{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T08:18:24Z","timestamp":1793261904874,"version":"4.5.0"},"reference-count":532,"publisher":"American Chemical Society (ACS)","issue":"6","license":[{"start":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T00:00:00Z","timestamp":1773273600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T00:00:00Z","timestamp":1773273600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T00:00:00Z","timestamp":1773273600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Chem. Rev."],"published-print":{"date-parts":[[2026,3,25]]},"DOI":"10.1021\/acs.chemrev.5c00779","type":"journal-article","created":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T17:37:26Z","timestamp":1773337046000},"page":"3829-3882","source":"Crossref","is-referenced-by-count":44,"title":["Smallest Bicycles in Medicinal Chemistry: Where Are We Now?"],"prefix":"10.1021","volume":"126","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4467-4205","authenticated-orcid":true,"given":"Vladimir","family":"Kubyshkin","sequence":"first","affiliation":[{"name":"Enamine Ltd., Winston Churchill Street 78, 02094 Kyiv, Ukraine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1821-9011","authenticated-orcid":true,"given":"Pavel K.","family":"Mykhailiuk","sequence":"additional","affiliation":[{"name":"Enamine Ltd., Winston Churchill Street 78, 02094 Kyiv, Ukraine"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,3,12]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"publisher","DOI":"10.1021\/jm4017625"},{"key":"ref2\/cit2","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.2c00473"},{"key":"ref3\/cit3","doi-asserted-by":"publisher","DOI":"10.1016\/j.drudis.2009.07.014"},{"key":"ref4\/cit4","doi-asserted-by":"publisher","DOI":"10.1016\/j.drudis.2010.11.014"},{"key":"ref5\/cit5","doi-asserted-by":"publisher","DOI":"10.1021\/jm901241e"},{"key":"ref6\/cit6","doi-asserted-by":"publisher","DOI":"10.1039\/c2md20347b"},{"key":"ref7\/cit7","doi-asserted-by":"publisher","DOI":"10.1016\/j.drudis.2020.07.017"},{"key":"ref8\/cit8","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.5c00287"},{"key":"ref9\/cit9","doi-asserted-by":"publisher","DOI":"10.1002\/0471266949.bmc259"},{"key":"ref10\/cit10","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jafc.3c00765"},{"key":"ref11\/cit11","doi-asserted-by":"publisher","DOI":"10.1039\/C8OB02812E"},{"key":"ref12\/cit12","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.1c01215"},{"key":"ref13\/cit13","doi-asserted-by":"publisher","DOI":"10.1038\/s41570-024-00623-0"},{"key":"ref14\/cit14","doi-asserted-by":"publisher","DOI":"10.1002\/chem.201804225"},{"key":"ref15\/cit15","doi-asserted-by":"publisher","DOI":"10.4155\/fmc-2022-0188"},{"key":"ref16\/cit16","doi-asserted-by":"publisher","DOI":"10.3762\/bjoc.20.78"},{"key":"ref17\/cit17","doi-asserted-by":"publisher","DOI":"10.1055\/s-0043-1775395"},{"key":"ref18\/cit18","unstructured":"Highest phase national clinical trials for\ndrugs containing bicyclo[1.1.1]pentane\nskeleton: Zemprocitinib (LNK01001) - NCT06277245 (Phase 3), NCT06276998\n(Phase 3); Tilpisertib (GS-4875) - NCT06029972 (Phase 2), NCT04130919\n(Phase 2); Telisotuzumab Adizutecan (ABBV-400) - NCT07155187 (Phase\n2\/3), NCT07005102 (Phase 2\/3), NCT06614192 (Phase 3); Asaretoclax\n(ZN-d5) - NCT05199337 (Phase 1\/2); ZN-c5 NCT03560531 (Phase 1\/2);\nEvetifator (DNL-343) - NCT05842941 (Phase 2\/3), NCT04297683 (Phase\n2\/3). National Library of Medicine\n(U.S.), https:\/\/clinicaltrials.gov\/ (accessed Nov 19, 2025)."},{"key":"ref19\/cit19","unstructured":"Behenna, D.; Deckhut, C.; Rovira, A.; Goldberg, S.; Kummer, D.; Keith, J.; Woods, C.; Rhorer, T.; Tanis, V.; Martin, C.; Meduna, S.; McCarver, S.; Valdes, A.; Loskot, S.; Xue, X. Imidazopyridazines as Modulators of Il-17. WO 2021\/222404, 2021."},{"key":"ref20\/cit20","unstructured":"Auch, L. A.; Bagdasarian, A. L.; Bucher, C. I.; Craig, R. A.; Fidalgo, J. D. V.; Estrada, A. A.; Fox, B. M.; Huffman, B. J.; Lexa, K. W.; Miyamoto, T.; Osipov, M.; Thottumkara, A. Compounds, Compositions, and Methods. WO 2023\/168298, 2023."},{"key":"ref21\/cit21","unstructured":"Burnett, G. L.; Cregg, J.; Gill, A. L.; Gliedt, M. J.; Knox, J. E.; Koltun, E. S.; Latimer, B. K.; Made, B. D.; Parsons, D. E.; Thompson, S.; Tomlinson, A.; Aay, N.; Buckl, A.; Luu, N. H. Q. Condensed Macrocyclic Compounds as Ras Inhibitors. WO 2024\/211663, 2024."},{"key":"ref22\/cit22","unstructured":"Bagdasarian, A. L.; Bucher, C.; Fidalgo, J. D. V.; Estrada, A. A.; Fox, B. M.; Huffman, B. J.; Lexa, K. W.; Osipov, M.; Widen, J. C. Compounds, Compositions, and Methods. WO 2025\/024329, 2025."},{"key":"ref23\/cit23","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202004183"},{"key":"ref24\/cit24","doi-asserted-by":"publisher","DOI":"10.1039\/D3SC05121H"},{"key":"ref25\/cit25","doi-asserted-by":"publisher","DOI":"10.1038\/s41557-023-01222-0"},{"key":"ref26\/cit26","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202000548"},{"key":"ref27\/cit27","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202319831"},{"key":"ref28\/cit28","doi-asserted-by":"publisher","DOI":"10.1021\/acs.joc.8b02071"},{"key":"ref29\/cit29","doi-asserted-by":"publisher","DOI":"10.1021\/acs.joc.7b00803"},{"key":"ref30\/cit30","doi-asserted-by":"publisher","DOI":"10.1039\/D5OB00919G"},{"key":"ref31\/cit31","doi-asserted-by":"publisher","DOI":"10.1039\/D5CS01128K"},{"key":"ref32\/cit32","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-022-05290-z"},{"key":"ref33\/cit33","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202505519"},{"key":"ref34\/cit34","doi-asserted-by":"publisher","DOI":"10.1021\/acs.orglett.5c00646"},{"key":"ref35\/cit35","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202304246"},{"key":"ref36\/cit36","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2014.10.057"},{"key":"ref37\/cit37","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-023-41298-3"},{"key":"ref38\/cit38","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202517814"},{"key":"ref39\/cit39","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201510675"},{"key":"ref40\/cit40","doi-asserted-by":"publisher","DOI":"10.1021\/cr500523x"},{"key":"ref41\/cit41","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.8b00888"},{"key":"ref42\/cit42","doi-asserted-by":"publisher","DOI":"10.1016\/S0040-4020(01)92797-8"},{"key":"ref43\/cit43","doi-asserted-by":"publisher","DOI":"10.1002\/anie.198603121"},{"key":"ref44\/cit44","doi-asserted-by":"publisher","DOI":"10.1016\/j.tet.2006.02.039"},{"key":"ref45\/cit45","doi-asserted-by":"publisher","DOI":"10.1039\/D0SC01386B"},{"key":"ref46\/cit46","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.6b13229"},{"key":"ref47\/cit47","doi-asserted-by":"publisher","DOI":"10.1039\/D2SC03948F"},{"key":"ref48\/cit48","doi-asserted-by":"publisher","DOI":"10.1038\/s42004-022-00811-3"},{"key":"ref49\/cit49","doi-asserted-by":"publisher","DOI":"10.1055\/a-2402-6920"},{"key":"ref50\/cit50","unstructured":"Fasching, B.; Ryckmans, T.; Flohr, A.; Ritz\u00e9n, A.; Harvey, F.; McAllister, L. Isoindolinone Compounds. WO 2022\/152821, 2022."