{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T19:44:37Z","timestamp":1792784677541,"version":"4.5.0"},"reference-count":230,"publisher":"American Chemical Society (ACS)","issue":"16","funder":[{"name":"Theragnostics Limited"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Chem. Rev."],"published-print":{"date-parts":[[2018,8,22]]},"DOI":"10.1021\/acs.chemrev.8b00254","type":"journal-article","created":{"date-parts":[[2018,7,23]],"date-time":"2018-07-23T08:02:37Z","timestamp":1532332957000},"page":"7657-7701","source":"Crossref","is-referenced-by-count":85,"title":["Hydroxypyridinone Journey into Metal Chelation"],"prefix":"10.1021","volume":"118","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9711-5183","authenticated-orcid":true,"given":"Agostino","family":"Cilibrizzi","sequence":"first","affiliation":[{"name":"Institute of Pharmaceutical Science, King\u2019s College London, Stamford Street, London SE1 9NH, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincenzo","family":"Abbate","sequence":"additional","affiliation":[{"name":"Institute of Pharmaceutical Science, King\u2019s College London, Stamford Street, London SE1 9NH, United Kingdom"},{"name":"King\u2019s Forensics, School of Population Health & Environmental Sciences, King\u2019s College London, Franklin-Wilkins Building, 150 Stamford Street, London SE1 9NH, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-Lin","family":"Chen","sequence":"additional","affiliation":[{"name":"Institute of Pharmaceutical Science, King\u2019s College London, Stamford Street, London SE1 9NH, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongmin","family":"Ma","sequence":"additional","affiliation":[{"name":"College of Pharmaceutical Science, Zhejiang Chinese Medical University, Hangzhou, P. R. China 311402"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4510-3639","authenticated-orcid":true,"given":"Tao","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Applied Chemistry, School of Food Science and Biotechnology, Zhejiang Gongshang University, Hangzhou, P. R. China 310018"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert C.","family":"Hider","sequence":"additional","affiliation":[{"name":"Institute of Pharmaceutical Science, King\u2019s College London, Stamford Street, London SE1 9NH, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2018,7,23]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"crossref","DOI":"10.1002\/9781118925645","volume-title":"Iron metabolism: From molecular mechanisms to clinical consequences","author":"Crichton R.","year":"2016"},{"key":"ref2\/cit2","doi-asserted-by":"crossref","DOI":"10.1093\/acprof:oso\/9780198717478.001.0001","volume-title":"Free radicals in biology and medicine","author":"Halliwell B.","year":"2015"},{"key":"ref3\/cit3","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.1998.00726.x"},{"key":"ref4\/cit4","doi-asserted-by":"publisher","DOI":"10.1021\/ja00905a001"},{"key":"ref5\/cit5","doi-asserted-by":"publisher","DOI":"10.1016\/0304-4165(73)90019-6"},{"key":"ref6\/cit6","doi-asserted-by":"publisher","DOI":"10.1039\/b906679a"},{"key":"ref7\/cit7","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-201x.1999.00510.x"},{"key":"ref8\/cit8","unstructured":"Hider, R.; Kontoghiorghes, G.; Silver, J. Patent GB-2118176, 1982; Br. UK Pat. Appl. 1983, 13."