{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T14:17:20Z","timestamp":1787581040564,"version":"build-2736575974"},"reference-count":79,"publisher":"American Chemical Society (ACS)","issue":"36","license":[{"start":{"date-parts":[[2024,8,28]],"date-time":"2024-08-28T00:00:00Z","timestamp":1724803200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,8,28]],"date-time":"2024-08-28T00:00:00Z","timestamp":1724803200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,8,28]],"date-time":"2024-08-28T00:00:00Z","timestamp":1724803200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22306173"],"award-info":[{"award-number":["22306173"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["42307512"],"award-info":[{"award-number":["42307512"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005356","name":"Zhejiang Shuren University","doi-asserted-by":"publisher","award":["2023R011"],"award-info":[{"award-number":["2023R011"]}],"id":[{"id":"10.13039\/501100005356","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004731","name":"Natural Science Foundation of Zhejiang Province","doi-asserted-by":"publisher","award":["LQ23D030001"],"award-info":[{"award-number":["LQ23D030001"]}],"id":[{"id":"10.13039\/501100004731","id-type":"DOI","asserted-by":"publisher"}]},{"name":"State Key Laboratory for Managing Biotic and Chemical Threats to the Quality and Safety of Agro-products","award":["2021DG700024-KF202411"],"award-info":[{"award-number":["2021DG700024-KF202411"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,9,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Exposure to bisphenol A (BPA) during gestation and lactation is considered to be a potential risk factor for autism spectrum disorder (ASD) in both humans and animals. As a novel alternative to BPA, 4-hydroxy-4\u2032-isopropoxydiphenylsulfone (BPSIP) is frequently detected in breast milk and placental barrier systems, suggesting potential transmission from the mother to offspring and increased risk of exposure. Gestation and lactation are critical periods for central nervous system development, which are vulnerable to certain environmental pollutants. Herein, we investigated the behavioral impacts and neurobiological effects of early-life exposure to BPSIP (0.02, 0.1, and 0.5 mg\/kg body weight\/day) in mice offspring. Behavioral studies indicated that BPSIP exposure induced ASD-like behaviors, including elevated anxiety-related behavior and decreased spatial memory, in both male and female pups. A distinct pattern of reduced social novelty was observed only in female offspring, accompanied by significant alterations in antioxidant levels. Transcriptome analysis demonstrated that differentially expressed genes (DEGs) were mainly enriched in pathways related to behaviors and neurodevelopment, which were consistent with the observed phenotype. Besides, a decrease in the protein levels of complex IV (COX IV) across all tested populations suggests a profound impact on mitochondrial function, potentially leading to abnormal energy metabolism in individuals with autism. Additionally, changes in synaptic proteins, evidenced by alterations in synapsin 1 (SYN1) and postsynaptic density protein-95 (PSD95) levels in the cerebellum and hippocampus, support the notion of synaptic involvement. These findings suggest that BPSIP may induce sex-specific neurotoxic effects that involve oxidative stress, energy generation, and synaptic plasticity.