{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T21:26:52Z","timestamp":1786742812958,"version":"build-2736575974"},"reference-count":52,"publisher":"American Chemical Society (ACS)","issue":"2","license":[{"start":{"date-parts":[[2020,1,7]],"date-time":"2020-01-07T00:00:00Z","timestamp":1578355200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2020,1,7]],"date-time":"2020-01-07T00:00:00Z","timestamp":1578355200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2020,1,7]],"date-time":"2020-01-07T00:00:00Z","timestamp":1578355200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000146","name":"Division of Chemical, Bioengineering, Environmental, and Transport Systems","doi-asserted-by":"publisher","award":["CBET-1553945"],"award-info":[{"award-number":["CBET-1553945"]}],"id":[{"id":"10.13039\/100000146","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000057","name":"National Institute of General Medical Sciences","doi-asserted-by":"publisher","award":["MIRA R35GM119691"],"award-info":[{"award-number":["MIRA R35GM119691"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000923","name":"Australia Research Council","doi-asserted-by":"crossref","award":["CE140100036"],"award-info":[{"award-number":["CE140100036"]}],"id":[{"id":"10.13039\/501100000923","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,2,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Alzheimer\u2019s disease (AD) is the most severe form of neurological disorder, characterized by the presence of extracellular amyloid-\u03b2 (A\u03b2) plaques and intracellular tau tangles. For decades, therapeutic strategies against the pathological symptoms of AD have often relied on the delivery of monoclonal antibodies to target specifically A\u03b2 amyloid or oligomers, largely to no avail. A\u03b2 can be traced in the brain as well as in cerebrospinal fluid and the circulation, giving rise to abundant opportunities to interact with their environmental proteins. Using liquid chromatography tandem-mass spectrometry, here we identified for the first time the protein coronae of the two major amyloid forms of A\u03b2\ue5f8A\u03b21\u201342 and A\u03b21\u201340\ue5f8exposed to human blood plasma. Out of the proteins identified in all groups, 58 proteins were unique to the A\u03b21\u201342 samples and 31 proteins unique to the A\u03b21\u201340 samples. Both fibrillar coronae consisted of proteins significant in complement activation, inflammation, and protein metabolic pathways involved in the pathology of AD. Structure-wise, the coronal proteins often possessed multidomains of high flexibility to maximize their association with the amyloid fibrils. The protein corona hindered recognition of A\u03b21\u201342 fibrils by their structurally specific antibodies and accelerated the aggregation but not the \u03b2-cell toxicity of human islet amyloid polypeptide, the peptide associated with type 2 diabetes. This study highlights the importance of understanding the structural, functional, and pathological implications of the amyloid protein corona for the development of therapeutics against AD and a range of amyloid diseases.<\/jats:p>","DOI":"10.1021\/acs.biomac.9b01650","type":"journal-article","created":{"date-parts":[[2020,1,7]],"date-time":"2020-01-07T13:09:41Z","timestamp":1578402581000},"page":"988-998","source":"Crossref","is-referenced-by-count":19,"title":["Human Plasma Protein Corona of A\u03b2 Amyloid and\nIts Impact on Islet Amyloid Polypeptide Cross-Seeding"],"prefix":"10.1021","volume":"21","author":[{"given":"Aparna","family":"Nandakumar","sequence":"first","affiliation":[{"name":"Monash University , , 381 Royal Parade , , ,","place":["Parkville, Victoria, Australia, 3052"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanting","family":"Xing","sequence":"additional","affiliation":[{"name":"Clemson University , , , ,","place":["Clemson, South Carolina, United States, 29634"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ritchlynn R.","family":"Aranha","sequence":"additional","affiliation":[{"name":"Monash University , , , ,","place":["Clayton, Victoria, Australia, 3800"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ava","family":"Faridi","sequence":"additional","affiliation":[{"name":"Monash University , , 381 Royal Parade , , ,","place":["Parkville, Victoria, Australia, 3052"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aleksandr","family":"Kakinen","sequence":"additional","affiliation":[{"name":"Monash University , , 381 Royal Parade , , ,","place":["Parkville, Victoria, Australia, 3052"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1101-5614","authenticated-orcid":true,"given":"Ibrahim","family":"Javed","sequence":"additional","affiliation":[{"name":"Monash University , , 381 Royal Parade , , ,","place":["Parkville, Victoria, Australia, 3052"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kairi","family":"Koppel","sequence":"additional","affiliation":[{"name":"Monash University , , 381 Royal Parade , , ,","place":["Parkville, Victoria, Australia, 3052"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emily H.","family":"Pilkington","sequence":"additional","affiliation":[{"name":"Monash University , , 381 Royal Parade , , ,","place":["Parkville, Victoria, Australia, 3052"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0532-8331","authenticated-orcid":true,"given":"Anthony Wayne","family":"Purcell","sequence":"additional","affiliation":[{"name":"Monash University , , , ,","place":["Clayton, Victoria, Australia, 3800"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2581-4986","authenticated-orcid":true,"given":"Thomas P.","family":"Davis","sequence":"additional","affiliation":[{"name":"Monash University , , 381 Royal Parade , , ,","place":["Parkville, Victoria, Australia, 3052"]},{"name":"The University of Queensland , , , ,","place":["Brisbane, Queensland, Australia, 4072"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pouya","family":"Faridi","sequence":"additional","affiliation":[{"name":"Monash University , , , ,","place":["Clayton, Victoria, Australia, 3800"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1850-6336","authenticated-orcid":true,"given":"Feng","family":"Ding","sequence":"additional","affiliation":[{"name":"Clemson University , , , ,","place":["Clemson, South Carolina, United States, 29634"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2134-0859","authenticated-orcid":true,"given":"Pu Chun","family":"Ke","sequence":"additional","affiliation":[{"name":"Monash University , , 381 Royal Parade , , ,","place":["Parkville, Victoria, Australia, 3052"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2020,1,7]]},"reference":[{"key":"2026081416131468500_cit1","doi-asserted-by":"publisher","first-page":"1097","DOI":"10.1001\/archneur.1985.04060100083029","article-title":"Diagnosis\nof Alzheimer\u2019s Disease","volume":"42","author":"Khachaturian","year":"1985","journal-title":"Arch. Neurol."},{"key":"2026081416131468500_cit2","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1111\/j.1365-2990.1996.tb00839.x","article-title":"Review: David\nOppenheimer Memorial\nLecture 1995: Some Neuropathological Aspects of Alzheimer\u2019s\nDisease and Its Relevance to Other Disciplines","volume":"22","author":"Wisniewski","year":"1996","journal-title":"Neuropathol. Appl. Neurobiol."},{"key":"2026081416131468500_cit3","doi-asserted-by":"publisher","first-page":"353","DOI":"10.1126\/science.1072994","article-title":"The Amyloid Hypothesis\nof Alzheimer\u2019s Disease:\nProgress and Problems on the Road to Therapeutics","volume":"297","author":"Hardy","year":"2002","journal-title":"Science"},{"key":"2026081416131468500_cit4","doi-asserted-by":"publisher","first-page":"595","DOI":"10.15252\/emmm.201606210","article-title":"The Amyloid Hypothesis\nof Alzheimer\u2019s Disease at 25 years","volume":"8","author":"Selkoe","year":"2016","journal-title":"EMBO\nMol. Med."},{"key":"2026081416131468500_cit5","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1016\/j.jalz.2008.10.004","article-title":"Amyloid Beta Peptides in Human Plasma and Tissues and\nTheir Significance for Alzheimer\u2019s Disease","volume":"5","author":"Roher","year":"2009","journal-title":"Alzheimer\u2019s Dementia"},{"key":"2026081416131468500_cit6","doi-asserted-by":"publisher","first-page":"311","DOI":"10.3233\/JAD-2010-1221","article-title":"Alzheimer\u2019s Disease and the\nAmyloid-Beta Peptide","volume":"19","author":"Murphy","year":"2010","journal-title":"J. Alzheimer\u2019s\nDis."