{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T03:40:49Z","timestamp":1791862849806,"version":"4.3.4"},"reference-count":49,"publisher":"American Chemical Society (ACS)","issue":"22","license":[{"start":{"date-parts":[[2020,11,4]],"date-time":"2020-11-04T00:00:00Z","timestamp":1604448000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2020,11,4]],"date-time":"2020-11-04T00:00:00Z","timestamp":1604448000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2020,11,4]],"date-time":"2020-11-04T00:00:00Z","timestamp":1604448000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81530086"],"award-info":[{"award-number":["81530086"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81673179"],"award-info":[{"award-number":["81673179"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["91643205"],"award-info":[{"award-number":["91643205"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["91843302"],"award-info":[{"award-number":["91843302"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Shenkang Hospital Development Center","award":["SHDC12016239"],"award-info":[{"award-number":["SHDC12016239"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,11,17]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Exposure to fine particulate matter (PM2.5) during pregnancy has been associated with preterm birth (PTB). However, the existing evidence is inconsistent, and the roles of specific PM2.5 chemical constituents remain unclear. Based on the China Labor and Delivery Survey, we included birth data from 89 hospitals in 25 provinces in mainland China, and conducted a national multicenter cohort study to examine the associations of PM2.5 and its chemical constituents with PTB risk in China. We applied satellite-based models to predict prenatal PM2.5 mass and six main component exposure. Multilevel logistic regression analysis was used to examine the associations, controlling for sociodemographic characteristics, seasonality, and spatial variation. We observe an increased PTB risk with an increase in PM2.5 mass and the most significant association is found during the third trimester when the adjusted odds ratio (OR) per interquartile range increases in PM2.5 total mass is 1.12 (95% confidence Interval, CI: 1.05\u20131.20). Infants conceived by assisted reproductive technology (ART) show greater PTB risk associated with PM2.5 exposure (OR = 1.33, 95% CI: 1.05\u20131.69) than those conceived naturally (OR = 1.11, 95% CI: 1.03\u20131.19). We also find black carbon, sulfate, ammonium and nitrate, often linked to fossil combustion, have comparable or larger estimates of the effect (OR = 1.07\u20131.14) than PM2.5. Our findings provide evidence that components mainly from fossil fuel combustion may have a perceptible influence on increased PTB risk associated with PM2.5 exposure in China. Additionally, compared to natural conception, conception through ART may be more susceptible to PM2.5 exposure.<\/jats:p>","DOI":"10.1021\/acs.est.0c02373","type":"journal-article","created":{"date-parts":[[2020,11,4]],"date-time":"2020-11-04T10:38:31Z","timestamp":1604486311000},"page":"14494-14501","source":"Crossref","is-referenced-by-count":82,"title":["Prenatal Exposure to Specific PM2.5 Chemical Constituents and Preterm Birth in China: A Nationwide Cohort Study"],"prefix":"10.1021","volume":"54","author":[{"given":"Jing","family":"Cai","sequence":"first","affiliation":[{"name":"Fudan University , , ,","place":["Shanghai, China, 200032"]},{"name":"Shanghai Typhoon Institute\/CMA , , ,","place":["Shanghai, China, 200030"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Zhao","sequence":"additional","affiliation":[{"name":"Tongji University School of Medicine , , ,","place":["Shanghai, China, 201204"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia","family":"Kan","sequence":"additional","affiliation":[{"name":"University of Bristol Medical School , ,","place":["Bristol, U.K., BS8 1TH"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renjie","family":"Chen","sequence":"additional","affiliation":[{"name":"Fudan University , , ,","place":["Shanghai, China, 200032"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Randall","family":"Martin","sequence":"additional","affiliation":[{"name":"Dalhousie University , , 6300 Coburg Road , , ,","place":["Halifax, Nova Scotia, Canada, B3H 3J5"]},{"name":"Harvard-Smithsonian Center for Astrophysics , , ,","place":["Cambridge, Massachusetts, United States, 02138"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aaron","family":"van Donkelaar","sequence":"additional","affiliation":[{"name":"Dalhousie University , , 6300 Coburg Road , , ,","place":["Halifax, Nova Scotia, Canada, B3H 3J5"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junjie","family":"Ao","sequence":"additional","affiliation":[{"name":"Shanghai Jiao Tong University School of Medicine , , ,","place":["Shanghai, China, 200096"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1706-1611","authenticated-orcid":true,"given":"Jun","family":"Zhang","sequence":"additional","affiliation":[{"name":"Shanghai Jiao Tong University School of Medicine , , ,","place":["Shanghai, China, 200096"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1871-8999","authenticated-orcid":true,"given":"Haidong","family":"Kan","sequence":"additional","affiliation":[{"name":"Fudan University , , ,","place":["Shanghai, China, 200032"]},{"name":"Children\u2019s Hospital of Fudan University , , ,","place":["Shanghai, China, 201102"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Hua","sequence":"additional","affiliation":[{"name":"Tongji University School of Medicine , , ,","place":["Shanghai, China, 201204"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2020,11,4]]},"reference":[{"key":"2026081717214380500_cit1","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1016\/s0140-6736(08)60136-1","article-title":"An overview of mortality and sequelae of preterm birth from infancy to adulthood","volume":"371","author":"Saigal","year":"2008","journal-title":"Lancet"},{"key":"2026081717214380500_cit2","unstructured":"March of Dimes\n          . Save the Children Born Too Soon: The Global Action Report on Preterm Birth; WHO, 2012."},{"key":"2026081717214380500_cit3","doi-asserted-by":"publisher","first-page":"S1","DOI":"10.1186\/1742-4755-10-s1-s1","article-title":"Born Too Soon Preterm Birth Action","volume":"10","author":"Howson","year":"2013","journal-title":"Reprod. 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