{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T15:49:00Z","timestamp":1791820140975,"version":"4.3.4"},"reference-count":61,"publisher":"American Chemical Society (ACS)","issue":"10","license":[{"start":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T00:00:00Z","timestamp":1790380800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T00:00:00Z","timestamp":1790380800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T00:00:00Z","timestamp":1790380800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,10,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Inspired by the DNA-cleaving potency of natural enediynes such as calicheamicin, we report the design and synthesis of maleimide\u2212enediyne conjugates integrated into poly(\u03b5-caprolactone) (PCL) as a next-generation platform for anticancer drug delivery. Maleimide-based enediynes typically suffer from poor aqueous solubility and nonspecific toxicity, addressed here by covalently incorporating enediyne groups into amphiphilic PCL block copolymers via post-polymerization functionalization. The resulting polymers form \u223c120 nm spherical micelles with a critical micelle concentration of 9.1 \u00d7 10\u22124 mg mL\u22121, enhancing enediyne solubility, promoting tumor accumulation through the EPR effect, and enabling encapsulation of hydrophobic drugs such as doxorubicin. Electron paramagnetic resonance confirmed radical formation and Bergman cyclization under physiological conditions. Cell viability assays showed enediyne-induced death in MDA-MB-231 breast cancer cells, and the functionalized PCL exhibited in vitro DNA cleaving activity, demonstrating that maleimide\u2212enediyne-functionalized PCL micelles are promising platforms for cancer chemotherapy.<\/jats:p>","DOI":"10.1021\/acs.biomac.6c00893","type":"journal-article","created":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T18:02:11Z","timestamp":1790445731000},"page":"6447-6461","source":"Crossref","is-referenced-by-count":0,"title":["Engineering Poly(\u03b5-caprolactone)-Based Maleimide\u2212Enediyne Micelles for Next-Generation Anticancer Therapies"],"prefix":"10.1021","volume":"27","author":[{"given":"Abhi","family":"Bhadran","sequence":"first","affiliation":[{"name":"University of Texas at Dallas , , , ,","place":["Richardson, Texas, United States, 75080"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Godwin K.","family":"Babanyinah","sequence":"additional","affiliation":[{"name":"University of Texas at Dallas , , , ,","place":["Richardson, Texas, United States, 75080"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6313-9518","authenticated-orcid":true,"given":"Himanshu","family":"Polara","sequence":"additional","affiliation":[{"name":"University of Texas at Dallas , , , ,","place":["Richardson, Texas, United States, 75080"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashutosh","family":"Shrivastava","sequence":"additional","affiliation":[{"name":"University of Texas at Dallas , , , ,","place":["Richardson, Texas, United States, 75080"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Orikeda","family":"Trashi","sequence":"additional","affiliation":[{"name":"University of Texas at Dallas , , , ,","place":["Richardson, Texas, United States, 75080"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rhiza Lyne","family":"Villone","sequence":"additional","affiliation":[{"name":"University of Texas at Dallas , , , ,","place":["Richardson, Texas, United States, 75080"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mai Phuong","family":"Vu","sequence":"additional","affiliation":[{"name":"University of Texas at Dallas , , , ,","place":["Richardson, Texas, United States, 75080"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4976-1401","authenticated-orcid":true,"given":"Gabriele","family":"Meloni","sequence":"additional","affiliation":[{"name":"University of Texas at Dallas , , , ,","place":["Richardson, Texas, United States, 75080"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6400-8106","authenticated-orcid":true,"given":"Jeremiah J.","family":"Gassensmith","sequence":"additional","affiliation":[{"name":"University of Texas at Dallas , , , ,","place":["Richardson, Texas, United States, 