{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T15:49:18Z","timestamp":1791820158603,"version":"4.3.4"},"reference-count":65,"publisher":"American Chemical Society (ACS)","issue":"10","license":[{"start":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T00:00:00Z","timestamp":1790121600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100013276","name":"Interreg","doi-asserted-by":"publisher","award":["ITAT-11-015 - SPARE"],"award-info":[{"award-number":["ITAT-11-015 - SPARE"]}],"id":[{"id":"10.13039\/100013276","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,10,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>A biopolymer-enriched matrix from hempseed waste (BMH extract) was extracted using hot water and characterized. Biochemical assays pointed out that the BMH extract contained carbohydrates, proteins, and phenols in different percentages, while NMR spectroscopy and monosaccharide analysis revealed starch as the dominant polysaccharide. The BMH extract showed biocompatibility and a stimulatory effect on fibroblast viability. Its antioxidant activity in biochemical and cellular assays was comparable to that of a known potent antioxidant. The BMH extract was added to a hyaluronic acid (HA) solution and exposed to reactive oxygen species (ROS). Rheological measurements on these samples showed that the extract provided protection from ROS-driven polysaccharide degradation, suggesting an application as a scavenger in HA-based viscosupplements. Overall, these results support using of hemp seed waste-derived matrices (either as such or as additives in biomaterials) for biomedical applications characterized by inflammation and oxidative stress to mitigate the negative effects associated with these conditions.<\/jats:p>","DOI":"10.1021\/acs.biomac.6c01704","type":"journal-article","created":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T23:02:09Z","timestamp":1790204529000},"page":"6986-6997","source":"Crossref","is-referenced-by-count":0,"title":["Antioxidant and Bioactive Properties of a Biopolymeric Matrix from Hemp Seed Waste: An Application as a Scavenger of Reactive Oxygen Species in Viscosupplements"],"prefix":"10.1021","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4968-2105","authenticated-orcid":true,"given":"Francesca","family":"Scognamiglio","sequence":"first","affiliation":[{"name":"University of Trieste , , Via Licio Giorgieri 5 , ,","place":["Trieste, Italy, 34127"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0700-4464","authenticated-orcid":true,"given":"Eleonora","family":"Marsich","sequence":"additional","affiliation":[{"name":"University of Trieste , , Piazza dell\u2019Ospitale 1 , ,","place":["Trieste, Italy, 34129"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-9763-324X","authenticated-orcid":true,"given":"Valeria","family":"Lizet Medrano Gutierrez","sequence":"additional","affiliation":[{"name":"University of Trieste , , Via Licio Giorgieri 5 , ,","place":["Trieste, Italy, 34127"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4483-5099","authenticated-orcid":true,"given":"Pasquale","family":"Sacco","sequence":"additional","affiliation":[{"name":"University of Trieste , , Via Licio Giorgieri 5 , ,","place":["Trieste, Italy, 34127"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3671-9060","authenticated-orcid":true,"given":"Olav","family":"Andrea Aarstad","sequence":"additional","affiliation":[{"name":"NTNU Norwegian University of Science and Technology , , Sem S\u00e6lands vei 6\/8 , ,","place":["Trondheim, Norway, 7491"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1613-4663","authenticated-orcid":true,"given":"Finn","family":"Lillelund Aachmann","sequence":"additional","affiliation":[{"name":"NTNU Norwegian University of Science and Technology , , Sem S\u00e6lands vei 6\/8 , ,","place":["Trondheim, Norway, 7491"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3752-8346","authenticated-orcid":true,"given":"Ivan","family":"Donati","sequence":"additional","affiliation":[{"name":"University of Trieste , , Via Licio Giorgieri 5 , ,","place":["Trieste, Italy, 34127"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,9,23]]},"reference":[{"issue":"1","key":"2026101210564442600_cit1","doi-asserted-by":"publisher","first-page":"184","DOI":"10.3390\/ddc3010011","article-title":"Plant-Derived Natural Products: A Source for Drug Discovery and Development","volume":"3","author":"Chaachouay","year":"2024","journal-title":"Drugs Drug Candidates"},{"key":"2026101210564442600_cit2","doi-asserted-by":"publisher","first-page":"1920208","DOI":"10.1155\/2016\/1920208","article-title":"Plant-Derived Antioxidants in Disease Prevention","volume":"2016","author":"Szymanska","year":"2016","journal-title":"Oxid. Med. Cell. Longevity"},{"issue":"2","key":"2026101210564442600_cit3","doi-asserted-by":"publisher","first-page":"449","DOI":"10.1016\/j.atherosclerosis.2015.09.032","article-title":"Berberine, a Plant Alkaloid with Lipid- and Glucose-Lowering Properties: From in Vitro Evidence to Clinical Studies","volume":"243","author":"Pirillo","year":"2015","journal-title":"Atherosclerosis"},{"issue":"16","key":"2026101210564442600_cit4","doi-asserted-by":"publisher","first-page":"9082","DOI":"10.3390\/ijms23169082","article-title":"Cellular Mechanisms Underlying the Cardioprotective Role of Allicin on Cardiovascular Diseases","volume":"23","author":"Sa\u0301nchez-Gloria","year":"2022","journal-title":"Int. J. Mol. Sci."},{"issue":"1","key":"2026101210564442600_cit5","doi-asserted-by":"publisher","first-page":"2497354","DOI":"10.1155\/2021\/2497354","article-title":"Pharmacological Properties and Health Benefits of Eugenol: A Comprehensive Review","volume":"2021","author":"Nisar","year":"2021","journal-title":"Oxid. Med. Cell. Longevity"},{"key":"2026101210564442600_cit6","doi-asserted-by":"publisher","first-page":"1608269","DOI":"10.3389\/fimmu.2025.1608269","article-title":"Antimicrobial and Immunomodulatory Activity of Natural Bioactive Compounds - an in Vitro Investigation with Potential Applications in Managing Hidradenitis Suppurativa","volume":"16","author":"Badaluta","year":"2025","journal-title":"Front. Immunol."},{"issue":"11","key":"2026101210564442600_cit7","doi-asserted-by":"publisher","DOI":"10.1002\/fsn3.71081","article-title":"A Review of Antioxidant Activity, Anti-Inflammatory Properties, Apoptosis-Regulatory Effects, and Immune System Modulation of Juglans Regia L. (Walnut)","volume":"13","author":"Ghasemzadeh Rahbardar","year":"2025","journal-title":"Food Sci. Nutr."},{"key":"2026101210564442600_cit8","doi-asserted-by":"publisher","first-page":"723233","DOI":"10.3389\/fphar.2021.723233","article-title":"Natural Compounds With Antimicrobial and Antiviral Effect and Nanocarriers Used for Their Transportation","volume":"12","author":"Stan","year":"2021","journal-title":"Front. Pharmacol."},{"issue":"24","key":"2026101210564442600_cit9","doi-asserted-by":"publisher","first-page":"7704","DOI":"10.3390\/ma14247704","article-title":"Biopolymers and Biomaterials for Special Applications within the Context of the Circular Economy","volume":"14","author":"Dziuba","year":"2021","journal-title":"Materials"},{"issue":"7","key":"2026101210564442600_cit10","doi-asserted-by":"publisher","first-page":"2771","DOI":"10.1039\/d4en00235k","article-title":"Self-Healing Materials in Biomedicine and the Circular Economy","volume":"11","author":"Venkateswaran","year":"2024","journal-title":"Environ. Sci.:Nano"},{"issue":"10","key":"2026101210564442600_cit11","doi-asserted-by":"publisher","first-page":"2105","DOI":"10.3390\/life13102105","article-title":"Plant-Derived Natural Products