},{"key":"ref51\/cit51","unstructured":"Lin, H.; Deng, C.; Li, Y.; Han, M. Polysubstituted Naphthenic Compound and Preparation Method Thereof. CN 119080652, 2024."},{"key":"ref52\/cit52","doi-asserted-by":"publisher","DOI":"10.1126\/science.aad6252"},{"key":"ref53\/cit53","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.0c07490"},{"key":"ref54\/cit54","doi-asserted-by":"publisher","DOI":"10.1039\/D3SC00224A"},{"key":"ref55\/cit55","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202420028"},{"key":"ref56\/cit56","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202314700"},{"key":"ref57\/cit57","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202319930"},{"key":"ref58\/cit58","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202512018"},{"key":"ref59\/cit59","doi-asserted-by":"publisher","DOI":"10.1021\/acs.joc.5c01474"},{"key":"ref60\/cit60","doi-asserted-by":"publisher","DOI":"10.1021\/jo052538z"},{"key":"ref61\/cit61","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.4c13298"},{"key":"ref62\/cit62","doi-asserted-by":"publisher","DOI":"10.1002\/jlac.198119810808"},{"key":"ref63\/cit63","doi-asserted-by":"publisher","DOI":"10.1039\/P19920000979"},{"key":"ref64\/cit64","doi-asserted-by":"publisher","DOI":"10.1021\/acs.orglett.8b03402"},{"key":"ref65\/cit65","doi-asserted-by":"publisher","DOI":"10.1021\/jo00823a023"},{"key":"ref66\/cit66","doi-asserted-by":"publisher","DOI":"10.1016\/S0040-4039(00)97375-1"},{"key":"ref67\/cit67","doi-asserted-by":"publisher","DOI":"10.1016\/0040-4039(95)00972-F"},{"key":"ref68\/cit68","doi-asserted-by":"publisher","DOI":"10.1021\/ol010023y"},{"key":"ref69\/cit69","doi-asserted-by":"publisher","DOI":"10.1016\/j.tet.2004.06.105"},{"key":"ref70\/cit70","doi-asserted-by":"publisher","DOI":"10.1002\/ejoc.200700354"},{"key":"ref71\/cit71","doi-asserted-by":"publisher","DOI":"10.1002\/ejoc.201000427"},{"key":"ref72\/cit72","doi-asserted-by":"publisher","DOI":"10.1021\/ja5096045"},{"key":"ref73\/cit73","doi-asserted-by":"publisher","DOI":"10.1021\/acs.joc.7b03115"},{"key":"ref74\/cit74","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2012.04.064"},{"key":"ref75\/cit75","unstructured":"Shimono, R.; Matsuda, D.; Masuda, S.; Yamamoto, S. Nitrogen-Containing Condensed Heterocyclic Compound. WO 2017\/069270, 2017."},{"key":"ref76\/cit76","unstructured":"Cox, M.; He, L.; Gangwar, S.; Gavai, A. V.; Broekema, M.; Cong, Q.; O\u2019Malley, D.; Puodel, Y. B.; Tarby, C. M. 1H-Pyrazolo[4,3-d]Pyrimidine Compounds as Toll-Like Receptor 7 (TLR7) Agonists. WO 2021\/154662, 2021."},{"key":"ref77\/cit77","doi-asserted-by":"publisher","DOI":"10.1021\/ja971949x"},{"key":"ref78\/cit78","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201711397"},{"key":"ref79\/cit79","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.1c12934"},{"key":"ref80\/cit80","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-022-33602-4"},{"key":"ref81\/cit81","doi-asserted-by":"publisher","DOI":"10.1016\/j.xcrp.2022.101233"},{"key":"ref82\/cit82","doi-asserted-by":"publisher","DOI":"10.1021\/ja0114862"},{"key":"ref83\/cit83","doi-asserted-by":"publisher","DOI":"10.1021\/ja9737634"},{"key":"ref84\/cit84","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.8b01263"},{"key":"ref85\/cit85","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmc.2022.116614"},{"key":"ref86\/cit86","unstructured":"Calculated with the Online Property Calculation\nService, Molinspiration: www.molinspiration.com (accessed\nJan 25, 2025)."},{"key":"ref88\/cit88","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202505803"},{"key":"ref89\/cit89","doi-asserted-by":"publisher","DOI":"10.1021\/ja02231a009"},{"key":"ref90\/cit90","doi-asserted-by":"publisher","DOI":"10.1039\/cs9790800563"},{"key":"ref91\/cit91","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.5c01641"},{"key":"ref92\/cit92","doi-asserted-by":"publisher","DOI":"10.1002\/cmdc.201402502"},{"key":"ref93\/cit93","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202418850"},{"key":"ref94\/cit94","doi-asserted-by":"publisher","DOI":"10.1021\/acs.joc.9b01947"},{"key":"ref95\/cit95","doi-asserted-by":"publisher","DOI":"10.1021\/acs.orglett.9b02026"},{"key":"ref96\/cit96","doi-asserted-by":"publisher","DOI":"10.1002\/ejoc.202200863"},{"key":"ref97\/cit97","unstructured":"Muelbaier, M.; Patel, V.; Marigo, M.; Dialer, C.; Kr\u00fcger, S. Sulfoximines as Inhibitors of Na\n                      V\n                      1.8. WO 2024\/126648, 2024."},{"key":"ref98\/cit98","doi-asserted-by":"publisher","DOI":"10.1021\/jm300094u"},{"key":"ref99\/cit99","doi-asserted-by":"publisher","DOI":"10.1021\/acsmedchemlett.6b00281"},{"key":"ref100\/cit100","doi-asserted-by":"publisher","DOI":"10.1021\/acsmedchemlett.7b00018"},{"key":"ref101\/cit101","doi-asserted-by":"publisher","DOI":"10.1002\/cmdc.201500510"},{"key":"ref102\/cit102","doi-asserted-by":"publisher","DOI":"10.1002\/cmdc.201700082"},{"key":"ref103\/cit103","doi-asserted-by":"publisher","DOI":"10.1021\/acs.orglett.2c02345"},{"key":"ref104\/cit104","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-022-33827-3"},{"key":"ref105\/cit105","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2021.127823"},{"key":"ref106\/cit106","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202316557"},{"key":"ref107\/cit107","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.8b01430"},{"key":"ref108\/cit108","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.2c00879"},{"key":"ref109\/cit109","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.2c02058"},{"key":"ref110\/cit110","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.4c02241"},{"key":"ref111\/cit111","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.2c00403"},{"key":"ref112\/cit112","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2025.117238"},{"key":"ref113\/cit113","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2108881118"},{"key":"ref114\/cit114","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.2c12163"},{"key":"ref115\/cit115","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202513768"},{"key":"ref116\/cit116","doi-asserted-by":"publisher","DOI":"10.1021\/ja01528a060"},{"key":"ref117\/cit117","doi-asserted-by":"publisher","DOI":"10.1021\/ja00955a020"},{"key":"ref118\/cit118","doi-asserted-by":"publisher","DOI":"10.1021\/ja00730a022"},{"key":"ref119\/cit119","doi-asserted-by":"publisher","DOI":"10.1021\/ma00058a001"},{"key":"ref120\/cit120","doi-asserted-by":"publisher","DOI":"10.1021\/acs.oprd.0c00422"},{"key":"ref121\/cit121","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.2c00923"},{"key":"ref122\/cit122","unstructured":"Luecking, U.; Goutopoulos, A.; Xu, Z.; Sotiriou, S.; Iacovino, L.; Freudenmann, A.; Querolle, O. 2,4-Dioxo-1,4-Dihydroquinazoline Derivatives as Parg Inhibitors for the Treatment of Cancer. WO 2023\/175185, 2023."