<\/jats:p>","DOI":"10.1021\/acs.est.4c04760","type":"journal-article","created":{"date-parts":[[2024,8,28]],"date-time":"2024-08-28T09:52:20Z","timestamp":1724838740000},"page":"15984-15996","source":"Crossref","is-referenced-by-count":23,"title":["Early-Life\nExposure to 4\u2011Hydroxy-4\u2032-Isopropoxydiphenylsulfone\nInduces Behavioral Deficits Associated with Autism Spectrum Disorders\nin Mice"],"prefix":"10.1021","volume":"58","author":[{"given":"Shengnan","family":"Zhang","sequence":"first","affiliation":[{"name":"Zhejiang Shuren University , , ,","place":["Hangzhou, China, 310015"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yitong","family":"Zhou","sequence":"additional","affiliation":[{"name":"Zhejiang Shuren University , , ,","place":["Hangzhou, China, 310015"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiatong","family":"Shen","sequence":"additional","affiliation":[{"name":"Zhejiang Shuren University , , ,","place":["Hangzhou, China, 310015"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yumeng","family":"Wang","sequence":"additional","affiliation":[{"name":"Zhejiang Shuren University , , ,","place":["Hangzhou, China, 310015"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Xia","sequence":"additional","affiliation":[{"name":"Zhejiang Shuren University , , ,","place":["Hangzhou, China, 310015"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenghan","family":"Li","sequence":"additional","affiliation":[{"name":"Zhejiang Shuren University , , ,","place":["Hangzhou, China, 310015"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1173-892X","authenticated-orcid":true,"given":"Weiping","family":"Liu","sequence":"additional","affiliation":[{"name":"Zhejiang Shuren University , , ,","place":["Hangzhou, China, 310015"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kashif","family":"Hayat","sequence":"additional","affiliation":[{"name":"Zhejiang Shuren University , , ,","place":["Hangzhou, China, 310015"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6011-872X","authenticated-orcid":true,"given":"Mingrong","family":"Qian","sequence":"additional","affiliation":[{"name":"Zhejiang Shuren University , , ,","place":["Hangzhou, China, 310015"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2024,8,28]]},"reference":[{"issue":"1","key":"2026081707131709700_cit1","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1176\/appi.ajp.2020.20111608","article-title":"Autism spectrum disorder genetics and the search for\npathological mechanisms","volume":"178","author":"Manoli","year":"2021","journal-title":"Am. J. Psychiatry"},{"key":"2026081707131709700_cit2","doi-asserted-by":"publisher","DOI":"10.1016\/j.psychres.2020.112922","article-title":"Prevalence of comorbid\npsychiatric\ndisorders among people with autism spectrum disorder: An umbrella\nreview of systematic reviews and meta-analyses","volume":"287","author":"Hossain","year":"2020","journal-title":"Psychiatry Res."},{"issue":"5","key":"2026081707131709700_cit3","doi-asserted-by":"publisher","first-page":"778","DOI":"10.1002\/aur.2696","article-title":"Global prevalence\nof autism: A systematic review update","volume":"15","author":"Zeidan","year":"2022","journal-title":"Autism\nRes."},{"key":"2026081707131709700_cit4","doi-asserted-by":"publisher","DOI":"10.1016\/j.envint.2023.108228","article-title":"Exposure to\nnonylphenol in early life causes behavioural deficits related with\nautism spectrum disorders in rats","volume":"180","author":"You","year":"2023","journal-title":"Environ.\nInt."},{"issue":"7","key":"2026081707131709700_cit5","doi-asserted-by":"publisher","first-page":"1275","DOI":"10.1007\/s00018-018-2988-4","article-title":"The contribution\nof environmental\nexposure to the etiology of autism spectrum disorder","volume":"76","author":"Bo\u0308lte","year":"2019","journal-title":"Cell. Mol. Life Sci."},{"key":"2026081707131709700_cit6","doi-asserted-by":"publisher","first-page":"344","DOI":"10.1016\/j.scitotenv.2016.02.022","article-title":"Maternal and early\nlife exposure to phthalates: The plastics and personal-care products\nuse in pregnancy (P4) study","volume":"551\u2013552","author":"Arbuckle","year":"2016","journal-title":"Sci. Total Environ."