{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T16:57:10Z","timestamp":1787504230781,"version":"build-2736575974"},"reference-count":83,"publisher":"American Chemical Society (ACS)","issue":"5","license":[{"start":{"date-parts":[[2025,1,28]],"date-time":"2025-01-28T00:00:00Z","timestamp":1738022400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100008638","name":"Environment and Climate Change Canada","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008638","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000041","name":"Fisheries and Oceans Canada","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000041","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100013217","name":"Fisheries Joint Management Committee","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100013217","id-type":"DOI","asserted-by":"publisher"}]},{"name":"The Whale Initiative Programs of Fisheries and Oceans Canada","award":["96196"],"award-info":[{"award-number":["96196"]}]},{"name":"National Contaminants Advisory Group"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Environ. Sci. Technol."],"published-print":{"date-parts":[[2025,2,11]]},"DOI":"10.1021\/acs.est.4c08272","type":"journal-article","created":{"date-parts":[[2025,1,28]],"date-time":"2025-01-28T16:13:19Z","timestamp":1738080799000},"page":"2389-2399","source":"Crossref","is-referenced-by-count":6,"title":["Contaminant-Associated Disruption of the Skin Transcriptome in the Endangered St. Lawrence Estuary Beluga"],"prefix":"10.1021","volume":"59","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2747-3030","authenticated-orcid":true,"given":"Antoine \u00c9.","family":"Simond","sequence":"first","affiliation":[{"name":"Fisheries and Oceans Canada, Pacific Science Enterprise Center, 4160 Marine Drive, West Vancouver, British Columbia V7V 1N6, Canada"},{"name":"Department of Biological Sciences, Simon Fraser University, 8888 University Drive, Burnaby, British Columbia V5A 1S6, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V\u00e9ronique","family":"Lesage","sequence":"additional","affiliation":[{"name":"Institut Maurice Lamontagne","place":["Mont-Joli, Canada"]},{"name":"Fisheries and Oceans Canada","place":["Mont-Joli, Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan","family":"Verreault","sequence":"additional","affiliation":[{"name":"Centre de recherche en toxicologie de l\u2019environnement (TOXEN), D\u00e9partement des sciences biologiques","place":["Montreal, Canada"]},{"name":"Universit\u00e9 du Qu\u00e9bec \u00e0 Montr\u00e9al","place":["Montreal, Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa","family":"Loseto","sequence":"additional","affiliation":[{"name":"Freshwater Institute, Fisheries and Oceans Canada, 501 University Crescent, Winnipeg, Manitoba R3T 2N6, Canada"},{"name":"Centre for Earth Observation Science, University of Manitoba, 535 Wallace Building, 125 Dysart Road, Winnipeg, Manitoba R3T 2N2, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5013-6529","authenticated-orcid":true,"given":"Magali","family":"Houde","sequence":"additional","affiliation":[{"name":"Environment and Climate Change Canada, Centre Saint-Laurent, 105 McGill Street, Montreal, Quebec H2Y 2E7, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashley","family":"Elliott","sequence":"additional","affiliation":[{"name":"Freshwater Institute, Fisheries and Oceans Canada, 501 University Crescent, Winnipeg, Manitoba