75080"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5249-6341","authenticated-orcid":true,"given":"Michael C.","family":"Biewer","sequence":"additional","affiliation":[{"name":"University of Texas at Dallas , , , ,","place":["Richardson, Texas, United States, 75080"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2475-4635","authenticated-orcid":true,"given":"Mihaela C.","family":"Stefan","sequence":"additional","affiliation":[{"name":"University of Texas at Dallas , , , ,","place":["Richardson, Texas, United States, 75080"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,9,26]]},"reference":[{"issue":"3","key":"2026101210513168300_cit1","doi-asserted-by":"publisher","first-page":"209","DOI":"10.3322\/caac.21660","article-title":"Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"71","author":"Sung","year":"2021","journal-title":"Ca-Cancer J. Clin."},{"issue":"1","key":"2026101210513168300_cit2","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1038\/s41392-024-01856-7","article-title":"Exploring treatment options in cancer: tumor treatment strategies","volume":"9","author":"Liu","year":"2024","journal-title":"Signal Transduction Targeted Ther."},{"issue":"4","key":"2026101210513168300_cit3","doi-asserted-by":"publisher","first-page":"1367","DOI":"10.1016\/j.gendis.2022.02.007","article-title":"Cancer chemotherapy and beyond: Current status, drug candidates, associated risks and progress in targeted therapeutics","volume":"10","author":"Anand","year":"2023","journal-title":"Genes Dis."},{"issue":"3","key":"2026101210513168300_cit4","doi-asserted-by":"publisher","first-page":"507","DOI":"10.1007\/s00262-021-03013-3","article-title":"Chemotherapy: a double-edged sword in cancer treatment","volume":"71","author":"Behranvand","year":"2022","journal-title":"Cancer Immunol., Immunother."},{"issue":"8","key":"2026101210513168300_cit5","doi-asserted-by":"publisher","DOI":"10.1002\/cam4.7190","article-title":"An empirical analysis of overall survival in drug approvals by the US FDA (2006\u22122023)","volume":"13","author":"Elbaz","year":"2024","journal-title":"Cancer Med."},{"issue":"6","key":"2026101210513168300_cit6","doi-asserted-by":"publisher","first-page":"760","DOI":"10.1016\/s1470-2045(24)00152-9","article-title":"Overall survival benefits of cancer drugs initially approved by the US Food and Drug Administration on the basis of immature survival data: a retrospective analysis","volume":"25","author":"Naci","year":"2024","journal-title":"Lancet Oncol."},{"issue":"3","key":"2026101210513168300_cit7","doi-asserted-by":"publisher","first-page":"627","DOI":"10.3390\/cancers14030627","article-title":"Chemotherapy side-effects: not all DNA damage is equal","volume":"14","author":"van den Boogaard","year":"2022","journal-title":"Cancers"},{"issue":"1","key":"2026101210513168300_cit8","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1038\/s41392-021-00572-w","article-title":"Small molecules in targeted cancer therapy: advances, challenges, and future perspectives","volume":"6","author":"Zhong","year":"2021","journal-title":"Signal Transduction Targeted Ther."},{"issue":"8","key":"2026101210513168300_cit9","doi-asserted-by":"publisher","first-page":"623","DOI":"10.1080\/1120009x.2023.2300217","article-title":"Mechanisms underlying dose-limiting toxicities of conventional chemotherapeutic agents","volume":"36","author":"Manavi","year":"2024","journal-title":"J. Chemother."},{"issue":"19","key":"2026101210513168300_cit10","doi-asserted-by":"publisher","first-page":"6645","DOI":"10.1039\/c8dt00838h","article-title":"The side effects of platinum-based chemotherapy drugs: a review for chemists","volume":"47","author":"Oun","year":"2018","journal-title":"Dalton Trans."},{"issue":"14","key":"2026101210513168300_cit11","doi-asserted-by":"publisher","first-page":"2303","DOI":"10.3390\/cancers17142303","article-title":"Advances in Doxorubicin Chemotherapy: Emerging Polymeric Nanocarriers for Drug Loading and Delivery","volume":"17","author":"Bhadran","year":"2025","journal-title":"Cancers"},{"issue":"9","key":"2026101210513168300_cit12","doi-asserted-by":"publisher","first-page":"1445","DOI":"10.1517\/14712598.4.9.1445","article-title":"Tumour-targeted chemotherapy with immunoconjugates of calicheamicin","volume":"4","author":"Damle","year":"2004","journal-title":"Expert Opin. Biol. Ther."