},{"key":"2026081707131709700_cit7","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1016\/j.yhbeh.2017.10.003","article-title":"Are endocrine disrupting compounds\nenvironmental risk factors for autism spectrum disorder?","volume":"101","author":"Moosa","year":"2018","journal-title":"Horm. Behav."},{"issue":"4","key":"2026081707131709700_cit8","doi-asserted-by":"publisher","DOI":"10.1289\/EHP4386","article-title":"Environmental\nchemicals and autism: A scoping review of the human and animal research","volume":"127","author":"Pelch\nKatherine","year":"2019","journal-title":"Environ. Health Perspect."},{"issue":"Suppl 3","key":"2026081707131709700_cit9","doi-asserted-by":"publisher","first-page":"511","DOI":"10.1289\/ehp.00108s3511","article-title":"Critical periods of vulnerability for the developing\nnervous system: Evidence from humans and animal models","volume":"108","author":"Rice","year":"2000","journal-title":"Environ. Health Perspect."},{"key":"2026081707131709700_cit10","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1146\/annurev-pharmtox-010818-021304","article-title":"Environmental obesogens: Mechanisms\nand controversies","volume":"59","author":"Heindel","year":"2019","journal-title":"Annu. Rev. Pharmacol. Toxicol."},{"key":"2026081707131709700_cit11","doi-asserted-by":"publisher","first-page":"94","DOI":"10.1016\/j.yhbeh.2017.11.008","article-title":"Exposure to polybrominated\ndiphenyl ethers (PBDEs) and child behavior:\nCurrent findings and future directions","volume":"101","author":"Vuong","year":"2018","journal-title":"Horm.\nBehav."},{"issue":"1","key":"2026081707131709700_cit12","doi-asserted-by":"publisher","DOI":"10.1186\/s12940-017-0251-3","article-title":"Prenatal chlorpyrifos\nleads to autism-like deficits in C57Bl6\/J mice","volume":"16","author":"Lan","year":"2017","journal-title":"Environ. Health"},{"key":"2026081707131709700_cit13","doi-asserted-by":"publisher","first-page":"234","DOI":"10.1016\/j.envpol.2017.04.039","article-title":"The association\nof environmental\ntoxicants and autism spectrum disorders in children","volume":"227","author":"Ye","year":"2017","journal-title":"Environ. Pollut."},{"issue":"5","key":"2026081707131709700_cit14","doi-asserted-by":"publisher","first-page":"513","DOI":"10.1289\/ehp.1307261","article-title":"Gestational\nexposure to endocrine-disrupting chemicals\nand reciprocal social, repetitive, and stereotypic behaviors in 4-\nand 5-year-old children: the HOME study","volume":"122","author":"Braun","year":"2014","journal-title":"Environ.\nHealth Perspect."},{"issue":"24","key":"2026081707131709700_cit15","doi-asserted-by":"publisher","DOI":"10.3390\/ijms222413201","article-title":"Autism-related\ntranscription factors underlying the sex-specific effects of prenatal\nbisphenol A exposure on transcriptome-interactome profiles in the\noffspring prefrontal cortex","volume":"22","author":"Kanlayaprasit","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"2026081707131709700_cit16","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhazmat.2019.121774","article-title":"Prenatal exposure\nto bisphenol A and its alternatives and child neurodevelopment at\n2 years","volume":"388","author":"Jiang","year":"2020","journal-title":"J. Hazard. 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Pharmacol."},{"key":"2026081707131709700_cit20","doi-asserted-by":"publisher","first-page":"238","DOI":"10.1016\/j.envpol.2018.10.049","article-title":"Assessment\nof bisphenol A alternatives in paper products from the Chinese market\nand their dermal exposure in the general population","volume":"244","author":"Yang","year":"2019","journal-title":"Environ. Pollut."