038000},"page":"2234-2250","source":"Crossref","is-referenced-by-count":1,"title":["AND-Gate-Enabled Extra-Small Nanoparticles Achieve Deep Penetration and Long Retention in Large Tumors for Efficient Cancer Stem Cells Dismission"],"prefix":"10.1021","volume":"27","author":[{"given":"Haolong","family":"Ma","sequence":"first","affiliation":[{"name":"School of Biomedical Engineering, Southern Medical University, 1023 Shatai South Road, Guangzhou, Guangdong 510515, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingdeng","family":"Fan","sequence":"additional","affiliation":[{"name":"School of Biomedical Engineering, Southern Medical University, 1023 Shatai South Road, Guangzhou, Guangdong 510515, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanwei","family":"Zeng","sequence":"additional","affiliation":[{"name":"School of Biomedical Engineering, Southern Medical University, 1023 Shatai South Road, Guangzhou, Guangdong 510515, China"},{"name":"Department of Radiology, Zhujiang Hospital","place":["Guangzhou, China"]},{"name":"Southern Medical University","place":["Guangzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haobin","family":"Cai","sequence":"additional","affiliation":[{"name":"School of Biomedical Engineering, Southern Medical University, 1023 Shatai South Road, Guangzhou, Guangdong 510515, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunmei","family":"Chen","sequence":"additional","affiliation":[{"name":"School of Biomedical Engineering, Southern Medical University, 1023 Shatai South Road, Guangzhou, Guangdong 510515, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ya","family":"Huang","sequence":"additional","affiliation":[{"name":"School of Biomedical Engineering, Southern Medical University, 1023 Shatai South Road, Guangzhou, Guangdong 510515, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Ren","sequence":"additional","affiliation":[{"name":"School of Biomedical Engineering, Southern Medical University, 1023 Shatai South Road, Guangzhou, Guangdong 510515, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zongheng","family":"Li","sequence":"additional","affiliation":[{"name":"School of Biomedical Engineering, Southern Medical University, 1023 Shatai South Road, Guangzhou, Guangdong 510515, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Huang","sequence":"additional","affiliation":[{"name":"School of Biomedical Engineering, Southern Medical University, 1023 Shatai South Road, Guangzhou, Guangdong 510515, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0350-375X","authenticated-orcid":true,"given":"Zheyu","family":"Shen","sequence":"additional","affiliation":[{"name":"School of Biomedical Engineering, Southern Medical University, 1023 Shatai South Road, Guangzhou, Guangdong 510515, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Yang","sequence":"additional","affiliation":[{"name":"School of Biomedical Engineering, Southern Medical University, 1023 Shatai South Road, Guangzhou, Guangdong 510515, China"},{"name":"Department of Radiology, Zhujiang Hospital","place":["Guangzhou, China"]},{"name":"Southern Medical University","place":["Guangzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,2,5]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202400929"},{"key":"ref2\/cit2","doi-asserted-by":"publisher","DOI":"10.1038\/s44222-024-00203-3"},{"key":"ref3\/cit3","doi-asserted-by":"publisher","DOI":"10.1039\/D5CS00596E"},{"key":"ref4\/cit4","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.0c00779"},{"key":"ref5\/cit5","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-025-02360-2"},{"key":"ref6\/cit6","doi-asserted-by":"publisher","DOI":"10.1186\/s12943-025-02265-2"},{"key":"ref7\/cit7","doi-asserted-by":"publisher","DOI":"10.1126\/science.adi7453"},{"key":"ref8\/cit8","doi-asserted-by":"publisher","DOI":"10.1038\/s41568-024-00760-0"},{"key":"ref9\/cit9","doi-asserted-by":"publisher","DOI":"10.1002\/cac2.70018"},{"key":"ref10\/cit10","doi-asserted-by":"publisher","DOI":"10.1038\/s43018-024-00759-4"},{"key":"ref11\/cit11","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-025-02340-6"},{"key":"ref12\/cit12","doi-asserted-by":"publisher","DOI":"10.1038\/s41551-025-01385-w"},{"key":"ref13\/cit13","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2319880121"},{"key":"ref14\/cit14","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202311869"},{"key":"ref15\/cit15","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202407927"},{"key":"ref16\/cit16","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202312374"},{"key":"ref17\/cit17","doi-asserted-by":"publisher","DOI":"10.1016\/j.apsb.2024.11.012"},{"key":"ref18\/cit18","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202307006"},{"key":"ref19\/cit19","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-025-02186-y"},{"key":"ref20\/cit20","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202211337"},{"key":"ref21\/cit21","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.1c08232"},{"key":"ref22\/cit22","doi-asserted-by":"publisher","DOI":"10.1016\/j.chempr.2025.102624"},{"key":"ref23\/cit23","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.5c10267"},{"key":"ref24\/cit24","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202410536"},{"key":"ref25\/cit25","doi-asserted-by":"publisher","DOI":"10.1126\/science.adu4125"},{"key":"ref26\/cit26","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202501184"},{"key":"ref27\/cit27","doi-asserted-by":"publisher","DOI":"10.1016\/j.apsb.2025.08.001"},{"key":"ref28\/cit28","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202506770"},{"key":"ref29\/cit29","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.adw7032"},{"key":"ref30\/cit30","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202318539"},{"key":"ref31\/cit31","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.3c10037"},{"key":"ref32\/cit32","doi-asserted-by":"publisher","DOI":"10.1021\/cr900138t"},{"key":"ref33\/cit33","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202421713"},{"key":"ref34\/cit34","doi-asserted-by":"publisher","DOI":"10.1007\/s40820-021-00666-8"},{"key":"ref35\/cit35","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-024-44736-y"},{"key":"ref36\/cit36","doi-asserted-by":"publisher","DOI":"10.1021\/acsapm.2c01357"},{"key":"ref37\/cit37","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202500996"},{"key":"ref38\/cit38","doi-asserted-by":"publisher","DOI":"10.1038\/s41563-024-02054-0"},{"key":"ref39\/cit39","doi-asserted-by":"publisher","DOI":"10.1186\/s12943-025-02443-2"},{"key":"ref40\/cit40","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202507526"},{"key":"ref41\/cit41","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.2c12874"},{"key":"ref42\/cit42","doi-asserted-by":"publisher","DOI":"10.1038\/s41578-024-00767-x"},{"key":"ref43\/cit43","doi-asserted-by":"publisher","DOI":"10.1007\/s42114-023-00799-x"},{"key":"ref44\/cit44","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.8b01048"},{"key":"ref45\/cit45","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-024-02088-5"},{"key":"ref46\/cit46","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2024.215906"},{"key":"ref47\/cit47","doi-asserted-by":"publisher","DOI":"10.1002\/EXP.20230117"},{"key":"ref48\/cit48","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202304098"},{"key":"ref49\/cit49","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202415656"},{"key":"ref50\/cit50","doi-asserted-by":"publisher","DOI":"10.1038\/s41580-025-00843-2"},{"key":"ref51\/cit51","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-025-08974-4"}],"container-title":["Biomacromolecules"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acs.biomac.5c02569","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acs.biomac.5c02569","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T07:43:57Z","timestamp":1773128637000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/acs.biomac.5c02569"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,5]]},"references-count":51,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,3,9]]}},"alternative-id":["10.1021\/acs.biomac.5c02569"],"URL":"https:\/\/doi.org\/10.1021\/acs.biomac.5c02569","relation":{},"ISSN":["1525-7797","1526-4602"],"issn-type":[{"value":"1525-7797","type":"print"},{"value":"1526-4602","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2,5]]}}}