and Their Biomedical Properties: Recent Advances and Future Directions","volume":"13","author":"Amerikanou","year":"2023","journal-title":"Life"},{"issue":"18","key":"2026101210564442600_cit12","doi-asserted-by":"publisher","first-page":"4406","DOI":"10.3390\/molecules29184406","article-title":"Sources and Extraction of Biopolymers and Manufacturing of Bio-Based Nanocomposites for Different Applications","volume":"29","author":"Azadi","year":"2024","journal-title":"Molecules"},{"issue":"6","key":"2026101210564442600_cit13","doi-asserted-by":"publisher","DOI":"10.1002\/efd2.37","article-title":"Guideline for the Extraction, Isolation, Purification, and Structural Characterization of Polysaccharides from Natural Resources","volume":"3","author":"Huang","year":"2022","journal-title":"eFood"},{"key":"2026101210564442600_cit14","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1016\/j.ijbiomac.2016.06.100","article-title":"Bioactivities, Isolation and Purification Methods of Polysaccharides from Natural Products: A Review","volume":"92","author":"Shi","year":"2016","journal-title":"Int. J. Biol. Macromol."},{"issue":"23","key":"2026101210564442600_cit15","doi-asserted-by":"publisher","first-page":"12730","DOI":"10.3390\/app152312730","article-title":"Hot-Water Infusion as an Efficient and Sustainable Extraction Approach for Edible Flower Teas","volume":"15","author":"Choi","year":"2025","journal-title":"Appl. Sci."},{"key":"2026101210564442600_cit16","doi-asserted-by":"publisher","first-page":"78","DOI":"10.1016\/j.biombioe.2016.03.028","article-title":"Effects of Hot Water Extraction Pretreatment on Physicochemical Changes of Douglas Fir","volume":"90","author":"Zhu","year":"2016","journal-title":"Biomass Bioenergy"},{"issue":"18","key":"2026101210564442600_cit17","doi-asserted-by":"publisher","first-page":"5746","DOI":"10.3390\/molecules27185746","article-title":"Extraction, Physicochemical Properties, Anti-Aging, and Antioxidant Activities of Polysaccharides from Industrial Hemp Residues","volume":"27","author":"Chang","year":"2022","journal-title":"Molecules"},{"key":"2026101210564442600_cit18","doi-asserted-by":"publisher","first-page":"102329","DOI":"10.1016\/j.fbio.2022.102329","article-title":"Identification of Possible Bioactive Compounds and a Comparative Study on in Vitro Biological Properties of Whole Hemp Seed and Stem","volume":"51","author":"Aloo","year":"2023","journal-title":"Food Biosci."},{"issue":"39","key":"2026101210564442600_cit19","doi-asserted-by":"publisher","first-page":"25764","DOI":"10.1039\/d2ra04081f","article-title":"Bioactive Compounds from Hemp (Cannabis Sativa L.) Seeds: Optimization of Phenolic Antioxidant Extraction Using Simplex Lattice Mixture Design and HPLC-DAD\/ESI-MS2 Analysis","volume":"12","author":"Benkirane","year":"2022","journal-title":"RSC Adv."},{"key":"2026101210564442600_cit20","doi-asserted-by":"publisher","first-page":"108900","DOI":"10.1016\/j.foodhyd.2023.108900","article-title":"Hempseed Polysaccharide (Cannabis Sativa L.): Physicochemical Characterization and Comparison with Flaxseed Polysaccharide","volume":"143","author":"Julakanti","year":"2023","journal-title":"Food Hydrocolloids"},{"issue":"4","key":"2026101210564442600_cit21","doi-asserted-by":"publisher","first-page":"408","DOI":"10.1111\/ics.12211","article-title":"Stability of cosmetic emulsion containing different amount of hemp oil","volume":"37","author":"Kowalska","year":"2015","journal-title":"Int. J. Cosmet. Sci."