{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T12:09:21Z","timestamp":1791979761082,"version":"4.4.0"},"reference-count":43,"publisher":"American Chemical Society (ACS)","issue":"10","license":[{"start":{"date-parts":[[2025,3,6]],"date-time":"2025-03-06T00:00:00Z","timestamp":1741219200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,3,6]],"date-time":"2025-03-06T00:00:00Z","timestamp":1741219200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,3,6]],"date-time":"2025-03-06T00:00:00Z","timestamp":1741219200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/100000066","name":"National Institute of Environmental Health Sciences","doi-asserted-by":"publisher","award":["NTR 12003"],"award-info":[{"award-number":["NTR 12003"]}],"id":[{"id":"10.13039\/100000066","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000066","name":"National Institute of Environmental Health Sciences","doi-asserted-by":"publisher","award":["ZIA ES021196-27"],"award-info":[{"award-number":["ZIA ES021196-27"]}],"id":[{"id":"10.13039\/100000066","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000066","name":"National Institute of Environmental Health Sciences","doi-asserted-by":"publisher","award":["ZIA ES103373"],"award-info":[{"award-number":["ZIA ES103373"]}],"id":[{"id":"10.13039\/100000066","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006108","name":"National Center for Advancing Translational Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Environ. Sci. Technol."],"published-print":{"date-parts":[[2025,3,18]]},"DOI":"10.1021\/acs.est.4c07995","type":"journal-article","created":{"date-parts":[[2025,3,6]],"date-time":"2025-03-06T04:50:21Z","timestamp":1741236621000},"page":"4778-4787","source":"Crossref","is-referenced-by-count":16,"title":["Profiling of Environmental Mixtures Containing Metals for Their Toxicity Pathways and Mechanism of Action"],"prefix":"10.1021","volume":"59","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2729-2619","authenticated-orcid":true,"given":"Masato","family":"Ooka","sequence":"first","affiliation":[{"name":"Division of Preclinical Innovation, National Center for Advancing Translational Sciences, National Institutes of Health, 9800 Medical Center Drive, Rockville 20850, Maryland, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinghua","family":"Zhao","sequence":"additional","affiliation":[{"name":"Division of Preclinical Innovation, National Center for Advancing Translational Sciences, National Institutes of Health, 9800 Medical Center Drive, Rockville 20850, Maryland, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Zhang","sequence":"additional","affiliation":[{"name":"Division of Preclinical Innovation, National Center for Advancing Translational Sciences, National Institutes of Health, 9800 Medical Center Drive, Rockville 20850, Maryland, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8886-8311","authenticated-orcid":true,"given":"Ruili","family":"Huang","sequence":"additional","affiliation":[{"name":"Division of Preclinical Innovation, National Center for Advancing Translational Sciences, National Institutes of Health, 9800 Medical Center Drive, Rockville 20850, Maryland, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9693-1832","authenticated-orcid":true,"given":"Srilatha","family":"Sakamuru","sequence":"additional","affiliation":[{"name":"Division of Preclinical Innovation, National Center for Advancing Translational Sciences, National Institutes of Health, 9800 Medical Center Drive, Rockville 20850, Maryland, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charlotte","family":"TeKrony","sequence":"additional","affiliation":[{"name":"Division of Preclinical Innovation, National Center for Advancing Translational Sciences, National Institutes of Health, 9800 Medical Center Drive, Rockville 20850, Maryland, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1620-1571","authenticated-orcid":true,"given":"Jui-Hua","family":"Hsieh","sequence":"additional","affiliation":[{"name":"Division of Translational Toxicology, National Institute of Environmental Health Sciences, National Institutes of Health, 111 T.W. Alexander Drive, Durham 27709, North Carolina, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bradley J.","family":"Collins","sequence":"additional","affiliation":[{"name":"Division of Translational Toxicology, National Institute of Environmental Health Sciences, National Institutes of Health, 111 T.W. Alexander Drive, Durham 27709, North Carolina, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"June K.","family":"Dunnick","sequence":"additional","affiliation":[{"name":"Division of Translational Toxicology, National Institute of Environmental Health Sciences, National Institutes of Health, 111 T.W. Alexander Drive, Durham 27709, North Carolina, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7001-2985","authenticated-orcid":true,"given":"Darlene","family":"Dixon","sequence":"additional","affiliation":[{"name":"Division of Translational Toxicology, National Institute of Environmental Health Sciences, National Institutes of Health, 111 T.W. Alexander Drive, Durham 27709, North Carolina, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7285-8469","authenticated-orcid":true,"given":"Menghang","family":"Xia","sequence":"additional","affiliation":[{"name":"Division of Preclinical Innovation, National Center for Advancing Translational Sciences, National Institutes of Health, 9800 Medical Center Drive, Rockville 20850, Maryland, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2025,3,6]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1016\/B978-0-12-823292-7.00018-8","volume-title":"Handbook on the Toxicology of Metals","author":"Bose-O\u2019Reilly S.","year":"2022","edition":"5"},{"key":"ref2\/cit2","unstructured":"EPA, U. Superfund: CERCLA Overview. https:\/\/www.epa.gov\/superfund\/superfund-cercla-overview (accessed Feb 18, 2025)."