},{"key":"2026081416131468500_cit7","doi-asserted-by":"publisher","first-page":"6492","DOI":"10.1039\/C7CS00372B","article-title":"Implications of Peptide\nAssemblies in Amyloid Diseases","volume":"46","author":"Ke","year":"2017","journal-title":"Chem. Soc. Rev."},{"key":"2026081416131468500_cit8","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1016\/S0925-4439(00)00029-6","article-title":"Alzheimer\u2019s\nAmyloid Fibrils: Structure and Assembly","volume":"1502","author":"Serpell","year":"2000","journal-title":"Biochim.\nBiophys. Acta, Mol. Basis Dis."},{"key":"2026081416131468500_cit9","doi-asserted-by":"publisher","first-page":"1232","DOI":"10.1073\/pnas.1617260114","article-title":"Flow-Assisted Assembly\nof Nanostructured Protein Microfibers","volume":"114","author":"Kamada","year":"2017","journal-title":"Proc.\nNatl. Acad. Sci. U. S. A."},{"key":"2026081416131468500_cit10","doi-asserted-by":"publisher","first-page":"2050","DOI":"10.1073\/pnas.0608582104","article-title":"Understanding the Nanoparticle-Protein\nCorona Using Methods to Quantify Exchange Rates and Affinities of\nProteins for Nanoparticles","volume":"104","author":"Cedervall","year":"2007","journal-title":"Proc. Natl. Acad.\nSci. U. S. A."},{"key":"2026081416131468500_cit11","doi-asserted-by":"publisher","first-page":"546","DOI":"10.1038\/nnano.2009.248","article-title":"What Does\nthe Cell See?","volume":"4","author":"Lynch","year":"2009","journal-title":"Nat. Nanotechnol."},{"key":"2026081416131468500_cit12","doi-asserted-by":"publisher","first-page":"1002","DOI":"10.3762\/bjnano.10.101","article-title":"Serum Type\nand Concentration Both Affect the Protein-Corona Composition of Plga\nNanoparticles","volume":"10","author":"Partikel","year":"2019","journal-title":"Beilstein J. Nanotechnol."},{"key":"2026081416131468500_cit13","doi-asserted-by":"publisher","first-page":"9162","DOI":"10.1039\/c3nr02147e","article-title":"Direct Observation\nof a Single Nanoparticle\u2013Ubiquitin\nCorona Formation","volume":"5","author":"Ding","year":"2013","journal-title":"Nanoscale"},{"key":"2026081416131468500_cit14","doi-asserted-by":"publisher","first-page":"2651","DOI":"10.1021\/ar500190q","article-title":"Nanoparticle\u2013Cell Interactions: Molecular Structure\nof the Protein Corona and Cellular Outcomes","volume":"47","author":"Fleischer","year":"2014","journal-title":"Acc. Chem. Res."},{"key":"2026081416131468500_cit15","doi-asserted-by":"publisher","first-page":"2439","DOI":"10.1021\/nn406018q","article-title":"Protein\nCorona Fingerprinting Predicts the Cellular Interaction of Gold and\nSilver Nanoparticles","volume":"8","author":"Walkey","year":"2014","journal-title":"ACS Nano"},{"key":"2026081416131468500_cit16","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0129008","article-title":"Proteomics\nAnalysis Reveals Distinct Corona Composition on Magnetic Nanoparticles\nwith Different Surface Coatings: Implications for Interactions with\nPrimary Human Macrophages","volume":"10","author":"Vogt","year":"2015","journal-title":"PLoS One"},{"key":"2026081416131468500_cit17","doi-asserted-by":"publisher","first-page":"6026","DOI":"10.1039\/C8TB01634H","article-title":"Nanoparticle\u2013Proteome\nin Vitro and in Vivo","volume":"6","author":"Wang","year":"2018","journal-title":"J. Mater. Chem. B"},{"key":"2026081416131468500_cit18","doi-asserted-by":"publisher","first-page":"1263","DOI":"10.1039\/b605536m","article-title":"Self-Assembled\nPeptide Nanostructures: The Design of Molecular Building Blocks and\nTheir Technological Utilization","volume":"36","author":"Gazit","year":"2007","journal-title":"Chem. Soc.\nRev."},{"key":"2026081416131468500_cit19","doi-asserted-by":"publisher","first-page":"2455","DOI":"10.1038\/s41598-017-02597-0","article-title":"Effects of Protein\nCorona on Iapp Amyloid Aggregation, Fibril Remodelling, and Cytotoxicity","volume":"7","author":"Pilkington","year":"2017","journal-title":"Sci. Rep."