},{"issue":"18","key":"2026101210564442600_cit22","doi-asserted-by":"publisher","first-page":"4078","DOI":"10.3390\/molecules25184078","article-title":"Industrial Hemp (Cannabis Sativa Subsp. Sativa) as an Emerging Source for Value-Added Functional Food Ingredients and Nutraceuticals","volume":"25","author":"Rupasinghe","year":"2020","journal-title":"Molecules"},{"key":"2026101210564442600_cit23","doi-asserted-by":"publisher","first-page":"102218","DOI":"10.1016\/j.mtla.2024.102218","article-title":"Effect of Hyaluronic Acid-Based Viscosupplementation on Cartilage Material Properties","volume":"38","author":"Patois","year":"2024","journal-title":"Materialia"},{"issue":"12","key":"2026101210564442600_cit24","doi-asserted-by":"publisher","first-page":"2595","DOI":"10.1002\/jbm.b.35114","article-title":"A Composite Device for Viscosupplementation Treatment Resistant to Degradation by Reactive Oxygen Species and Hyaluronidase","volume":"110","author":"Toropitsyn","year":"2022","journal-title":"J. Biomed. Mater. Res., Part B"},{"key":"2026101210564442600_cit25","doi-asserted-by":"publisher","first-page":"102928","DOI":"10.1016\/j.algal.2022.102928","article-title":"Sequential Extraction and Fractionation of Four Polysaccharides from Cultivated Brown Algae SaccharinaLatissima and AlariaEsculenta","volume":"69","author":"Birgersson","year":"2023","journal-title":"Algal Res."},{"key":"2026101210564442600_cit26","doi-asserted-by":"publisher","first-page":"103421","DOI":"10.1016\/j.algal.2024.103421","article-title":"Variations in the Chemical Composition of Norwegian Cultivated Brown Algae SaccharinaLatissima and AlariaEsculenta Based on Deployment and Harvest Times","volume":"78","author":"Arlov","year":"2024","journal-title":"Algal Res."},{"issue":"1","key":"2026101210564442600_cit27","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1016\/s0008-6215(00)84051-3","article-title":"Study of the Composition and Sequence of Uronate Residues in Alginates","volume":"68","author":"Grasdalen","year":"1979","journal-title":"Carbohydr. Res."},{"issue":"1","key":"2026101210564442600_cit28","doi-asserted-by":"publisher","first-page":"106","DOI":"10.1021\/bm2013026","article-title":"Alginate Sequencing: An Analysis of Block Distribution in Alginates Using Specific Alginate Degrading Enzymes","volume":"13","author":"Aarstad","year":"2012","journal-title":"Biomacromolecules"},{"issue":"2","key":"2026101210564442600_cit29","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1007\/bf00211777","article-title":"1H, 13C and 15N Chemical Shift Referencing in Biomolecular NMR","volume":"6","author":"Wishart","year":"1995","journal-title":"J. Biomol. NMR"},{"issue":"4","key":"2026101210564442600_cit30","doi-asserted-by":"publisher","first-page":"936","DOI":"10.1111\/1541-4337.12450","article-title":"Processing, Nutrition, and Functionality of Hempseed Protein: A Review","volume":"18","author":"Wang","year":"2019","journal-title":"Compr. Rev. Food Sci. Food Saf."},{"issue":"3","key":"2026101210564442600_cit31","doi-asserted-by":"publisher","first-page":"304","DOI":"10.1007\/s11130-015-0494-5","article-title":"Denaturation and Oxidative Stability of Hemp Seed (Cannabis Sativa L.) Protein Isolate as Affected by Heat Treatment","volume":"70","author":"Raikos","year":"2015","journal-title":"Plant Foods Hum. Nutr."},{"key":"2026101210564442600_cit32","doi-asserted-by":"publisher","first-page":"131754","DOI":"10.1016\/j.foodchem.2021.131754","article-title":"Chemical Composition and Biological Activities of Whole and Dehulled Hemp (Cannabis Sativa L.) Seeds","volume":"374","author":"Alonso-Esteban","year":"2022","journal-title":"Food Chem."},{"key":"2026101210564442600_cit33","doi-asserted-by":"publisher","first-page":"104516","DOI":"10.1016\/j.jfca.2022.104516","article-title":"Mineral Elements and Related Antinutrients, in Whole and Hulled Hemp (Cannabis Sativa L.) Seeds","volume":"109","author":"Alonso-Esteban","year":"2022","journal-title":"J. Food Compos. Anal."