},{"key":"2026081707131709700_cit21","doi-asserted-by":"publisher","first-page":"2356","DOI":"10.1897\/06-642R.1","article-title":"Occurrence and estrogenicity\nof phenolics in paper-recycling process water-pollutants originating\nfrom thermal paper in waste paper","volume":"26","author":"Terasaki","year":"2007","journal-title":"Environ.\nToxicol. Chem."},{"key":"2026081707131709700_cit22","doi-asserted-by":"publisher","first-page":"766","DOI":"10.1021\/acs.estlett.1c00545","article-title":"Occurrence and nationwide\ndistribution of multiple\nnovel bisphenol S analogues in municipal sewage sludge across China","volume":"8","author":"Pan","year":"2021","journal-title":"Environ. Sci. Technol. Lett."},{"key":"2026081707131709700_cit23","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1016\/j.chemosphere.2019.01.095","article-title":"Supramolecular solvent-based\nmicroextraction\nof emerging bisphenol A replacements (colour developers) in indoor\ndust from public environments","volume":"222","author":"Duen\u0303as-Mas","year":"2019","journal-title":"Chemosphere"},{"key":"2026081707131709700_cit24","doi-asserted-by":"publisher","first-page":"168","DOI":"10.1016\/j.emcon.2019.05.002","article-title":"Emerging bisphenol\nA replacements (colour developers) in indoor dust from Spain","volume":"5","author":"Duen\u0303as-Mas","year":"2019","journal-title":"Emerging Contam."},{"key":"2026081707131709700_cit25","doi-asserted-by":"publisher","first-page":"1506","DOI":"10.1021\/acs.est.7b00498","article-title":"Effects of 4-hydroxyphenyl\n4-isoprooxyphenylsulfone (BPSIP) exposure on reproduction and endocrine\nsystem of zebrafish","volume":"52","author":"Lee","year":"2018","journal-title":"Environ. Sci. Technol."},{"key":"2026081707131709700_cit26","doi-asserted-by":"publisher","first-page":"1368","DOI":"10.1002\/etc.4985","article-title":"Toxicity\nscreening of bisphenol A replacement compounds: Cytotoxicity and mRNA\nexpression in primary cepatocytes of chicken and double-crested cormorant","volume":"40","author":"Sharin","year":"2021","journal-title":"Environ. Toxicol. Chem."},{"key":"2026081707131709700_cit27","doi-asserted-by":"publisher","first-page":"2390","DOI":"10.1021\/acs.chemrestox.0c00148","article-title":"Simultaneous\nquantification of bisphenol A, its glucuronide metabolite, and commercial\nalternatives by LC-MS\/MS for in vitro skin absorption evaluation","volume":"33","author":"Reale","year":"2020","journal-title":"Chem. Res. Toxicol."},{"key":"2026081707131709700_cit28","doi-asserted-by":"publisher","first-page":"206","DOI":"10.1093\/annweh\/wxaa095","article-title":"Skin absorption of bisphenol A and\nits alternatives in thermal paper","volume":"65","author":"Reale","year":"2021","journal-title":"Ann. Work\nExposures Health"},{"key":"2026081707131709700_cit29","doi-asserted-by":"publisher","first-page":"437","DOI":"10.1289\/ehp.1409427","article-title":"Bisphenol\nA, bisphenol S, and 4-hydroxyphenyl 4-isoprooxyphenylsulfone (BPSIP)\nin urine and blood of cashiers","volume":"124","author":"Thayer","year":"2016","journal-title":"Environ. Health\nPerspect."},{"key":"2026081707131709700_cit30","doi-asserted-by":"publisher","first-page":"176","DOI":"10.1021\/acs.estlett.0c00883","article-title":"Occurrence\nof multiple bisphenol S derivatives in breast milk from Chinese lactating\nmomen and implications for exposure in breast-fed infants","volume":"8","author":"Luo","year":"2021","journal-title":"Environ. Sci. Technol. Lett."},{"key":"2026081707131709700_cit31","doi-asserted-by":"publisher","first-page":"3476","DOI":"10.1021\/acs.est.0c00206","article-title":"Occurrence and maternal transfer\nof multiple bisphenols, including an emerging derivative with unexpectedly\nhigh concentrations, in the human maternal-fetal-placental unit","volume":"54","author":"Pan","year":"2020","journal-title":"Environ. Sci. Technol."