{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T06:42:07Z","timestamp":1793947327974,"version":"4.8.0"},"reference-count":56,"publisher":"American Chemical Society (ACS)","issue":"8","license":[{"start":{"date-parts":[[2019,7,30]],"date-time":"2019-07-30T00:00:00Z","timestamp":1564444800000},"content-version":"vor","delay-in-days":27,"URL":"https:\/\/pubs.acs.org\/page\/policy\/authorchoice_ccby_termsofuse.html"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["SFB1066"],"award-info":[{"award-number":["SFB1066"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,8,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Liposomes are established drug carriers that are employed to transport and deliver hydrophilic drugs in the body. To minimize unspecific cellular uptake, nanocarriers are commonly modified with poly(ethylene glycol) (PEG), which is known to minimize unspecific protein adsorption. However, to date, it has not been studied whether this is an intrinsic and specific property of PEG or if it can be transferred to hyperbranched polyglycerol (hbPG) as well. Additionally, it remains unclear if the reduction of unspecific cell uptake is independent of the \u201cbasic\u201d carrier at which a surface functionalization with polymers is usually applied. Therefore, we studied the protein corona of differently functionalized liposomes (unfunctionalized vs PEG or hbPG-functionalized) using PEGylated and PGylated lipids. Their cellular uptake in macrophages was compared. For all three liposomal samples, rather similar protein corona compositions were found, and also\u2500more importantly\u2500the total amount of proteins adsorbed was very low compared to other nanoparticles. Interestingly, the cellular uptake was then significantly changed by the surface functionalization itself, despite the adsorption of a small amount of proteins: although the PEGylation of liposomes resulted in the abovementioned decreased cell uptake, functionalization with hbPG lead to enhanced macrophage interaction\u2500both in the media with and without proteins. In comparison to other nanocarrier systems, this seems to be a liposome-specific effect related to the low amount of adsorbed proteins.<\/jats:p>","DOI":"10.1021\/acs.biomac.9b00539","type":"journal-article","created":{"date-parts":[[2019,7,3]],"date-time":"2019-07-03T15:31:15Z","timestamp":1562167875000},"page":"2989-2999","source":"Crossref","is-referenced-by-count":93,"title":["Functionalization of Liposomes with Hydrophilic Polymers\nResults in Macrophage Uptake Independent of the Protein Corona"],"prefix":"10.1021","volume":"20","author":[{"given":"Claudia","family":"Weber","sequence":"first","affiliation":[{"name":"Max Planck Institute for Polymer Research , Ackermannweg 10 , ,","place":["Mainz, Germany, 55128"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthias","family":"Voigt","sequence":"additional","affiliation":[{"name":"Johannes Gutenberg-University , , Staudingerweg 5 , ,","place":["Mainz, Germany, 55128"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johanna","family":"Simon","sequence":"additional","affiliation":[{"name":"Max Planck Institute for Polymer Research , Ackermannweg 10 , ,","place":["Mainz, Germany, 55128"]},{"name":"University Medical Center of the Johannes Gutenberg-University Mainz , , Langenbeckstrasse 1 , ,","place":["Mainz, Germany, 55131"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ann-Kathrin","family":"Danner","sequence":"additional","affiliation":[{"name":"Johannes Gutenberg-University , , Duesbergweg 10-14 , ,","place":["Mainz, Germany, 55128"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9916-3103","authenticated-orcid":true,"given":"Holger","family":"Frey","sequence":"additional","affiliation":[{"name":"Johannes Gutenberg-University , , Duesbergweg 10-14 , ,","place":["Mainz, Germany, 55128"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6583-8136","authenticated-orcid":true,"given":"Volker","family":"Maila\u0308nder","sequence":"additional","affiliation":[{"name":"Max Planck Institute for Polymer Research , Ackermannweg 10 , ,","place":["Mainz, Germany, 55128"]},{"name":"University Medical Center of the Johannes Gutenberg-University Mainz , , Langenbeckstrasse 1 , ,","place":["Mainz, Germany, 