},{"key":"ref9\/cit9","doi-asserted-by":"publisher","DOI":"10.1021\/ja00485a018"},{"key":"ref10\/cit10","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1007\/978-1-60327-485-2_27","volume-title":"Iron Physiology and Pathophysiology in Humans","author":"Hider R. C.","year":"2012"},{"key":"ref11\/cit11","doi-asserted-by":"publisher","DOI":"10.1016\/S0010-8545(02)00050-4"},{"key":"ref12\/cit12","doi-asserted-by":"publisher","DOI":"10.1039\/DT9810000609"},{"key":"ref13\/cit13","doi-asserted-by":"publisher","DOI":"10.1039\/c2dt12159j"},{"key":"ref14\/cit14","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1016\/S0022-3565(25)31286-3","volume":"205","author":"Grady R. W.","year":"1978","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"ref15\/cit15","doi-asserted-by":"publisher","DOI":"10.1007\/s10534-009-9224-5"},{"key":"ref16\/cit16","doi-asserted-by":"publisher","DOI":"10.1111\/j.1574-6968.1992.tb05285.x"},{"key":"ref17\/cit17","doi-asserted-by":"publisher","DOI":"10.1002\/med.1027"},{"key":"ref18\/cit18","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinorgbio.2007.10.012"},{"key":"ref19\/cit19","doi-asserted-by":"publisher","DOI":"10.1016\/S0020-1693(00)86121-6"},{"key":"ref20\/cit20","doi-asserted-by":"publisher","DOI":"10.1002\/hlca.200490272"},{"key":"ref21\/cit21","doi-asserted-by":"publisher","DOI":"10.1021\/ja00514a037"},{"key":"ref22\/cit22","doi-asserted-by":"publisher","DOI":"10.1021\/cr00064a005"},{"key":"ref23\/cit23","doi-asserted-by":"publisher","DOI":"10.1007\/s10534-008-9185-0"},{"key":"ref24\/cit24","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1007\/3-540-13099-3_2","volume-title":"Structural Chemistry. Topics in Current Chemistry","volume":"123","author":"Raymond K. N.","year":"1984"},{"key":"ref25\/cit25","doi-asserted-by":"publisher","DOI":"10.4155\/fmc.11.191"},{"key":"ref26\/cit26","doi-asserted-by":"publisher","DOI":"10.1039\/JR9310003023"},{"key":"ref27\/cit27","doi-asserted-by":"publisher","DOI":"10.1002\/recl.19500690813"},{"key":"ref28\/cit28","doi-asserted-by":"publisher","DOI":"10.1002\/cber.19540870103"},{"key":"ref29\/cit29","doi-asserted-by":"publisher","DOI":"10.1021\/ja01584a027"},{"key":"ref30\/cit30","doi-asserted-by":"publisher","DOI":"10.1021\/ja01199a071"},{"key":"ref31\/cit31","doi-asserted-by":"publisher","DOI":"10.1071\/CH9761329"},{"key":"ref32\/cit32","doi-asserted-by":"publisher","DOI":"10.1139\/v62-210"},{"key":"ref33\/cit33","doi-asserted-by":"publisher","DOI":"10.1248\/yakushi1947.90.10_1222"},{"key":"ref34\/cit34","first-page":"1158","volume":"46","author":"Jones M. M.","year":"1996","journal-title":"Arzneim. Forsch."},{"key":"ref35\/cit35","first-page":"311","volume":"47","author":"Singh P. K.","year":"1997","journal-title":"Arzneim. Forsch."},{"key":"ref36\/cit36","doi-asserted-by":"publisher","DOI":"10.1021\/jm00069a002"},{"key":"ref37\/cit37","doi-asserted-by":"publisher","DOI":"10.1002\/jhet.5570300225"},{"key":"ref38\/cit38","doi-asserted-by":"publisher","DOI":"10.1021\/jm9707784"},{"key":"ref39\/cit39","unstructured":"Zbinden, P. EU Patent EP0768302A2, 1997; Eur. Pat. Appl. 1997, 41."},{"key":"ref40\/cit40","unstructured":"Tam, T. F.; Spino, M.; Li, W.; Wang, Y.; Zhao, Y.; Shah, B. H. Patent WO2005049609 A1, 2008; PCT Int. Appl. 2005, 77."},{"key":"ref41\/cit41","unstructured":"Hider, R. C.; Liu, Z. D.; Yu, Y.; Li, Z. EU Patent EP2692724 A1, 2011; PCT Int. Appl. 2012, 33."},{"key":"ref42\/cit42","unstructured":"Liu, S. EU Patent EP1474396B9, 2004; PCT Int. Appl. 2003, 52."