{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T17:23:26Z","timestamp":1793294606336,"version":"4.5.0"},"reference-count":49,"publisher":"American Chemical Society (ACS)","issue":"8","license":[{"start":{"date-parts":[[2017,7,25]],"date-time":"2017-07-25T00:00:00Z","timestamp":1500940800000},"content-version":"vor","delay-in-days":13,"URL":"https:\/\/pubs.acs.org\/page\/policy\/authorchoice_ccbyncnd_termsofuse.html"}],"funder":[{"DOI":"10.13039\/501100008530","name":"European Regional Development Fund","doi-asserted-by":"publisher","award":["EFRO 2011-014237"],"award-info":[{"award-number":["EFRO 2011-014237"]}],"id":[{"id":"10.13039\/501100008530","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003246","name":"Nederlandse Organisatie voor Wetenschappelijk Onderzoek","doi-asserted-by":"publisher","award":["KIEM 731.013.107"],"award-info":[{"award-number":["KIEM 731.013.107"]}],"id":[{"id":"10.13039\/501100003246","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003246","name":"Nederlandse Organisatie voor Wetenschappelijk Onderzoek","doi-asserted-by":"publisher","award":["LIFT 731.015.415"],"award-info":[{"award-number":["LIFT 731.015.415"]}],"id":[{"id":"10.13039\/501100003246","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Netherlands Institute for Regenerative Medicine","award":["NIRM, grant No. FES0908"],"award-info":[{"award-number":["NIRM, grant No. FES0908"]}]},{"name":"GATT Technologies bv"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,8,14]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>In order to prevent hemorrhage during surgical procedures, a wide range of hemostatic agents have been developed. However, their efficacy is variable; hemostatic devices that use bioactive components to accelerate coagulation are dependent on natural sources, which limits reproducibility. Hybrid devices in which chain-end reactive poly(ethylene glycol) is employed as active component sometimes suffer from irregular cross-linking and dissolution of the polar PEG when blood flow is substantial. Herein, we describe a synthetic, nonbioactive hemostatic product by coating N-hydroxysuccinimide ester (NHS)-functional poly(2-oxazoline)s (POx-NHS) onto gelatin patches, which acts by formation of covalent cross-links between polymer, host blood proteins, gelatin and tissue to seal the wound site and prevent hemorrhage during surgery. We studied different process parameters (including polymer, carrier, and coating technique) in direct comparison with clinical products (Hemopatch and Tachosil) to obtain deeper understanding of this class of hemostatic products. In this work, we successfully prove the hemostatic efficacy of POx-NHS as polymer powders and coated patches both in vitro and in vivo against Hemopatch and Tachosil, demonstrating that POx-NHS are excellent candidate polymers for the development of next generation hemostatic patches.<\/jats:p>","DOI":"10.1021\/acs.biomac.7b00683","type":"journal-article","created":{"date-parts":[[2017,7,12]],"date-time":"2017-07-12T10:59:22Z","timestamp":1499857162000},"page":"2529-2538","source":"Crossref","is-referenced-by-count":91,"title":["Next Generation Hemostatic Materials Based on NHS-Ester\nFunctionalized Poly(2-oxazoline)s"],"prefix":"10.1021","volume":"18","author":[{"given":"Marcel A.","family":"Boerman","sequence":"first","affiliation":[{"name":"Radboud University Nijmegen , , Heyendaalseweg 135 , ,","place":["Nijmegen, The Netherlands, 6525 AJ"]},{"name":"Radboudumc , , Philip v. Leydenlaan 25 , ,","place":["Nijmegen, The Netherlands, 6525 EX"]},{"name":"GATT-Technologies BV , Toernooiveld 1 , ,","place":["Nijmegen, The Netherlands, 6525 ED"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edwin","family":"Roozen","sequence":"additional","affiliation":[{"name":"Radboudumc , , Geert Grooteplein 10 , ,","place":["Nijmegen, The Netherlands, 6525 