{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T12:34:23Z","timestamp":1786365263956,"version":"build-2736575974"},"reference-count":32,"publisher":"American Chemical Society (ACS)","issue":"8","license":[{"start":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T00:00:00Z","timestamp":1784592000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T00:00:00Z","timestamp":1784592000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T00:00:00Z","timestamp":1784592000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/501100013770","name":"Beihua University","doi-asserted-by":"publisher","award":["[2024]024"],"award-info":[{"award-number":["[2024]024"]}],"id":[{"id":"10.13039\/501100013770","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013061","name":"Jilin Provincial Scientific and Technological Development Program","doi-asserted-by":"publisher","award":["20220402072GH"],"award-info":[{"award-number":["20220402072GH"]}],"id":[{"id":"10.13039\/501100013061","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100015800","name":"Jilin Province Development and Reform Commission","doi-asserted-by":"publisher","award":["2021C036-9"],"award-info":[{"award-number":["2021C036-9"]}],"id":[{"id":"10.13039\/100015800","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Innovation and Entrepreneurship Training Program for Chinese College Students","award":["202410201178"],"award-info":[{"award-number":["202410201178"]}]},{"name":"Innovation and Entrepreneurship Training Program for Chinese College Students","award":["202510201002"],"award-info":[{"award-number":["202510201002"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,8,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Severe microenvironmental imbalance in diabetic wounds infected with drug-resistant bacteria, a clinically prevalent issue yet often overlooked as a distinct pathological entity, results in a lack of coordinated multidimensional regulation of the wound microenvironment, which remains largely underexplored in current studies. Herein, we report a pH\/ROS-responsive multifunctional hydrogel (G@Ru) incorporating RuNPs. G@Ru is constructed via dynamic Schiff base and boronate ester linkages, which endow it with dual stimulus responsiveness, injectability, adhesiveness, self-healing, and hemostatic properties. In addition, the intrinsic antibacterial activity of RuNPs enables the inhibition of methicillin-resistant Staphylococcus aureus. Furthermore, in vivo studies confirm that G@Ru can regulate macrophage polarization, modulate reactive oxygen species levels, enhance cell proliferation, stimulate angiogenesis, and accelerate tissue regeneration, thereby reshaping the wound microenvironment in a multidimensional manner. Ultimately, G@Ru exhibits superior therapeutic efficacy, achieving a wound closure rate of 98% in infected diabetic wounds by day 14, highlighting its antibiotic-free therapeutic potential and promising clinical translational applications.<\/jats:p>","DOI":"10.1021\/acs.biomac.6c00727","type":"journal-article","created":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T01:24:21Z","timestamp":1784683461000},"page":"5432-5448","source":"Crossref","is-referenced-by-count":0,"title":["Ruthenium Dioxide-Incorporated\nDual-Responsive Hydrogel\nPromotes MRSA-Infected Diabetic Wound Healing via Microenvironment\nRemodeling"],"prefix":"10.1021","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-8939-6941","authenticated-orcid":true,"given":"Rongrong","family":"Li","sequence":"first","affiliation":[{"name":"Beihua University , , ,","place":["Jilin, China, 132013"]},{"name":"Beihua University , , ,","place":["Jilin, China, 132013"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-8142-1689","authenticated-orcid":true,"given":"Shangbo","family":"Zhang","sequence":"additional","affiliation":[{"name":"Beihua University , , ,","place":["Jilin, China, 132013"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zan","family":"Wang","sequence":"additional","affiliation":[{"name":"Beihua University , , ,","place":["Jilin, China, 132013"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junlei","family":"He","sequence":"additional","affiliation":[{"name":"Beihua University , , ,","place":["Jilin, China, 132013"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue","family":"Zhao","sequence":"additional","affiliation":[{"name":"Beihua University , , ,","place":["Jilin, China, 132013"]},{"name":"Beihua University , , ,","place":["Jilin, China, 132013"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongchao","family":"Liu","sequence":"additional","affiliation":[{"name":"Beihua University , , ,","place":["Jilin, China, 132013"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liyuan","family":"Sun","sequence":"additional","affiliation":[{"name":"Beihua University , , ,","place":["Jilin, China, 132013"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianbin","family":"Li","sequence":"additional","affiliation":[{"name":"Beihua University , , ,","place":["Jilin, China, 132013"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiahao","family":"Liu","sequence":"additional","affiliation":[{"name":"Beihua University , , ,","place":["Jilin, China, 132013"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianshun","family":"Zhang","sequence":"additional","affiliation":[{"name":"Beihua University , , ,","place":["Jilin, China, 132013"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shidong","family":"Zhang","sequence":"additional","affiliation":[{"name":"Zhongke