},{"key":"ref123\/cit123","unstructured":"Li, J.; Xiao, X.; Zhou, Z. 2-Azabicyclo[3.1.1]Heptene Derivative as Well as Synthesis Method and Application Thereof. CN 120483960, 2025."},{"key":"ref124\/cit124","doi-asserted-by":"publisher","DOI":"10.1016\/S0040-4039(01)82950-6"},{"key":"ref125\/cit125","doi-asserted-by":"publisher","DOI":"10.1021\/jo00134a012"},{"key":"ref126\/cit126","doi-asserted-by":"publisher","DOI":"10.1039\/c39920000650"},{"key":"ref127\/cit127","doi-asserted-by":"publisher","DOI":"10.1039\/p29930001617"},{"key":"ref128\/cit128","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.4c04438"},{"key":"ref129\/cit129","doi-asserted-by":"publisher","DOI":"10.1021\/ja802906k"},{"key":"ref130\/cit130","doi-asserted-by":"publisher","DOI":"10.1038\/s41557-018-0181-x"},{"key":"ref131\/cit131","doi-asserted-by":"publisher","DOI":"10.1002\/chem.201905539"},{"key":"ref132\/cit132","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202011739"},{"key":"ref133\/cit133","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.1c03492"},{"key":"ref134\/cit134","doi-asserted-by":"publisher","DOI":"10.1021\/acs.orglett.5c00705"},{"key":"ref135\/cit135","doi-asserted-by":"publisher","DOI":"10.1126\/science.aar4239"},{"key":"ref136\/cit136","doi-asserted-by":"publisher","DOI":"10.1021\/ja403811t"},{"key":"ref137\/cit137","doi-asserted-by":"publisher","DOI":"10.1021\/ol303217s"},{"key":"ref138\/cit138","doi-asserted-by":"publisher","DOI":"10.1021\/acs.orglett.3c01664"},{"key":"ref139\/cit139","doi-asserted-by":"publisher","DOI":"10.1021\/acs.orglett.3c01417"},{"key":"ref140\/cit140","doi-asserted-by":"publisher","DOI":"10.1021\/acs.joc.5c00043"},{"key":"ref141\/cit141","doi-asserted-by":"publisher","DOI":"10.1039\/D1SC01836A"},{"key":"ref142\/cit142","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.1c11244"},{"key":"ref143\/cit143","doi-asserted-by":"publisher","DOI":"10.1021\/acs.orglett.3c04030"},{"key":"ref144\/cit144","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.5c16702"},{"key":"ref145\/cit145","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.1c01139"},{"key":"ref146\/cit146","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jcim.1c00811"},{"key":"ref147\/cit147","doi-asserted-by":"publisher","DOI":"10.1002\/jlac.19707390132"},{"key":"ref148\/cit148","doi-asserted-by":"publisher","DOI":"10.1055\/s-1985-31366"},{"key":"ref149\/cit149","doi-asserted-by":"publisher","DOI":"10.1016\/S0040-4039(00)89189-3"},{"key":"ref150\/cit150","doi-asserted-by":"publisher","DOI":"10.1002\/1099-0690(200104)2001:7<1279::AID-EJOC1279>3.0.CO;2-9"},{"key":"ref151\/cit151","doi-asserted-by":"publisher","DOI":"10.1021\/jo00982a034"},{"key":"ref152\/cit152","doi-asserted-by":"publisher","DOI":"10.1039\/c39730000044"},{"key":"ref153\/cit153","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.4c04081"},{"key":"ref154\/cit154","doi-asserted-by":"publisher","DOI":"10.1002\/ejoc.200390137"},{"key":"ref155\/cit155","doi-asserted-by":"publisher","DOI":"10.1021\/acscatal.4c05067"},{"key":"ref156\/cit156","doi-asserted-by":"publisher","DOI":"10.1107\/S010827010100004X"},{"key":"ref157\/cit157","doi-asserted-by":"publisher","DOI":"10.1021\/ja043646q"},{"key":"ref158\/cit158","doi-asserted-by":"publisher","DOI":"10.1021\/ja00356a025"},{"key":"ref159\/cit159","doi-asserted-by":"publisher","DOI":"10.1107\/S0108768184002147"},{"key":"ref160\/cit160","doi-asserted-by":"publisher","DOI":"10.1002\/chem.202300008"},{"key":"ref161\/cit161","doi-asserted-by":"publisher","DOI":"10.1055\/a-2456-9789"},{"key":"ref162\/cit162","doi-asserted-by":"publisher","DOI":"10.31635\/ccschem.025.202505825"},{"key":"ref163\/cit163","doi-asserted-by":"publisher","DOI":"10.1007\/s11426-025-2941-2"},{"key":"ref164\/cit164","doi-asserted-by":"publisher","DOI":"10.1055\/a-2406-3243"},{"key":"ref165\/cit165","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-023-42102-y"},{"key":"ref166\/cit166","doi-asserted-by":"publisher","DOI":"10.1021\/jo01279a013"},{"key":"ref167\/cit167","doi-asserted-by":"publisher","DOI":"10.1021\/ma60020a001"},{"key":"ref168\/cit168","doi-asserted-by":"publisher","DOI":"10.1021\/acs.joc.9b03044"},{"key":"ref169\/cit169","doi-asserted-by":"publisher","DOI":"10.1002\/0471264180.os049.01"},{"key":"ref170\/cit170","doi-asserted-by":"publisher","DOI":"10.1021\/jo00282a032"},{"key":"ref171\/cit171","doi-asserted-by":"publisher","DOI":"10.1016\/S0040-4039(00)97246-0"},{"key":"ref172\/cit172","doi-asserted-by":"publisher","DOI":"10.1021\/jo00093a010"},{"key":"ref173\/cit173","doi-asserted-by":"publisher","DOI":"10.1021\/jo801199s"},{"key":"ref174\/cit174","doi-asserted-by":"publisher","DOI":"10.1021\/ja00990a067"},{"key":"ref175\/cit175","doi-asserted-by":"publisher","DOI":"10.1021\/jo00980a014"},{"key":"ref176\/cit176","doi-asserted-by":"publisher","DOI":"10.1016\/S0040-4039(00)74809-X"},{"key":"ref177\/cit177","doi-asserted-by":"publisher","DOI":"10.1016\/0040-4020(95)98694-D"},{"key":"ref178\/cit178","doi-asserted-by":"publisher","DOI":"10.1139\/v77-060"},{"key":"ref179\/cit179","doi-asserted-by":"publisher","DOI":"10.1021\/ja00481a026"},{"key":"ref180\/cit180","doi-asserted-by":"publisher","DOI":"10.1021\/ja00339a036"},{"key":"ref181\/cit181","doi-asserted-by":"publisher","DOI":"10.1021\/jo00225a064"},{"key":"ref182\/cit182","doi-asserted-by":"publisher","DOI":"10.1055\/s-1989-27401"},{"key":"ref183\/cit183","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202409226"},{"key":"ref184\/cit184","doi-asserted-by":"publisher","DOI":"10.1039\/D5SC02288F"},{"key":"ref185\/cit185","doi-asserted-by":"publisher","DOI":"10.1021\/acs.orglett.5c00054"},{"key":"ref186\/cit186","doi-asserted-by":"publisher","DOI":"10.1021\/acs.orglett.5c00468"},{"key":"ref187\/cit187","doi-asserted-by":"publisher","DOI":"10.1039\/p19850002509"},{"key":"ref188\/cit188","doi-asserted-by":"publisher","DOI":"10.1021\/ja00290a041"},{"key":"ref189\/cit189","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.3c06