{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T11:54:38Z","timestamp":1787313278429,"version":"build-2736575974"},"reference-count":44,"publisher":"American Chemical Society (ACS)","issue":"8","license":[{"start":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T00:00:00Z","timestamp":1784160000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T00:00:00Z","timestamp":1784160000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T00:00:00Z","timestamp":1784160000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/501100015406","name":"Tianjin Municipal Science and Technology Bureau","doi-asserted-by":"publisher","award":["24JCQNJC01400"],"award-info":[{"award-number":["24JCQNJC01400"]}],"id":[{"id":"10.13039\/501100015406","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/na","name":"Postdoctoral Fellowship Program of CPSF","doi-asserted-by":"publisher","award":["GZC20241202"],"award-info":[{"award-number":["GZC20241202"]}],"id":[{"id":"10.13039\/na","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,8,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Diabetic skin injury is a serious clinical challenge due to impaired healing and infection. Here, we developed a sandcastle worm-inspired hydrogel featuring a phosphate\u2013catechol\u2013amine synergistic network based on a poly(acrylic acid-co-acrylamide) network, functionalized with dopamine-grafted cellulose nanofibers (DA-PCNF) and quaternized chitosan (QCS), to accelerate diabetic wound healing. The hydrogel exhibits strong tissue adhesion (78.82 \u00b1 2.55 kPa) and broad-spectrum antibacterial activity (99.67% killing of Escherichia coli and 99.55% killing of Staphylococcus aureus in vitro). More importantly, it exhibits pH-responsive swelling and adhesion behaviors, maintaining robust adhesion under mildly acidic wound conditions while attenuating adhesion under neutral conditions to facilitate atraumatic dressing removal. Antioxidant assays indicated that the hydrogel exhibits scavenging activity against various free radicals with efficiencies ranging from 30% to 40%, attributable to the catechol groups. In vivo application of the hydrogel to infected diabetic wounds significantly accelerated healing (99.82%, on day 12 after Pseudomonas aeruginosa-infected wound formation), with reduced inflammation and enhanced tissue regeneration. These findings demonstrate that the catechol\u2013nanocellulose\/chitosan polymeric hydrogel effectively overcomes adhesion, infection, and oxidative stress barriers in diabetic wound healing, making it a promising candidate for difficult-to-heal chronic ulcers.<\/jats:p>","DOI":"10.1021\/acs.biomac.6c00795","type":"journal-article","created":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T14:41:02Z","timestamp":1784212862000},"page":"5491-5504","source":"Crossref","is-referenced-by-count":1,"title":["Bioinspired Catechol-Nanocellulose\/Chitosan\nPolymeric\nHydrogel with Enhanced Wet Adhesion and Antibacterial Activity for\nDiabetic Wound Healing"],"prefix":"10.1021","volume":"27","author":[{"given":"Sihao","family":"Liu","sequence":"first","affiliation":[{"name":"Tianjin University , , ,","place":["Tianjin, PR China, 300072"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chengyu","family":"Zhang","sequence":"additional","affiliation":[{"name":"Tianjin University of Traditional Chinese Medicine , , ,","place":["Tianjin, China, 301617"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenyu","family":"Chen","sequence":"additional","affiliation":[{"name":"Tianjin University of Traditional Chinese Medicine , , ,","place":["Tianjin, China, 301617"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-9306-2166","authenticated-orcid":true,"given":"Heng","family":"Chang","sequence":"additional","affiliation":[{"name":"Tianjin University , , ,","place":["Tianjin, PR China, 300072"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7378-1392","authenticated-orcid":true,"given":"Wei","family":"Qi","sequence":"additional","affiliation":[{"name":"Tianjin University , , ,","place":["Tianjin, PR China, 300072"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0956-6046","authenticated-orcid":true,"given":"Yuefei","family":"Wang","sequence":"additional","affiliation":[{"name":"Tianjin University of Traditional Chinese Medicine , , ,","place":["Tianjin, China, 301617"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9778-9113","authenticated-orcid":true,"given":"Rongxin","family":"Su","sequence":"additional","affiliation":[{"name":"Tianjin University , , ,","place":["Tianjin, PR China, 300072"]},{"name":"Tianjin University , , ,","place":["Tianjin, PR China, 300072"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,7,16]]},"reference":[{"issue":"8","key":"2026081008084700600_cit1","doi-asserted-by":"publisher","first-page":"507","DOI":"10.1038\/s41579-024-01035-z","article-title":"The Wound Microbiota: Microbial Mechanisms\nof Impaired Wound Healing and Infection","volume":"22","author":"Uberoi","year":"2024","journal-title":"Nat.\nRev. 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Mater."},{"key":"2026081008084700600_cit5","doi-asserted-by":"publisher","first-page":"446","DOI":"10.1016\/j.bioactmat.2022.03.033","article-title":"A Facile and\nGeneral Method for Synthesis of Antibiotic-Free\nProtein-Based Hydrogel: Wound Dressing for the Eradication of Drug-Resistant\nBacteria and Biofilms","volume":"18","author":"Ouyang","year":"2022","journal-title":"Bioact. 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