R3T 2N6, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie","family":"No\u00ebl","sequence":"additional","affiliation":[{"name":"Freshwater Institute, Fisheries and Oceans Canada, 501 University Crescent, Winnipeg, Manitoba R3T 2N6, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4604-1847","authenticated-orcid":true,"given":"Tanya M.","family":"Brown","sequence":"additional","affiliation":[{"name":"Fisheries and Oceans Canada, Pacific Science Enterprise Center, 4160 Marine Drive, West Vancouver, British Columbia V7V 1N6, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2025,1,28]]},"reference":[{"key":"ref1\/cit1","unstructured":"COSEWIC Assessment and Status\nReport on the Beluga Whale Delphinapterus\nleucas, St. Lawrence Estuary Population, in Canada\n                      , report\nNo. CW69-14\/703-2015E-PDF); COSEWIC: Ottawa, 2014, xii +\n64 pp. https:\/\/ecprccsarstacct.z9.web.core.windows.net\/files\/SARAFiles\/legacy\/cosewic\/sr_Beluga%20Whale_2014_e.pdf (accessed 2019-11-04)."},{"key":"ref2\/cit2","unstructured":"An Update of Beluga (Delphinaterus\nleucas) Abundance and Reported\nDeaths in the St. Lawrence River Estuary\n                      ; Science Advisory\nReport 2017\/015. DFO Canadian Science Advisory Secretariat, Mont-Joli. DFO, 2017; 10 pp. https:\/\/publications.gc.ca\/collections\/collection_2017\/mpo-dfo\/Fs70-6-2017-015-eng.pdf (accessed 2018-03-21)."},{"key":"ref3\/cit3","doi-asserted-by":"publisher","DOI":"10.1016\/j.scitotenv.2014.03.097"},{"key":"ref4\/cit4","doi-asserted-by":"publisher","DOI":"10.1016\/j.scitotenv.2023.161488"},{"key":"ref5\/cit5","doi-asserted-by":"publisher","DOI":"10.1016\/j.envres.2017.03.058"},{"key":"ref6\/cit6","doi-asserted-by":"publisher","DOI":"10.1016\/j.scitotenv.2020.137204"},{"key":"ref7\/cit7","doi-asserted-by":"publisher","DOI":"10.1016\/j.marpolbul.2019.05.029"},{"key":"ref8\/cit8","doi-asserted-by":"publisher","DOI":"10.33265\/polar.v40.5523"},{"key":"ref9\/cit9","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-374928-4.10014-8"},{"key":"ref10\/cit10","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2605.2008.00869.x"},{"key":"ref11\/cit11","doi-asserted-by":"publisher","DOI":"10.1139\/a11-010"},{"key":"ref12\/cit12","doi-asserted-by":"publisher","DOI":"10.1007\/s00244-020-00716-z"},{"key":"ref13\/cit13","doi-asserted-by":"publisher","DOI":"10.1016\/j.etap.2015.06.009"},{"issue":"7","key":"ref14\/cit14","first-page":"4623","volume":"26","author":"Okoro H. K.","year":"2017","journal-title":"Fresenius Environ. Bull."},{"key":"ref15\/cit15","doi-asserted-by":"publisher","DOI":"10.1016\/j.envres.2018.10.001"},{"key":"ref16\/cit16","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-804327-1.00202-8"},{"key":"ref17\/cit17","doi-asserted-by":"publisher","DOI":"10.1016\/j.envint.2024.108647"},{"key":"ref18\/cit18","doi-asserted-by":"publisher","DOI":"10.1016\/j.aquatox.2017.02.004"},{"key":"ref19\/cit19","doi-asserted-by":"publisher","DOI":"10.1016\/j.marenvres.2016.01.002"},{"key":"ref20\/cit20","doi-asserted-by":"publisher","DOI":"10.1016\/j.margen.2017.08.002"},{"key":"ref21\/cit21","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0130934"},{"key":"ref22\/cit22","doi-asserted-by":"publisher","DOI":"10.1021\/acs.est.8b06487"},{"key":"ref23\/cit23","doi-asserted-by":"publisher","DOI":"10.1021\/es5032294"},{"key":"ref24\/cit24","doi-asserted-by":"publisher","DOI":"10.1007\/s00244-016-0362-9"},{"key":"ref25\/cit25","doi-asserted-by":"publisher","DOI":"10.1021\/es403217r"},{"key":"ref26\/cit26","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-812144-3.00009-7"},{"key":"ref27\/cit27","doi-asserted-by":"publisher","DOI":"10.3389\/fmars.2022.818370"},{"key":"ref28\/cit28","doi-asserted-by":"publisher","DOI":"10.14430\/arctic687"},{"key":"ref29\/cit29","unstructured":"Method 