},{"issue":"13","key":"2026101210564442600_cit34","doi-asserted-by":"publisher","first-page":"5844","DOI":"10.3390\/su17135844","article-title":"Nutrient Profiles and Bioavailability in Industrial Hemp (Cannabis Sativa L.) Seeds from Diverse Provenances","volume":"17","author":"Islam","year":"2025","journal-title":"Sustainability"},{"issue":"1","key":"2026101210564442600_cit35","doi-asserted-by":"publisher","first-page":"7","DOI":"10.3390\/toxics6010007","article-title":"Cytotoxic, Apoptotic and Genotoxic Effects of Lipid-Based and Polymeric Nano Micelles, an In Vitro Evaluation","volume":"6","author":"Bahadori","year":"2017","journal-title":"Toxics"},{"issue":"1","key":"2026101210564442600_cit36","doi-asserted-by":"publisher","first-page":"66","DOI":"10.1038\/s41529-024-00487-1","article-title":"A Review of Biomaterial Degradation Assessment Approaches Employed in the Biomedical Field","volume":"8","author":"Mndlovu","year":"2024","journal-title":"npj Mater. Degrad."},{"key":"2026101210564442600_cit37","doi-asserted-by":"publisher","first-page":"1117","DOI":"10.1016\/j.foodchem.2017.07.055","article-title":"Antioxidant Activities of Ginger Extract and Its Constituents toward Lipids","volume":"239","author":"Si","year":"2018","journal-title":"Food Chem."},{"key":"2026101210564442600_cit38","doi-asserted-by":"publisher","first-page":"122490","DOI":"10.1016\/j.ijpharm.2022.122490","article-title":"In Vitro and in Vivo Immunogenicity Assessment of Protein Aggregate Characteristics","volume":"631","author":"Thorlaksen","year":"2023","journal-title":"Int. J. Pharm."},{"key":"2026101210564442600_cit39","doi-asserted-by":"publisher","first-page":"120745","DOI":"10.1016\/j.carbpol.2023.120745","article-title":"Hydrogels Based on Methylated-Alginates as a Platform to Investigate the Effect of Material Properties on Cell Activity. The Role of Material Compliance","volume":"311","author":"Scognamiglio","year":"2023","journal-title":"Carbohydr. Polym."},{"issue":"7","key":"2026101210564442600_cit40","doi-asserted-by":"publisher","first-page":"1534","DOI":"10.1002\/jbm.a.36924","article-title":"Development of Biodegradable Membranes for the Delivery of a Bioactive Chitosan-Derivative on Cartilage Defects: A Preliminary Investigation","volume":"108","author":"Scognamiglio","year":"2020","journal-title":"J. Biomed. Mater. Res., Part A"},{"key":"2026101210564442600_cit41","doi-asserted-by":"publisher","first-page":"116787","DOI":"10.1016\/j.carbpol.2020.116787","article-title":"A Hydrogel System Based on a Lactose-Modified Chitosan for Viscosupplementation in Osteoarthritis","volume":"248","author":"Scognamiglio","year":"2020","journal-title":"Carbohydr. Polym."},{"issue":"8","key":"2026101210564442600_cit42","doi-asserted-by":"publisher","first-page":"2248","DOI":"10.3390\/pr11082248","article-title":"DPPH Radical Scavenging Assay","volume":"11","author":"Gulcin","year":"2023","journal-title":"Processes"},{"issue":"17","key":"2026101210564442600_cit43","doi-asserted-by":"publisher","first-page":"6572","DOI":"10.1021\/jf048318o","article-title":"Rapid Peroxyl Radical Scavenging Capacity (PSC) Assay for Assessing Both Hydrophilic and Lipophilic Antioxidants","volume":"53","author":"Adom","year":"2005","journal-title":"J. Agric. Food Chem."},{"issue":"17","key":"2026101210564442600_cit44","doi-asserted-by":"publisher","first-page":"4178","DOI":"10.3390\/molecules29174178","article-title":"Profile of Polyphenols, Fatty Acids, and Terpenes in Henola Hemp Seeds Depending on the Method of Fertilization","volume":"29","author":"Przybylska-Balcerek","year":"2024","journal-title":"Molecules"},{"key":"2026101210564442600_cit45","doi-asserted-by":"publisher","first-page":"116951","DOI":"10.1016\/j.foodres.2025.116951","article-title":"Advancing Antioxidant Testing: Standardisation of a Human Plasma Oxidation Assay and Its Integration with Chemical and Cellular Protocols","volume":"218","author":"Franchin","year":"2025","journal-title":"Food Res. Int."