GA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mari\u0301a Jose\u0301","family":"Sa\u0301nchez-Ferna\u0301ndez","sequence":"additional","affiliation":[{"name":"Radboudumc , , Philip v. Leydenlaan 25 , ,","place":["Nijmegen, The Netherlands, 6525 EX"]},{"name":"GATT-Technologies BV , Toernooiveld 1 , ,","place":["Nijmegen, The Netherlands, 6525 ED"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abraham R.","family":"Keereweer","sequence":"additional","affiliation":[{"name":"GATT-Technologies BV , Toernooiveld 1 , ,","place":["Nijmegen, The Netherlands, 6525 ED"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosa P.","family":"Fe\u0301lix Lanao","sequence":"additional","affiliation":[{"name":"Radboud University Nijmegen , , Heyendaalseweg 135 , ,","place":["Nijmegen, The Netherlands, 6525 AJ"]},{"name":"GATT-Technologies BV , Toernooiveld 1 , ,","place":["Nijmegen, The Netherlands, 6525 ED"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johan C. M. E.","family":"Bender","sequence":"additional","affiliation":[{"name":"GATT-Technologies BV , Toernooiveld 1 , ,","place":["Nijmegen, The Netherlands, 6525 ED"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7398-2058","authenticated-orcid":true,"given":"Richard","family":"Hoogenboom","sequence":"additional","affiliation":[{"name":"Ghent University , , Krijgslaan 281 S4 , ,","place":["Ghent, Belgium, 9000"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sander C.","family":"Leeuwenburgh","sequence":"additional","affiliation":[{"name":"Radboudumc , , Philip v. Leydenlaan 25 , ,","place":["Nijmegen, The Netherlands, 6525 EX"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John A.","family":"Jansen","sequence":"additional","affiliation":[{"name":"Radboudumc , , Philip v. Leydenlaan 25 , ,","place":["Nijmegen, The Netherlands, 6525 EX"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harry","family":"Van Goor","sequence":"additional","affiliation":[{"name":"Radboudumc , , Geert Grooteplein 10 , ,","place":["Nijmegen, The Netherlands, 6525 GA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7973-2404","authenticated-orcid":true,"given":"Jan C. M.","family":"Van Hest","sequence":"additional","affiliation":[{"name":"Radboud University Nijmegen , , Heyendaalseweg 135 , ,","place":["Nijmegen, The Netherlands, 6525 AJ"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2017,7,12]]},"reference":[{"issue":"3","key":"2026092908091180100_cit1","doi-asserted-by":"publisher","first-page":"812","DOI":"10.1016\/j.transproceed.2006.01.047","article-title":"Pathophysiology\nof bleeding in surgery","volume":"38","author":"Marietta","year":"2006","journal-title":"Transplant. Proc."},{"issue":"10","key":"2026092908091180100_cit2","doi-asserted-by":"publisher","first-page":"2892","DOI":"10.1007\/s00464-012-2276-6","article-title":"Effectiveness\nof electrothermal bipolar vessel-sealing devices versus other electrothermal\nand ultrasonic devices for abdominal surgical hemostasis: a systematic\nreview","volume":"26","author":"Janssen","year":"2012","journal-title":"Surg. Endosc."},{"issue":"4","key":"2026092908091180100_cit3","doi-asserted-by":"publisher","first-page":"309","DOI":"10.1046\/j.1540-8175.2001.00309.x","article-title":"Therapeutic Ultrasound,\nPart II* High Intensity Focused Ultrasound: A Method of Hemostasis","volume":"18","author":"Siegal","year":"2001","journal-title":"Echocardiography"},{"issue":"10","key":"2026092908091180100_cit4","doi-asserted-by":"publisher","first-page":"609","DOI":"10.1002\/jhbp.389","article-title":"An update\non topical haemostatic\nagents in liver surgery: systematic review and meta analysis","volume":"23","author":"Brustia","year":"2016","journal-title":"J. Hepatobiliary. Pancreat. Sci."},{"issue":"2","key":"2026092908091180100_cit5","doi-asserted-by":"publisher","first-page":"408","DOI":"10.1097\/01.ju.0000076017.26789.6a","article-title":"Laparoscopic radical\nversus partial nephrectomy: assessment\nof complications","volume":"170","author":"Kim","year":"2003","journal-title":"J. Urol."