},{"key":"2026081416131468500_cit20","doi-asserted-by":"publisher","first-page":"6066","DOI":"10.1021\/acsnano.8b02346","article-title":"Profiling the Serum\nProtein Corona of Fibrillar Human Islet Amyloid Polypeptide","volume":"12","author":"Pilkington","year":"2018","journal-title":"ACS Nano"},{"key":"2026081416131468500_cit21","doi-asserted-by":"publisher","first-page":"750","DOI":"10.1006\/bbrc.2000.2222","article-title":"Amyloid-\u0392\nPeptides Interact with Plasma Proteins\nand Erythrocytes: Implications for Their Quantitation in Plasma","volume":"268","author":"Kuo","year":"2000","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"2026081416131468500_cit22","doi-asserted-by":"publisher","first-page":"16485","DOI":"10.1074\/jbc.R116.714576","article-title":"Cross-Interactions between the Alzheimer Disease Amyloid-\u0392\nPeptide and Other Amyloid Proteins: A Further Aspect of the Amyloid\nCascade Hypothesis","volume":"291","author":"Luo","year":"2016","journal-title":"J. Biol. Chem."},{"key":"2026081416131468500_cit23","doi-asserted-by":"publisher","first-page":"28163","DOI":"10.1074\/jbc.C112.360800","article-title":"Human Serum Albumin Can Regulate\nAmyloid-\u0392 Peptide\nFiber Growth in the Brain Interstitium: Implications for Alzheimer\nDisease","volume":"287","author":"Stanyon","year":"2012","journal-title":"J. Biol. Chem."},{"key":"2026081416131468500_cit24","doi-asserted-by":"publisher","first-page":"1692","DOI":"10.1002\/cbic.201300262","article-title":"Biophysical\nStudies of the Amyloid \u0392-Peptide: Interactions with Metal Ions\nand Small Molecules","volume":"14","author":"Wa\u0308rmla\u0308nder","year":"2013","journal-title":"ChemBioChem"},{"key":"2026081416131468500_cit25","doi-asserted-by":"publisher","first-page":"37061","DOI":"10.1074\/jbc.M403672200","article-title":"Proteomic Characterization of Postmortem\nAmyloid Plaques Isolated\nby Laser Capture Microdissection","volume":"279","author":"Liao","year":"2004","journal-title":"J. Biol. Chem."},{"key":"2026081416131468500_cit26","doi-asserted-by":"publisher","first-page":"142","DOI":"10.1161\/CIRCRESAHA.118.313563","article-title":"Getting\nto the Heart of Alzheimer Disease","volume":"124","author":"Tublin","year":"2019","journal-title":"Circula.\nRes."},{"key":"2026081416131468500_cit27","doi-asserted-by":"publisher","first-page":"1327","DOI":"10.1038\/mp.2016.230","article-title":"Molecular Interaction between Type\n2 Diabetes and Alzheimer\u2019s Disease through Cross-Seeding of\nProtein Misfolding","volume":"22","author":"Moreno-Gonzalez","year":"2017","journal-title":"Mol. Psychiatry"},{"key":"2026081416131468500_cit28","doi-asserted-by":"publisher","first-page":"474","DOI":"10.2337\/diabetes.53.2.474","article-title":"Increased Risk of Type 2 Diabetes\nin Alzheimer Disease","volume":"53","author":"Janson","year":"2004","journal-title":"Diabetes"},{"key":"2026081416131468500_cit29","doi-asserted-by":"publisher","first-page":"47","DOI":"10.2174\/1567205043480555","article-title":"The Clinical\nand Biological Relationship between Type II Diabetes Mellitus and\nAlzheimer\u2019s Disease","volume":"1","author":"Nicolls","year":"2004","journal-title":"Curr. Alzheimer\nRes."},{"key":"2026081416131468500_cit30","doi-asserted-by":"publisher","first-page":"3081","DOI":"10.1002\/anie.200904902","article-title":"Identification\nof Hot Regions of the A\u03b2\u2013Iapp\nInteraction Interface as High-Affinity Binding Sites in Both Cross-\nand Self-Association","volume":"49","author":"Andreetto","year":"2010","journal-title":"Angew. Chem., Int. Ed."},{"key":"2026081416131468500_cit31","doi-asserted-by":"publisher","first-page":"1759","DOI":"10.1021\/acschemneuro.5b00192","article-title":"Cross-Seeding\nInteraction between \u0392-Amyloid and Human Islet Amyloid Polypeptide","author":"Hu","year":"2015","journal-title":"ACS Chem. Neurosci."},{"key":"2026081416131468500_cit32","doi-asserted-by":"publisher","first-page":"15437","DOI":"10.1021\/ja8041806","article-title":"Inhibition\nof Amyloid \u0392 Protein Fibrillation by Polymeric Nanoparticles","volume":"130","author":"Cabaleiro-Lago","year":"2008","journal-title":"J. Am. Chem. Soc."},{"key":"2026081416131468500_cit33","doi-asserted-by":"publisher","first-page":"D447","DOI":"10.1093\/nar\/gku1003","article-title":"String V10:\nProtein-Protein Interaction Networks, Integrated\nover the Tree of Life","volume":"43","author":"Szklarczyk","year":"2015","journal-title":"Nucleic Acids Res."},{"key":"2026081416131468500_cit34","doi-asserted-by":"publisher","first-page":"D506","DOI":"10.1093\/nar\/gky1049","article-title":"Uniprot:\nA Worldwide Hub of Protein Knowledge","volume":"47","author":"The\nUniProt Consortium","year":"2019","journal-title":"Nucleic\nAcids Res."