},{"issue":"2","key":"2026101210513168300_cit13","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1016\/j.molimm.2014.09.014","article-title":"Preclinical and clinical development of inotuzumab-ozogamicin in hematological malignancies","volume":"67","author":"Shor","year":"2015","journal-title":"Mol. Immunol."},{"issue":"16","key":"2026101210513168300_cit14","doi-asserted-by":"publisher","first-page":"3195","DOI":"10.1039\/c4tb02018a","article-title":"Maleimide-based acyclic enediyne for efficient DNA-cleavage and tumor cell suppression","volume":"3","author":"Song","year":"2015","journal-title":"J. Mater. Chem. B"},{"issue":"1","key":"2026101210513168300_cit15","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1039\/c8tb02367k","article-title":"Self-delivery nanoparticles of an amphiphilic irinotecan-enediyne conjugate for cancer combination chemotherapy","volume":"7","author":"Li","year":"2019","journal-title":"J. Mater. Chem. B"},{"issue":"8","key":"2026101210513168300_cit16","doi-asserted-by":"publisher","first-page":"3142","DOI":"10.1073\/pnas.90.8.3142","article-title":"Cell-specific regulation of apoptosis by designed enediynes","volume":"90","author":"Nicolaou","year":"1993","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"11","key":"2026101210513168300_cit17","doi-asserted-by":"publisher","first-page":"1387","DOI":"10.1002\/anie.199113873","article-title":"Chemistry and Biology of the Enediyne Anticancer Antibiotics","volume":"30","author":"Nicolaou","year":"1991","journal-title":"Angew. Chem., Int. Ed. Engl."},{"issue":"5060","key":"2026101210513168300_cit18","doi-asserted-by":"publisher","first-page":"1172","DOI":"10.1126\/science.256.5060.1172","article-title":"Designed enediynes: a new class of DNA-cleaving molecules with potent and selective anticancer activity","volume":"256","author":"Nicolaou","year":"1992","journal-title":"Sci."},{"issue":"11","key":"2026101210513168300_cit19","doi-asserted-by":"publisher","first-page":"2103","DOI":"10.1021\/jm9600398","article-title":"The enediyne antibiotics","volume":"39","author":"Smith","year":"1996","journal-title":"J. Med. Chem."},{"issue":"18","key":"2026101210513168300_cit20","doi-asserted-by":"publisher","first-page":"7944","DOI":"10.1021\/ja00071a003","article-title":"Molecular design, chemical synthesis, kinetic studies, calculations, and biological studies of novel enediynes equipped with triggering, detection, and deactivating devices. Model dynemicin A epoxide and cis-diol systems","volume":"115","author":"Nicolaou","year":"2002","journal-title":"J. Am. Chem. Soc."},{"issue":"24","key":"2026101210513168300_cit21","doi-asserted-by":"publisher","first-page":"9279","DOI":"10.1021\/ja00050a006","article-title":"Redox-controlled Bergman cycloaromatizations. Designed enediynes with DNA-cleaving properties and antitumor activity","volume":"114","author":"Nicolaou","year":"2002","journal-title":"J. Am. Chem. Soc."},{"issue":"19","key":"2026101210513168300_cit22","doi-asserted-by":"publisher","first-page":"7360","DOI":"10.1021\/ja00045a005","article-title":"Design, synthesis, and study of simple monocyclic conjugated enediynes. The 10-membered ring enediyne moiety of the enediyne anticancer antibiotics","volume":"114","author":"Nicolaou","year":"2002","journal-title":"J. Am. Chem. Soc."},{"issue":"6","key":"2026101210513168300_cit23","doi-asserted-by":"publisher","first-page":"1112","DOI":"10.1158\/1535-7163.mct-20-0035","article-title":"Calicheamicin antibody\u2212drug conjugates with improved properties","volume":"20","author":"Vollmar","year":"2021","journal-title":"Mol. Cancer Ther."},{"key":"2026101210513168300_cit24","doi-asserted-by":"publisher","first-page":"2229101","DOI":"10.1080\/19420862.2023.2229101","article-title":"Exploration of the antibody\u2212drug conjugate clinical landscape","volume":"15","author":"Maecker","year":"2023","journal-title":"mAbs"},{"issue":"37","key":"2026101210513168300_cit25","doi-asserted-by":"publisher","first-page":"25416","DOI":"10.1021\/jacs.4c07754","article-title":"Tunable and Photoactivatable Mimics of Calicheamicin \u03b31 for DNA Cleavage","volume":"146","author":"Ben-Zvi","year":"2024","journal-title":"J. Am. Chem. Soc."