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Here, we report ternary nanoparticles formed by sequential complexation of aquated cisplatin with fucoidan, followed by stabilization with biodegradable cationic bis-MPA dendrimers. Fucoidan extracted from Fucus vesiculosus and Undaria pinnatifida, despite their differences in composition and structure, generated nanoparticles with comparable size, surface charge, and drug content. Both systems displayed pH-responsive cisplatin release, consistent with reversible interactions between platinum aqua species and fucoidan sulfate groups. The nanoparticles preserved cisplatin\u2019s cytotoxic activity in T98G and patient-derived glioblastoma cells and showed enhanced early intracellular platinum accumulation relative to free cisplatin. Hemocompatibility assays confirmed minimal hemolysis and no detectable impact on plasma coagulation. The nanoparticles also remained structurally stable after cryopreservation with 5% sucrose. These results identify fucoidan-cisplatin-dendrimer nanoparticles as a robust and biocompatible macromolecular platform for controlled delivery of platinum-based therapeutics.<\/jats:p>","DOI":"10.1021\/acs.biomac.6c00919","type":"journal-article","created":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T17:02:09Z","timestamp":1790355729000},"page":"6462-6471","source":"Crossref","is-referenced-by-count":0,"title":["Ternary Fucoidan-Cisplatin-Dendrimer Nanoparticles as a Platform for Drug Delivery in Glioblastoma"],"prefix":"10.1021","volume":"27","author":[{"given":"Filipe","family":"Olim","sequence":"first","affiliation":[{"name":"Universidade da Madeira , , Campus da Penteada , ,","place":["Funchal, Portugal, 9020-105"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fa\u0301tima","family":"Mendes","sequence":"additional","affiliation":[{"name":"Universidade da Madeira , , Campus da Penteada , ,","place":["Funchal, Portugal, 9020-105"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Rute","family":"Neves","sequence":"additional","affiliation":[{"name":"Universidade da Madeira , , Campus da Penteada , ,","place":["Funchal, Portugal, 9020-105"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria\u0301ngeles","family":"Vaz","sequence":"additional","affiliation":[{"name":"Ramo\u0301n y Cajal University Hospital, IRYCIS , , ,","place":["Madrid, Spain, 28034"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie","family":"Earl","sequence":"additional","affiliation":[{"name":"Ramo\u0301n y Cajal University Hospital, IRYCIS , , ,","place":["Madrid, Spain, 28034"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irene","family":"Rodriguez-Clemente","sequence":"additional","affiliation":[{"name":"University of Castilla-La Mancha , , ,","place":["Albacete, Spain, 02006"]},{"name":"Instituto de Salud Carlos III , , ,","place":["Madrid, Spain, 28029"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8928-3681","authenticated-orcid":true,"given":"Valenti\u0301n","family":"Cen\u0303a","sequence":"additional","affiliation":[{"name":"University of Castilla-La Mancha , , ,","place":["Albacete, Spain, 02006"]},{"name":"Instituto de Salud Carlos III , , ,","place":["Madrid, Spain, 28029"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7856-2041","authenticated-orcid":true,"given":"Helena","family":"Toma\u0301s","sequence":"additional","affiliation":[{"name":"Universidade da Madeira , , Campus da Penteada , ,","place":["Funchal, Portugal, 9020-105"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,9,25]]},"reference":[{"key":"2026101210514407500_cit1","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1038\/s41392-025-02299-4","article-title":"Glioblastoma at the Crossroads: Current Understanding and Future Therapeutic Horizons","volume":"10","author":"Singh","year":"2025","journal-title":"Signal Transduct. 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