{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T10:57:41Z","timestamp":1790506661763,"version":"4.1.0"},"reference-count":64,"publisher":"American Chemical Society (ACS)","issue":"12","license":[{"start":{"date-parts":[[2020,5,14]],"date-time":"2020-05-14T00:00:00Z","timestamp":1589414400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2020,5,14]],"date-time":"2020-05-14T00:00:00Z","timestamp":1589414400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2020,5,14]],"date-time":"2020-05-14T00:00:00Z","timestamp":1589414400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/501100002855","name":"Ministry of Science and Technology of the People's Republic of China","doi-asserted-by":"publisher","award":["2018YFD0900803"],"award-info":[{"award-number":["2018YFD0900803"]}],"id":[{"id":"10.13039\/501100002855","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["21806040"],"award-info":[{"award-number":["21806040"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,6,16]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Mercury (Hg) in fish poses a great threat to human health. Consumption of low-Hg-level fish species (e.g., rabbitfish, Siganus canaliculatus) could be one possible solution to balance the nutrient benefits and Hg exposure. However, the underlying mechanisms for the low Hg accumulation in rabbitfish remain unclear. This study quantitatively described the disposition of inorganic Hg\u00ad(II) and methylmercury (MeHg) in rabbitfish under different exposure routes by constructing a physiologically based pharmacokinetic (PBPK) model. The results strongly suggested that effective elimination (estimated rate constant of 0.060, 0.065, and 0.020 d\u20131 for waterborne Hg\u00ad(II)-, dietary Hg\u00ad(II)-, and MeHg-exposed fish, respectively) was the main reason for the low Hg accumulation in rabbitfish. By quantifying the possible pathways for Hg elimination, our study revealed that biliary coupled with fecal excretion played an important role in the elimination of dietary Hg. Although the biliary excretion rate for MeHg was remarkable (6.8 \u00b1 2.2 d\u20131) and the excreted amount per day could reach up to 790 ng, most of the MeHg in the bile was reabsorbed by the intestine and transferred back to the liver through enterohepatic circulation, leading to a prolonged retention time in the fish body. Moreover, branchial excretion dominated the Hg\u00ad(II) elimination following aqueous exposure, suggesting a flexible alteration on elimination pathways against different exposure scenarios. The present study provided important understanding of the unique strategies adopted by rabbitfish to maintain the low Hg levels.<\/jats:p>","DOI":"10.1021\/acs.est.0c00772","type":"journal-article","created":{"date-parts":[[2020,5,14]],"date-time":"2020-05-14T22:02:47Z","timestamp":1589493767000},"page":"7440-7449","source":"Crossref","is-referenced-by-count":10,"title":["Determination\nof the Low Hg Accumulation in Rabbitfish\n(\n                    <i>Siganus canaliculatus<\/i>\n                    ) by Various Elimination Pathways:\nSimulation by a Physiologically Based Pharmacokinetic Model"],"prefix":"10.1021","volume":"54","author":[{"given":"Xun","family":"Wang","sequence":"first","affiliation":[{"name":"South China Agricultural University , , ,","place":["Guangzhou, P. R. China, 510642"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9033-0158","authenticated-orcid":true,"given":"Wen-Xiong","family":"Wang","sequence":"additional","affiliation":[{"name":"City University of Hong Kong , , ,","place":["Kowloon, Hong Kong"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2020,5,14]]},"reference":[{"key":"2026081717190014200_cit1","doi-asserted-by":"publisher","first-page":"693","DOI":"10.1080\/10643389.2017.1326277","article-title":"Cycling of mercury\nin the environment: Sources, fate,\nand human health implications: A review","volume":"47","author":"Beckers","year":"2017","journal-title":"Crit.\nRev. Environ. Sci. 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Chem."},{"issue":"11","key":"2026081717190014200_cit33","doi-asserted-by":"publisher","first-page":"3972","DOI":"10.1021\/es0483490","article-title":"Comparative\neffects of dietary methylmercury on gene expression in liver, skeletal\nmuscle, and brain of the zebrafish (Danio rerio)","volume":"39","author":"Gonzalez","year":"2005","journal-title":"Environ. Sci. Technol."},{"issue":"2","key":"2026081717190014200_cit34","doi-asserted-by":"publisher","first-page":"162","DOI":"10.1016\/S0147-6513(02)00123-9","article-title":"Antioxidant\nresponses and bioaccumulation in Ictalurus melas under\nmercury exposure","volume":"55","author":"Elia","year":"2003","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"2026081717190014200_cit35","doi-asserted-by":"publisher","first-page":"134547","DOI":"10.1016\/j.scitotenv.2019.134547","article-title":"Metalloproteomic\napproach of mercury-binding proteins in liver and kidney tissues of Plagioscion squamosissimus (corvina) and Colossoma\nmacropomum (tambaqui) from Amazon region: Possible identification\nof mercury contamination biomarkers","volume":"711","author":"Bittarello","year":"2020","journal-title":"Sci. Total\nEnviron."},{"issue":"10","key":"2026081717190014200_cit36","doi-asserted-by":"publisher","first-page":"2682","DOI":"10.1002\/etc.4233","article-title":"Percentage of methylmercury\nin the muscle tissue of freshwater fish varies with body size and\nage and among species","volume":"37","author":"Lescord","year":"2018","journal-title":"Environ. Toxicol. 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Environ. Contam. Toxicol."},{"issue":"2","key":"2026081717190014200_cit50","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1016\/0269-7491(87)90043-1","article-title":"Histopathological\nand biochemical changes in the liver\nof a teleost fish, Channa punctatus (Bloch) induced\nby a mercurial fungicide","volume":"47","author":"Ram","year":"1987","journal-title":"Environ. 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