525"},{"key":"ref190\/cit190","doi-asserted-by":"publisher","DOI":"10.1039\/P19960002337"},{"key":"ref191\/cit191","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.3c05699"},{"key":"ref192\/cit192","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.5c17624"},{"key":"ref193\/cit193","doi-asserted-by":"publisher","DOI":"10.1002\/cber.19731060917"},{"key":"ref194\/cit194","doi-asserted-by":"publisher","DOI":"10.1016\/S0040-4039(00)84085-X"},{"key":"ref195\/cit195","doi-asserted-by":"publisher","DOI":"10.1016\/0040-4039(76)80118-9"},{"key":"ref196\/cit196","doi-asserted-by":"publisher","DOI":"10.1021\/acs.joc.1c00240"},{"key":"ref197\/cit197","doi-asserted-by":"publisher","DOI":"10.1002\/chem.201001550"},{"key":"ref198\/cit198","doi-asserted-by":"publisher","DOI":"10.1021\/ja00251a033"},{"key":"ref199\/cit199","doi-asserted-by":"publisher","DOI":"10.1002\/hlca.19760590448"},{"key":"ref200\/cit200","doi-asserted-by":"publisher","DOI":"10.1021\/ja00484a033"},{"key":"ref201\/cit201","doi-asserted-by":"publisher","DOI":"10.1107\/S1600536806000092"},{"key":"ref202\/cit202","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2023.116293"},{"key":"ref203\/cit203","doi-asserted-by":"publisher","DOI":"10.3390\/molecules19055940"},{"key":"ref204\/cit204","doi-asserted-by":"publisher","DOI":"10.1021\/acs.joc.4c02561"},{"key":"ref205\/cit205","doi-asserted-by":"publisher","DOI":"10.1002\/cmdc.202200020"},{"key":"ref206\/cit206","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.3c01101"},{"key":"ref207\/cit207","doi-asserted-by":"publisher","DOI":"10.1021\/cr990094z"},{"key":"ref208\/cit208","doi-asserted-by":"publisher","DOI":"10.1055\/s-0037-1610314"},{"key":"ref209\/cit209","doi-asserted-by":"publisher","DOI":"10.1002\/ajoc.201900589"},{"key":"ref210\/cit210","doi-asserted-by":"publisher","DOI":"10.1016\/j.cclet.2020.04.023"},{"key":"ref211\/cit211","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202106352"},{"key":"ref212\/cit212","doi-asserted-by":"publisher","DOI":"10.1021\/jacsau.3c00014"},{"key":"ref213\/cit213","doi-asserted-by":"publisher","DOI":"10.1039\/D3OB01036H"},{"key":"ref214\/cit214","doi-asserted-by":"publisher","DOI":"10.24820\/ark.5550190.p012.457"},{"key":"ref215\/cit215","doi-asserted-by":"publisher","DOI":"10.1021\/ja00162a022"},{"key":"ref216\/cit216","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201603951"},{"key":"ref217\/cit217","doi-asserted-by":"publisher","DOI":"10.1039\/D0CC01771J"},{"key":"ref218\/cit218","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.3c08206"},{"key":"ref219\/cit219","doi-asserted-by":"publisher","DOI":"10.1002\/ajoc.202400045"},{"key":"ref220\/cit220","doi-asserted-by":"publisher","DOI":"10.1016\/j.tchem.2024.100070"},{"key":"ref221\/cit221","doi-asserted-by":"publisher","DOI":"10.1016\/S0040-4039(01)83253-6"},{"key":"ref222\/cit222","doi-asserted-by":"publisher","DOI":"10.1021\/jo00146a031"},{"key":"ref223\/cit223","doi-asserted-by":"publisher","DOI":"10.1021\/ja00311a003"},{"key":"ref224\/cit224","doi-asserted-by":"publisher","DOI":"10.1002\/ejoc.202000679"},{"key":"ref225\/cit225","doi-asserted-by":"publisher","DOI":"10.1021\/acs.joc.1c01020"},{"key":"ref226\/cit226","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2524130122"},{"key":"ref227\/cit227","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202205103"},{"key":"ref228\/cit228","doi-asserted-by":"publisher","DOI":"10.1002\/adsc.202401475"},{"key":"ref229\/cit229","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.5c09039"},{"key":"ref230\/cit230","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202514232"},{"key":"ref231\/cit231","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202518508"},{"key":"ref232\/cit232","doi-asserted-by":"publisher","DOI":"10.1021\/jo00254a038"},{"key":"ref233\/cit233","doi-asserted-by":"publisher","DOI":"10.1021\/jm960254o"},{"key":"ref234\/cit234","doi-asserted-by":"publisher","DOI":"10.15227\/orgsyn.077.0249"},{"key":"ref235\/cit235","doi-asserted-by":"publisher","DOI":"10.1002\/chem.201404347"},{"key":"ref236\/cit236","doi-asserted-by":"publisher","DOI":"10.1021\/acs.joc.1c00977"},{"key":"ref237\/cit237","doi-asserted-by":"publisher","DOI":"10.1021\/ja00308a053"},{"key":"ref238\/cit238","doi-asserted-by":"publisher","DOI":"10.1002\/chem.201704105"},{"key":"ref239\/cit239","doi-asserted-by":"publisher","DOI":"10.1002\/chem.202000097"},{"key":"ref240\/cit240","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-024-55027-x"},{"key":"ref241\/cit241","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.3c00885"},{"key":"ref242\/cit242","doi-asserted-by":"publisher","DOI":"10.1021\/jo00001a058"},{"key":"ref243\/cit243","doi-asserted-by":"publisher","DOI":"10.1002\/1099-0690(200004)2000:7<1137::AID-EJOC1137>3.0.CO;2-2"},{"key":"ref244\/cit244","doi-asserted-by":"publisher","DOI":"10.1002\/anie.200600346"},{"key":"ref245\/cit245","doi-asserted-by":"publisher","DOI":"10.1016\/j.jfluchem.2009.10.004"},{"key":"ref246\/cit246","doi-asserted-by":"publisher","DOI":"10.1039\/C8SC01355A"},{"key":"ref247\/cit247","doi-asserted-by":"publisher","DOI":"10.1021\/acscatal.9b03190"},{"key":"ref248\/cit248","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.1c04180"},{"key":"ref249\/cit249","doi-asserted-by":"publisher","DOI":"10.1021\/acscatal.2c03498"},{"key":"ref250\/cit250","doi-asserted-by":"publisher","DOI":"10.1038\/s44160-024-00637-y"},{"key":"ref251\/cit251","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202213508"},{"key":"ref252\/cit252","doi-asserted-by":"publisher","DOI":"10.1021\/ol201883z"},{"key":"ref253\/cit253","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201909655"},{"key":"ref254\/cit254","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.7b11865"},{"key":"ref255\/cit255","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-020-2060-z"},{"key":"ref256\/cit256","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202211892"},{"key":"ref257\/cit257","doi-asserted-by":"publisher","DOI":"10.1038\/s41557-022-00979-0"},{"key":"ref258\/cit258","doi-asserted-by":"publisher","DOI":"10.1021\/acs.orglett.2c01707"},{"key":"ref259\/cit259","doi-asserted-by":"publisher","DOI":"10.1021\/acs.orglett.1c03681"},{"key":"ref260\/cit260","doi-asserted-by":"publisher","DOI":"10.1002\/ejoc.200300554"},{"key":"ref261\/cit261","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201706799"},{"key":"ref262\/cit262","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201810061"},{"key":"ref263\/cit263","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201905531"},{"key":"ref264\/cit264","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201914875"},{"key