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Herein, we covalently attached a Toll-like receptor 7\/8 agonist to poly(acrylic acid-co-styrene) to generate a multimodal cancer immunotherapy platform (AASTY-TLR7\/8ag.) that acts as a loco-regional Toll-like receptor 7\/8 agonist depot and as a nanodisc-driven in situ immunization platform. We show that AASTY-TLR7\/8ag. therapy translates into tumor growth inhibition in CT26 and other murine cancer models, with the induction of immune memory, synergy with anti-PD-1, and limited on-target\/off-tumor toxicity. By formulating nanodiscs from cancer cell membranes in vitro, we also observed that subcutaneous injection in mice leads to rapid distribution in lymph nodes and immune activation of dendritic cells, highlighting the broader potential of AASTY-TLR7\/8ag. as a tool for immunization.<\/jats:p>","DOI":"10.1021\/acs.biomac.6c00611","type":"journal-article","created":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T03:26:37Z","timestamp":1784258797000},"page":"5369-5386","source":"Crossref","is-referenced-by-count":0,"title":["Nanodisc-Forming\nPolymers as TLR7\/8 Agonist-Conjugated\nImmunotherapy Agents"],"prefix":"10.1021","volume":"27","author":[{"given":"Neil J.","family":"Borthwick","sequence":"first","affiliation":[{"name":"Technical University of Denmark , , ,","place":["Kongens Lyngby, Denmark, 2800"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ciara F.","family":"Pugh","sequence":"additional","affiliation":[{"name":"University of Copenhagen , , ,","place":["Copenhagen N, Denmark, 2200"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristoffer H.","family":"Johansen","sequence":"additional","affiliation":[{"name":"Technical University of Denmark , , ,","place":["Kongens Lyngby, Denmark, 2800"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caitlin L.","family":"Maikawa","sequence":"additional","affiliation":[{"name":"Brigham and Women\u2019s Hospital , , , ,","place":["Boston, Massachusetts, United States, 02115"]},{"name":"Harvard Medical School , , ,","place":["Boston, Massachusetts, United States, 02115"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ditte E.","family":"J\u00e6hger","sequence":"additional","affiliation":[{"name":"Technical University of Denmark , , ,","place":["Kongens Lyngby, Denmark, 2800"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sven","family":"Weller","sequence":"additional","affiliation":[{"name":"Technical University of Denmark , , ,","place":["Kongens Lyngby, Denmark, 2800"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jerry","family":"Yan","sequence":"additional","affiliation":[{"name":"Stanford University , , , ,","place":["Stanford, California, United States, 94305"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John H.","family":"Klich","sequence":"additional","affiliation":[{"name":"Stanford University , , , ,","place":["Stanford, California, United States, 94305"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Unnur J.","family":"Bjo\u0308rgvinsdo\u0301ttir","sequence":"additional","affiliation":[{"name":"Technical University of Denmark , , ,","place":["Kongens Lyngby, Denmark, 2800"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura O.","family":"Marchard","sequence":"additional","affiliation":[{"name":"Technical University of Denmark , , ,","place":["Kongens Lyngby, Denmark, 2800"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-4352-0281","authenticated-orcid":true,"given":"Charalampos","family":"Sideris","sequence":"additional","affiliation":[{"name":"Technical University of Denmark , , ,","place":["Kongens Lyngby, Denmark, 2800"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas L.","family":"Andresen","sequence":"additional","affiliation":[{"name":"Technical University of Denmark , , ,","place":["Kongens Lyngby, Denmark, 2800"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henriette E.","family":"Autzen","sequence":"additional","affiliation":[{"name":"University of Copenhagen , , ,","place":["Copenhagen N, Denmark, 2200"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anders E.","family":"Hansen","sequence":"additional","affiliation":[{"name":"Technical University of Denmark , , ,","place":["Kongens Lyngby, Denmark, 2800"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6728-5299","authenticated-orcid":true,"given":"Anton A.A.","family":"Autzen","sequence":"additional","affiliation":[{"name":"Technical University of Denmark , , ,","place":["Kongens Lyngby, Denmark, 2800"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,7,16]]},"reference":[{"issue":"11","key":"2026081008075713400_cit1","doi-asserted-by":"publisher","first-page":"1085","DOI":"10.1080\/17425247.2018.1529756","article-title":"Amphiphilic Block Copolymers in Drug Delivery: Advances\nin Formulation Structure and Performance","volume":"15","author":"Bodratti","year":"2018","journal-title":"Expert.\nOpin. 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