{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T02:59:15Z","timestamp":1787626755254,"version":"build-2736575974"},"reference-count":33,"publisher":"American Chemical Society (ACS)","issue":"12","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biomacromolecules"],"published-print":{"date-parts":[[2017,12,11]]},"DOI":"10.1021\/acs.biomac.7b00945","type":"journal-article","created":{"date-parts":[[2017,11,7]],"date-time":"2017-11-07T15:50:16Z","timestamp":1510069816000},"page":"3924-3935","source":"Crossref","is-referenced-by-count":24,"title":["Nano into Micro Formulations of Tobramycin for the Treatment of <i>Pseudomonas aeruginosa<\/i> Infections in Cystic Fibrosis"],"prefix":"10.1021","volume":"18","author":[{"given":"Barbara","family":"Porsio","sequence":"first","affiliation":[{"name":"Dipartimento\rdi Scienze e Tecnologie Biologiche Chimiche e Farmaceutiche (STEBICEF), Universit\u00e0 di Palermo, Via Archirafi 32, 90123 Palermo, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Grazia","family":"Cusimano","sequence":"additional","affiliation":[{"name":"Dipartimento\rdi Scienze e Tecnologie Biologiche Chimiche e Farmaceutiche (STEBICEF), Universit\u00e0 di Palermo, Via Archirafi 32, 90123 Palermo, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Domenico","family":"Schillaci","sequence":"additional","affiliation":[{"name":"Dipartimento\rdi Scienze e Tecnologie Biologiche Chimiche e Farmaceutiche (STEBICEF), Universit\u00e0 di Palermo, Via Archirafi 32, 90123 Palermo, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emanuela Fabiola","family":"Craparo","sequence":"additional","affiliation":[{"name":"Dipartimento\rdi Scienze e Tecnologie Biologiche Chimiche e Farmaceutiche (STEBICEF), Universit\u00e0 di Palermo, Via Archirafi 32, 90123 Palermo, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gaetano","family":"Giammona","sequence":"additional","affiliation":[{"name":"Dipartimento\rdi Scienze e Tecnologie Biologiche Chimiche e Farmaceutiche (STEBICEF), Universit\u00e0 di Palermo, Via Archirafi 32, 90123 Palermo, Italy"},{"name":"Mediterranean\rCenter for Human Health Advanced Biotechnologies (CHAB), ATeN Center, University of Palermo, Viale delle\rScienze, Ed. 18, Palermo, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0585-6564","authenticated-orcid":true,"given":"Gennara","family":"Cavallaro","sequence":"additional","affiliation":[{"name":"Dipartimento\rdi Scienze e Tecnologie Biologiche Chimiche e Farmaceutiche (STEBICEF), Universit\u00e0 di Palermo, Via Archirafi 32, 90123 Palermo, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2017,11,16]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra043184"},{"issue":"9","key":"ref2\/cit2","first-page":"1176","volume":"52","author":"Rogers D. F.","year":"2007","journal-title":"Respir. Care"},{"key":"ref3\/cit3","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2008.09.011"},{"key":"ref4\/cit4","doi-asserted-by":"publisher","DOI":"10.1513\/pats.2306014"},{"key":"ref5\/cit5","doi-asserted-by":"publisher","DOI":"10.1016\/j.pupt.2015.07.003"},{"key":"ref6\/cit6","doi-asserted-by":"publisher","DOI":"10.1172\/JCI0215217"},{"key":"ref7\/cit7","doi-asserted-by":"publisher","DOI":"10.1016\/j.pupt.2009.06.001"},{"key":"ref8\/cit8","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcf.2010.10.003"},{"key":"ref9\/cit9","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.21356"},{"key":"ref10\/cit10","doi-asserted-by":"publisher","DOI":"10.1089\/jamp.2010.0855"},{"key":"ref11\/cit11","unstructured":"TOBI Podhaler - Novartis,www.ema.europe.com."},{"key":"ref12\/cit12","doi-asserted-by":"publisher","DOI":"10.1111\/1462-2920.12155"},{"key":"ref13\/cit13","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2011.08.010"},{"key":"ref14\/cit14","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-5173(02)00080-7"},{"key":"ref15\/cit15","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2014.11.022"},{"key":"ref16\/cit16","doi-asserted-by":"publisher","DOI":"10.1002\/bit.23046"},{"key":"ref17\/cit17","doi-asserted-by":"publisher","DOI":"10.2217\/nnm-2016-0262"},{"key":"ref18\/cit18","doi-asserted-by":"publisher","DOI":"10.1016\/S0032-3861(03)00486-5"},{"key":"ref19\/cit19","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2010.12.024"},{"key":"ref20\/cit20","doi-asserted-by":"publisher","DOI":"10.1021\/acs.biomac.5b01480"},{"key":"ref21\/cit21","unstructured":"www.ema.europe.com."},{"key":"ref22\/cit22","doi-asserted-by":"publisher","DOI":"10.1002\/pola.1987.080251016"},{"key":"ref23\/cit23","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2005.09.027"},{"key":"ref24\/cit24","doi-asserted-by":"publisher","DOI":"10.1088\/0957-4484\/19\/48\/485603"},{"key":"ref25\/cit25","doi-asserted-by":"publisher","DOI":"10.1080\/08927011003718673"},{"key":"ref26\/cit26","doi-asserted-by":"publisher","DOI":"10.1080\/08927011003718673"},{"key":"ref27\/cit27","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcf.2012.12.008"},{"key":"ref28\/cit28","doi-asserted-by":"publisher","DOI":"10.1186\/s13023-014-0189-2"},{"key":"ref29\/cit29","unstructured":"Lynovex NM001-Novabiotics,https:\/\/www.novabiotics.co.uk\/pipeline\/lynovex-nm001(accessed Sep 11, 2017) ."},{"key":"ref30\/cit30","doi-asserted-by":"publisher","DOI":"10.1023\/A:1024907615244"},{"key":"ref31\/cit31","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsps.2015.02.025"},{"key":"ref32\/cit32","doi-asserted-by":"publisher","DOI":"10.1021\/acs.biomac.5b01480"},{"key":"ref33\/cit33","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.39.1.34"}],"container-title":["Biomacromolecules"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acs.biomac.7b00945","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,15]],"date-time":"2023-04-15T14:20:22Z","timestamp":1681568422000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/acs.biomac.7b00945"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,11,16]]},"references-count":33,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2017,12,11]]}},"alternative-id":["10.1021\/acs.biomac.7b00945"],"URL":"https:\/\/doi.org\/10.1021\/acs.biomac.7b00945","relation":{},"ISSN":["1525-7797","1526-4602"],"issn-type":[{"value":"1525-7797","type":"print"},{"value":"1526-4602","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,11,16]]}}}