},{"key":"2026081707131709700_cit32","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1093\/toxsci\/kfz173","article-title":"Characterization\nof estrogenic and androgenic activities for bisphenol A-like chemicals\n(BPs): In vitro estrogen and androgen receptors transcriptional\nactivation, gene regulation, and binding profiles","volume":"172","author":"Pelch","year":"2019","journal-title":"Toxicol. Sci."},{"issue":"7","key":"2026081707131709700_cit33","doi-asserted-by":"publisher","DOI":"10.1038\/tp.2012.61","article-title":"Evidence of oxidative\ndamage and\ninflammation associated with low glutathione redox status in the autism\nbrain","volume":"2","author":"Rose","year":"2012","journal-title":"Transl. Psychiatry"},{"issue":"6","key":"2026081707131709700_cit34","doi-asserted-by":"publisher","first-page":"866","DOI":"10.1212\/WNL.35.6.866","article-title":"Histoanatomic observations of the brain in early infantile\nautism","volume":"35","author":"Bauman","year":"1985","journal-title":"Neurology"},{"issue":"9","key":"2026081707131709700_cit35","doi-asserted-by":"publisher","first-page":"1276","DOI":"10.1093\/cercor\/bhj069","article-title":"Anatomical\ndifferences in the mirror neuron system and social cognition network\nin autism","volume":"16","author":"Hadjikhani","year":"2006","journal-title":"Cereb. Cortex"},{"issue":"11","key":"2026081707131709700_cit36","doi-asserted-by":"publisher","first-page":"2125","DOI":"10.1002\/aur.3029","article-title":"Altered markers of mitochondrial\nfunction in adults with autism spectrum\ndisorder","volume":"16","author":"Nickel","year":"2023","journal-title":"Autism Res."},{"key":"2026081707131709700_cit37","doi-asserted-by":"publisher","DOI":"10.1016\/j.spen.2020.100829","article-title":"Mitochondrial\ndysfunction in autism spectrum disorder: Unique abnormalities and\ntargeted treatments","volume":"35","author":"Frye","year":"2020","journal-title":"Semin. Pediatr. Neurol."},{"issue":"38","key":"2026081707131709700_cit38","doi-asserted-by":"publisher","first-page":"14248","DOI":"10.1021\/acs.est.3c00607","article-title":"Chronic ambient ozone\nexposure aggravates autism-like symptoms in\na susceptible mouse model","volume":"57","author":"Ling","year":"2023","journal-title":"Environ. Sci. Technol."},{"key":"2026081707131709700_cit39","doi-asserted-by":"publisher","DOI":"10.1016\/j.scitotenv.2023.168012","article-title":"Bisphenol and analogues\nin indoor dust from E-waste recycling sites, neighboring residential\nhomes, and urban residential homes: Implications for human exposure","volume":"907","author":"Pan","year":"2024","journal-title":"Sci. Total Environ."},{"issue":"5","key":"2026081707131709700_cit40","doi-asserted-by":"publisher","first-page":"290","DOI":"10.1038\/nrn3918","article-title":"Stress and the social\nbrain: Behavioural effects and\nneurobiological mechanisms","volume":"16","author":"Sandi","year":"2015","journal-title":"Nat. Rev. Neurosci."},{"issue":"2","key":"2026081707131709700_cit41","doi-asserted-by":"publisher","first-page":"1031","DOI":"10.1038\/s41380-021-01341-5","article-title":"The dopamine transporter\ngene SLC6A3: Multidisease risks","volume":"27","author":"Reith","year":"2022","journal-title":"Mol. Psychiatry"},{"key":"2026081707131709700_cit42","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.35242","article-title":"Alpha protocadherins\nand Pyk2 kinase regulate cortical neuron migration and cytoskeletal\ndynamics via Rac1 GTPase and WAVE complex in mice","volume":"7","author":"Fan","year":"2018","journal-title":"eLife"},{"key":"2026081707131709700_cit43","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2021.113562","article-title":"Sodium hydrosulfide reverses \u03b2(2)-microglobulin-induced\ndepressive-like behaviors of male Sprague-Dawley rats: Involving improvement\nof synaptic plasticity and enhancement of Warburg effect in hippocampus","volume":"417","author":"Yang","year":"2022","journal-title":"Behav. Brain Res."