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The tceA gene encoding the trichloroethene-dechlorinating RDase TceA is frequently detected in contaminated groundwater but not recognized as a biomarker for VC detoxification. We demonstrate that tceA-carrying Dehalococcoides mccartyi (Dhc) strains FL2 and 195 grow with VC as an electron acceptor when sufficient vitamin B12 (B12) is provided. Strain FL2 cultures that received 50 \u03bcg L\u20131 B12 completely dechlorinated VC to ethene at rates of 14.80 \u00b1 1.30 \u03bcM day\u20131 and attained 1.64 \u00b1 0.11 \u00d7 108 cells per \u03bcmol of VC consumed. Strain 195 attained similar growth yields of 1.80 \u00b1 1.00 \u00d7 108 cells per \u03bcmol of VC consumed, and both strains could be consecutively transferred with VC as the electron acceptor. Proteomic analysis demonstrated TceA expression in VC-grown strain FL2 cultures. Resequencing of the strain FL2 and strain 195 tceA genes identified non-synonymous substitutions, although their consequences for TceA function are currently unknown. The finding that Dhc strains expressing TceA respire VC can explain ethene formation at chlorinated solvent sites, where quantitative polymerase chain reaction analysis indicates that tceA dominates the RDase gene pool.<\/jats:p>","DOI":"10.1021\/acs.est.0c07354","type":"journal-article","created":{"date-parts":[[2021,3,8]],"date-time":"2021-03-08T14:53:15Z","timestamp":1615215195000},"page":"4831-4841","source":"Crossref","is-referenced-by-count":68,"title":["Respiratory\nVinyl Chloride Reductive Dechlorination\nto Ethene in TceA-Expressing\n                    <i>Dehalococcoides mccartyi<\/i>"],"prefix":"10.1021","volume":"55","author":[{"given":"Jun","family":"Yan","sequence":"first","affiliation":[{"name":"Chinese Academy of Sciences , , , ,","place":["Shenyang, Liaoning, China, 110016"]},{"name":"University of Tennessee , , , ,","place":["Knoxville, Tennessee, United States, 37996"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingjing","family":"Wang","sequence":"additional","affiliation":[{"name":"Chinese Academy of Sciences , , , ,","place":["Shenyang, Liaoning, China, 110016"]},{"name":"University of Chinese Academy of Sciences , ,","place":["Beijing, China, 100049"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuel I.","family":"Villalobos Solis","sequence":"additional","affiliation":[{"name":"Oak Ridge National Laboratory , , , ,","place":["Oak Ridge, Tennessee, United States, 37831"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huijuan","family":"Jin","sequence":"additional","affiliation":[{"name":"Chinese Academy of Sciences , , , ,","place":["Shenyang, Liaoning, China, 110016"]},{"name":"University of Chinese Academy of Sciences , ,","place":["Beijing, China, 100049"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karuna","family":"Chourey","sequence":"additional","affiliation":[{"name":"Oak Ridge National Laboratory , , , ,","place":["Oak Ridge, Tennessee, United States, 37831"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiuying","family":"Li","sequence":"additional","affiliation":[{"name":"Chinese Academy of Sciences , , , ,","place":["Shenyang, Liaoning, China, 110016"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3519-5472","authenticated-orcid":true,"given":"Yi","family":"Yang","sequence":"additional","affiliation":[{"name":"Chinese Academy of Sciences , , , ,","place":["Shenyang, Liaoning, China, 110016"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongchao","family":"Yin","sequence":"additional","affiliation":[{"name":"University of Tennessee , , , ,","place":["Knoxville, Tennessee, United States, 37996"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7708-786X","authenticated-orcid":true,"given":"Robert L.","family":"Hettich","sequence":"additional","affiliation":[{"name":"Oak Ridge National Laboratory , , , ,","place":["Oak Ridge, Tennessee, United States, 37831"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9797-4279","authenticated-orcid":true,"given":"Frank