55131"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0154-0928","authenticated-orcid":true,"given":"Mark","family":"Helm","sequence":"additional","affiliation":[{"name":"Johannes Gutenberg-University , , Staudingerweg 5 , ,","place":["Mainz, Germany, 55128"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9662-8190","authenticated-orcid":true,"given":"Svenja","family":"Morsbach","sequence":"additional","affiliation":[{"name":"Max Planck Institute for Polymer Research , Ackermannweg 10 , ,","place":["Mainz, Germany, 55128"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9591-4638","authenticated-orcid":true,"given":"Katharina","family":"Landfester","sequence":"additional","affiliation":[{"name":"Max Planck Institute for Polymer Research , Ackermannweg 10 , ,","place":["Mainz, Germany, 55128"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2019,7,3]]},"reference":[{"key":"2026090302014131500_cit1","doi-asserted-by":"publisher","first-page":"1818","DOI":"10.1126\/science.1095833","article-title":"Drug Delivery Systems:\nEntering the Mainstream","volume":"303","author":"Allen","year":"2004","journal-title":"Science"},{"key":"2026090302014131500_cit2","doi-asserted-by":"publisher","first-page":"1373","DOI":"10.1208\/s12248-016-9961-7","article-title":"Nanomedicines:\nFrom Bench to Bedside and Beyond","volume":"18","author":"Havel","year":"2016","journal-title":"AAPS J."},{"key":"2026090302014131500_cit3","doi-asserted-by":"publisher","first-page":"132","DOI":"10.1016\/j.ijpharm.2016.10.013","article-title":"Nanomedicines\nfor advanced cancer treatments: Transitioning towards responsive systems","volume":"515","author":"van Elk","year":"2016","journal-title":"Int. J. Pharm."},{"key":"2026090302014131500_cit4","doi-asserted-by":"publisher","first-page":"102","DOI":"10.1186\/1556-276x-8-102","article-title":"Liposome:\nclassification, preparation, and applications","volume":"8","author":"Akbarzadeh","year":"2013","journal-title":"Nanoscale Res. Lett."},{"key":"2026090302014131500_cit5","doi-asserted-by":"publisher","first-page":"667","DOI":"10.1002\/jps.1023","article-title":"Trends and developments\nin liposome drug delivery systems","volume":"90","author":"Lian","year":"2001","journal-title":"J. Pharm.\nSci."},{"key":"2026090302014131500_cit6","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1016\/s0378-5173(97)00135-x","article-title":"Liposomes in drug\ndelivery: Progress and limitations","volume":"154","author":"Sharma","year":"1997","journal-title":"Int. J.\nPharm."},{"key":"2026090302014131500_cit7","first-page":"987","article-title":"Prolonged\nCirculation Time and Enhanced Accumulation in Malignant Exudates of\nDoxorubicin Encapsulated in Polyethylene-glycol Coated Liposomes","volume":"54","author":"Gabizon","year":"1994","journal-title":"Cancer Res."},{"key":"2026090302014131500_cit8","doi-asserted-by":"publisher","first-page":"424","DOI":"10.1081\/cnv-100103136","article-title":"Pegylated\nLiposomal Doxorubicin: Metamorphosis of an Old Drug into a New Form\nof Chemotherapy","volume":"19","author":"Gabizon","year":"2001","journal-title":"Cancer Invest."},{"key":"2026090302014131500_cit9","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/s0960-9776(01)80001-1","article-title":"Liposome technology\nand the development of MyocetTM; (liposomal doxorubicin\ncitrate)","volume":"10","author":"Swenson","year":"2001","journal-title":"Breast"},{"key":"2026090302014131500_cit10","doi-asserted-by":"publisher","first-page":"2373","DOI":"10.1007\/s11095-016-1958-5","article-title":"Nanoparticle-Based\nMedicines: A Review of FDA-Approved Materials and Clinical Trials\nto Date","volume":"33","author":"Bobo","year":"2016","journal-title":"Pharm. Res."},{"key":"2026090302014131500_cit11","doi-asserted-by":"publisher","first-page":"14265","DOI":"10.1073\/pnas.0805135105","article-title":"Nanoparticle size and surface properties\ndetermine\nthe protein corona with possible implications for biological impacts","volume":"105","author":"Lundqvist","year":"2008","journal-title":"Proc. Natl. Acad. Sci. 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J."