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In this study, the IAPP21\u201327 segment was modified with a biotin linker at the N-terminus (Btn-GNNFGAIL) to immobilize peptide fibrils on streptavidin-coated surfaces. Key residues for fibril formation of the N-terminal biotinylated IAPP21\u201327 segment were identified by using an alanine scanning approach combined with molecular dynamics simulations, thioflavin T fluorescence measurements, and scanning electron microscopy. Significant contributions of phenylalanine (F23), leucine (L27), and isoleucine (I26) for the fibrillation of the short peptide segment were identified. The fibril morphologies of the peptide variants differed depending on their primary sequence, ranging from flexible and semiflexible to stiff and crystal-like structures. These insights could advance the design of new functional hybrid bionanomaterials and fibril-engineered surface coatings using short peptide segments. To validate this concept, the biotinylated fibrils were immobilized on streptavidin-coated surfaces under spatial control.<\/jats:p>","DOI":"10.1021\/acs.biomac.9b01466","type":"journal-article","created":{"date-parts":[[2019,12,30]],"date-time":"2019-12-30T15:28:45Z","timestamp":1577719725000},"page":"783-792","source":"Crossref","is-referenced-by-count":4,"title":["Growth, Polymorphism, and Spatially Controlled Surface\nImmobilization of Biotinylated Variants of IAPP21\u201327 Fibrils"],"prefix":"10.1021","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6059-5964","authenticated-orcid":true,"given":"Torsten","family":"John","sequence":"first","affiliation":[{"name":"Leibniz-Institute of Surface Engineering (IOM) , Permoserstra\u00dfe 15 , ,","place":["Leipzig, Germany, 04318"]},{"name":"Leipzig University , , Linne\u0301stra\u00dfe 3 , ,","place":["Leipzig, Germany, 04103"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juhaina","family":"Bandak","sequence":"additional","affiliation":[{"name":"Leibniz-Institute of Surface Engineering (IOM) , Permoserstra\u00dfe 15 , ,","place":["Leipzig, Germany, 04318"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nilushiya","family":"Sarveson","sequence":"additional","affiliation":[{"name":"Leibniz-Institute of Surface Engineering (IOM) , Permoserstra\u00dfe 15 , ,","place":["Leipzig, Germany, 04318"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"Hackl","sequence":"additional","affiliation":[{"name":"Leibniz-Institute of Surface Engineering (IOM) , Permoserstra\u00dfe 15 , ,","place":["Leipzig, Germany, 04318"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Herre Jelger","family":"Risselada","sequence":"additional","affiliation":[{"name":"Leibniz-Institute of Surface Engineering (IOM) , Permoserstra\u00dfe 15 , ,","place":["Leipzig, Germany, 04318"]},{"name":"Georg-August-Universita\u0308t Go\u0308ttingen , , Friedrich-Hund-Platz 1 , ,","place":["Go\u0308ttingen, Germany, 37077"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Prager","sequence":"additional","affiliation":[{"name":"Leibniz-Institute of Surface Engineering (IOM) , Permoserstra\u00dfe 15 , ,","place":["Leipzig, Germany, 04318"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Elsner","sequence":"additional","affiliation":[{"name":"Leibniz-Institute of Surface Engineering (IOM) , Permoserstra\u00dfe 15 , ,","place":["Leipzig, Germany, 04318"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6032-1680","authenticated-orcid":true,"given":"Bernd","family":"Abel","sequence":"additional","affiliation":[{"name":"Leibniz-Institute of Surface Engineering (IOM) , Permoserstra\u00dfe 15 , ,","place":["Leipzig, Germany, 04318"]},{"name":"Leipzig University , , Linne\u0301stra\u00dfe 3 , ,","place":["Leipzig, Germany, 04103"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2019,12,30]]},"reference":[{"issue":"21","key":"2026081416133686800_cit1","doi-asserted-by":"publisher","first-page":"6492","DOI":"10.1039\/C7CS00372B","article-title":"Implications of Peptide\nAssemblies in Amyloid Diseases","volume":"46","author":"Ke","year":"2017","journal-title":"Chem. 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