},{"key":"ref3\/cit3","doi-asserted-by":"publisher","DOI":"10.1080\/2330443X.2017.1408439"},{"key":"ref4\/cit4","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2021.643972"},{"key":"ref5\/cit5","doi-asserted-by":"publisher","DOI":"10.3390\/molecules26196060"},{"key":"ref6\/cit6","doi-asserted-by":"publisher","DOI":"10.15430\/JCP.2015.20.4.232"},{"key":"ref7\/cit7","unstructured":"DHHS U.S. Department of Health and\nHuman Services. 15th Report\non Carcinogens. https:\/\/ntp.niehs.nih.gov\/whatwestudy\/assessments\/cancer\/roc (accessed Feb 18, 2025)."},{"key":"ref8\/cit8","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-7643-8340-4_6"},{"key":"ref9\/cit9","doi-asserted-by":"publisher","DOI":"10.3390\/ijms161226183"},{"key":"ref10\/cit10","doi-asserted-by":"publisher","DOI":"10.1089\/15230860152542970"},{"key":"ref11\/cit11","doi-asserted-by":"publisher","DOI":"10.3390\/app12063210"},{"key":"ref12\/cit12","doi-asserted-by":"publisher","DOI":"10.1021\/cr300015c"},{"key":"ref13\/cit13","doi-asserted-by":"publisher","DOI":"10.1155\/2011\/431287"},{"key":"ref14\/cit14","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph120605905"},{"key":"ref15\/cit15","unstructured":"EPA List 10 - Contaminants at CERCLIS Sites. https:\/\/www.epa.gov\/superfund\/list-10-contaminants-cerclis-sites (accessed Feb 18, 2025)."},{"key":"ref16\/cit16","doi-asserted-by":"publisher","DOI":"10.3390\/toxics6040065"},{"key":"ref17\/cit17","doi-asserted-by":"publisher","DOI":"10.1016\/j.envint.2020.106206"},{"key":"ref18\/cit18","volume-title":"High-Throughput Screening Assays in Toxicology","volume":"1473","author":"Huang R.","year":"2016","edition":"1"},{"key":"ref19\/cit19","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-0716-2213-1_13"},{"key":"ref20\/cit20","doi-asserted-by":"publisher","DOI":"10.2174\/1875397301004010057"},{"key":"ref21\/cit21","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph18126644"},{"key":"ref22\/cit22","doi-asserted-by":"publisher","DOI":"10.1046\/j.1432-1327.2000.01595.x"},{"key":"ref23\/cit23","doi-asserted-by":"publisher","DOI":"10.1007\/s00204-022-03291-5"},{"key":"ref24\/cit24","doi-asserted-by":"publisher","DOI":"10.1016\/j.crtox.2022.100102"},{"key":"ref25\/cit25","doi-asserted-by":"publisher","DOI":"10.1177\/2472630317729792"},{"key":"ref26\/cit26","doi-asserted-by":"publisher","DOI":"10.1016\/j.semcancer.2021.05.009"},{"key":"ref27\/cit27","doi-asserted-by":"publisher","DOI":"10.1007\/s10646-022-02543-5"},{"key":"ref28\/cit28","doi-asserted-by":"publisher","DOI":"10.1080\/17435390.2016.1241908"},{"key":"ref29\/cit29","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0082363"},{"key":"ref30\/cit30","doi-asserted-by":"publisher","DOI":"10.1016\/j.jocn.2019.02.019"},{"key":"ref31\/cit31","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.16572"},{"key":"ref32\/cit32","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22115421"},{"key":"ref33\/cit33","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-021-00658-5"},{"key":"ref34\/cit34","doi-asserted-by":"publisher","DOI":"10.1021\/pr060665l"},{"key":"ref35\/cit35","doi-asserted-by":"publisher","DOI":"10.3390\/ijms232314574"},{"key":"ref36\/cit36","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/7432797"},{"key":"ref37\/cit37","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-pharmtox-112122-104310"},{"key":"ref38\/cit38","doi-asserted-by":"publisher","DOI":"10.1289\/ehp.0800168"},{"key":"ref39\/cit39","doi-asserted-by":"publisher","DOI":"10.3390\/toxics9030042"},{"key":"ref40\/cit40","unstructured":"CDC National Health and Nutrition Examination\nSurvey https:\/\/www.cdc.gov\/nchs\/nhanes\/?CDC_AAref_Val=https:\/\/www.cdc.gov\/nchs\/nhanes\/index.htm (accessed Feb 18, 2025)."},{"key":"ref41\/cit41","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph17124558"},{"key":"ref42\/cit42","doi-asserted-by":"publisher","DOI":"10.1016\/S0039-9140(01)00645-2"},{"key":"ref43\/cit43","doi-asserted-by":"publisher","DOI":"10.1289\/ehp.1509912"}],"container-title":["Environmental Science &amp; Technology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acs.est.4c07995","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acs.est.4c07995","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,18]],"date-time":"2025-03-18T04:38:25Z","timestamp":1742272705000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/acs.est.4c07995"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3,6]]},"references-count":43,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2025,3,18]]}},"alternative-id":["10.1021\/acs.est.4c07995"],"URL":"https:\/\/doi.org\/10.1021\/acs.est.4c07995","relation":{},"ISSN":["0013-936X","1520-5851"],"issn-type":[{"value":"0013-936X","type":"print"},{"value":"1520-5851","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,3,6]]}}}