},{"key":"2026101210564442600_cit46","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1007\/978-3-319-56017-5_2","article-title":"Ultraviolet Light Induced Generation of Reactive Oxygen Species","volume":"996","author":"de Jager","year":"2017","journal-title":"Adv. Exp. Med. Biol."},{"issue":"2","key":"2026101210564442600_cit47","doi-asserted-by":"publisher","first-page":"456","DOI":"10.3390\/ma17020456","article-title":"Biomaterials for Drug Delivery and Human Applications","volume":"17","author":"Trucillo","year":"2024","journal-title":"Materials"},{"issue":"18","key":"2026101210564442600_cit48","doi-asserted-by":"publisher","first-page":"3211","DOI":"10.3390\/foods14183211","article-title":"Optimizing Extraction Methods for Bioactive Polysaccharides from Rosa Rugosa and Rosa Damascena","volume":"14","author":"Ashraf","year":"2025","journal-title":"Foods"},{"issue":"12","key":"2026101210564442600_cit49","doi-asserted-by":"publisher","first-page":"1630","DOI":"10.3390\/plants13121630","article-title":"The Potential of Hemp Extracts to Modify the Course of Oxidative-Stress Related Conditions","volume":"13","author":"Bijelic\u0301","year":"2024","journal-title":"Plants"},{"key":"2026101210564442600_cit50","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1016\/j.foodchem.2018.04.078","article-title":"Nutraceutical Potential of Hemp (Cannabis Sativa L.) Seeds and Sprouts","volume":"262","author":"Frassinetti","year":"2018","journal-title":"Food Chem."},{"issue":"21","key":"2026101210564442600_cit51","doi-asserted-by":"publisher","first-page":"3429","DOI":"10.3390\/foods13213429","article-title":"Characteristics of Polysaccharides from Industrial Hemp (Cannabis Sativa L.) Kernels","volume":"13","author":"Wei","year":"2024","journal-title":"Foods"},{"key":"2026101210564442600_cit52","doi-asserted-by":"publisher","first-page":"976","DOI":"10.1016\/j.ijbiomac.2018.06.139","article-title":"Physicochemical Characterization, Antioxidant and Anti-Proliferative Activities of a Polysaccharide Extracted from Psyllium (P.Ovata) Leaves","volume":"118","author":"Patel","year":"2018","journal-title":"Int. J. Biol. Macromol."},{"key":"2026101210564442600_cit53","doi-asserted-by":"publisher","DOI":"10.7717\/peerj.13623","article-title":"Phytotoxic Effects of Acacia Saligna Dry Leachates on Germination, Seedling Growth, Photosynthetic Performance, and Gene Expression of Economically Important Crops","volume":"10","author":"Sakit ALHaithloul","year":"2022","journal-title":"PeerJ"},{"issue":"1","key":"2026101210564442600_cit54","doi-asserted-by":"publisher","first-page":"389","DOI":"10.1007\/s42729-023-01550-7","article-title":"Ultrastructural, Secondary Metabolite, and Antioxidant Modulation in Response to Salt-Affected Habitats Induced Oxidative Stress and Their Accumulation in Malva Parviflora L. and Rumex Dentatus L","volume":"24","author":"Kazamel","year":"2023","journal-title":"J. Soil Sci. Plant Nutr."},{"issue":"4","key":"2026101210564442600_cit55","doi-asserted-by":"publisher","DOI":"10.1111\/1541-4337.13361","article-title":"Progress of Plant-Derived Non-Starch Polysaccharides and Their Challenges and Applications in Future Foods","volume":"23","author":"Guo","year":"2024","journal-title":"Compr. Rev. Food Sci. Food Saf."},{"key":"2026101210564442600_cit56","doi-asserted-by":"publisher","first-page":"7066432","DOI":"10.1155\/mi\/7066432","article-title":"Decoding Fibroblast Heterogeneity in Osteoarthritis: Identification of a Fibrosis-Associated Subtype and Novel Diagnostic Biomarkers","volume":"2025","author":"Sun","year":"2025","journal-title":"Mediators Inflammation"},{"issue":"11","key":"2026101210564442600_cit57","doi-asserted-by":"publisher","first-page":"1358","DOI":"10.1016\/j.joca.2024.06.011","article-title":"Immunomodulation and Fibroblast Dynamics Driving Nociceptive Joint Pain within Inflammatory Synovium: Unravelling Mechanisms for Therapeutic Advancements in Osteoarthritis","volume":"32","author":"Wijesinghe","year":"2024","journal-title":"Osteoarthritis Cartilage"},{"key":"2026101210564442600_cit58","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2019\/7513404","article-title":"A Review on the Effect of Plant Extract on Mesenchymal Stem Cell Proliferation and Differentiation","volume":"2019","author":"Saud","year":"2019","journal-title":"Stem Cells Int."