},{"issue":"3","key":"2026092908091180100_cit6","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1007\/s10047-005-0296-x","article-title":"Clinical benefits\nand risk analysis of topical hemostats: a review","volume":"8","author":"Tomizawa","year":"2005","journal-title":"J. Artif. Organs"},{"issue":"7","key":"2026092908091180100_cit7","doi-asserted-by":"publisher","first-page":"1375","DOI":"10.1016\/j.progpolymsci.2014.02.001","article-title":"The chemistry\nof tissue adhesive materials","volume":"39","author":"Bouten","year":"2014","journal-title":"Prog. Polym. Sci."},{"issue":"3","key":"2026092908091180100_cit8","doi-asserted-by":"publisher","first-page":"305","DOI":"10.1016\/j.transci.2011.10.013","article-title":"Topical hemostatic agents in surgical practice","volume":"45","author":"Emilia","year":"2011","journal-title":"Transfus. Apher. Sci."},{"issue":"1","key":"2026092908091180100_cit9","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s13019-014-0134-4","article-title":"Microporous\npolysaccharide hemosphere\nabsorbable hemostat use in cardiothoracic surgical procedures","volume":"9","author":"Bruckner","year":"2014","journal-title":"J. Cardiothorac. Surg."},{"issue":"1","key":"2026092908091180100_cit10","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1097\/00005373-200301000-00023","article-title":"Effect of a chitosan-based\nhemostatic dressing on blood loss and survival in a model of severe\nvenous hemorrhage and hepatic injury in swine","volume":"54","author":"Pusateri","year":"2003","journal-title":"J. Trauma"},{"issue":"3","key":"2026092908091180100_cit11","doi-asserted-by":"publisher","first-page":"1023","DOI":"10.1016\/j.carbpol.2012.01.058","article-title":"Oxidized regenerated\ncellulose-based hemostat with microscopically\ngradient structure","volume":"88","author":"Wu","year":"2012","journal-title":"Carbohydr. Polym."},{"key":"2026092908091180100_cit12","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1007\/s10353-013-0222-z","article-title":"Comparison of regenerated and non-regenerated oxidized\ncellulose hemostatic agents","volume":"45","author":"Lewis","year":"2013","journal-title":"Eur. Surg."},{"issue":"2","key":"2026092908091180100_cit13","doi-asserted-by":"publisher","first-page":"372","DOI":"10.1002\/jbm.b.31663","article-title":"A novel gelatin sponge for accelerated hemostasis","volume":"94","author":"Hajosch","year":"2010","journal-title":"J. Biomed. Mater. Res., Part B"},{"issue":"3","key":"2026092908091180100_cit14","doi-asserted-by":"publisher","first-page":"457","DOI":"10.1016\/j.cap.2010.08.031","article-title":"Preparation and characterization\nof absorbable hemostat crosslinked gelatin sponges for surgical applications","volume":"11","author":"Kabiri","year":"2011","journal-title":"Curr. Appl. Phys."},{"key":"2026092908091180100_cit15","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1186\/1745-6215-11-109","article-title":"Comparison\nof the collagen haemostat Sangustop(R) versus a carrier-bound fibrin\nsealant during liver resection; ESSCALIVER-Study","volume":"11","author":"Moench","year":"2010","journal-title":"Trials"},{"issue":"7","key":"2026092908091180100_cit16","doi-asserted-by":"publisher","first-page":"1820","DOI":"10.1039\/C4CS00332B","article-title":"The chemistry\nand engineering of polymeric hydrogel\nadhesives for wound closure: a tutorial","volume":"44","author":"Ghobril","year":"2015","journal-title":"Chem.\nSoc. Rev."},{"issue":"4","key":"2026092908091180100_cit17","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1111\/j.1445-2197.2007.04020.x","article-title":"Surgical applications of cyanoacrylate\nadhesives: a review of toxicity","volume":"77","author":"Leggat","year":"2007","journal-title":"ANZ. J. Surg."