},{"issue":"33","key":"2026101210513168300_cit26","doi-asserted-by":"publisher","first-page":"11929","DOI":"10.1073\/pnas.0403799101","article-title":"The essence of total synthesis","volume":"101","author":"Nicolaou","year":"2004","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"9","key":"2026101210513168300_cit27","doi-asserted-by":"publisher","first-page":"1421","DOI":"10.1039\/a605837j","article-title":"Synthesis of the aromatic unit of calicheamicin \u03b31I","volume":"1","author":"Hu","year":"1997","journal-title":"J. Chem. Soc., Perkin Trans. 1"},{"issue":"43","key":"2026101210513168300_cit28","doi-asserted-by":"publisher","first-page":"8584","DOI":"10.1039\/c5tb01867f","article-title":"An acyclic enediyne with a furyl tethering group for efficient inhibition of tumor cell viability","volume":"3","author":"Song","year":"2015","journal-title":"J. Mater. Chem. B"},{"key":"2026101210513168300_cit29","doi-asserted-by":"publisher","first-page":"138899","DOI":"10.1016\/j.cplett.2021.138899","article-title":"Intermolecular proton transfer assisted 1,4-Michael addition for enediyne conversion to enyne-allene","volume":"780","author":"Ding","year":"2021","journal-title":"Chem. Phys. Lett."},{"issue":"23","key":"2026101210513168300_cit30","doi-asserted-by":"publisher","first-page":"7069","DOI":"10.1002\/slct.202001282","article-title":"Preparation of Maleimide-Based Enediynes with Propargyl Ester for Efficient Tumor Cell Suppression","volume":"5","author":"Chen","year":"2020","journal-title":"ChemistrySelect"},{"issue":"3","key":"2026101210513168300_cit31","doi-asserted-by":"publisher","first-page":"622","DOI":"10.3390\/cancers14030622","article-title":"Targeted delivery methods for anticancer drugs","volume":"14","author":"Veselov","year":"2022","journal-title":"Cancers"},{"issue":"7","key":"2026101210513168300_cit32","doi-asserted-by":"publisher","first-page":"1977","DOI":"10.3390\/pharmaceutics15071977","article-title":"Recent advances in polycaprolactones for anticancer drug delivery","volume":"15","author":"Bhadran","year":"2023","journal-title":"Pharmaceutics"},{"issue":"13","key":"2026101210513168300_cit33","doi-asserted-by":"publisher","first-page":"2369","DOI":"10.1039\/c4py01628a","article-title":"Recent developments in micellar drug carriers featuring substituted poly(\u03b5-caprolactone)s","volume":"6","author":"Rainbolt","year":"2015","journal-title":"Polym. Chem."},{"issue":"2","key":"2026101210513168300_cit34","doi-asserted-by":"publisher","first-page":"743","DOI":"10.1021\/acsbiomaterials.2c01201","article-title":"Structural Engineering of Star Block Biodegradable Polymer Unimolecular Micelles for Drug Delivery in Cancer Cells","volume":"9","author":"Pranav","year":"2023","journal-title":"ACS Biomater. Sci. Eng."},{"issue":"12","key":"2026101210513168300_cit35","doi-asserted-by":"publisher","first-page":"3484","DOI":"10.1039\/b820162p","article-title":"Synthesis of polycaprolactone: a review","volume":"38","author":"Labet","year":"2009","journal-title":"Chem. Soc. Rev."},{"key":"2026101210513168300_cit36","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1002\/0471440264.pst658","article-title":"Polycaprolactone: Synthesis, Properties, and Applications","author":"Guarino","year":"2017","journal-title":"Encycl. Polym. Sci. Technol."},{"key":"2026101210513168300_cit37","doi-asserted-by":"publisher","first-page":"774","DOI":"10.1080\/00222348.2025.2468118","article-title":"Advancing Structure-Property Insights of Poly (Lactic-co-Glycolic Acids): A Mini Review on the Biodegradable Polymers Applications in Drug Delivery","volume":"65","author":"Thakkar","year":"2025","journal-title":"J. Macromol. Sci., Part B:Phys."