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Ugi four-component reactions (U-4CRs) involving carboxymethyl cellulose (CMC), formaldehyde, a glycine-based isocyanide (ethyl isocyanoacetate), and six different amino acid methyl esters as the carboxylic acid, aldehyde, isocyanide, and amine components, respectively, were employed to introduce pseudo-peptide pendants onto the cellulose backbone. The reactions proceeded successfully under weakly acidic conditions (pH 4), yielding derivatives with degrees of substitution (DSs) of 0.37\u22120.44, whereas reactions at pH 1\u22123 and 5 were hindered by competing side reactions. The derivatives were characterized by FTIR, NMR, size-exclusion chromatography, and elemental analysis. Furthermore, they were successfully electrospun using poly(ethylene oxide) as a carrier polymer, producing uniform and continuous nanofibers. These results demonstrate the feasibility of combining U\u22124CR with electrospinning to fabricate functional cellulose-based nanofibrous materials for potential chiral recognition applications.<\/jats:p>","DOI":"10.1021\/acs.biomac.6c01517","type":"journal-article","created":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T11:02:03Z","timestamp":1790247723000},"page":"6879-6889","source":"Crossref","is-referenced-by-count":0,"title":["One-Pot Synthesis and Electrospinning of Cellulose Derivatives Bearing Pseudo-Peptide Pendants via Ugi Four\u2212Component Reaction for Functional Nanofiber Fabrication"],"prefix":"10.1021","volume":"27","author":[{"given":"Steve","family":"Nono-Tagne","sequence":"first","affiliation":[{"name":"Univ. 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Grenoble-Alpes, CNRS, CERMAV , ,","place":["Grenoble, France, 38000"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8968-9574","authenticated-orcid":true,"given":"Atsushi","family":"Narumi","sequence":"additional","affiliation":[{"name":"Yamagata University , , 4-3-16 Jonan , , ,","place":["Yonezawa, Yamagata, Japan, 992-8510"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0977-6940","authenticated-orcid":true,"given":"Ryohei","family":"Kakuchi","sequence":"additional","affiliation":[{"name":"Gunma University , , 1-5-1 Tenjin , , ,","place":["Kiryu, Gunma, Japan, 376-8515"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9049-7350","authenticated-orcid":true,"given":"Issei","family":"Otsuka","sequence":"additional","affiliation":[{"name":"Univ. 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