},{"issue":"7","key":"2026092908091180100_cit18","doi-asserted-by":"publisher","first-page":"548","DOI":"10.1111\/hpb.12009","article-title":"A multicentre, randomized clinical\ntrial comparing the Veriset haemostatic patch with fibrin sealant\nfor the management of bleeding during hepatic surgery","volume":"15","author":"O\u0308llinger","year":"2013","journal-title":"HPB"},{"issue":"5","key":"2026092908091180100_cit19","doi-asserted-by":"publisher","first-page":"780","DOI":"10.1177\/0885328214545500","article-title":"Swelling, sealing, and hemostatic\nability of a novel biomaterial: A polyethylene glycol-coated collagen\npad","volume":"29","author":"Lewis","year":"2014","journal-title":"J. Biomater. Appl."},{"key":"2026092908091180100_cit20","doi-asserted-by":"publisher","first-page":"1","DOI":"10.2147\/MDER.S90591","article-title":"Control of\nbleeding in surgical procedures:\ncritical appraisal of HEMOPATCH (Sealing Hemostat)","volume":"9","author":"Lewis","year":"2015","journal-title":"Med. Devices: Evidence Res."},{"issue":"9","key":"2026092908091180100_cit21","doi-asserted-by":"publisher","first-page":"940","DOI":"10.1016\/j.ijsu.2014.07.017","article-title":"Hemostatic efficacy of a novel, PEG-coated collagen\npad in clinically relevant animal models","volume":"12","author":"Lewis","year":"2014","journal-title":"Int.\nJ. Surg."},{"key":"2026092908091180100_cit22","doi-asserted-by":"publisher","first-page":"186","DOI":"10.1016\/j.avsg.2015.09.007","article-title":"A Novel Hemostatic\nPatch That Stops\nBleeding in Cardiovascular and Peripheral Vascular Procedures","volume":"31","author":"Howk","year":"2016","journal-title":"Ann. Vasc. Surg."},{"issue":"9","key":"2026092908091180100_cit23","doi-asserted-by":"publisher","first-page":"2253","DOI":"10.1002\/pol.1966.150040919","article-title":"Homopolymerization of 2-alkyl- and\n2-aryl-2-oxazolines","volume":"4","author":"Tomalia","year":"1966","journal-title":"J. Polym. Sci., Part A-1:\nPolym. Chem."},{"key":"2026092908091180100_cit24","doi-asserted-by":"publisher","first-page":"875","DOI":"10.1002\/anie.196608751","article-title":"Recent syntheses and\nreactions of\ncyclic imidic esters","volume":"5","author":"Seeliger","year":"1966","journal-title":"Angew. Chem., Int. Ed.\nEngl."},{"issue":"7","key":"2026092908091180100_cit25","doi-asserted-by":"publisher","first-page":"1883","DOI":"10.1002\/pol.1968.150060711","article-title":"Polymerization of cyclic iminoethers. V. 1,3-oxazolines with hydroxy-,\nacetoxy-, and carboxymethyl-alkyl groups in the 2 position and their\npolymers","volume":"6","author":"Levy","year":"1968","journal-title":"J. Polym. Sci., Part A-1: Polym. Chem."},{"issue":"7","key":"2026092908091180100_cit26","doi-asserted-by":"publisher","first-page":"441","DOI":"10.1002\/pol.1966.110040701","article-title":"Ring-opening polymerization\nof 2-substituted 2-oxazolines","volume":"4","author":"Kagiya","year":"1966","journal-title":"J. Polym. Sci.,\nPart B: Polym. Lett."},{"issue":"43","key":"2026092908091180100_cit27","doi-asserted-by":"publisher","first-page":"7978","DOI":"10.1002\/anie.200901607","article-title":"Poly(2-oxazoline)s:\na polymer class with numerous potential applications","volume":"48","author":"Hoogenboom","year":"2009","journal-title":"Angew. Chem., Int. Ed."},{"issue":"3","key":"2026092908091180100_cit28","doi-asserted-by":"publisher","first-page":"956","DOI":"10.3390\/polym5030956","article-title":"Design Strategies\nfor Functionalized\nPoly(2-oxazoline)s and Derived Materials","volume":"5","author":"Rossegger","year":"2013","journal-title":"Polymers"},{"issue":"19","key":"2026092908091180100_cit29","doi-asserted-by":"publisher","first-page":"1600","DOI":"10.1002\/marc.201200266","article-title":"How to modulate\nthe chemical structure of polyoxazolines by appropriate functionalization","volume":"33","author":"Guillerm","year":"2012","journal-title":"Macromol. Rapid Commun."