},{"key":"ref43\/cit43","doi-asserted-by":"publisher","DOI":"10.1002\/jhet.5570290460"},{"key":"ref44\/cit44","doi-asserted-by":"publisher","DOI":"10.1021\/jm0504306"},{"key":"ref45\/cit45","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2003.09.033"},{"key":"ref46\/cit46","doi-asserted-by":"publisher","DOI":"10.1080\/15257779508010712"},{"key":"ref47\/cit47","doi-asserted-by":"publisher","DOI":"10.1016\/0040-4020(95)01016-5"},{"key":"ref48\/cit48","doi-asserted-by":"publisher","DOI":"10.1002\/ardp.200200754"},{"key":"ref49\/cit49","doi-asserted-by":"publisher","DOI":"10.1021\/jm991080o"},{"key":"ref50\/cit50","doi-asserted-by":"publisher","DOI":"10.1016\/S0040-4020(01)00222-8"},{"key":"ref51\/cit51","doi-asserted-by":"publisher","DOI":"10.4155\/fmc.15.154"},{"key":"ref52\/cit52","doi-asserted-by":"publisher","DOI":"10.1211\/0022357021778592"},{"key":"ref53\/cit53","doi-asserted-by":"publisher","DOI":"10.1016\/S0968-0896(00)00273-X"},{"key":"ref54\/cit54","doi-asserted-by":"publisher","DOI":"10.1002\/chem.200902455"},{"key":"ref55\/cit55","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2008.10.022"},{"key":"ref56\/cit56","doi-asserted-by":"publisher","DOI":"10.1246\/cl.141133"},{"key":"ref57\/cit57","first-page":"445","volume":"27","author":"Aytemir M. D.","year":"2003","journal-title":"Turk. J. Chem."},{"key":"ref58\/cit58","doi-asserted-by":"publisher","DOI":"10.1016\/S0040-4020(99)00008-3"},{"key":"ref59\/cit59","doi-asserted-by":"publisher","DOI":"10.1021\/jm201475u"},{"key":"ref60\/cit60","doi-asserted-by":"publisher","DOI":"10.1016\/j.tetlet.2010.07.134"},{"key":"ref61\/cit61","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2016.03.014"},{"key":"ref62\/cit62","doi-asserted-by":"publisher","DOI":"10.1080\/17474086.2017.1318052"},{"key":"ref63\/cit63","doi-asserted-by":"publisher","DOI":"10.1021\/ja01169a020"},{"key":"ref64\/cit64","first-page":"29","volume":"16","author":"Mizukami S.","year":"1966","journal-title":"Rep. Shionogi Res. Lab"},{"key":"ref65\/cit65","doi-asserted-by":"publisher","DOI":"10.1002\/recl.19550740913"},{"key":"ref66\/cit66","doi-asserted-by":"publisher","DOI":"10.1021\/ja01520a021"},{"key":"ref67\/cit67","first-page":"475","volume":"35","author":"Talik Z.","year":"1961","journal-title":"Rocz. Chem."},{"key":"ref68\/cit68","doi-asserted-by":"publisher","DOI":"10.1021\/jo50003a022"},{"key":"ref69\/cit69","doi-asserted-by":"publisher","DOI":"10.1021\/ic00200a030"},{"key":"ref70\/cit70","unstructured":"Lohaus, G.; Dittmar, W. U.S. Patent US05499988, 1978; Ger. Offen. 1973, 17."},{"key":"ref71\/cit71","doi-asserted-by":"publisher","DOI":"10.1016\/S0040-4020(01)92954-0"},{"key":"ref72\/cit72","doi-asserted-by":"publisher","DOI":"10.1021\/jm00168a033"},{"key":"ref73\/cit73","doi-asserted-by":"publisher","DOI":"10.1021\/jm00014a013"},{"key":"ref74\/cit74","doi-asserted-by":"publisher","DOI":"10.1021\/ja00485a019"},{"key":"ref75\/cit75","doi-asserted-by":"publisher","DOI":"10.1021\/ja00309a020"},{"key":"ref76\/cit76","doi-asserted-by":"publisher","DOI":"10.1021\/ic700364t"},{"key":"ref77\/cit77","doi-asserted-by":"publisher","DOI":"10.1021\/ic901161z"},{"key":"ref78\/cit78","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinorgbio.2016.01.006"},{"key":"ref79\/cit79","doi-asserted-by":"publisher","DOI":"10.1021\/ic980993q"},{"key":"ref80\/cit80","doi-asserted-by":"publisher","DOI":"10.1002\/chem.201002372"},{"key":"ref81\/cit81","doi-asserted-by":"publisher","DOI":"10.1002\/ejic.200601088"},{"key":"ref82\/cit82","doi-asserted-by":"publisher","DOI":"10.1039\/C4CC10339D"},{"key":"ref83\/cit83","doi-asserted-by":"publisher","DOI":"10.1021\/ar800250h"},{"key":"ref84\/cit84","doi-asserted-by":"publisher","DOI":"10.1021\/ic801730u"},{"key":"ref85\/cit85","doi-asserted-by":"publisher