},{"key":"2026081416131468500_cit35","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1385\/1-59259-890-0:571","article-title":"Protein Identification\nand Analysis Tools on the Expasy Server","volume-title":"The Proteomics Protocols Handbook","author":"Gasteiger","year":"2005"},{"key":"2026081416131468500_cit36","doi-asserted-by":"publisher","first-page":"1701528","DOI":"10.1002\/smll.201701528","article-title":"Plasma Proteome\nAssociation and Catalytic Activity\nof Stealth Polymer-Grafted Iron Oxide Nanoparticles","volume":"13","author":"Wang","year":"2017","journal-title":"Small"},{"key":"2026081416131468500_cit37","doi-asserted-by":"publisher","first-page":"716","DOI":"10.1111\/ggi.12147","article-title":"Serum Levels\nof Albumin-Amyloid Beta Complexes Are Decreased in Alzheimer\u2019s\nDisease","volume":"14","author":"Yamamoto","year":"2014","journal-title":"Geriatr. Gerontol. Int."},{"key":"2026081416131468500_cit38","doi-asserted-by":"publisher","first-page":"248","DOI":"10.1016\/j.bbrc.2019.01.081","article-title":"The Binding\nof Monomeric Amyloid \u0392 Peptide to Serum Albumin Is Affected\nby Major Plasma Unsaturated Fatty Acids","volume":"510","author":"Litus","year":"2019","journal-title":"Biochem.\nBiophys. Res. Commun."},{"key":"2026081416131468500_cit39","doi-asserted-by":"publisher","first-page":"260","DOI":"10.1038\/s41565-018-0344-3","article-title":"Immunoglobulin Deposition\non Biomolecule Corona Determines Complement Opsonization Efficiency\nof Preclinical and Clinical Nanoparticles","volume":"14","author":"Vu","year":"2019","journal-title":"Nat.\nNanotechnol."},{"key":"2026081416131468500_cit40","doi-asserted-by":"publisher","first-page":"383","DOI":"10.1016\/S0197-4580(00)00124-X","article-title":"Inflammation and Alzheimer\u2019s\nDisease","volume":"21","author":"Akiyama","year":"2000","journal-title":"Neurobiol. Aging"},{"key":"2026081416131468500_cit41","doi-asserted-by":"publisher","first-page":"652","DOI":"10.14336\/AD.2019.0118","article-title":"Emerging Roles\nof Complement Protein C1q in Neurodegeneration","volume":"10","author":"Cho","year":"2019","journal-title":"Aging Dis."},{"key":"2026081416131468500_cit42","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1007\/s00281-017-0662-9","article-title":"Complement\nin the Pathogenesis of Alzheimer\u2019s Disease","volume":"40","author":"Morgan","year":"2018","journal-title":"Semin Immunopathol."},{"key":"2026081416131468500_cit43","doi-asserted-by":"publisher","first-page":"388","DOI":"10.1016\/S1474-4422(15)70016-5","article-title":"Neuroinflammation in Alzheimer\u2019s Disease","volume":"14","author":"Heneka","year":"2015","journal-title":"Lancet Neurol."},{"key":"2026081416131468500_cit44","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0034078","article-title":"Plasma\nApolipoprotein Levels Are\nAssociated with Cognitive Status and Decline in a Community Cohort\nof Older Individuals","volume":"7","author":"Song","year":"2012","journal-title":"PLoS One"},{"key":"2026081416131468500_cit45","doi-asserted-by":"publisher","first-page":"545","DOI":"10.1016\/j.dadm.2018.07.001","article-title":"Apolipoproteins\nand Alzheimer\u2019s Pathophysiology","volume":"10","author":"Koch","year":"2018","journal-title":"Alzheimer\u2019s\nDementia: Diagn., Assess., Dis. Monit."},{"key":"2026081416131468500_cit46","doi-asserted-by":"publisher","first-page":"106","DOI":"10.1038\/nrneurol.2012.263","article-title":"Apolipoprotein\nE and Alzheimer Disease: Risk, Mechanisms and Therapy","volume":"9","author":"Liu","year":"2013","journal-title":"Nat. Rev. Neurol."},{"key":"2026081416131468500_cit47","doi-asserted-by":"publisher","first-page":"493","DOI":"10.3109\/13547500903108423","article-title":"Proteomics-Derived Cerebrospinal\nFluid Markers of Autopsy-Confirmed\nAlzheimer\u2019s Disease","volume":"14","author":"Roher","year":"2009","journal-title":"Biomarkers"},{"key":"2026081416131468500_cit48","doi-asserted-by":"publisher","first-page":"409","DOI":"10.3389\/fnagi.2018.00409","article-title":"Plasma Protein\nBiomarkers for the\nPrediction of Csf Amyloid and Tau and [18f]-Flutemetamol Pet Scan\nResult","volume":"10","author":"Westwood","year":"2018","journal-title":"Front. 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