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Although the thermodynamics and kinetics of these processes are well understood, synthetic materials integrating both functionalities remain rare. Inspired by the conserved IDR\u2013assembly domain (AD) architecture of amyloidogenic proteins, we hypothesized that modular recombinant constructs combining LLPS-capable IDRs with \u03b2-sheet-forming ADs could generate materials with tunable structural properties. To test this, we engineered a library of elastin-like polypeptides (ELPs) fused to amphiphilic anionic or cationic amyloidogenic peptides, enabling systematic investigation of how sequence parameters\u2500including ELP length, AD charge, and hydrophilicity\u2500and environmental conditions, including temperature, pH, and salt concentration, influence material behavior. Our results reveal links between molecular design and emergent multiscale structures, including micelles and vesicles embedded within coacervates. This work provides a framework for designing hybrid proteins coupling LLPS and self-assembly.<\/jats:p>","DOI":"10.1021\/acs.biomac.6c00295","type":"journal-article","created":{"date-parts":[[2026,8,8]],"date-time":"2026-08-08T15:01:48Z","timestamp":1786201308000},"page":"5898-5907","source":"Crossref","is-referenced-by-count":0,"title":["Temperature-Triggered\nNanoscale Morphological Transitions\nin a Synthetic Intrinsically Disordered Protein"],"prefix":"10.1021","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4152-0670","authenticated-orcid":true,"given":"Yulia","family":"Shmidov","sequence":"first","affiliation":[{"name":"Duke University , , , ,","place":["Durham, North Carolina, United States, 27708"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lixin","family":"Fan","sequence":"additional","affiliation":[{"name":"SAXS Facility of the National Cancer Institute , , , ,","place":["Fredrick, Maryland, United States, 21702"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Max","family":"Ney","sequence":"additional","affiliation":[{"name":"Duke University , , , ,","place":["Durham, North Carolina, United States, 27708"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sonal","family":"Deshpande","sequence":"additional","affiliation":[{"name":"Duke University , , , ,","place":["Durham, North Carolina, United States, 27708"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Parul","family":"Sirohi","sequence":"additional","affiliation":[{"name":"Duke University , , , ,","place":["Durham, North Carolina, United States, 27708"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joshua J","family":"Milligan","sequence":"additional","affiliation":[{"name":"Duke University , , , ,","place":["Durham, North Carolina, United States, 27708"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1569-2228","authenticated-orcid":true,"given":"Ashutosh","family":"Chilkoti","sequence":"additional","affiliation":[{"name":"Duke University , , , ,","place":["Durham, North Carolina, United States, 27708"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,8,8]]},"reference":[{"issue":"7","key":"2026091407062167300_cit1","doi-asserted-by":"publisher","first-page":"1113","DOI":"10.1038\/s41557-024-01489-x","article-title":"Expanding the molecular language\nof protein liquid\u2013liquid phase separation","volume":"16","author":"Rekhi","year":"2024","journal-title":"Nat. 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