{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T13:28:20Z","timestamp":1786368500866,"version":"build-2736575974"},"reference-count":44,"publisher":"American Chemical Society (ACS)","issue":"8","license":[{"start":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T00:00:00Z","timestamp":1785369600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T00:00:00Z","timestamp":1785369600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T00:00:00Z","timestamp":1785369600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"name":"Xinjiang Normal University Research Foundation for Doctoral Program","award":["XJNUBS2307"],"award-info":[{"award-number":["XJNUBS2307"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,8,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Microenvironmental imbalance and bacterial infection are core causes of intractable chronic wounds by hindering nutrient transport and tissue repair. Herein, we innovatively fabricated a hydrophilic antibacterial scaffold based on silk fibroin (SF) and uniformly integrated it into PEGDA microneedle (MN) matrices. The composite MN system can efficiently load hydrophilic model drugs including lidocaine and rhodamine B, achieving uniform drug incorporation and improved drug-loading versatility with controllable, long-term sustained drug release behavior. Biological tests verified that the developed MN possesses excellent broad-spectrum antibacterial capacity against Staphylococcus aureus and Escherichia coli. It also exhibits favorable biocompatibility without obvious cytotoxicity and effectively promotes cell migration. In vivo experiments on full-thickness skin defect models demonstrated that the MN remarkably accelerates wound healing and optimizes healing quality. This work offers an innovative technical strategy for antibacterial drug delivery microneedles, holding great potential for clinical chronic wound treatment.<\/jats:p>","DOI":"10.1021\/acs.biomac.6c01070","type":"journal-article","created":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T13:20:39Z","timestamp":1785849639000},"page":"5725-5741","source":"Crossref","is-referenced-by-count":0,"title":["Transdermal Delivery\nof Silk-AgNPs through Sucrose\/Silk-AgNPs\nAntibacterial Fibroin Scaffold Packed in PEGDA Microneedles for Enhanced\nWound Healing"],"prefix":"10.1021","volume":"27","author":[{"given":"Nengqing","family":"Wang","sequence":"first","affiliation":[{"name":"Xinjiang Normal University , , ,","place":["Urumqi, China, 830054"]},{"name":"Xinjiang Key Laboratory of Energy Storage and Photoelectrocatalytic Materials , ,","place":["Urumqi, China, 830054"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linying","family":"Li","sequence":"additional","affiliation":[{"name":"Xinjiang Normal University , , ,","place":["Urumqi, China, 830054"]},{"name":"Xinjiang Key Laboratory of Energy Storage and Photoelectrocatalytic Materials , ,","place":["Urumqi, China, 830054"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingyang","family":"Wang","sequence":"additional","affiliation":[{"name":"Xinjiang Normal University , , ,","place":["Urumqi, China, 830054"]},{"name":"Xinjiang Key Laboratory of Energy Storage and Photoelectrocatalytic Materials , ,","place":["Urumqi, China, 830054"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-3708-1774","authenticated-orcid":true,"given":"Ya","family":"Gao","sequence":"additional","affiliation":[{"name":"Xinjiang Normal University , , ,","place":["Urumqi, China, 830054"]},{"name":"Xinjiang Key Laboratory of Energy Storage and Photoelectrocatalytic Materials , ,","place":["Urumqi, China, 830054"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5602-5616","authenticated-orcid":true,"given":"Yingbo","family":"Wang","sequence":"additional","affiliation":[{"name":"Xinjiang Normal University , , ,","place":["Urumqi, China, 830054"]},{"name":"Xinjiang Key Laboratory of Energy Storage and Photoelectrocatalytic Materials , ,","place":["Urumqi, China, 830054"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,7,30]]},"reference":[{"issue":"6","key":"2026081008082042100_cit1","doi-asserted-by":"publisher","first-page":"476","DOI":"10.1038\/s41580-024-00825-w","article-title":"Microenvironmental Determinants of\nEndothelial Cell Heterogeneity","volume":"26","author":"Gomez-Salinero","year":"2025","journal-title":"Nat. Rev. Mol.\nCell Biol."