},{"key":"2026090302014131500_cit28","doi-asserted-by":"publisher","first-page":"11460","DOI":"10.1073\/pnas.88.24.11460","article-title":"Sterically stabilized liposomes: improvements in pharmacokinetics\nand antitumor therapeutic efficacy","volume":"88","author":"Papahadjopoulos","year":"1991","journal-title":"Proc. Natl.\nAcad. Sci. U.S.A."},{"key":"2026090302014131500_cit29","doi-asserted-by":"publisher","first-page":"3723","DOI":"10.1021\/acsnano.6b00261","article-title":"Exploring Cellular\nInteractions of Liposomes Using Protein Corona Fingerprints and Physicochemical\nProperties","volume":"10","author":"Bigdeli","year":"2016","journal-title":"ACS Nano"},{"key":"2026090302014131500_cit30","doi-asserted-by":"publisher","first-page":"7419","DOI":"10.1039\/c4tb01316f","article-title":"The liposome\u2013protein\ncorona in mice and humans and its implications for in vivo delivery","volume":"2","author":"Caracciolo","year":"2014","journal-title":"J. Mater. Chem. B"},{"key":"2026090302014131500_cit31","doi-asserted-by":"publisher","first-page":"2782","DOI":"10.1039\/c3nr05559k","article-title":"Effect of\npolyethyleneglycol (PEG) chain length on the bio-nano-interactions\nbetween PEGylated lipid nanoparticles and biological fluids: from\nnanostructure to uptake in cancer cells","volume":"6","author":"Pozzi","year":"2014","journal-title":"Nanoscale"},{"key":"2026090302014131500_cit32","doi-asserted-by":"publisher","first-page":"2440","DOI":"10.1021\/bm5003027","article-title":"Click Modification of Multifunctional\nLiposomes Bearing Hyperbranched Polyether Chains","volume":"15","author":"Fritz","year":"2014","journal-title":"Biomacromolecules"},{"key":"2026090302014131500_cit33","doi-asserted-by":"publisher","first-page":"568","DOI":"10.1021\/bm901123j","article-title":"Hyperbranched Polyglycerol-Based\nLipids via Oxyanionic Polymerization:\nToward Multifunctional Stealth Liposomes","volume":"11","author":"Hofmann","year":"2010","journal-title":"Biomacromolecules"},{"key":"2026090302014131500_cit34","doi-asserted-by":"publisher","first-page":"4648","DOI":"10.1021\/ma200367c","article-title":"Rapid Access to Polyfunctional Lipids\nwith Complex Architecture via Oxyanionic Ring-Opening Polymerization","volume":"44","author":"Hofmann","year":"2011","journal-title":"Macromolecules"},{"key":"2026090302014131500_cit35","doi-asserted-by":"publisher","first-page":"11578","DOI":"10.1002\/chem.201602758","article-title":"Orthogonal Click Conjugation to the\nLiposomal Surface Reveals the Stability of the Lipid Anchorage as\nCrucial for Targeting","volume":"22","author":"Fritz","year":"2016","journal-title":"Chem.\u2500Eur. J."},{"key":"2026090302014131500_cit36","doi-asserted-by":"publisher","first-page":"2506","DOI":"10.1021\/acs.biomac.8b00115","article-title":"Comparison\nof Linear and Hyperbranched Polyether Lipids for Liposome Shielding\nby 18F-Radiolabeling and Positron Emission Tomography","volume":"19","author":"Wagener","year":"2018","journal-title":"Biomacromolecules"},{"key":"2026090302014131500_cit37","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1016\/0010-4655(82)90174-6","article-title":"CONTIN:\nA general purpose constrained regularization program for inverting\nnoisy linear algebraic and integral equations","volume":"27","author":"Provencher","year":"1982","journal-title":"Comput. Phys. Commun."},{"key":"2026090302014131500_cit38","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1002\/macp.1979.021800119","article-title":"Inverse\nproblems in polymer characterization: Direct analysis of polydispersity\nwith photon correlation spectroscopy","volume":"180","author":"Provencher","year":"1979","journal-title":"Die Makromolekulare\nChem."},{"key":"2026090302014131500_cit39","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1016\/j.jconrel.2007.09.010","article-title":"Dual asymmetric\ncentrifugation (DAC)--a\nnew technique for liposome preparation","volume":"125","author":"Massing","year":"2008","journal-title":"J. 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Nanotechnol."