{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T20:48:45Z","timestamp":1786999725472,"version":"build-2736575974"},"reference-count":69,"publisher":"American Chemical Society (ACS)","issue":"26","license":[{"start":{"date-parts":[[2025,6,26]],"date-time":"2025-06-26T00:00:00Z","timestamp":1750896000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,6,26]],"date-time":"2025-06-26T00:00:00Z","timestamp":1750896000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,6,26]],"date-time":"2025-06-26T00:00:00Z","timestamp":1750896000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/100017055","name":"National Natural Science Foundation of China-Shandong Joint Fund","doi-asserted-by":"publisher","award":["U2006214"],"award-info":[{"award-number":["U2006214"]}],"id":[{"id":"10.13039\/100017055","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["42177207"],"award-info":[{"award-number":["42177207"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Environ. Sci. Technol."],"published-print":{"date-parts":[[2025,7,8]]},"DOI":"10.1021\/acs.est.4c12932","type":"journal-article","created":{"date-parts":[[2025,6,26]],"date-time":"2025-06-26T09:46:55Z","timestamp":1750931215000},"page":"13131-13142","source":"Crossref","is-referenced-by-count":8,"title":["Enhanced Ecological Risk of PFOA Degradation Products: Insights from Concentration-Dependent Transcriptomics, Adverse Outcome Pathways, and Biomarker Verification"],"prefix":"10.1021","volume":"59","author":[{"given":"Mingyang","family":"Li","sequence":"first","affiliation":[{"name":"Environment Research Institute","place":["Qingdao, China"]},{"name":"Shandong University","place":["Qingdao, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao","family":"Gou","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Pollution Control & Resource Reuse, School of the Environment","place":["Nanjing, China"]},{"name":"Nanjing University","place":["Nanjing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chao","family":"Zhang","sequence":"additional","affiliation":[{"name":"Environment Research Institute","place":["Qingdao, China"]},{"name":"Shandong University","place":["Qingdao, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8974-9963","authenticated-orcid":true,"given":"Xiaowei","family":"Zhang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Pollution Control & Resource Reuse, School of the Environment","place":["Nanjing, China"]},{"name":"Nanjing University","place":["Nanjing, China"]},{"name":"School of Ecology and Environmental Science","place":["Kunming, China"]},{"name":"Yunnan University & Yunnan Key Laboratory for Plateau Mountain Ecology and Restoration of Degraded Environments","place":["Kunming, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9933-5625","authenticated-orcid":true,"given":"Wei","family":"Jiang","sequence":"additional","affiliation":[{"name":"Environment Research Institute","place":["Qingdao, China"]},{"name":"Shandong University","place":["Qingdao, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2025,6,26]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"publisher","DOI":"10.1126\/science.abg9065"},{"key":"ref2\/cit2","doi-asserted-by":"publisher","DOI":"10.1016\/j.envint.2014.04.013"},{"key":"ref3\/cit3","doi-asserted-by":"publisher","DOI":"10.1021\/acs.est.4c03985"},{"key":"ref4\/cit4","doi-asserted-by":"publisher","DOI":"10.1021\/acs.est.7b06128"},{"key":"ref5\/cit5","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2022.113515"},{"key":"ref6\/cit