{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T09:35:56Z","timestamp":1788341756775,"version":"build-2803163510"},"reference-count":82,"publisher":"American Chemical Society (ACS)","issue":"33","license":[{"start":{"date-parts":[[2023,8,11]],"date-time":"2023-08-11T00:00:00Z","timestamp":1691712000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000066","name":"National Institute of Environmental Health Sciences","doi-asserted-by":"publisher","award":["P30ES005022"],"award-info":[{"award-number":["P30ES005022"]}],"id":[{"id":"10.13039\/100000066","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000066","name":"National Institute of Environmental Health Sciences","doi-asserted-by":"publisher","award":["R01ES031080"],"award-info":[{"award-number":["R01ES031080"]}],"id":[{"id":"10.13039\/100000066","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000066","name":"National Institute of Environmental Health Sciences","doi-asserted-by":"publisher","award":["R35ES031709"],"award-info":[{"award-number":["R35ES031709"]}],"id":[{"id":"10.13039\/100000066","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006108","name":"National Center for Advancing Translational Sciences","doi-asserted-by":"publisher","award":["UL1TR003017"],"award-info":[{"award-number":["UL1TR003017"]}],"id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000057","name":"National Institute of General Medical Sciences","doi-asserted-by":"publisher","award":["R01GM148743"],"award-info":[{"award-number":["R01GM148743"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000001","name":"National Science Foundation","doi-asserted-by":"publisher","award":["2211489"],"award-info":[{"award-number":["2211489"]}],"id":[{"id":"10.13039\/100000001","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Environ. Sci. Technol."],"published-print":{"date-parts":[[2023,8,22]]},"DOI":"10.1021\/acs.est.3c02792","type":"journal-article","created":{"date-parts":[[2023,8,11]],"date-time":"2023-08-11T15:36:36Z","timestamp":1691768196000},"page":"12291-12301","source":"Crossref","is-referenced-by-count":10,"title":["Integrating Concentration-Dependent Toxicity Data and Toxicokinetics To Inform Hepatotoxicity Response Pathways"],"prefix":"10.1021","volume":"57","author":[{"given":"Daniel P.","family":"Russo","sequence":"first","affiliation":[{"name":"Department of Chemistry and Biochemistry, Rowan University, Glassboro, New Jersey 08028, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lauren M.","family":"Aleksunes","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Toxicology, Ernest Mario School of Pharmacy, Rutgers University, Piscataway, New Jersey 08854, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katy","family":"Goyak","sequence":"additional","affiliation":[{"name":"ExxonMobil Biomedical Sciences, Inc., Annandale, New Jersey 08801, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hua","family":"Qian","sequence":"additional","affiliation":[{"name":"ExxonMobil Biomedical Sciences, Inc., Annandale, New Jersey 08801, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3559-6129","authenticated-orcid":true,"given":"Hao","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Biochemistry, Rowan University, Glassboro, New Jersey 08028, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2023,8,11]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0034-1375962"},{"key":"ref2\/cit2","doi-asserted-by":"publisher","DOI":"10.1289\/ehp.0800074"},{"key":"ref3\/cit3","doi-asserted-by":"publisher","DOI":"10.1006\/rtph.2000.1399"},{"key":"ref4\/cit4","doi-asserted-by":"publisher","DOI":"10.1080\/15569543.2019.1639060"},{"key":"ref5\/cit5","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacbts.2019.10.008"},{"key":"ref6\/cit6","doi-asserted-by":"publisher","DOI":"10.1038\/tpj.2012.45"},{"key":"ref7\/cit7","doi-asserted-by":"publisher","DOI":"10.1177\/0091270007299930"},{"key":"ref8\/cit8","doi-asserted-by":"publisher","DOI":"10.1177\/0192623312448935"},{"key":"ref9\/cit9","doi-asserted-by":"publisher","DOI":"10.1093\/toxsci\/kfr350"},{"key":