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Here, gyroid scaffolds were fabricated by fused deposition modeling using a metamaterial approach to couple shape recovery with mechanistically tunable degradation. Polylactic acid (PLA) was plasticized with 10 wt % polyethylene glycol (PEG) to lower the glass transition temperature (Tg), while 2.5 and 5 wt % magnesium (Mg) particles were incorporated to regulate degradation, reinforcement, and biocompatibility. Thermal and viscoelastic analyses confirmed Tg reduction to \u223c44 \u00b0C, enabling body-safe activation. PLA\/10PEG\/2.5Mg achieved the best shape-memory response, with a shape recovery ratio (Rr) of 90.4% within \u223c71 s. Physicochemical and mechanical degradation tracking over 12 weeks revealed that PEG leaching, Mg corrosion, and gyroid interconnectivity synergistically promoted bulk-like degradation, yielding up to \u223c600% higher weight loss and mechanical retention. Cytocompatibility further improved with Mg incorporation. This work establishes a mechanistic framework for codesigning degradation and shape recovery in 4D-printed PLA\/PEG\/Mg scaffolds.<\/jats:p>","DOI":"10.1021\/acs.biomac.6c00690","type":"journal-article","created":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T09:14:59Z","timestamp":1784193299000},"page":"5399-5418","source":"Crossref","is-referenced-by-count":1,"title":["4D-Printed PLA\/PEG\/Mg\nGyroid Metamaterial Scaffolds:\nMechanistically Tunable Degradation and Body-Safe Shape Transformation"],"prefix":"10.1021","volume":"27","author":[{"given":"Roozbeh","family":"Aghabarari","sequence":"first","affiliation":[{"name":"Sharif University of Technology , , ,","place":["Tehran, Iran, 14588-89694"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reza","family":"Alizadeh","sequence":"additional","affiliation":[{"name":"Sharif University of Technology , , ,","place":["Tehran, Iran, 14588-89694"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahboubeh","family":"Bohlouli","sequence":"additional","affiliation":[{"name":"Shahid Beheshti University of Medical Sciences , , ,","place":["Tehran, Iran, 19689-17313"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0458-3293","authenticated-orcid":true,"given":"Juan P.","family":"Ferna\u0301ndez-Bla\u0301zquez","sequence":"additional","affiliation":[{"name":"IMDEA Materials Institute , c\/Eric Kandel 2 , , ,","place":["Getafe, Madrid, Spain, 28906"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,7,16]]},"reference":[{"issue":"7","key":"2026081008083411300_cit1","doi-asserted-by":"publisher","first-page":"518","DOI":"10.1038\/nmat1421","article-title":"Porous\nScaffold Design for Tissue Engineering","volume":"4","author":"Hollister","year":"2005","journal-title":"Nat.\nMater."},{"issue":"23","key":"2026081008083411300_cit2","doi-asserted-by":"publisher","first-page":"3303","DOI":"10.3390\/polym16233303","article-title":"Advances and Challenges in Polymer-Based Scaffolds\nfor Bone Tissue Engineering: A Path towards Personalized Regenerative\nMedicine","volume":"16","author":"Farjaminejad","year":"2024","journal-title":"Polymers"},{"issue":"4","key":"2026081008083411300_cit3","doi-asserted-by":"publisher","first-page":"398","DOI":"10.1002\/ar.1049","article-title":"From Wolff\u2019s\nLaw to the Utah Paradigm: Insights about Bone Physiology and Its Clinical\nApplications","volume":"262","author":"Frost","year":"2001","journal-title":"Anat. 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