},{"issue":"6","key":"2026092908091180100_cit30","doi-asserted-by":"publisher","first-page":"1457","DOI":"10.1007\/s10856-012-4621-7","article-title":"Immunomodulatory efficiency of poly(2-oxazolines)","volume":"23","author":"Kronek","year":"2012","journal-title":"J. Mater. Sci.: Mater. Med."},{"issue":"7","key":"2026092908091180100_cit31","doi-asserted-by":"publisher","first-page":"986","DOI":"10.1002\/mabi.201200017","article-title":"Poly(2-ethyl-2-oxazoline)\nas alternative for the stealth\npolymer poly(ethylene glycol): comparison of in vitro cytotoxicity\nand hemocompatibility","volume":"12","author":"Bauer","year":"2012","journal-title":"Macromol. Biosci."},{"issue":"15","key":"2026092908091180100_cit32","doi-asserted-by":"publisher","first-page":"1504","DOI":"10.1016\/j.addr.2007.08.018","article-title":"Poly(2-oxazolines) in biological and biomedical application\ncontexts","volume":"59","author":"Adams","year":"2007","journal-title":"Adv. Drug Delivery Rev."},{"issue":"3","key":"2026092908091180100_cit33","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1016\/j.jconrel.2007.02.015","article-title":"Synthesis,\nbiodistribution and excretion of radiolabeled poly(2-alkyl-2-oxazoline)s","volume":"119","author":"Gaertner","year":"2007","journal-title":"J. Controlled Release"},{"key":"2026092908091180100_cit34","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1016\/j.jconrel.2016.05.048","article-title":"muPET imaging of the pharmacokinetic\nbehavior of medium and high molar mass (89)Zr-labeled poly(2-ethyl-2-oxazoline)\nin comparison to poly(ethylene glycol)","volume":"235","author":"Wyffels","year":"2016","journal-title":"J. Controlled\nRelease"},{"issue":"5","key":"2026092908091180100_cit35","doi-asserted-by":"publisher","first-page":"1211","DOI":"10.1007\/s10856-013-5034-y","article-title":"Poly(2-oxazoline)s as materials for biomedical applications","volume":"25","author":"de la Rosa","year":"2014","journal-title":"J. Mater. Sci.: Mater. Med."},{"key":"2026092908091180100_cit36","doi-asserted-by":"publisher","first-page":"524","DOI":"10.1016\/j.eurpolymj.2016.09.052","article-title":"Clinical development\nof a poly(2-oxazoline) (POZ) polymer therapeutic for the treatment\nof Parkinson\u2019s disease \u2013 Proof of concept of POZ as\na versatile polymer platform for drug development in multiple therapeutic\nindications","volume":"88","author":"Moreadith","year":"2017","journal-title":"Eur. Polym. J."},{"issue":"2","key":"2026092908091180100_cit37","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1021\/js9504043","article-title":"Evaluation of Blood\nClearance Rates and Biodistribution of Poly(2-oxazoline)-Grafted Liposomes\u00a7","volume":"85","author":"Zalipsky","year":"1996","journal-title":"J. Pharm. Sci."},{"issue":"9","key":"2026092908091180100_cit38","doi-asserted-by":"publisher","first-page":"3261","DOI":"10.1016\/j.actbio.2012.05.001","article-title":"Rapidly curable\nchitosan-PEG hydrogels as tissue adhesives for hemostasis and wound\nhealing","volume":"8","author":"Lih","year":"2012","journal-title":"Acta Biomater."},{"key":"#cr-split#-2026092908091180100_cit39.1","unstructured":"ASTM F2258-05(2015), Standard Test Method for Strength Properties of Tissue Adhesives in Tension"},{"key":"#cr-split#-2026092908091180100_cit39.2","unstructured":"ASTM International: West Conshohocken, PA, 2015, www.astm.org. In ASTM F2258-05(2015), Standard Test Method for Strength Properties of Tissue Adhesives in Tension, ASTM International, West Conshohocken, PA, 2015, www.astm.org."