},{"issue":"9","key":"2026101210513168300_cit38","doi-asserted-by":"publisher","first-page":"1779","DOI":"10.1039\/c4tb02016b","article-title":"Fine-tuning thermoresponsive functional poly(epsilon-caprolactone)s to enhance micelle stability and drug loading","volume":"3","author":"Rainbolt","year":"2015","journal-title":"J. Mater. Chem. B"},{"issue":"12","key":"2026101210513168300_cit39","doi-asserted-by":"publisher","first-page":"5823","DOI":"10.1021\/acs.biomac.3c00832","article-title":"Reversible Cross-linked Thermoresponsive Polycaprolactone Micelles for Enhanced Stability and Controlled Release","volume":"24","author":"Bhadran","year":"2023","journal-title":"Biomacromolecules"},{"issue":"7","key":"2026101210513168300_cit40","doi-asserted-by":"publisher","first-page":"2163","DOI":"10.1021\/bm300823y","article-title":"Thermally controlled release of anticancer drug from self-assembled gamma-substituted amphiphilic poly(epsilon-caprolactone) micellar nanoparticles","volume":"13","author":"Cheng","year":"2012","journal-title":"Biomacromolecules"},{"key":"2026101210513168300_cit41","doi-asserted-by":"publisher","first-page":"105219","DOI":"10.1016\/j.jmbbm.2022.105219","article-title":"Mechanical properties of polycaprolactone (PCL) scaffolds for hybrid 3D-bioprinting with alginate-gelatin hydrogel","volume":"130","author":"Koch","year":"2022","journal-title":"J. Mech. Behav. Biomed. Mater."},{"issue":"4","key":"2026101210513168300_cit42","doi-asserted-by":"publisher","first-page":"1427","DOI":"10.1021\/acs.biomac.9b01742","article-title":"Enhancement of loading efficiency by coloading of doxorubicin and quercetin in thermoresponsive polymeric micelles","volume":"21","author":"Soltantabar","year":"2020","journal-title":"Biomacromolecules"},{"key":"2026101210513168300_cit43","doi-asserted-by":"publisher","first-page":"1356639","DOI":"10.3389\/fphar.2024.1356639","article-title":"Effect of aromatic substituents on thermoresponsive functional polycaprolactone micellar carriers for doxorubicin delivery","volume":"15","author":"Wang","year":"2024","journal-title":"Front. Pharmacol."},{"issue":"11","key":"2026101210513168300_cit44","doi-asserted-by":"publisher","first-page":"2106","DOI":"10.1039\/c6tb03038f","article-title":"HDAC Inhibitor Conjugated Polymeric Prodrug Micelles for Doxorubicin Delivery","volume":"5","author":"Senevirathne","year":"2017","journal-title":"J. Mater. Chem. B"},{"issue":"24","key":"2026101210513168300_cit45","doi-asserted-by":"publisher","first-page":"3544","DOI":"10.1039\/d1py00483b","article-title":"Self-assembly behavior of oligo(ethylene glycol) substituted polycaprolactone homopolymers","volume":"12","author":"Calubaquib","year":"2021","journal-title":"Polym. Chem."},{"issue":"29","key":"2026101210513168300_cit46","doi-asserted-by":"publisher","first-page":"10623","DOI":"10.1039\/c1jm11288k","article-title":"Temperature-sensitive aliphatic polyesters: synthesis and characterization of \u03b3-substituted caprolactone monomers and polymers","volume":"21","author":"Hao","year":"2011","journal-title":"J. Mater. Chem."},{"issue":"22","key":"2026101210513168300_cit47","doi-asserted-by":"publisher","first-page":"4502","DOI":"10.1039\/d1tb00142f","article-title":"Synthesis of maleimide-based enediynes with cyclopropane moieties for enhanced cytotoxicity under normoxic and hypoxic conditions","volume":"9","author":"Wang","year":"2021","journal-title":"J. Mater. Chem. B"},{"key":"2026101210513168300_cit48","doi-asserted-by":"publisher","first-page":"127353","DOI":"10.1016\/j.talanta.2024.127353","article-title":"Visual and real-time detection of the critical micelle concentration of nonionic surfactants using a supramolecular aggregate probe responsive to stable micelles","volume":"285","author":"Cai","year":"2025","journal-title":"Talanta"},{"issue":"26","key":"2026101210513168300_cit49","doi-asserted-by":"publisher","first-page":"9987","DOI":"10.1039\/d4sc01625d","article-title":"Maleimide functionalized polycaprolactone micelles for glutathione quenching and doxorubicin delivery","volume":"15","author":"Babanyinah","year":"2024","journal-title":"Chem. Sci."},{"issue":"15","key":"2026101210513168300_cit50","doi-asserted-by":"publisher","first-page":"9808","DOI":"10.1021\/acs.joc.0c01124","article-title":"Triggering the Antitumor Activity of Acyclic Enediyne through Maleimide-Assisted Rearrangement and Cycloaromatization","volume":"85","author":"Zhang","year":"2020","journal-title":"Am. J. Org. Chem."},{"issue":"2","key":"2026101210513168300_cit51","doi-asserted-by":"publisher","first-page":"593","DOI":"10.1158\/0008-5472.can-08-2753","article-title":"C-1027, a radiomimetic enediyne anticancer drug, preferentially targets hypoxic cells","volume":"69","author":"Beerman","year":"2009","journal-title":"Cancer Res."