{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T02:29:19Z","timestamp":1789093759660,"version":"build-2803163510"},"reference-count":34,"publisher":"American Chemical Society (ACS)","issue":"8","license":[{"start":{"date-parts":[[2018,7,9]],"date-time":"2018-07-09T00:00:00Z","timestamp":1531094400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2018,7,9]],"date-time":"2018-07-09T00:00:00Z","timestamp":1531094400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2018,7,9]],"date-time":"2018-07-09T00:00:00Z","timestamp":1531094400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/501100001700","name":"Ministry of Education, Culture, Sports, Science and Technology","doi-asserted-by":"publisher","award":["16H02637"],"award-info":[{"award-number":["16H02637"]}],"id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008670","name":"Terumo Foundation for Life Sciences and Arts","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008670","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Tokyo Society of Medical Sciences"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018,8,13]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>We have developed a new hydrogel hemostat composed of hyaluronan (HA) conjugated with inorganic polyphosphate (PolyP). A hemostatic hydrogel, HAX-PolyP, was formed rapidly by mixing aldehyde-modified HA and hydrazide-modified HA conjugated with PolyP (HA-PolyP). Although the gelation rate decreased with increasing PolyP content, the gelation time was below 5 min. In addition, the hydrogel swelling volume decreased with increasing PolyP content, but the degradation rate did not depend on PolyP content and the hydrogel underwent complete degradation through hydrolysis over 3 weeks in phosphate buffered saline. HAX-PolyP showed similar biocompatibility with the HA hydrogel without PolyP conjugation in vitro and in vivo. Intraperitoneal administration of HAX-PolyP did not induce any adhesion in the peritoneum and clot formation in the lungs. Finally, HA-PolyP accelerated the coagulation rate of human plasma ex vivo, and HAX-PolyP showed as strong a hemostatic effect as fibrin glue in a mouse liver bleeding model in vivo.<\/jats:p>","DOI":"10.1021\/acs.biomac.8b00588","type":"journal-article","created":{"date-parts":[[2018,7,9]],"date-time":"2018-07-09T15:30:28Z","timestamp":1531150228000},"page":"3280-3290","source":"Crossref","is-referenced-by-count":62,"title":["Injectable Hemostat Composed of a Polyphosphate-Conjugated\nHyaluronan Hydrogel"],"prefix":"10.1021","volume":"19","author":[{"given":"Megumu","family":"Sakoda","sequence":"first","affiliation":[{"name":"The University of Tokyo , , 7-3-1 Hongo , , ,","place":["Bunkyo-ku, Tokyo, Japan, 113-8656"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3100-2477","authenticated-orcid":true,"given":"Makoto","family":"Kaneko","sequence":"additional","affiliation":[{"name":"The University of Tokyo , , 7-3-1 Hongo , , ,","place":["Bunkyo-ku, Tokyo, Japan, 113-0033"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4775-8199","authenticated-orcid":true,"given":"Seiichi","family":"Ohta","sequence":"additional","affiliation":[{"name":"The University of Tokyo , , 7-3-1 Hongo , , ,","place":["Bunkyo-ku, Tokyo, Japan, 113-0033"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pan","family":"Qi","sequence":"additional","affiliation":[{"name":"The University of Tokyo , , 7-3-1 Hongo , , ,","place":["Bunkyo-ku, Tokyo, Japan, 113-0033"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shigetoshi","family":"Ichimura","sequence":"additional","affiliation":[{"name":"Kanagawa Institute of Technology , , 1030 Shimo-ogino , , ,","place":["Atsugi, Kanagawa, Japan, 243-0292"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yutaka","family":"Yatomi","sequence":"additional","affiliation":[{"name":"The University of Tokyo , , 7-3-1 Hongo , , ,","place":["Bunkyo-ku, Tokyo, Japan, 113-0033"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1589-8242","authenticated-orcid":true,"given":"Taichi","family":"Ito","sequence":"additional","affiliation":[{"name":"The University of Tokyo , , 7-3-1 Hongo , , ,","place":["Bunkyo-ku, Tokyo, Japan, 113-8656"]},{"name":"The University of Tokyo , , 7-3-1 Hongo , , ,","place":["Bunkyo-ku, Tokyo, Japan, 113-0033"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2018,7,9]]},"reference":[{"issue":"2","key":"2026081800200628900_cit1","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1097\/SLA.0b013e3181c3bcca","article-title":"A Comprehensive\nReview of Topical Hemostatic Agents:\nEfficacy and Recommendations for Use","volume":"251","author":"Achneck","year":"2010","journal-title":"Ann. 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