{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T12:05:19Z","timestamp":1789387519104,"version":"build-2803163510"},"reference-count":56,"publisher":"American Chemical Society (ACS)","issue":"9","license":[{"start":{"date-parts":[[2026,8,8]],"date-time":"2026-08-08T00:00:00Z","timestamp":1786147200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,8,8]],"date-time":"2026-08-08T00:00:00Z","timestamp":1786147200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,8,8]],"date-time":"2026-08-08T00:00:00Z","timestamp":1786147200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,9,14]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Breast carcinoma is the most commonly diagnosed cancer and a leading cause of cancer-related death among women globally. Conventional treatments are limited by poor targeting, systemic toxicity, and susceptibility to secondary infections, highlighting the need for localized multifunctional therapeutic systems. This study aimed to develop poly(vinyl alcohol)-loaded madecassoside nanofibers (PVA@MAD) as a localized therapeutic platform for breast cancer treatment. Fabricated nanofibers exhibited spider-web-like architecture, swelling behavior, hydrophilicity, degradation, and sustained drug release (\u223c95% at 72 h under acidic conditions). PVA@MAD showed cytotoxicity against MDA-MB-231 cells, with an IC50 value of 49.31 \u00b1 0.010 \u03bcg\/mL, inducing ROS-mediated apoptosis and inhibiting cell migration, indicating antimetastatic potential. In addition, the nanofibers showed antibacterial activity against Staphylococcus aureus and Escherichia coli. Hemocompatibility, brine shrimp, acute, and subacute toxicity studies confirmed excellent biocompatibility. Overall, PVA@MAD nanofibers offer a promising localized therapeutic approach combining anticancer and antibacterial activities for improved breast cancer management.<\/jats:p>","DOI":"10.1021\/acs.biomac.6c00696","type":"journal-article","created":{"date-parts":[[2026,8,8]],"date-time":"2026-08-08T16:02:04Z","timestamp":1786204924000},"page":"5958-5975","source":"Crossref","is-referenced-by-count":0,"title":["Designing Single-Molecule\nNanofiber Therapeutics for\nBreast Cancer and Biofilm Suppression"],"prefix":"10.1021","volume":"27","author":[{"given":"Aishwarya","family":"Jayakumar","sequence":"first","affiliation":[{"name":"Alagappa University , , , ,","place":["Karaikudi, Tamil Nadu, India, 630 003"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arjun","family":"Velusamy","sequence":"additional","affiliation":[{"name":"Alagappa University , , , ,","place":["Karaikudi, Tamil Nadu, India, 630 003"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8880-000X","authenticated-orcid":true,"given":"Karuppuchamy","family":"Subbian","sequence":"additional","affiliation":[{"name":"Alagappa University , , , ,","place":["Karaikudi, Tamil Nadu, India, 630 003"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1273-8497","authenticated-orcid":true,"given":"Suganthy","family":"Natarajan","sequence":"additional","affiliation":[{"name":"Alagappa University , , , ,","place":["Karaikudi, Tamil Nadu, India, 630 003"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,8,8]]},"reference":[{"issue":"1","key":"2026091407071958400_cit1","doi-asserted-by":"publisher","DOI":"10.1038\/s41523-022-00468-0","article-title":"Triple Negative Breast Cancer: Pitfalls and Progress","volume":"8","author":"Zagami","year":"2022","journal-title":"npj Breast Cancer"},{"issue":"2","key":"2026091407071958400_cit2","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1038\/s41571-021-00565-2","article-title":"Treatment Landscape\nof Triple-Negative Breast Cancer \u2500 Expanded Options, Evolving\nNeeds","volume":"19","author":"Bianchini","year":"2022","journal-title":"Nat. Rev. Clin. Oncol."},{"issue":"7","key":"2026091407071958400_cit3","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0305222","article-title":"High Caveolin-1\nmRNA Expression in Triple-Negative\nBreast Cancer Is Associated with an Aggressive Tumor Microenvironment,\nChemoresistance, and Poor Clinical Outcome","volume":"19","author":"Godina","year":"2024","journal-title":"PLoS One"},{"issue":"9","key":"2026091407071958400_cit4","doi-asserted-by":"publisher","first-page":"1411","DOI":"10.1021\/acsbiomaterials.6b00281","article-title":"Fiber Based Approaches as Medicine\nDelivery Systems","volume":"2","author":"Sharifi","year":"2016","journal-title":"ACS Biomater. Sci. 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Macromol."},{"issue":"12","key":"2026091407071958400_cit28","doi-asserted-by":"publisher","DOI":"10.1007\/s12032-025-03092-7","article-title":"Essential Oil from\nTragopogon Dubius Selectively Inhibits Breast (MCF-7) and Glioblastoma\n(LN-18) Cancer Cell Proliferation; Insights into Antioxidant, Genoprotective\nPotential, and GCMS, GCGCTOFMS-Based Profiling","volume":"42","author":"Ahmad","year":"2025","journal-title":"Med. Oncol."},{"issue":"5","key":"2026091407071958400_cit29","doi-asserted-by":"publisher","first-page":"1812","DOI":"10.1007\/s12011-020-02304-7","article-title":"Apoptotic\nEffect and Anticancer Activity of Biosynthesized Silver Nanoparticles\nfrom Marine Algae Chaetomorpha Linum Extract Against Human Colon Cancer\nCell HCT-116","volume":"199","author":"Acharya","year":"2021","journal-title":"Biol. Trace Elem. 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J.\nPharm."},{"issue":"4","key":"2026091407071958400_cit32","doi-asserted-by":"publisher","first-page":"2847","DOI":"10.1021\/acsabm.4c01532","article-title":"Poly(Vinyl\nAlcohol)\/Polycaprolactone Nanofiber Enriched with Lichenysin against\nMultidrug-Resistance Bacterial Infection in Wound Healing: In Vitro\nStudies and In Vivo Evaluation in Wistar Rats","volume":"8","author":"Yadav","year":"2025","journal-title":"ACS Appl. Bio Mater."},{"key":"2026091407071958400_cit33","doi-asserted-by":"publisher","DOI":"10.1155\/2022\/5268613","article-title":"Evaluation\nof Dermal Toxicity and\nWound Healing Activity of Cnestis Ferruginea Vahl Ex DC","volume":"2022","author":"Ankomah","year":"2022","journal-title":"Adv. Pharmacol. Pharm. 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