1668C - Chlorinated\nBiphenyl Congeners in Water, Soil, Sediment,\nBiosolids, and Tissue by HRGC\/HRMS\n                      (Report No. EPA-820-R-10-005). Environmental Protection Agency: Washington, DC, 2010. viii + 110 pp. https:\/\/www.epa.gov\/sites\/default\/files\/2015-09\/documents\/method_1668c_2010.pdf (accessed 2019-07-09)."},{"key":"ref30\/cit30","doi-asserted-by":"publisher","DOI":"10.1093\/gigascience\/giz037"},{"key":"ref31\/cit31","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btu170"},{"key":"ref32\/cit32","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/bts635"},{"key":"ref33\/cit33","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btu638"},{"key":"ref34\/cit34","volume-title":"R: A Language and Environment for Statistical Computing","author":"R Core Team","year":"2024"},{"key":"ref35\/cit35","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkv007"},{"key":"ref36\/cit36","doi-asserted-by":"publisher","DOI":"10.18129\/B9.bioc.omicRexposome"},{"key":"ref37\/cit37","doi-asserted-by":"publisher","DOI":"10.1186\/s12859-016-1455-1"},{"key":"ref38\/cit38","doi-asserted-by":"publisher","unstructured":"Hernandez-Ferrer, C.; Gonzalez, J. R.; Escrib\u00e0-Montagut, X. rexposome: exposome exploration and outcome data analysis. R package version 1.22.0. 10.18129\/B9.bioc.rexposome.","DOI":"10.18129\/B9.bioc.rexposome"},{"key":"ref39\/cit39","doi-asserted-by":"publisher","DOI":"10.1111\/j.2517-6161.1995.tb02031.x"},{"key":"ref40\/cit40","doi-asserted-by":"publisher","DOI":"10.1007\/s00227-018-3439-3"},{"key":"ref41\/cit41","doi-asserted-by":"publisher","DOI":"10.1016\/j.aquatox.2013.08.004"},{"key":"ref42\/cit42","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbpc.2010.05.006"},{"key":"ref43\/cit43","doi-asserted-by":"publisher","DOI":"10.1021\/es201541j"},{"key":"ref44\/cit44","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0146021"},{"key":"ref45\/cit45","doi-asserted-by":"publisher","DOI":"10.1186\/s13040-019-0204-1"},{"issue":"2","key":"ref46\/cit46","first-page":"108","volume":"9","author":"Hu Z.-L.","year":"2008","journal-title":"Online Journal of Bioinformatics"},{"key":"ref47\/cit47","doi-asserted-by":"publisher","DOI":"10.1021\/acs.est.9b06607"},{"key":"ref48\/cit48","doi-asserted-by":"publisher","DOI":"10.47536\/jcrm.v6i2.781"},{"key":"ref49\/cit49","doi-asserted-by":"publisher","DOI":"10.1016\/j.scitotenv.2017.05.193"},{"key":"ref50\/cit50","doi-asserted-by":"publisher","DOI":"10.1016\/j.scitotenv.2013.06.017"},{"key":"ref51\/cit51","doi-asserted-by":"publisher","DOI":"10.1038\/npre.2007.638.1"},{"key":"ref52\/cit52","doi-asserted-by":"publisher","DOI":"10.1038\/nrm1619"},{"key":"ref53\/cit53","doi-asserted-by":"publisher","DOI":"10.4155\/tde.12.118"},{"key":"ref54\/cit54","doi-asserted-by":"publisher","DOI":"10.1177\/2041731414557112"},{"key":"ref55\/cit55","doi-asserted-by":"publisher","DOI":"10.1016\/B978-012088562-6\/50005-4"},{"key":"ref56\/cit56","doi-asserted-by":"publisher","DOI":"10.1029\/2020GL090844"},{"key":"ref57\/cit57","doi-asserted-by":"publisher","DOI":"10.3390\/antiox11061121"},{"key":"ref58\/cit58","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24043755"},{"key":"ref59\/cit59","doi-asserted-by":"publisher","DOI":"10.1139\/z90-051"},{"key":"ref60\/cit60","unstructured":"Keith, A. Molecular responses to catastrophic molting in a wild marine mammal. Master\u2019s thesis, University of the Pacific, 2021. https:\/\/scholarlycommons.pacific.edu\/uop_etds\/3745 (accessed 2023-01-09)."