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Up to the optimal nucleating concentration of 2 wt %, LIN was fully encapsulated, increasing PCL crystallinity from 33% to 72% and PHA crystallization enthalpy by 56%. At 3 wt %, PHA\/PBS fibers developed discrete hollow, anisotropic LIN crystalline clusters through confinement-directed growth, whereas PHA\/PCL fibers displayed a homogeneous nano-granular surface coating of LIN. Solid-state NMR revealed closer segmental interactions in PHA\/PBS and moderate phase separation in PHA\/PCL. In situ tensile SAXS and SEM disclosed brittle craze-to-crack fracture in PHA\/PBS\u2212LIN fibers but semi-ductile deformation in PHA\/PCL\u2212LIN fibers, involving multiple crazes, necking, and the in situ generation of an internal nanofibrillar bridging network within the craze cavities. This morphology, formed by flow-induced and LIN-nucleated crystallization, modulates the deformation mechanism and supports the design of PHA antibiotic-loaded scaffolds with controlled release.<\/jats:p>","DOI":"10.1021\/acs.biomac.6c01387","type":"journal-article","created":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T12:02:38Z","timestamp":1790769758000},"page":"6789-6801","source":"Crossref","is-referenced-by-count":0,"title":["Antibiotic-Loaded Fibers of Polyhydroxyalkanoate Blends: Morphological Evolutions and Strain-Induced Micromechanics"],"prefix":"10.1021","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7853-4246","authenticated-orcid":true,"given":"Ramin","family":"Hosseinnezhad","sequence":"first","affiliation":[{"name":"Polish Academy of Sciences , , ,","place":["Lodz, Poland, 90-363"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3723-0331","authenticated-orcid":true,"given":"Dhanumalayan","family":"Elumalai","sequence":"additional","affiliation":[{"name":"Polish Academy of Sciences , , ,","place":["Lodz, Poland, 90-363"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1436-932X","authenticated-orcid":true,"given":"Mehrnaz","family":"Khalaji","sequence":"additional","affiliation":[{"name":"Polish Academy of Sciences , , ,","place":["Lodz, Poland, 90-363"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,9,30]]},"reference":[{"issue":"7","key":"2026101210564739900_cit1","doi-asserted-by":"publisher","first-page":"2170019","DOI":"10.1002\/mabi.202170019","article-title":"Drug-eluting medical textiles: From fiber production and textile fabrication to drug loading and delivery","volume":"21","author":"Rostamitabar","year":"2021","journal-title":"Macromol. 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