":"ref265\/cit265","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202009340"},{"key":"ref266\/cit266","doi-asserted-by":"publisher","DOI":"10.1039\/D1SC01349A"},{"key":"ref267\/cit267","doi-asserted-by":"publisher","DOI":"10.1021\/acs.orglett.9b02426"},{"key":"ref268\/cit268","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202111291"},{"key":"ref269\/cit269","doi-asserted-by":"publisher","DOI":"10.1021\/acs.orglett.2c02875"},{"key":"ref270\/cit270","doi-asserted-by":"publisher","DOI":"10.1021\/acs.orglett.1c01558"},{"key":"ref271\/cit271","doi-asserted-by":"publisher","DOI":"10.1038\/s41557-023-01159-4"},{"key":"ref272\/cit272","doi-asserted-by":"publisher","DOI":"10.1021\/jo00049a030"},{"key":"ref273\/cit273","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201608116"},{"key":"ref274\/cit274","doi-asserted-by":"publisher","DOI":"10.1038\/s41929-019-0417-1"},{"key":"ref275\/cit275","doi-asserted-by":"publisher","DOI":"10.1021\/acs.orglett.0c00242"},{"key":"ref276\/cit276","doi-asserted-by":"publisher","DOI":"10.1021\/acs.orglett.0c02115"},{"key":"ref277\/cit277","doi-asserted-by":"publisher","DOI":"10.1021\/acs.oprd.0c00446"},{"key":"ref278\/cit278","doi-asserted-by":"publisher","DOI":"10.1021\/acscatal.1c05076"},{"key":"ref279\/cit279","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.2c03025"},{"key":"ref280\/cit280","doi-asserted-by":"publisher","DOI":"10.1038\/s44160-023-00277-8"},{"key":"ref281\/cit281","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202506785"},{"key":"ref282\/cit282","doi-asserted-by":"publisher","DOI":"10.1016\/j.chempr.2025.102537"},{"key":"ref283\/cit283","doi-asserted-by":"publisher","DOI":"10.1021\/ol053039n"},{"key":"ref284\/cit284","doi-asserted-by":"publisher","DOI":"10.1021\/acs.orglett.0c03612"},{"key":"ref285\/cit285","doi-asserted-by":"publisher","DOI":"10.1002\/chem.202502396"},{"key":"ref286\/cit286","doi-asserted-by":"publisher","DOI":"10.1038\/s41557-021-00786-z"},{"key":"ref287\/cit287","doi-asserted-by":"publisher","DOI":"10.1038\/s41557-023-01342-7"},{"key":"ref288\/cit288","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.3c02616"},{"key":"ref289\/cit289","doi-asserted-by":"publisher","DOI":"10.1021\/acscatal.5c01734"},{"key":"ref290\/cit290","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.5c03542"},{"key":"ref291\/cit291","doi-asserted-by":"publisher","DOI":"10.1038\/s41557-024-01710-x"},{"key":"ref292\/cit292","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.3c10542"},{"key":"ref293\/cit293","doi-asserted-by":"publisher","DOI":"10.1021\/acs.orglett.3c00412"},{"key":"ref294\/cit294","doi-asserted-by":"publisher","DOI":"10.1002\/chem.202304070"},{"key":"ref295\/cit295","doi-asserted-by":"publisher","DOI":"10.1021\/ja01016a021"},{"key":"ref296\/cit296","doi-asserted-by":"publisher","DOI":"10.1107\/S0108270100008994"},{"key":"ref297\/cit297","doi-asserted-by":"publisher","DOI":"10.1039\/C5OB02066B"},{"key":"ref298\/cit298","doi-asserted-by":"publisher","DOI":"10.1021\/acs.joc.0c02432"},{"key":"ref299\/cit299","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202302771"},{"key":"ref300\/cit300","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202303585"},{"key":"ref301\/cit301","doi-asserted-by":"publisher","DOI":"10.3762\/bjoc.20.259"},{"key":"ref302\/cit302","doi-asserted-by":"publisher","DOI":"10.1021\/jacsau.4c00864"},{"key":"ref303\/cit303","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.4c08867"},{"key":"ref304\/cit304","doi-asserted-by":"publisher","DOI":"10.1002\/ejoc.202001564"},{"key":"ref305\/cit305","doi-asserted-by":"publisher","DOI":"10.1021\/acsmedchemlett.0c00195"},{"key":"ref306\/cit306","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.3c02422"},{"key":"ref307\/cit307","doi-asserted-by":"publisher","DOI":"10.1016\/j.molstruc.2020.129628"},{"key":"ref308\/cit308","doi-asserted-by":"publisher","DOI":"10.1039\/D1CE00620G"},{"key":"ref309\/cit309","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.0c00208"},{"key":"ref310\/cit310","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-024-52045-7"},{"key":"ref311\/cit311","doi-asserted-by":"publisher","DOI":"10.1172\/JCI129126"},{"key":"ref312\/cit312","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2025.130307"},{"key":"ref313\/cit313","doi-asserted-by":"publisher","DOI":"10.1016\/S0960-894X(01)81251-8"},{"key":"ref314\/cit314","doi-asserted-by":"publisher","DOI":"10.1002\/psc.854"},{"key":"ref315\/cit315","unstructured":"Wan, Z.; Vazquez, M. L. Tricyclic Janus Kinase 1 Inhibitors, and Compositions and Methods Thereof. WO 2020\/088659, 2020."},{"key":"ref316\/cit316","unstructured":"Bacon, E. M.; Balan, G.; Chou, C.H.; Clark, C. T.; Cottell, J. J.; Kim, M.; Kirschberg, T. A.; Link, J. O.; Phillips, G.; Schroeder, S. D.; Squires, N. H.; Stevens, K. L.; Taylor, J. G.; Watkins, W. J.; Wright, N. E.; Zipfel, S. M. COT Modulators and Methods of Use Thereof. WO 2017\/007689, 2017."},{"key":"ref317\/cit317","doi-asserted-by":"publisher","DOI":"10.1186\/s13045-025-01704-3"},{"key":"ref318\/cit318","unstructured":"Pinchman, J. R.; Huang, P. Q.; Bunker, K.; Sit, R. K.; Matar, A. A. Benzamide Compounds. WO 2019\/139900, 2019."},{"key":"ref319\/cit319","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.5c00887"},{"key":"ref320\/cit320","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.5c00362"},{"key":"ref321\/cit321","doi-asserted-by":"publisher","DOI":"10.1021\/acsmedchemlett.5c00013"},{"key":"ref322\/cit322","doi-asserted-by":"publisher","DOI":"10.1021\/acsmedchemlett.5c00189"},{"key":"ref323\/cit323","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.5c00855"},{"key":"ref324\/cit324","doi-asserted-by":"publisher","DOI":"10.1158\/1535-7163.MCT-24-1208"},{"key":"ref325\/cit325","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.5c00945"},{"key":"ref326\/cit326","doi-asserted-by":"publisher","DOI":"10.1002\/chem.202002866"},{"key":"ref327\/cit327","doi-asserted-by":"publisher","DOI":"10.1021\/ja044089a"},{"key":"ref328\/cit328","doi-asserted-by":"publisher","DOI":"10.1021\/ja058370g"},{"key":"ref329\/cit329","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.6b10706"},{"key":"ref330\/cit330","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201910901"},{"key":"ref331\/cit331","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202201584"},{"key":"ref332\/cit332","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.4c13713"},{"key":"ref333\/cit333","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.5c09164"},{"key":"ref334\/cit334","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1810706115"},{"key":"ref335\/cit335","doi-asserted-by":"publisher","