},{"issue":"1","key":"2026092908091180100_cit40","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s11239-008-0249-3","article-title":"Acute in-vivo\nevaluation of bleeding with Gelfoam plus saline and Gelfoam plus human\nthrombin using a liver square lesion model in swine","volume":"28","author":"Adams","year":"2009","journal-title":"J. Thromb. Thrombolysis"},{"issue":"11","key":"2026092908091180100_cit41","doi-asserted-by":"publisher","first-page":"3531","DOI":"10.1021\/acs.macromol.5b00290","article-title":"Functional\nPoly(2-oxazoline)s by Direct Amidation of\nMethyl Ester Side Chains","volume":"48","author":"Mees","year":"2015","journal-title":"Macromolecules"},{"issue":"3","key":"2026092908091180100_cit42","doi-asserted-by":"publisher","first-page":"208","DOI":"10.1080\/15685551.2013.840471","article-title":"Synthesis and characterization of new pH- and thermo-responsive hydrogels\nbased on N-isopropylacrylamide and 2-oxazolines","volume":"17","author":"Rueda","year":"2014","journal-title":"Des. Monomers Polym."},{"issue":"8","key":"2026092908091180100_cit43","doi-asserted-by":"publisher","first-page":"761","DOI":"10.1080\/15685551.2015.1078109","article-title":"Synthesis and characterization\nof new bi-sensitive copoly(2-oxazolines)","volume":"18","author":"Rueda","year":"2015","journal-title":"Des.\nMonomers Polym."},{"issue":"11","key":"2026092908091180100_cit44","doi-asserted-by":"publisher","first-page":"1573","DOI":"10.1002\/pola.28011","article-title":"Synthesis of\npH- and thermoresponsive poly(2-n-propyl-2-oxazoline) based copolymers","volume":"54","author":"Boerman","year":"2016","journal-title":"J. Polym. Sci., Part A: Polym. Chem."},{"issue":"4","key":"2026092908091180100_cit45","doi-asserted-by":"publisher","first-page":"514","DOI":"10.1039\/C4PY01373E","article-title":"Accelerated living cationic ring-opening\npolymerization of a methyl ester functionalized 2-oxazoline monomer","volume":"6","author":"Bouten","year":"2015","journal-title":"Polym. Chem."},{"issue":"22","key":"2026092908091180100_cit46","doi-asserted-by":"publisher","first-page":"2649","DOI":"10.1002\/pola.27733","article-title":"Synthesis\nof poly(2-oxazoline)s with side chain methyl ester functionalities:\nDetailed understanding of living copolymerization behavior of methyl\nester containing monomers with 2-alkyl-2-oxazolines","volume":"53","author":"Bouten","year":"2015","journal-title":"J. Polym. Sci., Part A: Polym. Chem."},{"issue":"12","key":"2026092908091180100_cit47","doi-asserted-by":"publisher","first-page":"5025","DOI":"10.1021\/ma0474170","article-title":"Investigation\nof the Living Cationic Ring-Opening Polymerization of 2-Methyl-, 2-Ethyl-,\n2-Nonyl-, and 2-Phenyl-2-oxazoline in a Single-Mode Microwave Reactor\u2020","volume":"38","author":"Wiesbrock","year":"2005","journal-title":"Macromolecules"},{"issue":"23","key":"2026092908091180100_cit48","doi-asserted-by":"publisher","first-page":"1958","DOI":"10.1002\/marc.200400408","article-title":"Characterization of a Poly(2-oxazoline)\nLibrary by\nHigh-Throughput, Automated Contact-Angle Measurements and Surface-Energy\nCalculations","volume":"25","author":"Wijnans","year":"2004","journal-title":"Macromol. Rapid Commun."}],"container-title":["Biomacromolecules"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acs.biomac.7b00683","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/bomaf6\/article-pdf\/18\/8\/2529\/67279060\/acs.biomac.7b00683.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/pubs.acs.org\/bomaf6\/article-pdf\/18\/8\/2529\/67279060\/acs.biomac.7b00683.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T12:49:43Z","timestamp":1790686183000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/bomaf6\/article\/18\/8\/2529\/730449\/Next-Generation-Hemostatic-Materials-Based-on-NHS"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,7,12]]},"references-count":49,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2017,7,12]]},"published-print":{"date-parts":[[2017,8,14]]}},"URL":"https:\/\/doi.org\/10.1021\/acs.biomac.7b00683","relation":{},"ISSN":["1525-7797","1526-4602"],"issn-type":[{"value":"1525-7797","type":"print"},{"value":"1526-4602","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,7,12]]}}}