},{"key":"2026101210513168300_cit52","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1016\/j.dnarep.2014.06.001","article-title":"The radiomimetic enediyne, 20\u2032-deschloro-C-1027 induces inter-strand DNA crosslinks in hypoxic cells and overcomes cytotoxic radioresistance","volume":"21","author":"Beerman","year":"2014","journal-title":"DNA Repair"},{"issue":"10","key":"2026101210513168300_cit53","doi-asserted-by":"publisher","first-page":"2187","DOI":"10.1002\/pola.23988","article-title":"Formation of conjugated polynaphthalene via Bergman cyclization","volume":"48","author":"Miao","year":"2010","journal-title":"J. Polym. Sci. Part A:Polym. Chem."},{"issue":"23","key":"2026101210513168300_cit54","doi-asserted-by":"publisher","first-page":"4352","DOI":"10.1002\/asia.201901182","article-title":"Coordination-Accelerated Radical Formation from Acyclic Enediynes for Tumor Cell Suppression","volume":"14","author":"Li","year":"2019","journal-title":"Chem. - Asian J."},{"issue":"23","key":"2026101210513168300_cit55","doi-asserted-by":"publisher","first-page":"3412","DOI":"10.1039\/d2py00259k","article-title":"Bergman cyclization of main-chain enediyne polymers for enhanced DNA cleavage","volume":"13","author":"Cai","year":"2022","journal-title":"Polym. Chem."},{"issue":"4","key":"2026101210513168300_cit56","doi-asserted-by":"publisher","first-page":"514","DOI":"10.1039\/d2py01444k","article-title":"Self-assembly behavior of thermoresponsive difunctionalized \u03b3-amide polycaprolactone amphiphilic diblock copolymers","volume":"14","author":"Wang","year":"2023","journal-title":"Polym. Chem."},{"issue":"5","key":"2026101210513168300_cit57","doi-asserted-by":"publisher","first-page":"3213","DOI":"10.1021\/acs.biomac.5c00280","article-title":"Improved Drug Delivery through Amide-Functionalized Polycaprolactones: Enhanced Loading Capacity and Sustained Drug Release","volume":"26","author":"Polara","year":"2025","journal-title":"Biomacromolecules"},{"key":"2026101210513168300_cit58","doi-asserted-by":"publisher","first-page":"501","DOI":"10.1016\/b978-0-08-101997-9.00022-9","article-title":"Stimuli-responsive poly (\u03b5-caprolactone)s for drug delivery applications","volume":"1","author":"Washington","year":"2018","journal-title":"Stimuli Responsive Polym. Nanocarriers Drug Delivery Appl."},{"issue":"3","key":"2026101210513168300_cit59","doi-asserted-by":"publisher","first-page":"192092","DOI":"10.1098\/rsos.192092","article-title":"Influence factors on the critical micelle concentration determination using pyrene as a probe and a simple method of preparing samples","volume":"7","author":"Li","year":"2020","journal-title":"R. Soc. Open Sci."},{"issue":"7","key":"2026101210513168300_cit60","doi-asserted-by":"publisher","first-page":"1254","DOI":"10.1021\/acs.bioconjchem.2c00144","article-title":"Preparation of Maleimide-Modified Oligonucleotides from the Corresponding Amines Using N-Methoxycarbonylmaleimide","volume":"33","author":"Kjaersgaard","year":"2022","journal-title":"Bioconjugate Chem."},{"key":"2026101210513168300_cit61","doi-asserted-by":"publisher","first-page":"114449","DOI":"10.1016\/j.addr.2022.114449","article-title":"Strategies to enhance drug delivery to solid tumors by harnessing the EPR effects and alternative targeting mechanisms","volume":"188","author":"Zi","year":"2022","journal-title":"Adv. Drug Delivery Rev."}],"container-title":["Biomacromolecules"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acs.biomac.6c00893","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/bomaf6\/article-pdf\/27\/10\/6447\/68667817\/bm6c00893.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/pubs.acs.org\/bomaf6\/article-pdf\/27\/10\/6447\/68667817\/bm6c00893.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T15:09:17Z","timestamp":1791817757000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/bomaf6\/article\/27\/10\/6447\/5439417\/Engineering-Poly-caprolactone-Based-Maleimide"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,26]]},"references-count":61,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2026,9,26]]},"published-print":{"date-parts":[[2026,10,12]]}},"URL":"https:\/\/doi.org\/10.1021\/acs.biomac.6c00893","relation":{},"ISSN":["1525-7797","1526-4602"],"issn-type":[{"value":"1525-7797","type":"print"},{"value":"1526-4602","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,26]]}}}