{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T14:19:03Z","timestamp":1791987543979,"version":"4.4.0"},"reference-count":93,"publisher":"American Chemical Society (ACS)","issue":"15","license":[{"start":{"date-parts":[[2023,4,6]],"date-time":"2023-04-06T00:00:00Z","timestamp":1680739200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,4,6]],"date-time":"2023-04-06T00:00:00Z","timestamp":1680739200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,4,6]],"date-time":"2023-04-06T00:00:00Z","timestamp":1680739200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/501100002338","name":"Ministry of Education of the People's Republic of China","doi-asserted-by":"publisher","award":["T2014089"],"award-info":[{"award-number":["T2014089"]}],"id":[{"id":"10.13039\/501100002338","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002855","name":"Ministry of Science and Technology of the People's Republic of China","doi-asserted-by":"publisher","award":["2013AA065204"],"award-info":[{"award-number":["2013AA065204"]}],"id":[{"id":"10.13039\/501100002855","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81273035"],"award-info":[{"award-number":["81273035"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81325017"],"award-info":[{"award-number":["81325017"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81930094"],"award-info":[{"award-number":["81930094"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Environ. Sci. Technol."],"published-print":{"date-parts":[[2023,4,18]]},"DOI":"10.1021\/acs.est.2c08627","type":"journal-article","created":{"date-parts":[[2023,4,6]],"date-time":"2023-04-06T12:16:53Z","timestamp":1680783413000},"page":"6072-6084","source":"Crossref","is-referenced-by-count":28,"title":["Thyroid-Disrupting Effects of Exposure to Fipronil and Its Metabolites from Drinking Water Based on Human Thyroid Follicular Epithelial Nthy-ori 3-1 Cell Lines"],"prefix":"10.1021","volume":"57","author":[{"given":"Jianhui","family":"Zhuang","sequence":"first","affiliation":[{"name":"Key Laboratory of the Public Health Safety, Ministry of Education, Department of Environmental Health, School of Public Health, Fudan University, Shanghai 200032, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6198-2445","authenticated-orcid":true,"given":"Zhiqiang","family":"Jiang","sequence":"additional","affiliation":[{"name":"Key Laboratory of the Public Health Safety, Ministry of Education, Department of Environmental Health, School of Public Health, Fudan University, Shanghai 200032, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4015-2557","authenticated-orcid":true,"given":"Dawei","family":"Chen","sequence":"additional","affiliation":[{"name":"China National Center for Food Safety Risk Assessment, Beijing 100022, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0525-7027","authenticated-orcid":true,"given":"Jingguang","family":"Li","sequence":"additional","affiliation":[{"name":"China National Center for Food Safety Risk Assessment, Beijing 100022, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. James C.","family":"Crabbe","sequence":"additional","affiliation":[{"name":"Wolfson College, Oxford University, Oxford OX2 6UD, U.K."},{"name":"Institute of Biomedical and Environmental Science & Technology, University of Bedfordshire, Luton LU1 3JU, U.K."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8774-1175","authenticated-orcid":true,"given":"Meiyue","family":"Qiu","sequence":"additional","affiliation":[{"name":"Key Laboratory of the Public Health Safety, Ministry of Education, Department of Environmental Health, School of Public Health, Fudan University, Shanghai 200032, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuxin","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of Occupational and Environmental Health, School of Public Health, Qingdao University, No. 308 Ningxia Road, Qingdao 266071, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8863-9671","authenticated-orcid":true,"given":"Weidong","family":"Qu","sequence":"additional","affiliation":[{"name":"Key Laboratory of the Public Health Safety, Ministry of Education, Department of Environmental Health, School of Public Health, Fudan University, Shanghai 