","DOI":"10.1039\/b004880l"},{"key":"ref86\/cit86","doi-asserted-by":"publisher","DOI":"10.1021\/ic0614869"},{"key":"ref87\/cit87","doi-asserted-by":"publisher","DOI":"10.1021\/ic025610+"},{"key":"ref88\/cit88","doi-asserted-by":"publisher","DOI":"10.1021\/ja068026z"},{"key":"ref89\/cit89","doi-asserted-by":"publisher","DOI":"10.1021\/ja970718n"},{"key":"ref90\/cit90","doi-asserted-by":"publisher","DOI":"10.1021\/ic902595c"},{"key":"ref91\/cit91","doi-asserted-by":"publisher","DOI":"10.1016\/S0040-4020(98)01091-6"},{"key":"ref92\/cit92","doi-asserted-by":"publisher","DOI":"10.1002\/jhet.2372"},{"key":"ref93\/cit93","doi-asserted-by":"publisher","DOI":"10.1080\/00958970512331328644"},{"key":"ref94\/cit94","doi-asserted-by":"publisher","DOI":"10.1016\/j.tetlet.2004.12.115"},{"key":"ref95\/cit95","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2011.08.097"},{"key":"ref96\/cit96","doi-asserted-by":"publisher","DOI":"10.1111\/cbdd.12358"},{"key":"ref97\/cit97","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinorgbio.2008.10.014"},{"key":"ref98\/cit98","doi-asserted-by":"publisher","DOI":"10.1039\/C2DT32361C"},{"key":"ref99\/cit99","doi-asserted-by":"publisher","DOI":"10.1002\/chem.201001335"},{"key":"ref100\/cit100","doi-asserted-by":"publisher","DOI":"10.1021\/acs.inorgchem.5b00748"},{"key":"ref101\/cit101","doi-asserted-by":"publisher","DOI":"10.1021\/jm500389b"},{"key":"ref102\/cit102","doi-asserted-by":"publisher","DOI":"10.1021\/ja5116524"},{"key":"ref103\/cit103","doi-asserted-by":"publisher","DOI":"10.1021\/ja00082a003"},{"key":"ref104\/cit104","doi-asserted-by":"publisher","DOI":"10.1039\/C7CC03572A"},{"key":"ref105\/cit105","doi-asserted-by":"publisher","DOI":"10.1039\/C7DT02196H"},{"key":"ref106\/cit106","doi-asserted-by":"publisher","DOI":"10.1002\/1521-3765(20010105)7:1<272::AID-CHEM272>3.0.CO;2-Y"},{"key":"ref107\/cit107","doi-asserted-by":"publisher","DOI":"10.1021\/jm0600949"},{"key":"ref108\/cit108","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2005.08.008"},{"key":"ref109\/cit109","first-page":"177","volume-title":"Iron Chelators: New Development Strategies","author":"O\u2019Sullivan B.","year":"2000"},{"key":"ref110\/cit110","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhazmat.2010.12.084"},{"key":"ref111\/cit111","doi-asserted-by":"publisher","DOI":"10.1163\/156856292X00367"},{"key":"ref112\/cit112","doi-asserted-by":"publisher","DOI":"10.1002\/app.1994.070520103"},{"key":"ref113\/cit113","doi-asserted-by":"publisher","DOI":"10.1016\/0014-3057(94)90028-0"},{"key":"ref114\/cit114","doi-asserted-by":"publisher","DOI":"10.1016\/j.polymer.2016.01.073"},{"key":"ref115\/cit115","doi-asserted-by":"publisher","DOI":"10.1016\/j.jelechem.2008.10.023"},{"key":"ref116\/cit116","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2007.06651.x"},{"key":"ref117\/cit117","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.86.24.10108"},{"key":"ref118\/cit118","doi-asserted-by":"publisher","DOI":"10.1021\/bm701122u"},{"key":"ref119\/cit119","doi-asserted-by":"publisher","DOI":"10.1039\/C5MD00264H"},{"key":"ref120\/cit120","doi-asserted-by":"publisher","DOI":"10.1021\/cr400546e"},{"key":"ref121\/cit121","doi-asserted-by":"publisher","DOI":"10.1021\/cr078203u"},{"key":"ref122\/cit122","doi-asserted-by":"publisher","DOI":"10.1016\/S0040-4039(97)01753-X"},{"key":"ref123\/cit123","doi-asserted-by":"publisher","DOI":"10.1021\/jm049751s"},{"key":"ref124\/cit124","doi-asserted-by":"publisher","DOI":"10.1021\/jm8001247"},{"key":"ref125\/cit125","doi-asserted-by":"publisher","DOI":"10.1042\/BJ20150149"},{"key":"ref126\/cit126","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2015.06.059"},{"key":"ref127\/cit127","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2005.05.010"},{"key":"ref128\/cit128","doi-asserted-by":"publisher","DOI":"10.1016\/j.snb.2015.02.072"},{"key":"ref129\/cit129","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmc.2009.09.052"},{"key":"ref130\/cit130","doi-asserted-by":"publisher","DOI":"10.1007\/s00775-010-0650-1"},{"key":"ref131\/cit131","doi-asserted-by":"publisher","DOI":"10.1042\/BJ20141083"},{"key":"ref132\/cit132","doi-asserted-by":"publisher","DOI":"10.1039\/c2dt31254a"},{"key":"ref133\/cit133","doi-asserted-by":"publisher","DOI":"10.1016\/S0898-8838(09)00204-9"},{"key":"ref134\/cit134","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4757-5506-0"},{"key":"ref135\/cit135","doi-asserted-by":"publisher","DOI":"10.1016\/0020-1693(94)03984-4"},{"key":"ref136\/cit136","doi-asserted-by":"publisher","DOI":"10.1016\/S0020-1693(00)86122-8"},{"key":"ref137\/cit137","doi-asserted-by":"publisher","DOI":"10.1016\/S0020-1693(00)87531-3"},{"key":"ref138\/cit138","doi-asserted-by":"publisher","DOI":"10.1351\/pac196306010097"},{"key":"ref139\/cit139","doi-asserted-by":"crossref","DOI":"10.1007\/978-1-4899-1486-6","volume-title":"Metal complexes in aqueous solutions","author":"Martell A. E.","year":"1996"},{"key":"ref140\/cit140","doi-asserted-by":"publisher","DOI":"10.1021\/ja00984a014"},{"key":"ref141\/cit141","doi-asserted-by":"publisher","DOI":"10.2174\/092986712800609724"},{"key":"ref142\/cit142","doi-asserted-by":"publisher","DOI":"10.1111\/jphp.12373"},{"key":"ref143\/cit143","doi-asserted-by":"publisher","DOI":"10.1111\/jphp.12013"},{"key":"ref144\/cit144","doi-asserted-by":"publisher","DOI":"10.1021\/ic00329a021"},{"key":"ref145\/cit145","doi-asserted-by":"publisher","DOI":"10.1016\/S0162-0134(02)00483-X"},{"key":"ref146\/cit146","doi-asserted-by":"publisher","DOI":"10.1039\/c1cc12123e"},{"key":"ref147\/cit147","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinorgbio.2005.06.022"},{"key":"ref148\/cit148","doi-asserted-by":"publisher","DOI":"10.1039\/b416256k"},{"key":"ref149\/cit149","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/S0090-9556(25)07251-4","volume":"24","author":"Yokel R. A.","year":"1996","journal-title":"Drug Metab. Dispos."},{"key":"ref150\/cit150","doi-asserted-by":"publisher","DOI":"10.1038\/nrc882"},{"key":"ref151\/cit151","doi-asserted-by":"publisher","DOI":"10.7150\/thno.14261"},{"key":"ref152\/cit152","doi-asserted-by":"publisher","DOI":"10.1039\/C4DT02978J"},{"key":"ref153\/cit153","doi-asserted-by":"publisher","DOI":"10.3390\/molecules23030638"},{"key":"ref154\/cit154","doi-asserted-by":"publisher","DOI":"10.1021\/cr900325h"},{"key":"ref155\/cit155","doi-asserted-by":"publisher","DOI":"10.1021\/cr980440x"},{"key":"ref156\/cit156","doi-asserted-by":"publisher","DOI":"10.1351\/pac199365030515"},{"key":"ref157\/cit157","doi-asserted-by":"publisher","DOI":"10.1021\/ja00132a025"},{"key":"ref158\/cit158","doi-asserted-by":"publisher","DOI":"10.1016\/S0010-8545(99)90232-1"},{"key":"ref159\/cit159","doi-asserted-by":"publisher","DOI":"10.1039\/c2dt32237d"},{"key":"ref160\/cit160","doi-asserted-by":"publisher","DOI":"10.1021\/cr990114x"},{"key":"ref161\/cit161","doi-asserted-by":"publisher","DOI":"10.1080\/095530000138853"},{"key":"ref162\/cit162","doi-asserted-by":"publisher","DOI":"10.1093\/rpd\/53.1-4.319"},{"key":"ref163\/cit163","doi-asserted-by":"publisher","DOI":"10.1039