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Red blood cells (RBCs), or erythrocytes, are the predominant cell type in peripheral blood and are crucial for the maintenance of physiological health. This investigation employed oral gavage to examine the effects of TCEP exposure on erythrocyte counts in mice and to clarify the underlying mechanisms. The results demonstrated a marked increase in circulating RBC counts post-TCEP exposure, concomitantly heightening the risk of polycythemia vera (PV). TCEP exposure stimulated erythropoiesis across all stages of medullary development, including the differentiation of hematopoietic stem cells into erythroid progenitors, the progression of erythrocyte development, and the maturation of erythrocyte. Moreover, TCEP potentiated extramedullary erythropoiesis in the spleen and liver. Subsequent bioinformatics analysis implied that TCEP-induced erythropoiesis was attributed to p53 downregulation. Thus, these findings indicate that TCEP disrupts erythrocyte-mediated hematological homeostasis through the enhancement of both medullary and extramedullary erythropoiesis, leading to the alteration of hematological equilibrium.<\/jats:p>","DOI":"10.1021\/acs.est.4c09436","type":"journal-article","created":{"date-parts":[[2025,1,2]],"date-time":"2025-01-02T01:52:31Z","timestamp":1735782751000},"page":"199-211","source":"Crossref","is-referenced-by-count":4,"title":["Tris(2-chloroethyl)\nPhosphate Leads to Unbalanced\nCirculating Erythrocyte in Mice by Activating both Medullary and Extramedullary\nErythropoiesis"],"prefix":"10.1021","volume":"59","author":[{"given":"Jingxu","family":"Zhang","sequence":"first","affiliation":[{"name":"Qingdao University , , ,","place":["Qingdao, China, 266071"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Liu","sequence":"additional","affiliation":[{"name":"Qingdao University , , ,","place":["Qingdao, China, 266071"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Ding","sequence":"additional","affiliation":[{"name":"Qingdao University , , ,","place":["Qingdao, China, 266071"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongyan","family":"Yu","sequence":"additional","affiliation":[{"name":"Qingdao University , , ,","place":["Qingdao, China, 266071"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziyuan","family":"Li","sequence":"additional","affiliation":[{"name":"Qingdao University , , ,","place":["Qingdao, China, 266071"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yidi","family":"Chen","sequence":"additional","affiliation":[{"name":"Qingdao University , , ,","place":["Qingdao, China, 266071"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0307-3531","authenticated-orcid":true,"given":"Yongfeng","family":"Lin","sequence":"additional","affiliation":[{"name":"Qingdao University , , ,","place":["Qingdao, China, 266071"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong","family":"Niu","sequence":"additional","affiliation":[{"name":"National Institute for Occupational Health and Poison Control, Chinese Center for Disease Control and Prevention , , ,","place":["Beijing, China, 100050"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Lu","sequence":"additional","affiliation":[{"name":"Qingdao University , , ,","place":["Qingdao, China, 266071"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6526-8046","authenticated-orcid":true,"given":"Xiaoting","family":"Jin","sequence":"additional","affiliation":[{"name":"Qingdao University , , ,","place":["Qingdao, China, 266071"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuxin","family":"Zheng","sequence":"additional","affiliation":[{"name":"Qingdao University , , ,","place":["Qingdao, China, 266071"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2025,1,2]]},"reference":[{"issue":"6","key":"2026081212022588200_cit1","doi-asserted-by":"publisher","DOI":"10.3390\/toxics12060391","article-title":"Global Trends and Hotspots in Research on the Health\nRisks of Organophosphate Flame Retardants: A Bibliometric and Visual\nAnalysis","volume":"12","author":"Du","year":"2024","journal-title":"Toxics"},{"issue":"1","key":"2026081212022588200_cit2","doi-asserted-by":"publisher","first-page":"31","DOI":"10.3390\/jox14010003","article-title":"An Initial Survey\non Occurrence,\nFate, and Environmental Risk Assessment of Organophosphate Flame Retardants\nin Romanian Waterways","volume":"14","author":"Paun","year":"2024","journal-title":"J. Xenobiot."},{"key":"2026081212022588200_cit3","doi-asserted-by":"publisher","DOI":"10.1016\/j.envint.2020.105741","article-title":"Halogenated\nand organophosphorous flame retardants in surface soils from an e-waste\ndismantling park and its surrounding area: Distributions, sources,\nand human health risks","volume":"139","author":"Ge","year":"2020","journal-title":"Environ. Int."},{"issue":"3","key":"2026081212022588200_cit4","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1021\/envhealth.3c00059","article-title":"Organophosphate\nEsters in Air and Seawater of the South China Sea:\nSpatial Distribution, Transport, and Air-Sea Exchange","volume":"1","author":"Mi","year":"2023","journal-title":"Environ. 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Endocrinol."},{"issue":"9","key":"2026081212022588200_cit37","doi-asserted-by":"publisher","first-page":"1187","DOI":"10.1038\/sj.onc.1201638","article-title":"Nuclear\nfactor - kappaB-dependent regulation of p53 gene expression induced\nby daunomycin genotoxic drug","volume":"16","author":"Hellin","year":"1998","journal-title":"Oncogene"},{"issue":"7","key":"2026081212022588200_cit38","doi-asserted-by":"publisher","first-page":"490","DOI":"10.1080\/15376516.2020.1765060","article-title":"Neurotoxicity and related mechanisms of flame retardant\nTCEP exposure in mice","volume":"30","author":"Wang","year":"2020","journal-title":"Toxicol. Mech. 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Toxicol.\nPharmacol."},{"issue":"2","key":"2026081212022588200_cit41","doi-asserted-by":"publisher","first-page":"27","DOI":"10.4103\/0976-0105.177703","article-title":"A simple practice guide for dose\nconversion between animals and human","volume":"7","author":"Nair","year":"2016","journal-title":"J. Basic\nClin. Pharm."},{"key":"2026081212022588200_cit42","doi-asserted-by":"publisher","DOI":"10.1016\/j.envint.2019.105321","article-title":"Estimating renal and\nhepatic clearance rates of organophosphate esters\nin humans: Impacts of intrinsic metabolism and binding affinity with\nplasma proteins","volume":"134","author":"Wang","year":"2020","journal-title":"Environ. Int."},{"key":"2026081212022588200_cit43","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1146\/annurev-chembioeng-011720-103410","article-title":"How Do Cells Adapt?\nStories Told in Landscapes","volume":"11","author":"Agozzino","year":"2020","journal-title":"Annu. Rev. Chem.\nBiomol. 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