},{"key":"2026081008082042100_cit2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mtbio.2026.102882","article-title":"pH-Responsive\nPrintable Conductive\nHydrogels Loaded with ApoVs Promote Diabetic Wound Repair through\nOxidative Stress Scavenging and Macrophage Reprogramming","volume":"37","author":"Yan","year":"2026","journal-title":"Mater. Today Bio"},{"issue":"22","key":"2026081008082042100_cit3","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202113269","article-title":"Microneedle\nPatches Integrated with Biomineralized Melanin Nanoparticles for Simultaneous\nSkin Tumor Photothermal Therapy and Wound Healing","volume":"32","author":"Lei","year":"2022","journal-title":"Adv. Funct. Mater."},{"issue":"16","key":"2026081008082042100_cit4","doi-asserted-by":"publisher","DOI":"10.1002\/admt.202400219","article-title":"Microneedles\nfor Enhanced Bacterial Pathogen Inactivation and Accelerated Wound\nHealing","volume":"9","author":"Krishnakumar","year":"2024","journal-title":"Adv. Mater. Technol."},{"issue":"28","key":"2026081008082042100_cit5","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202315576","article-title":"Bioinspired Sonodynamic\nNano Spray Accelerates Infected Wound Healing via Targeting and Disturbing\nBacterial Metabolism","volume":"34","author":"Qian","year":"2024","journal-title":"Adv. Funct. Mater."},{"issue":"1","key":"2026081008082042100_cit6","doi-asserted-by":"publisher","DOI":"10.1186\/s12951-024-02390-y","article-title":"Construction of Programmed Time-Released\nMultifunctional Hydrogel with Antibacterial and Anti-Inflammatory\nProperties for Impaired Wound Healing","volume":"22","author":"Peng","year":"2024","journal-title":"J. Nanobiotechnol."},{"issue":"6","key":"2026081008082042100_cit7","doi-asserted-by":"publisher","first-page":"3953","DOI":"10.1021\/acssensors.4c03428","article-title":"Nanocellulose\nWound\nDressings with Integrated Protease Sensors for Detection of Wound\nPathogens","volume":"10","author":"Eskilson","year":"2025","journal-title":"ACS Sens."},{"key":"2026081008082042100_cit8","doi-asserted-by":"publisher","DOI":"10.1016\/j.colsurfb.2024.114213","article-title":"Bacterial-Responsive\nBiodegradable\nSilver Nanoclusters Composite Hydrogel for Infected Wound Therapy","volume":"245","author":"Guo","year":"2025","journal-title":"Colloids Surf., B"},{"issue":"3","key":"2026081008082042100_cit9","doi-asserted-by":"publisher","first-page":"760","DOI":"10.1097\/ALN.0000000000000036","article-title":"Anesthesia, Microcirculation,\nand Wound Repair in Aging","volume":"120","author":"Bentov","year":"2014","journal-title":"Anesthesiology"},{"issue":"11","key":"2026081008082042100_cit10","doi-asserted-by":"publisher","first-page":"2824","DOI":"10.1039\/D2MH00591C","article-title":"Hybrid Suture Coating for Dual-Staged\nControl over Antibacterial Actions to Match Well Wound Healing Progression","volume":"9","author":"Chen","year":"2022","journal-title":"Mater. 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Sci."},{"key":"2026081008082042100_cit24","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2024.130573","article-title":"Extracellular Matrix-Mimetic Immunomodulatory\nFibrous Scaffold Based\non a Peony Stamens Polysaccharide for Accelerated Wound Healing","volume":"264","author":"Huang","year":"2024","journal-title":"Int. J. Biol. 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Healthcare Mater."},{"key":"2026081008082042100_cit27","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1016\/j.ijbiomac.2022.04.212","article-title":"Eggshell Membrane-Mimicking\nMultifunctional Nanofiber for in-Situ Skin Wound Healing","volume":"210","author":"Chen","year":"2022","journal-title":"Int. J. Biol. Macromol."},{"issue":"7","key":"2026081008082042100_cit28","doi-asserted-by":"publisher","first-page":"1850","DOI":"10.1039\/D2MH00115B","article-title":"Leveraging\nthe Advancements in Functional Biomaterials and Scaffold Fabrication\nTechnologies for Chronic Wound Healing Applications","volume":"9","author":"Zahid","year":"2022","journal-title":"Mater. Horiz."},{"issue":"9","key":"2026081008082042100_cit29","doi-asserted-by":"publisher","first-page":"907","DOI":"10.1016\/j.tibtech.2018.04.004","article-title":"Overview of Silk\nFibroin Use in Wound Dressings","volume":"36","author":"Farokhi","year":"2018","journal-title":"Trends Biotechnol."},{"key":"2026081008082042100_cit30","doi-asserted-by":"publisher","DOI":"10.1155\/2021\/9069924","article-title":"Silk Fibroin: A Promising Tool for Wound Healing and\nSkin Regeneration","volume":"2021","author":"Vidya","year":"2021","journal-title":"Int. J. Polym. Sci."