E.","family":"Lo\u0308ffler","sequence":"additional","affiliation":[{"name":"University of Tennessee , , , ,","place":["Knoxville, Tennessee, United States, 37996"]},{"name":"Oak Ridge National Laboratory , , , ,","place":["Oak Ridge, Tennessee, United States, 37831"]},{"name":"University of Tennessee , , , ,","place":["Knoxville, Tennessee, United States, 37996"]},{"name":"Oak Ridge National Laboratory , , , ,","place":["Oak Ridge, Tennessee, United States, 37831"]},{"name":"University of Tennessee , , , ,","place":["Knoxville, Tennessee, United States, 37996"]},{"name":"University of Tennessee , , , ,","place":["Knoxville, Tennessee, United States, 37996"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2021,3,8]]},"reference":[{"key":"2026081711134107000_cit1","doi-asserted-by":"publisher","first-page":"20120316","DOI":"10.1098\/rstb.2012.0316","article-title":"Organohalide\nrespiration: microbes\nbreathing chlorinated molecules","volume":"368","author":"Leys","year":"2013","journal-title":"Philos. 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Biochem."},{"key":"2026081711134107000_cit5","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1038\/nchembio.2512","article-title":"Purinyl-cobamide\nis a native prosthetic group of reductive dehalogenases","volume":"14","author":"Yan","year":"2018","journal-title":"Nat. Chem. Biol."},{"key":"2026081711134107000_cit6","doi-asserted-by":"publisher","first-page":"6630","DOI":"10.1128\/aem.01535-12","article-title":"Unexpected\nspecificity of interspecies cobamide transfer from Geobacter spp. to organohalide-respiring Dehalococcoides mccartyi strains","volume":"78","author":"Yan","year":"2012","journal-title":"Appl. Environ. Microbiol."},{"key":"2026081711134107000_cit7","doi-asserted-by":"publisher","first-page":"20120320","DOI":"10.1098\/rstb.2012.0320","article-title":"Guided\ncobalamin biosynthesis supports Dehalococcoides mccartyi reductive dechlorination activity","volume":"368","author":"Yan","year":"2013","journal-title":"Philos.\nTrans. R. 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Announce."},{"key":"2026081711134107000_cit22","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1128\/aem.02017-15","article-title":"Dehalogenimonas sp.\nstrain WBC-2 genome and identification of its trans-dichloroethene reductive dehalogenase, TdrA","volume":"82","author":"Molenda","year":"2016","journal-title":"Appl. Environ. Microbiol."},{"key":"2026081711134107000_cit23","doi-asserted-by":"publisher","first-page":"3108","DOI":"10.1128\/AEM.65.7.3108-3113.1999","article-title":"Reductive\ndechlorination of chlorinated\nethenes and 1, 2-dichloroethane by \u2033Dehalococcoides\nethenogenes\u2033 195","volume":"65","author":"Maymo\u0301-Gatell","year":"1999","journal-title":"Appl. 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Sci.\nTechnol."},{"key":"2026081711134107000_cit26","doi-asserted-by":"publisher","first-page":"1422","DOI":"10.1021\/es025985u","article-title":"Bioreactive\nbarriers: A comparison of bioaugmentation and biostimulation for chlorinated\nsolvent remediation","volume":"37","author":"Lendvay","year":"2003","journal-title":"Environ. Sci. 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Environ.\nMicrobiol."},{"key":"2026081711134107000_cit44","doi-asserted-by":"publisher","first-page":"843","DOI":"10.1128\/aem.01482-09","article-title":"Correlation of Dehalococcoides 16S rRNA and chloroethene-reductive dehalogenase\ngenes with geochemical conditions in chloroethene-contaminated groundwater","volume":"76","author":"van\nder Zaan","year":"2010","journal-title":"Appl. Environ. Microbiol."},{"key":"2026081711134107000_cit45","doi-asserted-by":"publisher","first-page":"4346","DOI":"10.1039\/c1cs15118e","article-title":"Vitamin B12-derivatives-enzyme\ncofactors and ligands of proteins and nucleic acids","volume":"40","author":"Gruber","year":"2011","journal-title":"Chem. Soc. 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