200032, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2023,4,6]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"publisher","DOI":"10.1007\/s11356-014-3229-5"},{"key":"ref2\/cit2","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2022.113086"},{"key":"ref3\/cit3","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4899-7283-5_1"},{"key":"ref4\/cit4","doi-asserted-by":"publisher","DOI":"10.3390\/molecules27228072"},{"key":"ref5\/cit5","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2019.125746"},{"key":"ref6\/cit6","doi-asserted-by":"publisher","DOI":"10.3390\/foods10123077"},{"key":"ref7\/cit7","doi-asserted-by":"publisher","DOI":"10.1016\/j.chemosphere.2020.126385"},{"key":"ref8\/cit8","doi-asserted-by":"publisher","DOI":"10.1021\/es901292a"},{"key":"ref9\/cit9","doi-asserted-by":"publisher","DOI":"10.1093\/toxsci\/kfs094"},{"key":"ref10\/cit10","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2019.00743"},{"key":"ref11\/cit11","doi-asserted-by":"publisher","DOI":"10.1016\/j.ecoenv.2021.112677"},{"key":"ref12\/cit12","doi-asserted-by":"publisher","DOI":"10.1016\/j.envpol.2019.03.038"},{"key":"ref13\/cit13","doi-asserted-by":"publisher","DOI":"10.1016\/j.envpol.2021.118210"},{"key":"ref14\/cit14","doi-asserted-by":"publisher","DOI":"10.1016\/j.envres.2019.108926"},{"key":"ref15\/cit15","doi-asserted-by":"publisher","DOI":"10.1016\/j.scitotenv.2022.160556"},{"key":"ref16\/cit16","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxlet.2016.04.005"},{"key":"ref17\/cit17","doi-asserted-by":"publisher","DOI":"10.1093\/jee\/98.2.509"},{"key":"ref18\/cit18","doi-asserted-by":"publisher","DOI":"10.1081\/clt-200041784"},{"key":"ref19\/cit19","doi-asserted-by":"publisher","DOI":"10.1007\/s11356-014-4034-x"},{"key":"ref20\/cit20","doi-asserted-by":"publisher","DOI":"10.1021\/jf100872f"},{"key":"ref21\/cit21","unstructured":"Users\u2019 Manual for the IPCS Health and Safety Guides\n                      ; International Programme for Chemical Safety &\nWorld Health Organization, 1996; https:\/\/apps.who.int\/iris\/handle\/10665\/41829."},{"key":"ref22\/cit22","doi-asserted-by":"publisher","DOI":"10.1007\/s11356-019-07344-8"},{"key":"ref23\/cit23","doi-asserted-by":"publisher","DOI":"10.1080\/10408444.2016.1223014"},{"key":"ref24\/cit24","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijheh.2019.01.009"},{"key":"ref25\/cit25","doi-asserted-by":"publisher","DOI":"10.1081\/clt-120030948"},{"key":"ref26\/cit26","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jafc.8b00573"},{"key":"ref27\/cit27","doi-asserted-by":"publisher","DOI":"10.1016\/j.envint.2019.104994"},{"key":"ref28\/cit28","doi-asserted-by":"publisher","DOI":"10.1124\/mol.105.015313"},{"key":"ref29\/cit29","doi-asserted-by":"publisher","DOI":"10.1021\/acs.est.9b02825"},{"key":"ref30\/cit30","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2018.01.055"},{"key":"ref31\/cit31","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1016\/B978-0-12-386454-3.00144-5","volume-title":"Encyclopedia of Toxicology","author":"Fent G. M.","year":"2014","edition":"3"},{"key":"ref32\/cit32","doi-asserted-by":"publisher","DOI":"10.1080\/09593330.2012.665494"},{"key":"ref33\/cit33","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhazmat.2021.127939"},{"key":"ref34\/cit34","doi-asserted-by":"publisher","DOI":"10.1016\/j.etap.2020.103408"},{"key":"ref35\/cit35","doi-asserted-by":"publisher","DOI":"10.1021\/tx980157t"},{"key":"ref36\/cit36","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxrep.2015.02.009"},{"key":"ref37\/cit37","unstructured":"Ministry\nof Agriculture and\nRural affairs of the People\u2019s Republic of China.\n                      Announcement No. 1157 of Ministry of Agriculture\n                      . 2009. http:\/\/www.moa.gov.cn\/gk\/tzgg_1\/gg\/200902\/t20090227_1226994.htm."},{"key":"ref38\/cit38","doi-asserted-by":"publisher","DOI":"10.1016\/j.tox.2008.09.026"},{"key":"ref39\/cit39","doi-asserted-by":"publisher","DOI":"10.3109\/15563650.2010.507548"},{"key":"ref40\/cit40","doi-asserted-by":"publisher","DOI":"10.1016\/j.pestbp.2014.10.013"},{"key":"ref41\/cit41","doi-asserted-by":"publisher","DOI":"10.1007\/s12640-021-00364-8"},{"key":"ref42\/cit42","doi-asserted-by":"publisher","DOI":"10.1016\/j.physbeh.2016.06.035"},{"key":"ref43\/cit43","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-02255-5"},{"key":"ref44\/cit44","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijheh.2016.05.006"},{"key":"ref45\/cit45","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2010.0449"},{"key":"ref46\/cit46","doi-asserted-by":"publisher","DOI":"10.1089\/thy.1997.7.177"},{"key":"ref47\/cit47","doi-asserted-by":"publisher","DOI":"10.1007\/s00253-021-11605-3"},{"key":"ref48\/cit48","doi-asserted-by":"publisher","DOI":"10.1016\/j.micres.2022.127247"},{"key":"ref49\/cit49","unstructured":"New Pesticide Fact Sheet - Fipronil\n                      ; U.S.\nEnvironmental Protection Agency, Office of Prevention, Pesticides\nand Toxic Substances, Office of Pesticide Programs, U.S. Government\nPrinting Office Washington, DC, EPA, 1996; 737-F-96-005; pp 1-10."