},{"issue":"7","key":"2026081707131709700_cit44","doi-asserted-by":"publisher","first-page":"490","DOI":"10.1038\/nrn2851","article-title":"Behavioural phenotyping\nassays for mouse models of autism","volume":"11","author":"Silverman","year":"2010","journal-title":"Nat. Rev.\nNeurosci."},{"issue":"1","key":"2026081707131709700_cit45","doi-asserted-by":"publisher","DOI":"10.1186\/s12951-021-00967-5","article-title":"Pregnancy\nexposure of titanium dioxide nanoparticles causes intestinal dysbiosis\nand neurobehavioral impairments that are not significant postnatally\nbut emerge in adulthood of offspring","volume":"19","author":"Su","year":"2021","journal-title":"J. Nanobiotechnol."},{"issue":"5","key":"2026081707131709700_cit46","doi-asserted-by":"publisher","first-page":"287","DOI":"10.1111\/j.1601-1848.2004.00076.x","article-title":"Sociability and\npreference for social novelty in five inbred strains: An approach\nto assess autistic-like behavior in mice","volume":"3","author":"Moy","year":"2004","journal-title":"Genes\nBrain Behav."},{"key":"2026081707131709700_cit47","doi-asserted-by":"publisher","DOI":"10.1016\/j.physbeh.2022.113747","article-title":"Sex-dependent and long-lasting\neffects of bisphenol AF exposure on emotional behaviors in mice","volume":"249","author":"Gong","year":"2022","journal-title":"Physiol. Behav."},{"issue":"3","key":"2026081707131709700_cit48","doi-asserted-by":"publisher","first-page":"162","DOI":"10.1159\/000499105","article-title":"Sex-specific\neffects of stress on mood-related gene expression","volume":"5","author":"Barko","year":"2019","journal-title":"Mol. Neuropsychiatry"},{"key":"2026081707131709700_cit49","doi-asserted-by":"publisher","DOI":"10.1016\/j.chemosphere.2023.137935","article-title":"Early-life bisphenol AP exposure impacted neurobehaviors in adulthood\nthrough microglial activation in mice","volume":"317","author":"Wu","year":"2023","journal-title":"Chemosphere"},{"issue":"1","key":"2026081707131709700_cit50","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-39386-w","article-title":"Sex differences\nin the effects of\nprenatal bisphenol A exposure on genes associated with autism spectrum\ndisorder in the hippocampus","volume":"9","author":"Thongkorn","year":"2019","journal-title":"Sci. Rep."},{"issue":"8","key":"2026081707131709700_cit51","doi-asserted-by":"publisher","first-page":"1681","DOI":"10.1007\/s11064-012-0775-4","article-title":"Brain region-specific\nglutathione\nredox imbalance in autism","volume":"37","author":"Chauhan","year":"2012","journal-title":"Neurochem. Res."},{"issue":"2","key":"2026081707131709700_cit52","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1111\/j.1471-4159.2011.07189.x","article-title":"Brain region-specific\ndeficit in mitochondrial electron\ntransport chain complexes in children with autism","volume":"117","author":"Chauhan","year":"2011","journal-title":"J. Neurochem."},{"issue":"1","key":"2026081707131709700_cit53","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-023-44393-7","article-title":"Surplus fatty acid synthesis increases oxidative stress\nin adipocytes and induces lipodystrophy","volume":"15","author":"Weng","year":"2024","journal-title":"Nat.\nCommun."},{"key":"2026081707131709700_cit54","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/8416763","article-title":"Oxidative stress: Harms and benefits\nfor human health","volume":"2017","author":"Pizzino","year":"2017","journal-title":"Oxid. Med. Cell. 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