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Hydrogels were prepared through amino-yne click conjugation of gentamicin sulfate (Gs) and thiol-yne cross-linking, followed by ciprofloxacin (CPX) loading via swelling-diffusion. The materials exhibited tunable gelation time, swelling capacity, and drug release profiles depending on thiol content. A dual-release mechanism was achieved, consisting of an initial burst release of CPX followed by a sustained, pH-responsive release of conjugated Gs through acid cleavage of \u03b2-aminoacrylate linkages. The hydrogels showed effective wide spectrum antibacterial activity against methicillin-resistant Staphylococcus aureus and Pseudomonas aeruginosa, while cytotoxicity studies confirmed cytocompatibility at bactericidal concentrations. The results support the potential of these hydrogels as safe and effective dual-antibiotic wound dressings, allowing for the immediate elimination of invading bacteria after wounding (burst release), while maintaining long-term antibiotic release to minimize reinfection risk.<\/jats:p>","DOI":"10.1021\/acs.biomac.6c01230","type":"journal-article","created":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T10:01:59Z","timestamp":1786960919000},"page":"6175-6189","source":"Crossref","is-referenced-by-count":0,"title":["Dual Release\nof Antibiotics with Additive Effect from\nCleavable Hydrogels Based on Amino\/Thiol\u2013Yne Click Chemistry"],"prefix":"10.1021","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-6456-4856","authenticated-orcid":true,"given":"Sara","family":"Besco\u0301s-Ramo","sequence":"first","affiliation":[{"name":"CSIC-Universidad de Zaragoza , , ,","place":["Zaragoza, Spain, 50009"]},{"name":"Universidad de Zaragoza , , ,","place":["Zaragoza, Spain, 50009"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1505-498X","authenticated-orcid":true,"given":"Cristina","family":"Yus","sequence":"additional","affiliation":[{"name":"CSIC-Universidad de Zaragoza , , ,","place":["Zaragoza, Spain, 50009"]},{"name":"Universidad de Zaragoza , , ,","place":["Zaragoza, Spain, 50018"]},{"name":"Aragon Health Research Institute (IIS Arago\u0301n) , ,","place":["Zaragoza, Spain, 50009"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3165-0156","authenticated-orcid":true,"given":"Manuel","family":"Arruebo","sequence":"additional","affiliation":[{"name":"CSIC-Universidad de Zaragoza , , ,","place":["Zaragoza, Spain, 50009"]},{"name":"Universidad de Zaragoza , , ,","place":["Zaragoza, Spain, 50018"]},{"name":"Aragon Health Research Institute (IIS Arago\u0301n) , ,","place":["Zaragoza, Spain, 50009"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5556-2172","authenticated-orcid":true,"given":"Milagros","family":"Pin\u0303ol","sequence":"additional","affiliation":[{"name":"CSIC-Universidad de Zaragoza , , ,","place":["Zaragoza, Spain, 50009"]},{"name":"Universidad de Zaragoza , , ,","place":["Zaragoza, Spain, 50009"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0922-5615","authenticated-orcid":true,"given":"Luis","family":"Oriol","sequence":"additional","affiliation":[{"name":"CSIC-Universidad de Zaragoza , , ,","place":["Zaragoza, Spain, 50009"]},{"name":"Universidad de Zaragoza , , ,","place":["Zaragoza, Spain, 50009"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,8,17]]},"reference":[{"issue":"9","key":"2026091407064772000_cit1","doi-asserted-by":"publisher","first-page":"560","DOI":"10.1089\/wound.2015.0635","article-title":"Challenges in the Treatment of Chronic Wounds","volume":"4","author":"Frykberg","year":"2015","journal-title":"Adv. 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