},{"key":"ref50\/cit50","doi-asserted-by":"publisher","DOI":"10.1007\/s11356-014-3470-y"},{"key":"ref51\/cit51","doi-asserted-by":"publisher","DOI":"10.1021\/jf970874d"},{"key":"ref52\/cit52","doi-asserted-by":"publisher","DOI":"10.1007\/s11356-014-3332-7"},{"key":"ref53\/cit53","unstructured":"Standard examination methods for drinking\nwater - collection and\npreservation of water samples; Standardization\nAdministration of the People\u2019s Republic of China (SAC). http:\/\/c.gb688.cn\/bzgk\/gb\/showGb?type=online&hcno=CA71F3AD8B8B22D908B7ED0FBCF703DF (accessed December 29, 2006)."},{"key":"ref54\/cit54","doi-asserted-by":"publisher","DOI":"10.1016\/s0273-2300(02)00032-6"},{"key":"ref55\/cit55","doi-asserted-by":"publisher","DOI":"10.1021\/es502855x"},{"key":"ref56\/cit56","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.2017.317"},{"key":"ref57\/cit57","doi-asserted-by":"publisher","DOI":"10.1021\/acschembio.6b00651"},{"key":"ref58\/cit58","doi-asserted-by":"publisher","DOI":"10.1186\/1476-4598-10-43"},{"key":"ref59\/cit59","doi-asserted-by":"publisher","DOI":"10.1186\/s13148-021-01109-2"},{"key":"ref60\/cit60","doi-asserted-by":"publisher","DOI":"10.1159\/000479537"},{"key":"ref61\/cit61","doi-asserted-by":"publisher","DOI":"10.1124\/dmd.120.000088"},{"key":"ref62\/cit62","doi-asserted-by":"publisher","DOI":"10.1016\/j.taap.2019.114873"},{"key":"ref63\/cit63","doi-asserted-by":"publisher","DOI":"10.1016\/j.chemosphere.2014.07.015"},{"key":"ref64\/cit64","doi-asserted-by":"publisher","DOI":"10.1111\/j.1539-6924.2009.01336.x"},{"key":"ref65\/cit65","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2017.7342"},{"key":"ref66\/cit66","doi-asserted-by":"publisher","DOI":"10.1016\/j.ecoenv.2022.114239"},{"key":"ref67\/cit67","doi-asserted-by":"publisher","DOI":"10.1007\/s11356-019-06579-9"},{"key":"ref68\/cit68","doi-asserted-by":"publisher","DOI":"10.3390\/nu10091137"},{"key":"ref69\/cit69","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamcr.2018.02.010"},{"key":"ref70\/cit70","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-pharmtox-010818-021856"},{"key":"ref71\/cit71","doi-asserted-by":"publisher","DOI":"10.1002\/mds.27878"},{"key":"ref72\/cit72","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2016.11.005"},{"key":"ref73\/cit73","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/bgaa039"},{"key":"ref74\/cit74","doi-asserted-by":"publisher","DOI":"10.1042\/bj20030405"},{"key":"ref75\/cit75","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.2001.280.2.E254"},{"key":"ref76\/cit76","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-pharmtox-011112-140320"},{"key":"ref77\/cit77","doi-asserted-by":"publisher","DOI":"10.1038\/cdd.2014.150"},{"key":"ref78\/cit78","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.272.29.18104"},{"key":"ref79\/cit79","doi-asserted-by":"publisher","DOI":"10.1089\/thy.1997.7.655"},{"key":"ref80\/cit80","doi-asserted-by":"publisher","DOI":"10.1210\/en.2012-1567"},{"key":"ref81\/cit81","doi-asserted-by":"publisher","DOI":"10.1007\/s00223-016-0159-x"},{"key":"ref82\/cit82","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198803103181003"},{"key":"ref83\/cit83","doi-asserted-by":"publisher","DOI":"10.4248\/BR201302004"},{"key":"ref84\/cit84","volume-title":"Levothyroxine","author":"Eghtedari B.","year":"2022"},{"key":"ref85\/cit85","doi-asserted-by":"publisher","DOI":"10.3109\/10715762.2011.653969"},{"key":"ref86\/cit86","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2016.07.003"},{"key":"ref87\/cit87","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2019.7832"},{"key":"ref88\/cit88","first-page":"3","volume":"3","author":"Cabiscol E.","year":"2000","journal-title":"Int. Microbiol."},{"key":"ref89\/cit89","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/5010423"},{"key":"ref90\/cit90","doi-asserted-by":"publisher","DOI":"10.1080\/10715762.2019.1620939"},{"key":"ref91\/cit91","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-020-03355-3"},{"key":"ref92\/cit92","doi-asserted-by":"publisher","DOI":"10.2741\/1257"},{"key":"ref93\/cit93","doi-asserted-by":"publisher","DOI":"10.1096\/fj.201700170R"}],"container-title":["Environmental Science &amp; Technology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acs.est.2c08627","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acs.est.2c08627","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,18]],"date-time":"2023-04-18T04:49:39Z","timestamp":1681793379000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/acs.est.2c08627"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,4,6]]},"references-count":93,"journal-issue":{"issue":"15","published-print":{"date-parts":[[2023,4,18]]}},"alternative-id":["10.1021\/acs.est.2c08627"],"URL":"https:\/\/doi.org\/10.1021\/acs.est.2c08627","relation":{},"ISSN":["0013-936X","1520-5851"],"issn-type":[{"value":"0013-936X","type":"print"},{"value":"1520-5851","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,4,6]]}}}