},{"key":"ref61\/cit61","doi-asserted-by":"publisher","DOI":"10.1038\/s41577-022-00792-3"},{"key":"ref62\/cit62","doi-asserted-by":"publisher","DOI":"10.1016\/j.semcdb.2014.03.005"},{"key":"ref63\/cit63","unstructured":"NCBI. Gene [Internet]. Bethesda (MD): National Library\nof Medicine (US), National Center for Biotechnology Information. https:\/\/www.ncbi.nlm.nih.gov\/gene\/ (accessed 2024-01-03)."},{"key":"ref64\/cit64","doi-asserted-by":"publisher","DOI":"10.1016\/j.semcdb.2017.05.018"},{"key":"ref65\/cit65","doi-asserted-by":"publisher","DOI":"10.1177\/1535370219828694"},{"key":"ref66\/cit66","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.802346"},{"key":"ref67\/cit67","doi-asserted-by":"publisher","DOI":"10.1016\/j.envint.2015.10.007"},{"key":"ref68\/cit68","doi-asserted-by":"publisher","DOI":"10.1201\/9780203165577.ch14"},{"key":"ref69\/cit69","doi-asserted-by":"publisher","DOI":"10.1006\/enrs.1998.3942"},{"key":"ref70\/cit70","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0176299"},{"key":"ref71\/cit71","doi-asserted-by":"publisher","DOI":"10.1177\/0300985815604726"},{"key":"ref72\/cit72","doi-asserted-by":"publisher","DOI":"10.3390\/cells9020352"},{"key":"ref73\/cit73","doi-asserted-by":"publisher","DOI":"10.1038\/ijo.2008.207"},{"key":"ref74\/cit74","doi-asserted-by":"publisher","DOI":"10.1016\/j.aquatox.2013.11.015"},{"key":"ref75\/cit75","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-16820-5"},{"key":"ref76\/cit76","doi-asserted-by":"publisher","DOI":"10.1021\/acs.est.6b03020"},{"key":"ref77\/cit77","doi-asserted-by":"publisher","DOI":"10.1089\/15209150260007381"},{"key":"ref78\/cit78","doi-asserted-by":"publisher","DOI":"10.4103\/2231-4040.90879"},{"key":"ref79\/cit79","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-540-89656-2_21"},{"key":"ref80\/cit80","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbalip.2007.02.004"},{"key":"ref81\/cit81","doi-asserted-by":"publisher","DOI":"10.1016\/j.aquatox.2006.12.017"},{"key":"ref82\/cit82","doi-asserted-by":"publisher","DOI":"10.1002\/ieam.104"},{"key":"ref83\/cit83","doi-asserted-by":"publisher","DOI":"10.1111\/eva.13195"}],"container-title":["Environmental Science & Technology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acs.est.4c08272","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acs.est.4c08272","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,11]],"date-time":"2025-02-11T04:29:20Z","timestamp":1739248160000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/acs.est.4c08272"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1,28]]},"references-count":83,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2025,2,11]]}},"alternative-id":["10.1021\/acs.est.4c08272"],"URL":"https:\/\/doi.org\/10.1021\/acs.est.4c08272","relation":{},"ISSN":["0013-936X","1520-5851"],"issn-type":[{"value":"0013-936X","type":"print"},{"value":"1520-5851","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1,28]]}}}