},{"issue":"15","key":"2026081008082042100_cit31","doi-asserted-by":"publisher","DOI":"10.3390\/ma13153361","article-title":"Bioinspired Materials\nfor Wound Healing Application:\nThe Potential of Silk Fibroin","volume":"13","author":"Pollini","year":"2020","journal-title":"Materials"},{"key":"2026081008082042100_cit32","doi-asserted-by":"publisher","DOI":"10.1016\/j.compositesb.2021.109165","article-title":"Bioactive Silk Fibroin\nScaffold with\nNanoarchitecture for Wound Healing","volume":"224","author":"Wang","year":"2021","journal-title":"Composites,\nPart B"},{"key":"2026081008082042100_cit33","doi-asserted-by":"publisher","first-page":"78","DOI":"10.1016\/j.bbrc.2021.08.026","article-title":"Regulating the Mechanics\nof Silk Fibroin Scaffolds Promotes Wound Vascularization","volume":"574","author":"Guo","year":"2021","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"2026081008082042100_cit34","doi-asserted-by":"publisher","DOI":"10.1016\/j.jddst.2025.107384","article-title":"Multifunctional Gelatin\u2013Silk\nFibroin Composite Hydrogel for Skin Wound Healing","volume":"113","author":"Chen","year":"2025","journal-title":"J. Drug Delivery Sci. Technol."},{"key":"2026081008082042100_cit35","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1016\/j.actbio.2017.12.006","article-title":"NF-\u03baB\nSignaling Is Key in the Wound Healing Processes of Silk Fibroin","volume":"67","author":"Park","year":"2018","journal-title":"Acta Biomater."},{"issue":"37","key":"2026081008082042100_cit36","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202529119","article-title":"Decoding the Hydro-Mechanical\nMechanism of a Shape\nMemory Microneedle Scaffold for Adaptive Vaginal Wound Repair","volume":"36","author":"Gong","year":"2026","journal-title":"Adv. Funct. Mater."},{"key":"2026081008082042100_cit37","doi-asserted-by":"publisher","DOI":"10.1016\/j.inoche.2023.111611","article-title":"Silk Fibroin-Based\nGreen Colloidal Silver Nanoparticle Synthesis and Their Antibacterial\nand Anticancer Properties","volume":"158","author":"Shivananda","year":"2023","journal-title":"Inorg. Chem. Commun."},{"key":"2026081008082042100_cit38","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1016\/j.jcis.2024.01.147","article-title":"Dissolving Microneedle\nSystem Containing Ag Nanoparticle-Decorated\nSilk Fibroin Microspheres and Antibiotics for Synergistic Therapy\nof Bacterial Biofilm Infection","volume":"661","author":"Li","year":"2024","journal-title":"J. Colloid Interface\nSci."},{"key":"2026081008082042100_cit39","doi-asserted-by":"publisher","DOI":"10.1016\/j.inoche.2024.113593","article-title":"Eri Silk Fibroin Derived Silver Nanoparticles for Antibacterial\nand Photocatalytic Applications","volume":"171","author":"Brahma","year":"2025","journal-title":"Inorg. Chem.\nCommun."},{"key":"2026081008082042100_cit40","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2025.146256","article-title":"Dual Effect\nof Silk Fibroin Hydrogels with Curcumin-STS Micelles for Enhanced\nWound Healing and Anti-Inflammation","volume":"321","author":"Jitpibull","year":"2025","journal-title":"Int. J.\nBiol. Macromol."},{"issue":"5","key":"2026081008082042100_cit41","doi-asserted-by":"publisher","DOI":"10.3390\/polym16050648","article-title":"Electrospinning Silk-Fibroin-Based\nFibrous Membranes with AgNPs for Antimicrobial Application","volume":"16","author":"Li","year":"2024","journal-title":"Polymers"},{"key":"2026081008082042100_cit42","doi-asserted-by":"publisher","DOI":"10.1016\/j.cej.2025.165250","article-title":"A Carrier-Free Hydrogel Loading Silver Nanoparticles with Photothermal\nEffect to Heal Refractory Diabetic Wound by Robust Bacteria Elimination\nand Repair-Promotion","volume":"519","author":"Hao","year":"2025","journal-title":"Chem. Eng. J."},{"key":"2026081008082042100_cit43","doi-asserted-by":"publisher","DOI":"10.1016\/j.mtbio.2025.101605","article-title":"A Brief Strategy for\nthe Preparation of Silk Fibroin-Copper Sulfide-Based\nElectrospun Nanofibrous Membranes with Photothermal Antimicrobial\nProperties to Accelerate the Infected Wound Healing","volume":"31","author":"Cai","year":"2025","journal-title":"Mater. Today Bio"},{"key":"2026081008082042100_cit44","doi-asserted-by":"publisher","first-page":"7469","DOI":"10.2147\/IJN.S521956","article-title":"Nano-Biomimetic\nFibronectin\/Lysostaphin-Co-Loaded Silk\nFibroin Dressing Accelerates Full-Thickness Wound Healing via ECM-Mimicking\nMicroarchitecture and Dual-Function Modulation","volume":"20","author":"Liu","year":"2025","journal-title":"Int. J. 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