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Whether its early exposure and discontinued exposure alter thyroid function remains unknown. We investigate adverse effects after early-life exposure and discontinued exposure to BB-80 and hydroxylated BB-80 (OH-BB-80) on thyroid hormone (TH) levels, thyroid tissue, and transcriptome profiles in zebrafish larvae. BB-80 at 10 \u03bcg\/L induces pathological changes of thyroid with reduced thyroid follicles in larvae (P &amp;lt; 0.05), whereas OH-BB-80 significantly increases T4 and T3 contents (1.8 and 2.5 times of the control, P &amp;lt; 0.05) at 14 days postfertilization (dpf) without morphological thyroid alterations. BB-80 and OH-BB-80 cause transcriptome aberrations with key differentially expressed genes involved in the disruption of TH synthesis and signal transduction (BB-80 at 14 dpf) or TH pathway activation (OH-BB-80 at 21 dpf). After 7 days of discontinued exposure, thyroglobulin (tg) and thyroid peroxidase (tpo) genes are downregulated (P &amp;lt; 0.05) by 52 and 48% for BB-80 and by 49 and 39% for OH-BB-80, respectively; however, the whole-body TH levels fail to fully recover, and the locomotor activity is impaired more by BB-80. Our results indicate significant adverse impacts of BB-80 and OH-BB-80 on TH homeostasis and thyroid function of zebrafish.<\/jats:p>","DOI":"10.1021\/acs.est.1c07767","type":"journal-article","created":{"date-parts":[[2022,1,25]],"date-time":"2022-01-25T08:24:51Z","timestamp":1643099091000},"page":"2519-2528","source":"Crossref","is-referenced-by-count":26,"title":["Thyroid\nDysfunction of Zebrafish (\n                    <i>Danio rerio<\/i>\n                    ) after Early-Life\nExposure and Discontinued Exposure to Tetrabromobiphenyl\n(BB-80) and OH-BB-80"],"prefix":"10.1021","volume":"56","author":[{"given":"Xiaofang","family":"Zhang","sequence":"first","affiliation":[{"name":"Zhejiang University , , ,","place":["Hangzhou, China, 310058"]},{"name":"Hangzhou Normal University , , ,","place":["Hangzhou, China, 310018"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yumiao","family":"Sun","sequence":"additional","affiliation":[{"name":"Chinese Academy of Sciences , , ,","place":["Wuhan, China, 430072"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuchen","family":"Gao","sequence":"additional","affiliation":[{"name":"Zhejiang University , , ,","place":["Hangzhou, China, 310058"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiquan","family":"Liu","sequence":"additional","affiliation":[{"name":"Hangzhou Normal University , , ,","place":["Hangzhou, China, 310018"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiafeng","family":"Ding","sequence":"additional","affiliation":[{"name":"Hangzhou Normal University , , ,","place":["Hangzhou, China, 310018"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunlong","family":"Zhang","sequence":"additional","affiliation":[{"name":"University of Houston , , , ,","place":["Clear Lake, Texas, United\nStates, 77058"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1173-892X","authenticated-orcid":true,"given":"Weiping","family":"Liu","sequence":"additional","affiliation":[{"name":"Zhejiang University , , ,","place":["Hangzhou, China, 310058"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3281-6093","authenticated-orcid":true,"given":"Hangjun","family":"Zhang","sequence":"additional","affiliation":[{"name":"Hangzhou Normal University , , ,","place":["Hangzhou, China, 310018"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7774-7239","authenticated-orcid":true,"given":"Shulin","family":"Zhuang","sequence":"additional","affiliation":[{"name":"Zhejiang University , , ,","place":["Hangzhou, China, 310006"]},{"name":"Zhejiang University , , ,","place":["Hangzhou, China, 310058"]},{"name":"Zhejiang University , , ,","place":["Hangzhou, China, 310058"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2022,1,25]]},"reference":[{"key":"2026081414105983800_cit1","doi-asserted-by":"publisher","first-page":"1953","DOI":"10.1289\/ehp.0901015","article-title":"Prenatal\nexposure to organohalogens,\nincluding brominated flame retardants, influences motor, cognitive,\nand behavioral performance at school age","volume":"117","author":"Roze","year":"2009","journal-title":"Environ.\nHealth Perspect."},{"key":"2026081414105983800_cit2","doi-asserted-by":"publisher","first-page":"410","DOI":"10.1038\/sj.jes.7500633","article-title":"A decay model for assessing\npolybrominated biphenyl exposure among women in the Michigan Long-Term\nPBB Study","volume":"18","author":"Terrell","year":"2008","journal-title":"J. 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