Juyan (Changchun) Biomedicine Co., Ltd. , ,","place":["Changchun, China, 130000"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ting","family":"Liu","sequence":"additional","affiliation":[{"name":"Zhongke Juyan (Jilin) Stem Cell Technology Co., Ltd. , ,","place":["Jilin, China, 132000"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianxi","family":"Song","sequence":"additional","affiliation":[{"name":"Beihua University , , ,","place":["Jilin, China, 132013"]},{"name":"Beihua University , , ,","place":["Jilin, China, 132013"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,7,21]]},"reference":[{"issue":"11","key":"2026081008085313100_cit1","doi-asserted-by":"publisher","first-page":"2417354","DOI":"10.1002\/adfm.202417354","article-title":"Photo-Responsive Nanozyme Disrupts\nBacterial Electron Transport Chain for Enhanced Anti-Biofilm Therapy","volume":"35","author":"Chen","year":"2025","journal-title":"Adv. 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Clin.\nMed."},{"key":"2026081008085313100_cit23","doi-asserted-by":"publisher","first-page":"120153","DOI":"10.1016\/j.carbpol.2022.120153","article-title":"Absorption,\nmetabolism, and functions of hyaluronic acid and its therapeutic prospects\nin combination with microorganisms: A review","volume":"299","author":"Zheng","year":"2023","journal-title":"Carbohydr. Polym."},{"key":"2026081008085313100_cit24","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1016\/j.addr.2017.07.014","article-title":"The good and the bad collagens of fibrosis \u2013\nTheir role in signaling and organ function","volume":"121","author":"Karsdal","year":"2017","journal-title":"Adv. Drug Delivery Rev."},{"issue":"1","key":"2026081008085313100_cit25","doi-asserted-by":"publisher","first-page":"5","DOI":"10.26502\/fccm.92920302","article-title":"Regulation\nof collagen I and collagen III in tissue\ninjury and regeneration","volume":"7","author":"Singh","year":"2023","journal-title":"Cardiol. Cardiovasc.\nMed."},{"key":"2026081008085313100_cit26","doi-asserted-by":"publisher","first-page":"794037","DOI":"10.3389\/fbioe.2022.794037","article-title":"Hyaluronic\nAcid Facilitates Angiogenesis\nof Endothelial Colony Forming Cell Combining With Mesenchymal Stem\nCell via CD44\/MicroRNA-139\u20135p Pathway","volume":"10","author":"Luo","year":"2022","journal-title":"Front. Bioeng. Biotechnol."},{"issue":"9","key":"2026081008085313100_cit27","doi-asserted-by":"publisher","DOI":"10.1002\/mabi.202500084","article-title":"Development of an Injectable\nSynergistically Crosslinked\nPolysaccharide Hydrogel with Antioxidant and Antibacterial Properties\nfor Promoting Wound Healing","volume":"25","author":"Li","year":"2025","journal-title":"Macromol. Biosci."},{"issue":"10","key":"2026081008085313100_cit28","doi-asserted-by":"publisher","first-page":"6814","DOI":"10.1021\/acs.biomac.4c01041","article-title":"Smart Hydrogel\nDressing Enhances\nthe Healing of Chronic Infectious Diabetic Wounds through Dual-Barrier\nDrug Delivery Action","volume":"25","author":"Li","year":"2024","journal-title":"Biomacromolecules"},{"issue":"4","key":"2026081008085313100_cit29","doi-asserted-by":"publisher","first-page":"524","DOI":"10.1631\/bdm.2400436","article-title":"Ultrasmall\nruthenium nanoparticles with enhanced and tunable multienzyme-like\nactivity for periodontitis treatment","volume":"8","author":"Shao","year":"2025","journal-title":"Bio-Des.\nManuf."},{"key":"2026081008085313100_cit30","doi-asserted-by":"publisher","first-page":"127121","DOI":"10.1016\/j.talanta.2024.127121","article-title":"A RuNPs-based multifunctional nanoplatform\nwith excellent dual enzyme-mimic activities for diabetes diagnosis,\ncancer cell elimination, and in vitro antibacterial","volume":"283","author":"Wang","year":"2025","journal-title":"Talanta"},{"issue":"3","key":"2026081008085313100_cit31","doi-asserted-by":"publisher","first-page":"a041779","DOI":"10.1101\/cshperspect.a041779","article-title":"Angiogenesis:\nBiology and Pathology, Second Edition","volume":"15","author":"Bielenberg","year":"2025","journal-title":"Cold\nSpring Harb. Perspect. Med."},{"issue":"19","key":"2026081008085313100_cit32","doi-asserted-by":"publisher","first-page":"4673","DOI":"10.1039\/D3TB02941G","article-title":"3D printing of Rg3-loaded\nhydrogel scaffolds: anti-inflammatory and scar-formation related collagen\ninhibitory effects for scar-free wound healing","volume":"12","author":"Wang","year":"2024","journal-title":"J. Mater. Chem. B"}],"container-title":["Biomacromolecules"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acs.biomac.6c00727","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/bomaf6\/article-pdf\/27\/8\/5432\/66106480\/acs.biomac.6c00727.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/pubs.acs.org\/bomaf6\/article-pdf\/27\/8\/5432\/66106480\/acs.biomac.6c00727.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T12:26:48Z","timestamp":1786364808000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/bomaf6\/article\/27\/8\/5432\/5225713\/Ruthenium-Dioxide-Incorporated-Dual-Responsive"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,21]]},"references-count":32,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2026,7,21]]},"published-print":{"date-parts":[[2026,8,10]]}},"URL":"https:\/\/doi.org\/10.1021\/acs.biomac.6c00727","relation":{},"ISSN":["1525-7797","1526-4602"],"issn-type":[{"value":"1525-7797","type":"print"},{"value":"1526-4602","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,21]]}}}