},{"key":"2026101210564442600_cit59","doi-asserted-by":"publisher","first-page":"1714898","DOI":"10.3389\/fimmu.2025.1714898","article-title":"Astragalus Polysaccharides: Structure-Immunomodulation Relationships, Multi-Target Pharmacological Activities, and Cutting-Edge Applications in Immune Modulation","volume":"16","author":"Wang","year":"2025","journal-title":"Front. Immunol."},{"issue":"1","key":"2026101210564442600_cit60","doi-asserted-by":"publisher","first-page":"8196","DOI":"10.1038\/s41598-025-91201-x","article-title":"Aloe Polysaccharide Promotes Keratinocyte Proliferation, Migration, and Differentiation by Upregulating the EGFR\/PKC-Dependent Signaling Pathways","volume":"15","author":"Cheng","year":"2025","journal-title":"Sci. Rep."},{"issue":"5","key":"2026101210564442600_cit61","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0298487","article-title":"Cannabis Sativa (Hemp) Seed-Derived Peptides WVYY and PSLPA Modulate the Nrf2 Signaling Pathway in Human Keratinocytes","volume":"19","author":"Kim","year":"2024","journal-title":"PLoS One"},{"key":"2026101210564442600_cit62","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1016\/j.ijbiomac.2019.05.082","article-title":"Hemp Seed Polysaccharides Protect Intestinal Epithelial Cells from Hydrogen Peroxide-Induced Oxidative Stress","volume":"135","author":"Wen","year":"2019","journal-title":"Int. J. Biol. Macromol."},{"issue":"1","key":"2026101210564442600_cit63","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2020\/1813798","article-title":"Polysaccharides from Hemp Seed Protect against Cyclophosphamide-Induced Intestinal Oxidative Damage via Nrf2-Keap1 Signaling Pathway in Mice","volume":"2020","author":"Xue","year":"2020","journal-title":"Oxid. Med. Cell. Longevity"},{"key":"2026101210564442600_cit64","doi-asserted-by":"publisher","first-page":"785","DOI":"10.3389\/fphar.2020.00785","article-title":"The Enigma of Bioactivity and Toxicity of Botanical Oils for Skin Care","volume":"11","author":"Moore","year":"2020","journal-title":"Front. Pharmacol."},{"issue":"1","key":"2026101210564442600_cit65","doi-asserted-by":"publisher","first-page":"12","DOI":"10.15386\/mpr-1422","article-title":"The Evaluation of Oxidative Stress in Osteoarthritis","volume":"93","author":"Zahan","year":"2020","journal-title":"Med. Pharm. Rep."}],"container-title":["Biomacromolecules"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acs.biomac.6c01704","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/bomaf6\/article-pdf\/27\/10\/6986\/68629752\/bm6c01704.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/pubs.acs.org\/bomaf6\/article-pdf\/27\/10\/6986\/68629752\/bm6c01704.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T15:11:43Z","timestamp":1791817903000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/bomaf6\/article\/27\/10\/6986\/5437138\/Antioxidant-and-Bioactive-Properties-of-a"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,23]]},"references-count":65,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2026,9,23]]},"published-print":{"date-parts":[[2026,10,12]]}},"URL":"https:\/\/doi.org\/10.1021\/acs.biomac.6c01704","relation":{},"ISSN":["1525-7797","1526-4602"],"issn-type":[{"value":"1525-7797","type":"print"},{"value":"1526-4602","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,23]]}}}