DOI":"10.1021\/ja00520a008"},{"key":"ref336\/cit336","doi-asserted-by":"publisher","DOI":"10.1016\/S0040-4020(01)87609-2"},{"key":"ref337\/cit337","doi-asserted-by":"publisher","DOI":"10.1016\/j.tetlet.2024.155369"},{"key":"ref338\/cit338","doi-asserted-by":"publisher","DOI":"10.1016\/0040-4020(72)80085-1"},{"key":"ref339\/cit339","doi-asserted-by":"publisher","DOI":"10.1021\/ja00443a058"},{"key":"ref340\/cit340","doi-asserted-by":"publisher","DOI":"10.1021\/jo981775h"},{"key":"ref341\/cit341","doi-asserted-by":"publisher","DOI":"10.1016\/S0040-4020(01)85833-6"},{"key":"ref342\/cit342","doi-asserted-by":"publisher","DOI":"10.1021\/ja00903a056"},{"key":"ref343\/cit343","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.3c01591"},{"key":"ref344\/cit344","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201604102"},{"key":"ref345\/cit345","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201703803"},{"key":"ref346\/cit346","doi-asserted-by":"publisher","DOI":"10.1021\/acs.orglett.2c01228"},{"key":"ref347\/cit347","doi-asserted-by":"publisher","DOI":"10.1039\/D3SC00651D"},{"key":"ref348\/cit348","doi-asserted-by":"publisher","DOI":"10.1016\/j.cclet.2022.05.026"},{"key":"ref349\/cit349","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jnatprod.8b00458"},{"key":"ref350\/cit350","doi-asserted-by":"publisher","DOI":"10.1023\/A:1022431514386"},{"key":"ref351\/cit351","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.0c06454"},{"key":"ref352\/cit352","doi-asserted-by":"publisher","DOI":"10.1107\/S0108270198099107"},{"key":"ref353\/cit353","doi-asserted-by":"publisher","DOI":"10.1002\/ejoc.201800058"},{"key":"ref354\/cit354","doi-asserted-by":"publisher","DOI":"10.1007\/s00203-008-0364-8"},{"key":"ref355\/cit355","doi-asserted-by":"publisher","DOI":"10.1016\/j.scitotenv.2022.154715"},{"key":"ref356\/cit356","unstructured":"Mccartney, J.; Abela, A. R.; Abraham, S.; Anderson, C. D.; Arumugam, V.; Chau, J.; Clemens, J.; Cleveland, T.; Coon, T. R.; Dwight, T. A.; Fanning, L. T. D.; Frieman, B. A.; Gulevich, A. V.; Ruah, S. S. H.; Ishihara, Y.; Khatuya, H.; Krenitsky, P.; Melillo, V.; Miller, M. T.; Paraselli, P.; Pierre, F.; Silina, A.; Tran, J. A.; Uy, J.; Valdez, L.; Vickers, T.; Zhou, J.; Grootenhuis, P. Modulators of Cystic Fibrosis Transmembrane Conductance Regulator. WO 2022\/076622, 2022."},{"key":"ref357\/cit357","unstructured":"Ketcham, J. M.; Smith, C. R.; Marx, M. A.; Lawson, J. D.; Harwood, S.; Burns, A. C.; Caddell-Haatveit, K.; Pearson, K. E.; Aloiau, A. N. G.; Kuehler, J.; Bobeck, B.; Watkins, A. H.; Jones, B. D.; Ivetac, A. D.; Wang, X. Substituted Pyridopyrimidinones. WO 2024\/044769, 2024."},{"key":"ref358\/cit358","unstructured":"Gu, Z.; Ji, F.; Shao, S.; Zhou, Y.; Chen, Z.; Qu, M.; Bai, L.; Luo, J.; Fang, L.; Chen, B.; Wang, S.; Zhang, P. Complement Factor b Inhibitor, Pharmaceutical Composition and Use Thereof. WO 2024\/141011, 2024."},{"key":"ref359\/cit359","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.0c01473"},{"key":"ref360\/cit360","doi-asserted-by":"publisher","DOI":"10.1055\/s-1974-23326"},{"key":"ref361\/cit361","doi-asserted-by":"publisher","DOI":"10.1021\/cr960153y"},{"key":"ref362\/cit362","doi-asserted-by":"publisher","DOI":"10.1070\/RC2012v081n08ABEH004230"},{"key":"ref363\/cit363","doi-asserted-by":"publisher","DOI":"10.1021\/cr400291c"},{"key":"ref364\/cit364","doi-asserted-by":"publisher","DOI":"10.1002\/prac.18960540106"},{"key":"ref365\/cit365","doi-asserted-by":"publisher","DOI":"10.1002\/cber.19130460128"},{"key":"ref366\/cit366","doi-asserted-by":"publisher","DOI":"10.1021\/ja01230a515"},{"key":"ref367\/cit367","doi-asserted-by":"publisher","DOI":"10.1021\/ja01233a047"},{"key":"ref368\/cit368","doi-asserted-by":"publisher","DOI":"10.1021\/ja01211a073"},{"key":"ref369\/cit369","doi-asserted-by":"publisher","DOI":"10.1021\/jo01118a042"},{"key":"ref370\/cit370","doi-asserted-by":"publisher","DOI":"10.1021\/jo01105a037"},{"key":"ref371\/cit371","doi-asserted-by":"publisher","DOI":"10.1055\/s-1974-23434"},{"key":"ref372\/cit372","doi-asserted-by":"publisher","DOI":"10.1055\/s-1975-23743"},{"key":"ref373\/cit373","doi-asserted-by":"publisher","DOI":"10.1002\/cber.19921251124"},{"key":"ref374\/cit374","doi-asserted-by":"publisher","DOI":"10.1016\/0040-4020(77)80094-X"},{"key":"ref375\/cit375","doi-asserted-by":"publisher","DOI":"10.1016\/S0040-4020(01)89261-9"},{"key":"ref376\/cit376","doi-asserted-by":"publisher","DOI":"10.1002\/anie.200461166"},{"key":"ref377\/cit377","doi-asserted-by":"publisher","DOI":"10.1002\/chem.200600111"},{"key":"ref378\/cit378","doi-asserted-by":"publisher","DOI":"10.1002\/adsc.201700857"},{"key":"ref379\/cit379","doi-asserted-by":"publisher","DOI":"10.1055\/s-0039-1691560"},{"key":"ref380\/cit380","doi-asserted-by":"publisher","DOI":"10.1002\/ejoc.201700991"},{"key":"ref381\/cit381","doi-asserted-by":"publisher","DOI":"10.1021\/acs.orglett.5c02374"},{"key":"ref382\/cit382","doi-asserted-by":"publisher","DOI":"10.1021\/jo00054a040"},{"key":"ref383\/cit383","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1099-0690(199911)1999:11<3105::AID-EJOC3105>3.0.CO;2-1"},{"key":"ref384\/cit384","doi-asserted-by":"publisher","DOI":"10.1021\/jo020138v"},{"key":"ref385\/cit385","doi-asserted-by":"publisher","DOI":"10.1055\/s-2005-918514"},{"key":"ref386\/cit386","doi-asserted-by":"publisher","DOI":"10.1021\/jo00113a054"},{"key":"ref387\/cit387","doi-asserted-by":"publisher","DOI":"10.1007\/BF01431804"},{"key":"ref388\/cit388","doi-asserted-by":"publisher","DOI":"10.1021\/jo991030r"},{"key":"ref389\/cit389","doi-asserted-by":"publisher","DOI":"10.1055\/s-2006-926320"},{"key":"ref390\/cit390","doi-asserted-by":"publisher","DOI":"10.1139\/v69-202"},{"key":"ref391\/cit391","doi-asserted-by":"publisher","DOI":"10.1021\/ol0165140"},{"key":"ref392\/cit392","doi-asserted-by":"publisher","DOI":"10.1039\/b908205k"},{"key":"ref393\/cit393","doi-asserted-by":"publisher","DOI":"10.1021\/ja00744a039"},{"key":"ref394\/cit394","doi-asserted-by":"publisher","DOI":"10.1021\/ja00744a040"},{"key":"ref395\/cit395","doi-asserted-by":"publisher","DOI":"10.1021\/ja00797a035"},{"key":"ref396\/cit396","doi-asserted-by":"publisher","DOI":"10.1021\/jo01026a511"},{"key":"ref397\/cit397","doi-asserted-by":"publisher","DOI":"10.1021\/ja00023a031"},{"key":"ref398\/cit398","unstructured":"Patel, S.; Hamilton, G.; Stivala, C.; Chen, H.; Daniels, B. Bicyclic Sulfones and Sulfoxides and Methods of Use Thereof. US 2019\/0127382, 2019."