"ref10\/cit10","doi-asserted-by":"publisher","DOI":"10.1093\/toxsci\/kft178"},{"key":"ref11\/cit11","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrestox.7b00339"},{"key":"ref12\/cit12","doi-asserted-by":"publisher","DOI":"10.1093\/toxsci\/kfz058"},{"key":"ref13\/cit13","doi-asserted-by":"publisher","DOI":"10.1007\/s00204-020-02691-9"},{"key":"ref14\/cit14","doi-asserted-by":"publisher","DOI":"10.1093\/toxsci\/kfw018"},{"key":"ref15\/cit15","doi-asserted-by":"publisher","DOI":"10.1007\/s00204-016-1814-8"},{"key":"ref16\/cit16","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2021.06.021"},{"key":"ref17\/cit17","unstructured":"Council NR. Toxicity Testing in the 21st Century: A Vision and\na Strategy, 2007."},{"key":"ref18\/cit18","doi-asserted-by":"publisher","DOI":"10.1021\/tx500345j"},{"key":"ref19\/cit19","doi-asserted-by":"publisher","DOI":"10.1002\/etc.34"},{"key":"ref20\/cit20","doi-asserted-by":"publisher","DOI":"10.1080\/10937404.2010.483176"},{"key":"ref21\/cit21","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrestox.6b00135"},{"key":"ref22\/cit22","doi-asserted-by":"publisher","DOI":"10.1021\/acs.est.5b02641"},{"key":"ref23\/cit23","doi-asserted-by":"publisher","DOI":"10.1093\/toxsci\/kfv168"},{"key":"ref24\/cit24","doi-asserted-by":"publisher","DOI":"10.1021\/acs.est.1c02656"},{"key":"ref25\/cit25","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1007\/978-1-4939-7677-5_7","volume-title":"Drug-Induced Liver Toxicity","author":"Atienzar F. A.","year":"2018"},{"key":"ref26\/cit26","doi-asserted-by":"publisher","DOI":"10.1289\/EHP3614"},{"key":"ref27\/cit27","doi-asserted-by":"publisher","DOI":"10.1093\/toxsci\/kfaa005"},{"key":"ref28\/cit28","doi-asserted-by":"publisher","DOI":"10.1093\/toxsci\/kfr254"},{"key":"ref29\/cit29","doi-asserted-by":"publisher","DOI":"10.1080\/10937404.2010.483940"},{"key":"ref30\/cit30","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrestox.8b00393"},{"key":"ref31\/cit31","doi-asserted-by":"publisher","DOI":"10.1021\/acssuschemeng.1c00483"},{"key":"ref32\/cit32","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrestox.5b00465"},{"key":"ref33\/cit33","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btw680"},{"key":"ref34\/cit34","doi-asserted-by":"publisher","DOI":"10.1111\/j.2517-6161.1995.tb02031.x"},{"key":"ref35\/cit35","doi-asserted-by":"publisher","DOI":"10.1021\/tx500145h"},{"key":"ref36\/cit36","doi-asserted-by":"publisher","DOI":"10.1177\/1087057110389039"},{"key":"ref37\/cit37","doi-asserted-by":"publisher","DOI":"10.18637\/jss.v079.i04"},{"key":"ref38\/cit38","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrestox.0c00264"},{"key":"ref39\/cit39","doi-asserted-by":"publisher","DOI":"10.1016\/j.mrgentox.2015.05.010"},{"key":"ref40\/cit40","doi-asserted-by":"publisher","DOI":"10.1289\/ehp.0900842"},{"key":"ref41\/cit41","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-pharmtox-011112-140320"},{"key":"ref42\/cit42","doi-asserted-by":"publisher","DOI":"10.18053\/jctres.04.201801.005"},{"key":"ref43\/cit43","doi-asserted-by":"publisher","DOI":"10.1023\/a:1007649815992"},{"key":"ref44\/cit44","doi-asserted-by":"publisher","DOI":"10.1634\/theoncologist.5-5-388"},{"key":"ref45\/cit45","first-page":"1131","volume":"60","author":"Scott J. A.","year":"1999","journal-title":"Am. Fam. Physician"},{"key":"ref46\/cit46","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.1000038"},{"key":"ref47\/cit47","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.9b00726"},{"key":"ref48\/cit48","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-019-5377-y"},{"key":"ref49\/cit49","doi-asserted-by":"publisher","DOI":"10.1021\/jf403840c"},{"key":"ref50\/cit50","doi-asserted-by":"publisher","DOI":"10.1016\/j.yrtph.2016.11.002"},{"key":"ref51\/cit51","doi-asserted-by":"publisher","DOI":"10.1007\/s10753-015-0127-z"},{"key":"ref52\/cit52","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0099863"},{"key":"ref53\/cit53","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btw640"},{"key":"ref54\/cit54","doi-asserted-by":"publisher","DOI":"10.1021\/ci9803381"},{"key":"ref55\/cit55","doi-asserted-by":"crossref","unstructured":"Chitturi, S.; Farrell, G. Chapter 33. Adverse Effects of Hormones and Hormone Antagonists on the Liver. In\n                      Drug-Induced Liver Disease\n                      , 2013; pp 605 \u2212619.","DOI":"10.1016\/B978-0-12-387817-5.00033-9"},{"key":"ref56\/cit56","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1007\/978-3-319-70178-3_12","volume-title":"Sex and Gender Factors Affecting Metabolic Homeostasis, Diabetes and Obesity","author":"Palmisano B. T.","year":"2017"},{"key":"ref57\/cit57","doi-asserted-by":"publisher","DOI":"10.3390\/metabo11050320"},{"key":"ref58\/cit58","doi-asserted-by":"publisher","DOI":"10.1038\/sj.leu.2402114"},{"key":"ref59\/cit59","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/B978-0-12-387817-5.00005-4","volume-title":"Drug-Induced Liver Disease","author":"Lemasters J. J.","year":"2013","edition":"3"},{"key":"ref60\/cit60","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1016\/B978-0-12-387817-5.00028-5","volume-title":"Drug-Induced Liver Disease","author":"N\u00fa\u00f1ez M.","year":"2013","edition":"3"},{"key":"ref61\/cit61","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2796.1994.tb01088.x"},{"key":"ref62\/cit62","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/B978-0-12-387817-5.00006-6","volume-title":"Drug-Induced Liver Disease","author":"Dara L.","year":"2013","edition":"3"},{"key":"ref63\/cit63","doi-asserted-by":"publisher","DOI":"10.1186\/s12929-019-0517-x"},{"key":"ref64\/cit64","doi-asserted-by":"publisher","DOI":"10.1007\/s40618-020-01208-6"},{"key":"ref65\/cit65","doi-asserted-by":"publisher","DOI":"10.1002\/hep.31296"},{"key":"ref66\/cit66","doi-asserted-by":"publisher","DOI":"10.1038\/nrendo.2018.10"},{"key":"ref67\/cit67","doi-asserted-by":"publisher","DOI":"10.1194\/jlr.C088955"},{"key":"ref68\/cit68","first-page":"10","volume":"6","author":"Radzikowska E.","year":"2012","journal-title":"J. Pre-Clin. Clin. Res."},{"key":"ref69\/cit69","doi-asserted-by":"publisher","DOI":"10.1097\/00004836-198404000-00009"},{"key":"ref70\/cit70","doi-asserted-by":"publisher","DOI":"10.1007\/BF01314771"},{"key":"ref71\/cit71","doi-asserted-by":"publisher","DOI":"10.2147\/JHC.S48956"},{"key":"ref72\/cit72","doi-asserted-by":"publisher","DOI":"10.1530\/ERC-13-0283"},{"key":"ref73\/cit73","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.2001.281.2.G342"},{"key":"ref74\/cit74","doi-asserted-by":"publisher","DOI":"10.1093\/toxsci\/kfr326"},{"key":"ref75\/cit75","doi-asserted-by":"publisher","DOI":"10.1002\/hep.510290535"},{"key":"ref76\/cit76","doi-asserted-by":"publisher","DOI":"10.2165\/00003088-200342040-00004"},{"key":"ref77\/cit77","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6601630"},{"key":"ref78\/cit78","doi-asserted-by":"publisher","DOI":"10.1517\/14740338.2015.1014799"},{"key":"ref79\/cit79","doi-asserted-by":"publisher","DOI":"10.1016\/j.comtox.2021.100166"},{"key":"ref80\/cit80","doi-asserted-by":"publisher","DOI":"10.1038\/s41374-020-00477-2"},{"key":"ref81\/cit81","doi-asserted-by":"publisher","DOI":"10.1289\/ehp.1509763"},{"key":"ref82\/cit82","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhazmat.2022.129193"}],"container-title":["Environmental Science & Technology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acs.est.3c02792","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acs.est.3c02792","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,22]],"date-time":"2023-08-22T04:59:44Z","timestamp":1692680384000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/acs.est.3c02792"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,8,11]]},"references-count":82,"journal-issue":{"issue":"33","published-print":{"date-parts":[[2023,8,22]]}},"alternative-id":["10.1021\/acs.est.3c02792"],"URL":"https:\/\/doi.org\/10.1021\/acs.est.3c02792","relation":{},"ISSN":["0013-936X","1520-5851"],"issn-type":[{"value":"0013-936X","type":"print"},{"value":"1520-5851","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,8,11]]}}}