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Herein, we identified dextran from screening different polysaccharides and synthetic polymers as an ideal ice-crystal modifier for protein amyloid fibril-polyphenol hydrogels. Formation of the ternary composite hydrogel and F\u2013T resistance were positively dependent on dextran molecular weight and concentration, with a tolerance for exceeding 50 times F\u2013T cycles. Low-temperature differential scanning calorimetry (DSC) and ice-crystal observation showed reduced freezable water and restricted ice growth in hydrogels, while rheology and microstructure characterization revealed enhanced strength and a denser, more uniform porous network after F\u2013T treatment. These improvements were attributed to dextran-mediated network confinement, which imposed strong constraints on ice formation and growth. Furthermore, the hydrogel retained in vitro and in vivo anti-inflammatory activities with high biocompatibility. This work provided a polysaccharide-modulated ice templating for hydrogel engineering in bioactive delivery.<\/jats:p>","DOI":"10.1021\/acs.biomac.6c00906","type":"journal-article","created":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T14:05:33Z","timestamp":1785852333000},"page":"6044-6057","source":"Crossref","is-referenced-by-count":0,"title":["Dextran-Mediated\nControl of Ice Crystallization in\nPolyphenol-Protein Fibril Networks for Freeze\u2013Thawing-Stable\nHydrogels with Anti-Inflammatory Activity"],"prefix":"10.1021","volume":"27","author":[{"given":"Mengyao","family":"Sun","sequence":"first","affiliation":[{"name":"Nanjing Agricultural University , , , ,","place":["Nanjing, Jiangsu, China, 211800"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Zhao","sequence":"additional","affiliation":[{"name":"Nanjing Agricultural University , , , ,","place":["Nanjing, Jiangsu, China, 211800"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiqi","family":"Bai","sequence":"additional","affiliation":[{"name":"Nanjing Agricultural University , , , ,","place":["Nanjing, Jiangsu, China, 211800"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siying","family":"Cheng","sequence":"additional","affiliation":[{"name":"Nanjing Agricultural University , , , ,","place":["Nanjing, Jiangsu, China, 211800"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9983-8927","authenticated-orcid":true,"given":"Salvatore","family":"Assenza","sequence":"additional","affiliation":[{"name":"Universidad Auto\u0301noma de Madrid , , ,","place":["Madrid, Spain, 28049"]},{"name":"Universidad Auto\u0301noma de Madrid , , ,","place":["Madrid, Spain, 28049"]},{"name":"Universidad Auto\u0301noma de Madrid , , ,","place":["Madrid, Spain, 28049"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6563-531X","authenticated-orcid":true,"given":"Bing","family":"Hu","sequence":"additional","affiliation":[{"name":"Nanjing Agricultural University , , , ,","place":["Nanjing, Jiangsu, China, 211800"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,8,1]]},"reference":[{"issue":"1","key":"2026091407071441200_cit1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-023-43334-8","article-title":"Ultra-Durable Cell-Free Bioactive\nHydrogel with Fast Shape Memory and On-Demand Drug Release for Cartilage\nRegeneration","volume":"14","author":"Yang","year":"2023","journal-title":"Nat. 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