},{"key":"ref399\/cit399","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.2c07370"},{"key":"ref400\/cit400","doi-asserted-by":"publisher","DOI":"10.1126\/science.ads5974"},{"key":"ref401\/cit401","doi-asserted-by":"publisher","DOI":"10.1039\/b610181j"},{"key":"ref402\/cit402","doi-asserted-by":"publisher","DOI":"10.1039\/D1SC04910K"},{"key":"ref403\/cit403","doi-asserted-by":"publisher","DOI":"10.1021\/ja00177a034"},{"key":"ref404\/cit404","doi-asserted-by":"publisher","DOI":"10.1107\/S0108768192013612"},{"key":"ref405\/cit405","doi-asserted-by":"publisher","DOI":"10.1107\/S010876819600105X"},{"key":"ref406\/cit406","doi-asserted-by":"publisher","DOI":"10.1002\/1521-3765(20020215)8:4<828::AID-CHEM828>3.0.CO;2-Y"},{"key":"ref407\/cit407","doi-asserted-by":"publisher","DOI":"10.1021\/ja031648p"},{"key":"ref408\/cit408","doi-asserted-by":"publisher","DOI":"10.1002\/ejoc.201101715"},{"key":"ref409\/cit409","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.2c01605"},{"key":"ref410\/cit410","doi-asserted-by":"publisher","DOI":"10.1021\/bi00108a021"},{"key":"ref411\/cit411","doi-asserted-by":"publisher","DOI":"10.1158\/2159-8290.CD-20-1437"},{"key":"ref412\/cit412","doi-asserted-by":"publisher","DOI":"10.1021\/jm00389a018"},{"key":"ref413\/cit413","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2011.05.128"},{"key":"ref414\/cit414","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01181-10"},{"key":"ref415\/cit415","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.0c00916"},{"key":"ref416\/cit416","doi-asserted-by":"publisher","DOI":"10.1021\/acsmedchemlett.3c00179"},{"key":"ref417\/cit417","unstructured":"Liu, C.; Yang, M. G.; Xiao, Z.; Chen, L.; Moslin, R. M.; Tokarski, J. S.; Weinstein, D. S. Sulfone Pyridine Alkyl Amide-Substituted Heteroaryl Compounds. US 2019\/0152948, 2019."},{"key":"ref418\/cit418","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-2600(24)00411-9"},{"key":"ref419\/cit419","doi-asserted-by":"publisher","DOI":"10.1139\/v60-226"},{"key":"ref420\/cit420","doi-asserted-by":"publisher","DOI":"10.2533\/chimia.1968.193"},{"key":"ref421\/cit421","doi-asserted-by":"publisher","DOI":"10.1002\/recl.19861050916"},{"key":"ref422\/cit422","doi-asserted-by":"publisher","DOI":"10.1002\/hlca.19970800816"},{"key":"ref423\/cit423","doi-asserted-by":"publisher","DOI":"10.1021\/ja5012542"},{"key":"ref424\/cit424","doi-asserted-by":"publisher","DOI":"10.1002\/chem.201705708"},{"key":"ref425\/cit425","doi-asserted-by":"publisher","DOI":"10.1002\/ejoc.202000346"},{"key":"ref426\/cit426","doi-asserted-by":"publisher","DOI":"10.1021\/acs.orglett.2c02790"},{"key":"ref427\/cit427","doi-asserted-by":"publisher","DOI":"10.1039\/D5CC00479A"},{"key":"ref428\/cit428","doi-asserted-by":"publisher","DOI":"10.1002\/bscb.19560650305"},{"key":"ref429\/cit429","doi-asserted-by":"publisher","DOI":"10.1021\/jo01274a031"},{"key":"ref430\/cit430","doi-asserted-by":"publisher","DOI":"10.1007\/BF00956960"},{"key":"ref431\/cit431","doi-asserted-by":"publisher","DOI":"10.1016\/j.tetlet.2003.09.083"},{"key":"ref432\/cit432","doi-asserted-by":"publisher","DOI":"10.1021\/ol0491989"},{"key":"ref433\/cit433","doi-asserted-by":"publisher","DOI":"10.1055\/s-0029-1217103"},{"key":"ref434\/cit434","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201814123"},{"key":"ref435\/cit435","unstructured":"Cunningham, C.; Beroza, P. P.; Crawford, J. J.; Lee, W.; Rene, O.; Zbieg, J. R.; Liao, J.; Wang, T.; Yu, C. Carboxamide and Sulfonamide Derivatives Useful as Tead Modulators. WO 2020\/051099, 2020."},{"key":"ref436\/cit436","doi-asserted-by":"publisher","DOI":"10.1002\/ejoc.202001614"},{"key":"ref437\/cit437","doi-asserted-by":"publisher","DOI":"10.1039\/D5OB00691K"},{"key":"ref438\/cit438","doi-asserted-by":"publisher","DOI":"10.1126\/science.adw4177"},{"key":"ref439\/cit439","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202216799"},{"key":"ref440\/cit440","doi-asserted-by":"publisher","DOI":"10.1039\/D5OB00055F"},{"key":"ref441\/cit441","doi-asserted-by":"publisher","DOI":"10.1021\/acs.orglett.5c00395"},{"key":"ref442\/cit442","doi-asserted-by":"publisher","DOI":"10.1021\/jo00236a031"},{"key":"ref443\/cit443","doi-asserted-by":"publisher","DOI":"10.1021\/ja00153a006"},{"key":"ref444\/cit444","doi-asserted-by":"publisher","DOI":"10.1002\/slct.202402108"},{"key":"ref445\/cit445","doi-asserted-by":"publisher","DOI":"10.1002\/1521-3765(20011217)7:24<5382::AID-CHEM5382>3.0.CO;2-Y"},{"key":"ref446\/cit446","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202319157"},{"key":"ref447\/cit447","unstructured":"Bock, W. J.; Cho-Schultz, S.; Deal, J. G.; Donaldson, J. S.; Jalaie, M.; Jeffreys, M. S.; Kaiser, S. E.; Kath, J. C.; Montgomery, T. P.; Nair, S. K.; Patman, R. L.; Tran, K. T.; Wisniewska, H. M.; Zhou, R. Substituted Bicyclic Pyridone Derivatives. WO 2024\/105563, 2024."},{"key":"ref448\/cit448","doi-asserted-by":"publisher","DOI":"10.1039\/D3SC06600B"},{"key":"ref449\/cit449","doi-asserted-by":"publisher","DOI":"10.1021\/jo01055a003"},{"key":"ref450\/cit450","doi-asserted-by":"publisher","DOI":"10.1021\/jo00357a004"},{"key":"ref451\/cit451","doi-asserted-by":"publisher","DOI":"10.1021\/ja00082a041"},{"key":"ref452\/cit452","doi-asserted-by":"publisher","DOI":"10.1055\/s-1996-4392"},{"key":"ref453\/cit453","doi-asserted-by":"publisher","DOI":"10.1002\/ejoc.200700531"},{"key":"ref454\/cit454","doi-asserted-by":"publisher","DOI":"10.1021\/acs.orglett.7b01023"},{"key":"ref455\/cit455","doi-asserted-by":"publisher","DOI":"10.1039\/C8OB01765D"},{"key":"ref456\/cit456","doi-asserted-by":"publisher","DOI":"10.1002\/ejoc.201900518"},{"key":"ref457\/cit457","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201912834"},{"key":"ref458\/cit458","doi-asserted-by":"publisher","DOI":"10.3406\/barb.1968.62188"},{"key":"ref459\/cit459","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.3c09789"},{"key":"ref460\/cit460","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202521633"},{"key":"ref461\/cit461","doi-asserted-by":"publisher","DOI":"10.1002\/cber.19811140707"},{"key":"ref462\/cit462","doi-asserted-by":"publisher","DOI":"10.1021\/ja973118x"},{"key":"ref463\/cit463","doi-asserted-by":"publisher","DOI":"10.1107\/S0108270199099618"},{"key":"ref464\/cit464","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-025-56893-9"},{"key":"ref465\/cit465","doi-asserted-by":"publisher","DOI":"10.1126\/science.abo7201"},{"key":"ref466\/cit466","doi-asserted-by":"publisher","DOI":"10.1080\/17460441.2016.1195367"},{"key":"ref467\/cit467","doi-asserted-by":"publisher","DOI":"10.1080\/17460441.2022.2055544"},{"key":"ref468\/cit468","doi-asserted-by":"publisher","DOI":"10.1021\/acsmedchemlett.8b00018"},{"key":"ref469\/cit469","doi-asserted-by":"publisher","DOI":"10.1021\/ml100251u"},{"key":"ref470\/cit470","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