\/c2cs35152h"},{"key":"ref164\/cit164","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2008.03.008"},{"key":"ref165\/cit165","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2011.09.010"},{"key":"ref166\/cit166","doi-asserted-by":"publisher","DOI":"10.1211\/0022357023196"},{"key":"ref167\/cit167","doi-asserted-by":"publisher","DOI":"10.1042\/BJ20051496"},{"key":"ref168\/cit168","doi-asserted-by":"publisher","DOI":"10.1038\/nature08300"},{"key":"ref169\/cit169","doi-asserted-by":"publisher","DOI":"10.1039\/C2AN36186H"},{"key":"ref170\/cit170","doi-asserted-by":"publisher","DOI":"10.1039\/C5AN00123D"},{"key":"ref171\/cit171","doi-asserted-by":"publisher","DOI":"10.1016\/S0169-409X(96)00423-1"},{"key":"ref172\/cit172","doi-asserted-by":"publisher","DOI":"10.4137\/117739010700200005"},{"key":"ref173\/cit173","doi-asserted-by":"publisher","DOI":"10.1039\/C4MT00214H"},{"key":"ref174\/cit174","doi-asserted-by":"publisher","DOI":"10.1039\/C5CC06170A"},{"key":"ref175\/cit175","doi-asserted-by":"publisher","DOI":"10.1002\/jps.21583"},{"key":"ref176\/cit176","doi-asserted-by":"publisher","DOI":"10.1039\/C2DT32149A"},{"key":"ref177\/cit177","doi-asserted-by":"publisher","DOI":"10.1042\/BJ20140795"},{"key":"ref178\/cit178","doi-asserted-by":"publisher","DOI":"10.1177\/1087057106287142"},{"key":"ref179\/cit179","doi-asserted-by":"publisher","DOI":"10.1128\/AEM.69.3.1492-1498.2003"},{"key":"ref180\/cit180","doi-asserted-by":"publisher","DOI":"10.1021\/ar800211j"},{"key":"ref181\/cit181","doi-asserted-by":"publisher","DOI":"10.1039\/C4DT02846E"},{"key":"ref182\/cit182","doi-asserted-by":"publisher","DOI":"10.1111\/j.1754-9485.2011.02327.x"},{"key":"ref183\/cit183","doi-asserted-by":"publisher","DOI":"10.1007\/s00259-013-2525-5"},{"key":"ref184\/cit184","doi-asserted-by":"publisher","DOI":"10.3390\/ijms18010116"},{"key":"ref185\/cit185","doi-asserted-by":"publisher","DOI":"10.1021\/acs.bioconjchem.5b00335"},{"key":"ref186\/cit186","doi-asserted-by":"publisher","DOI":"10.1186\/s13550-015-0131-1"},{"key":"ref187\/cit187","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.117.191882"},{"key":"ref188\/cit188","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.117.199554"},{"key":"ref189\/cit189","doi-asserted-by":"publisher","DOI":"10.1021\/bc200279b"},{"key":"ref190\/cit190","doi-asserted-by":"publisher","DOI":"10.1007\/s11307-018-1160-8"},{"key":"ref191\/cit191","doi-asserted-by":"publisher","DOI":"10.1007\/s00259-017-3924-9"},{"key":"ref192\/cit192","doi-asserted-by":"publisher","DOI":"10.1021\/acs.bioconjchem.5b00572"},{"key":"ref193\/cit193","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.112.109777"},{"key":"ref194\/cit194","doi-asserted-by":"publisher","DOI":"10.1002\/anie.200800212"},{"key":"ref195\/cit195","doi-asserted-by":"crossref","DOI":"10.1039\/9781782623892","volume-title":"Metal chelation in medicine","author":"Crichton R. R.","year":"2016"},{"key":"ref196\/cit196","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1182\/blood.V91.1.295","volume":"91","author":"Hoffbrand A. V.","year":"1998","journal-title":"Blood"},{"key":"ref197\/cit197","doi-asserted-by":"publisher","DOI":"10.1006\/bcmd.2002.0510"},{"key":"ref198\/cit198","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2002-10-3280"},{"key":"ref199\/cit199","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2009.019042"},{"key":"ref200\/cit200","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2014.00217"},{"key":"ref201\/cit201","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.14712"},{"key":"ref202\/cit202","doi-asserted-by":"publisher","DOI":"10.1021\/ic000239g"},{"key":"ref203\/cit203","doi-asserted-by":"publisher","DOI":"10.1016\/j.pneurobio.2010.04.003"},{"key":"ref204\/cit204","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(87)91361-4"},{"key":"ref205\/cit205","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.1989.tb07264.x"},{"key":"ref206\/cit206","first-page":"865","volume":"46","author":"Lynch S. G.","year":"2000","journal-title":"Cell Mol. Biol."