},{"key":"2026090302014131500_cit43","doi-asserted-by":"publisher","first-page":"301","DOI":"10.1016\/s0927-7765(99)00156-3","article-title":"\u201cStealth\u201d\ncorona-core nanoparticles surface modified by polyethylene glycol\n(PEG): influences of the corona (PEG chain length and surface density)\nand of the core composition on phagocytic uptake and plasma protein\nadsorption","volume":"18","author":"Gref","year":"2000","journal-title":"Colloids Surf., B"},{"key":"2026090302014131500_cit44","doi-asserted-by":"publisher","first-page":"8858","DOI":"10.1039\/c7nr02977b","article-title":"Visualization of the protein corona:\ntowards a biomolecular\nunderstanding of nanoparticle-cell-interactions","volume":"9","author":"Kokkinopoulou","year":"2017","journal-title":"Nanoscale"},{"key":"2026090302014131500_cit45","first-page":"297","article-title":"Stealth liposomes:\nreview of the\nbasic science, rationale, and clinical applications, existing and\npotential","volume":"1","author":"Immordino","year":"2006","journal-title":"Int. J. Nanomed."},{"key":"2026090302014131500_cit46","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1016\/j.addr.2015.09.012","article-title":"PEGylation as a\nstrategy for improving nanoparticle-based drug and gene delivery","volume":"99","author":"Suk","year":"2016","journal-title":"Adv. Drug Delivery Rev."},{"key":"2026090302014131500_cit47","doi-asserted-by":"publisher","first-page":"2525","DOI":"10.1021\/ja107583h","article-title":"Physical-chemical aspects of protein\ncorona: relevance to in vitro and in vivo biological impacts of nanoparticles","volume":"133","author":"Monopoli","year":"2011","journal-title":"J. Am. Chem. Soc."},{"key":"2026090302014131500_cit48","doi-asserted-by":"publisher","first-page":"3881","DOI":"10.1021\/acs.molpharmaceut.8b00355","article-title":"PEG-Peptide\nInhibition of Scavenger\nReceptor Uptake of Nanoparticles by the Liver","volume":"15","author":"Allen","year":"2018","journal-title":"Mol. Pharmaceutics"},{"key":"2026090302014131500_cit49","doi-asserted-by":"publisher","first-page":"4321","DOI":"10.1021\/acs.molpharmaceut.5b00513","article-title":"Structure\u2013Activity\nRelationship\nof PEGylated Polylysine Peptides as Scavenger Receptor Inhibitors\nfor Non-Viral Gene Delivery","volume":"12","author":"Baumhover","year":"2015","journal-title":"Mol. Pharmaceutics"},{"key":"2026090302014131500_cit50","doi-asserted-by":"publisher","first-page":"612","DOI":"10.1126\/science.1175202","article-title":"Identification of splenic reservoir\nmonocytes and their\ndeployment to inflammatory sites","volume":"325","author":"Swirski","year":"2009","journal-title":"Science"},{"key":"2026090302014131500_cit51","doi-asserted-by":"publisher","first-page":"5393","DOI":"10.1016\/j.biomaterials.2014.03.041","article-title":"Polyglycerol-coated\nnanodiamond as\na macrophage-evading platform for selective drug delivery in cancer\ncells","volume":"35","author":"Zhao","year":"2014","journal-title":"Biomaterials"},{"key":"2026090302014131500_cit52","doi-asserted-by":"publisher","first-page":"2166","DOI":"10.1016\/j.biomaterials.2010.11.042","article-title":"Multifunctional polyglycerol-grafted\nFe3O4@SiO2 nanoparticles for targeting ovarian cancer cells","volume":"32","author":"Wang","year":"2011","journal-title":"Biomaterials"},{"key":"2026090302014131500_cit53","doi-asserted-by":"publisher","first-page":"378","DOI":"10.1039\/c6bm00921b","article-title":"Personalized protein corona on nanoparticles\nand its\nclinical implications","volume":"5","author":"Corbo","year":"2017","journal-title":"Biomater. Sci."},{"key":"2026090302014131500_cit54","doi-asserted-by":"publisher","first-page":"1210","DOI":"10.1039\/c4bm00131a","article-title":"Personalized\nprotein coronas: a \u201ckey\u201d factor at the nanobiointerface","volume":"2","author":"Hajipour","year":"2014","journal-title":"Biomater. Sci."},{"key":"2026090302014131500_cit55","doi-asserted-by":"publisher","first-page":"180","DOI":"10.1016\/j.biocel.2015.09.002","article-title":"Personalized liposome\u2013protein\ncorona in the blood of breast, gastric and pancreatic cancer patients","volume":"75","author":"Colapicchioni","year":"2016","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"2026090302014131500_cit56","doi-asserted-by":"publisher","first-page":"1802199","DOI":"10.1002\/advs.201802199","article-title":"Prevention of Dominant IgG Adsorption\non Nanocarriers in IgG-Enriched Blood Plasma by Clusterin Precoating","volume":"6","author":"Prozeller","year":"2019","journal-title":"Adv. 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