6","doi-asserted-by":"publisher","DOI":"10.1016\/j.envpol.2024.123721"},{"key":"ref7\/cit7","doi-asserted-by":"publisher","DOI":"10.1016\/j.envres.2024.120082"},{"key":"ref8\/cit8","doi-asserted-by":"publisher","DOI":"10.1021\/acs.est.3c05109"},{"key":"ref9\/cit9","doi-asserted-by":"publisher","DOI":"10.1007\/s40572-024-00441-y"},{"key":"ref10\/cit10","doi-asserted-by":"publisher","DOI":"10.1021\/acs.est.2c09716"},{"key":"ref11\/cit11","doi-asserted-by":"publisher","DOI":"10.1021\/acs.est.3c05023"},{"key":"ref12\/cit12","doi-asserted-by":"publisher","DOI":"10.1021\/acs.est.4c06017"},{"key":"ref13\/cit13","doi-asserted-by":"publisher","DOI":"10.1016\/j.envint.2024.108437"},{"key":"ref14\/cit14","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhepr.2022.100550"},{"key":"ref15\/cit15","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2023.104831"},{"key":"ref16\/cit16","unstructured":"US EPA,\nO. Final PFAS National Primary\nDrinking Water Regulation. https:\/\/www.epa.gov\/sdwa\/and-polyfluoroalkyl-substances-pfas. (accessed November 12, 2024)."},{"key":"ref17\/cit17","doi-asserted-by":"publisher","DOI":"10.1016\/j.watres.2020.116219"},{"key":"ref18\/cit18","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhazmat.2022.129580"},{"key":"ref19\/cit19","doi-asserted-by":"publisher","DOI":"10.1016\/j.coesh.2024.100565"},{"key":"ref20\/cit20","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhazmat.2024.136685"},{"key":"ref21\/cit21","doi-asserted-by":"publisher","DOI":"10.1016\/j.coche.2023.100943"},{"key":"ref22\/cit22","doi-asserted-by":"publisher","DOI":"10.1016\/j.cej.2023.147443"},{"key":"ref23\/cit23","doi-asserted-by":"publisher","DOI":"10.1016\/j.jece.2023.111422"},{"key":"ref24\/cit24","doi-asserted-by":"publisher","DOI":"10.1002\/jat.3418"},{"key":"ref25\/cit25","doi-asserted-by":"publisher","DOI":"10.1021\/acs.est.2c00381"},{"key":"ref26\/cit26","doi-asserted-by":"publisher","DOI":"10.1016\/j.jes.2019.08.016"},{"key":"ref27\/cit27","doi-asserted-by":"publisher","DOI":"10.1016\/j.scitotenv.2024.172000"},{"key":"ref28\/cit28","doi-asserted-by":"publisher","DOI":"10.1016\/j.taap.2022.115991"},{"key":"ref29\/cit29","doi-asserted-by":"publisher","DOI":"10.1016\/j.scitotenv.2022.153669"},{"key":"ref30\/cit30","doi-asserted-by":"publisher","DOI":"10.1016\/j.cej.2022.138352"},{"key":"ref31\/cit31","doi-asserted-by":"publisher","DOI":"10.1016\/j.envint.2020.106206"},{"key":"ref32\/cit32","doi-asserted-by":"publisher","DOI":"10.1021\/acs.est.7b02648"},{"key":"ref33\/cit33","doi-asserted-by":"publisher","DOI":"10.1021\/acs.est.3c03282"},{"key":"ref34\/cit34","doi-asserted-by":"publisher","DOI":"10.1021\/acs.est.9b04879"},{"key":"ref35\/cit35","doi-asserted-by":"publisher","DOI":"10.1021\/acs.est.0c08796"},{"key":"ref36\/cit36","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms6357"},{"key":"ref37\/cit37","doi-asserted-by":"publisher","DOI":"10.1007\/s11356-022-19616-x"},{"key":"ref38\/cit38","doi-asserted-by":"publisher","DOI":"10.1016\/j.jallcom.2022.163851"},{"key":"ref39\/cit39","doi-asserted-by":"publisher","DOI":"10.1038\/s41545-023-00286-2"},{"key":"ref40\/cit40","doi-asserted-by":"publisher","DOI":"10.1016\/j.seppur.2020.116637"},{"key":"ref41\/cit41","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhazmat.2020.123021"},{"key":"ref42\/cit42","doi-asserted-by":"publisher","DOI":"10.1021\/acs.est.3c03242"},{"key":"ref43\/cit43","doi-asserted-by":"publisher","DOI":"10.1021\/acs.est.7b04073"},{"key":"ref44\/cit44","