},{"key":"ref207\/cit207","doi-asserted-by":"publisher","DOI":"10.2174\/138945012802002375"},{"key":"ref208\/cit208","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.10-6207"},{"key":"ref209\/cit209","doi-asserted-by":"publisher","DOI":"10.2174\/0929867324666170330092304"},{"key":"ref210\/cit210","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-2952(99)00031-3"},{"key":"ref211\/cit211","doi-asserted-by":"publisher","DOI":"10.1039\/c0mt00087f"},{"key":"ref212\/cit212","doi-asserted-by":"publisher","DOI":"10.1016\/0006-2952(94)00521-M"},{"key":"ref213\/cit213","doi-asserted-by":"publisher","DOI":"10.1007\/s00702-010-0531-3"},{"key":"ref214\/cit214","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2013.5593"},{"key":"ref215\/cit215","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-01402-2"},{"key":"ref216\/cit216","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2006-12-065433"},{"key":"ref217\/cit217","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2008-06-161919"},{"key":"ref218\/cit218","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2016.03.041"},{"key":"ref219\/cit219","doi-asserted-by":"publisher","DOI":"10.1039\/b705461k"},{"key":"ref220\/cit220","doi-asserted-by":"publisher","DOI":"10.1023\/A:1007612905378"},{"key":"ref221\/cit221","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1089\/clm.1996.14.289","volume":"14","author":"Kennedy J. C.","year":"1996","journal-title":"J. Clin. Laser Med. Surg."},{"key":"ref222\/cit222","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.1998.671"},{"key":"ref223\/cit223","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.7b00346"},{"key":"ref224\/cit224","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1013092107"},{"key":"ref225\/cit225","doi-asserted-by":"publisher","DOI":"10.1111\/j.2042-7158.2011.01291.x"},{"key":"ref226\/cit226","doi-asserted-by":"publisher","DOI":"10.1111\/j.1574-6968.2010.02153.x"},{"key":"ref227\/cit227","doi-asserted-by":"publisher","DOI":"10.1007\/s00044-012-0229-1"},{"key":"ref228\/cit228","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2015.02.050"},{"key":"ref229\/cit229","doi-asserted-by":"publisher","DOI":"10.1111\/1574-6968.12465"},{"key":"ref230\/cit230","doi-asserted-by":"publisher","DOI":"10.1097\/00004032-200005000-00008"}],"container-title":["Chemical Reviews"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acs.chemrev.8b00254","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,7,5]],"date-time":"2025-07-05T19:32:11Z","timestamp":1751743931000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/acs.chemrev.8b00254"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,7,23]]},"references-count":230,"journal-issue":{"issue":"16","published-print":{"date-parts":[[2018,8,22]]}},"alternative-id":["10.1021\/acs.chemrev.8b00254"],"URL":"https:\/\/doi.org\/10.1021\/acs.chemrev.8b00254","relation":{},"ISSN":["0009-2665","1520-6890"],"issn-type":[{"value":"0009-2665","type":"print"},{"value":"1520-6890","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,7,23]]}}}