2013.05.070"},{"key":"ref471\/cit471","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.5b01062"},{"key":"ref472\/cit472","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.3c00519"},{"key":"ref473\/cit473","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2025.117488"},{"key":"ref474\/cit474","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.4c02225"},{"key":"ref475\/cit475","doi-asserted-by":"publisher","DOI":"10.1002\/ejoc.202500738"},{"key":"ref476\/cit476","doi-asserted-by":"publisher","DOI":"10.1002\/jlac.19616480107"},{"key":"ref477\/cit477","doi-asserted-by":"publisher","DOI":"10.1002\/jlac.19636660113"},{"key":"ref478\/cit478","doi-asserted-by":"publisher","DOI":"10.1007\/BF00601590"},{"key":"ref479\/cit479","doi-asserted-by":"publisher","DOI":"10.1002\/cber.19660990514"},{"key":"ref480\/cit480","doi-asserted-by":"publisher","DOI":"10.1021\/ja00010a064"},{"key":"ref481\/cit481","doi-asserted-by":"publisher","DOI":"10.1021\/jo00063a036"},{"key":"ref482\/cit482","doi-asserted-by":"publisher","DOI":"10.1002\/anie.199621371"},{"key":"ref483\/cit483","doi-asserted-by":"publisher","DOI":"10.1016\/j.tetasy.2008.12.016"},{"key":"ref484\/cit484","doi-asserted-by":"publisher","DOI":"10.1021\/jo901892d"},{"key":"ref485\/cit485","doi-asserted-by":"publisher","DOI":"10.1055\/s-0031-1289702"},{"key":"ref486\/cit486","doi-asserted-by":"publisher","DOI":"10.1248\/cpb.c15-00386"},{"key":"ref487\/cit487","doi-asserted-by":"publisher","DOI":"10.1016\/j.tet.2015.12.081"},{"key":"ref488\/cit488","doi-asserted-by":"publisher","DOI":"10.1002\/ejoc.202100804"},{"key":"ref489\/cit489","doi-asserted-by":"publisher","DOI":"10.1002\/ejoc.202000432"},{"key":"ref490\/cit490","doi-asserted-by":"publisher","DOI":"10.1002\/ejoc.202500587"},{"key":"ref491\/cit491","unstructured":"Azimioara, M.; Chen, B.; Epple, R.; Hardy, D.; Honda, A.; Lam, P.; Malik, H. A.; Meier, F.; Nguyen, T. N.; Okram, B.; Patel, S.; Rodriguez, R.; Shaw, D.; Shen, Y.; Wu, B. N-(Pyridin-2-Ylsulfonyl)Cyclopropanecarboxamide Derivatives and Their Use in the Treatment of a Cftr Mediated Disease. WO 2020\/128768, 2020."},{"key":"ref492\/cit492","doi-asserted-by":"publisher","DOI":"10.1021\/ja00451a040"},{"key":"ref493\/cit493","doi-asserted-by":"publisher","DOI":"10.1016\/j.tet.2003.08.045"},{"key":"ref494\/cit494","doi-asserted-by":"publisher","DOI":"10.1039\/c3ra47725h"},{"key":"ref495\/cit495","doi-asserted-by":"publisher","DOI":"10.1021\/acs.joc.5b00323"},{"key":"ref496\/cit496","doi-asserted-by":"publisher","DOI":"10.1021\/acs.joc.6b02445"},{"key":"ref497\/cit497","doi-asserted-by":"publisher","DOI":"10.1039\/D2OB00146B"},{"key":"ref498\/cit498","doi-asserted-by":"publisher","DOI":"10.1016\/j.tet.2023.133296"},{"key":"ref499\/cit499","doi-asserted-by":"publisher","DOI":"10.1016\/S0040-4039(97)10298-2"},{"key":"ref500\/cit500","doi-asserted-by":"publisher","DOI":"10.1021\/ja3104582"},{"key":"ref501\/cit501","doi-asserted-by":"publisher","DOI":"10.1021\/acs.orglett.5c01265"},{"key":"ref502\/cit502","doi-asserted-by":"publisher","DOI":"10.1016\/S0040-4039(00)95014-7"},{"key":"ref503\/cit503","doi-asserted-by":"publisher","DOI":"10.1016\/S0040-4039(00)80803-5"},{"key":"ref504\/cit504","doi-asserted-by":"publisher","DOI":"10.1016\/S0040-4020(01)85699-4"},{"key":"ref505\/cit505","doi-asserted-by":"publisher","DOI":"10.1016\/0040-4020(95)00486-R"},{"key":"ref506\/cit506","doi-asserted-by":"publisher","DOI":"10.1016\/S0040-4020(03)00617-3"},{"key":"ref507\/cit507","doi-asserted-by":"publisher","DOI":"10.1021\/acs.joc.6b01446"},{"key":"ref508\/cit508","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.1c01173"},{"key":"ref509\/cit509","doi-asserted-by":"publisher","DOI":"10.1039\/D3SC00144J"},{"key":"ref510\/cit510","doi-asserted-by":"publisher","DOI":"10.1002\/anie.198710231"},{"key":"ref511\/cit511","doi-asserted-by":"publisher","DOI":"10.1016\/j.tetlet.2014.11.050"},{"key":"ref512\/cit512","doi-asserted-by":"publisher","DOI":"10.1016\/j.tet.2003.11.081"},{"key":"ref513\/cit513","doi-asserted-by":"publisher","DOI":"10.1021\/jo7017558"},{"key":"ref514\/cit514","doi-asserted-by":"publisher","DOI":"10.1016\/j.tetlet.2015.02.112"},{"key":"ref515\/cit515","doi-asserted-by":"publisher","DOI":"10.1016\/j.tetlet.2016.04.092"},{"key":"ref516\/cit516","doi-asserted-by":"publisher","DOI":"10.1016\/j.tetlet.2016.06.097"},{"key":"ref517\/cit517","doi-asserted-by":"publisher","DOI":"10.1016\/j.tetlet.2017.06.033"},{"key":"ref518\/cit518","doi-asserted-by":"publisher","DOI":"10.1002\/hlca.202100022"},{"key":"ref519\/cit519","doi-asserted-by":"publisher","DOI":"10.1039\/p19900003215"},{"key":"ref520\/cit520","doi-asserted-by":"publisher","DOI":"10.1021\/acs.orglett.2c01378"},{"key":"ref521\/cit521","doi-asserted-by":"publisher","DOI":"10.1021\/jo00976a022"},{"key":"ref522\/cit522","doi-asserted-by":"publisher","DOI":"10.1021\/ja00426a010"},{"key":"ref523\/cit523","doi-asserted-by":"publisher","DOI":"10.1002\/anie.199114921"},{"key":"ref524\/cit524","doi-asserted-by":"publisher","DOI":"10.1107\/S1600536802009674"},{"key":"ref525\/cit525","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmc.2019.02.017"},{"key":"ref526\/cit526","doi-asserted-by":"publisher","DOI":"10.1021\/acsmedchemlett.0c00025"},{"key":"ref527\/cit527","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2020.127419"},{"key":"ref528\/cit528","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmc.2020.115791"},{"key":"ref529\/cit529","doi-asserted-by":"publisher","DOI":"10.1021\/acsmedchemlett.2c00379"},{"key":"ref530\/cit530","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.4c01998"},{"key":"ref531\/cit531","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.3c00884"},{"key":"ref532\/cit532","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2023.129324"},{"key":"ref533\/cit533","doi-asserted-by":"publisher","DOI":"10.1021\/jm00299a030"}],"container-title":["Chemical Reviews"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acs.chemrev.5c00779","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acs.chemrev.5c00779","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T08:10:36Z","timestamp":1774426236000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/acs.chemrev.5c00779"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,12]]},"references-count":532,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2026,3,25]]}},"alternative-id":["10.1021\/acs.chemrev.5c00779"],"URL":"https:\/\/doi.org\/10.1021\/acs.chemrev.5c00779","relation":{},"ISSN":["0009-2665","1520-6890"],"issn-type":[{"value":"0009-2665","type":"print"},{"value":"1520-6890","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3,12]]}}}