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.59388"},{"key":"ref45\/cit45","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines12081639"},{"key":"ref46\/cit46","doi-asserted-by":"publisher","DOI":"10.1089\/aivt.2017.0017"},{"key":"ref47\/cit47","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-023-39448-8"},{"key":"ref48\/cit48","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhazmat.2024.135823"},{"key":"ref49\/cit49","doi-asserted-by":"publisher","DOI":"10.1016\/j.envpol.2018.09.042"},{"key":"ref50\/cit50","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhazmat.2023.131714"},{"key":"ref51\/cit51","unstructured":"Shoemaker, J. A.; Grimmett, P.; Boutin, B. Determination of Selected Perfluorinated Alkyl Acids in Drinking Water by Solid Phase Extraction and Liquid Chromatography\/Tandem Mass Spectrometry (LC\/MS\/MS). https:\/\/cfpub.epa.gov\/si\/si_public_record_report.cfm?Lab=NERL&dirEntryId=198984. (accessed July 08, 2024)."},{"key":"ref52\/cit52","doi-asserted-by":"publisher","DOI":"10.1021\/es802047v"},{"key":"ref53\/cit53","doi-asserted-by":"publisher","DOI":"10.1021\/acs.est.3c06178"},{"key":"ref54\/cit54","doi-asserted-by":"publisher","DOI":"10.1016\/j.envint.2019.105324"},{"key":"ref55\/cit55","doi-asserted-by":"publisher","DOI":"10.1021\/acs.est.1c07176"},{"key":"ref56\/cit56","doi-asserted-by":"publisher","DOI":"10.1016\/j.chemosphere.2023.137931"},{"key":"ref57\/cit57","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-065X.2012.01153.x"},{"key":"ref58\/cit58","doi-asserted-by":"publisher","DOI":"10.1080\/10408444.2021.1888073"},{"key":"ref59\/cit59","doi-asserted-by":"publisher","DOI":"10.1016\/j.taap.2022.115991"},{"key":"ref60\/cit60","doi-asserted-by":"publisher","DOI":"10.1007\/s00204-024-03814-2"},{"key":"ref61\/cit61","doi-asserted-by":"publisher","DOI":"10.1177\/2047487319848214"},{"key":"ref62\/cit62","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbi.2010.07.011"},{"key":"ref63\/cit63","first-page":"69","volume":"51","author":"Adamek E.","year":"2005","journal-title":"Ann. Acad. Med. Stetin."},{"key":"ref64\/cit64","doi-asserted-by":"crossref","DOI":"10.1007\/978-3-319-17512-6","volume-title":"Fluoride Toxicity in Animals","author":"Ranjan R.","year":"2015"},{"key":"ref65\/cit65","doi-asserted-by":"publisher","DOI":"10.1007\/s00204-020-02687-5"},{"key":"ref66\/cit66","doi-asserted-by":"publisher","DOI":"10.1016\/j.aquatox.2012.11.022"},{"key":"ref67\/cit67","doi-asserted-by":"publisher","DOI":"10.1038\/nchembio.2097"},{"key":"ref68\/cit68","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-024-07692-7"},{"key":"ref69\/cit69","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-05125-4"}],"container-title":["Environmental Science & Technology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acs.est.4c12932","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acs.est.4c12932","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,7,8]],"date-time":"2025-07-08T04:11:39Z","timestamp":1751947899000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/acs.est.4c12932"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6,26]]},"references-count":69,"journal-issue":{"issue":"26","published-print":{"date-parts":[[2025,7,8]]}},"alternative-id":["10.1021\/acs.est.4c12932"],"URL":"https:\/\/doi.org\/10.1021\/acs.est.4c12932","relation":{},"ISSN":["0013-936X","1520-5851"],"issn-type":[{"value":"0013-936X","type":"print"},{"value":"1520-5851","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,6,26]]}}}