{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T21:02:02Z","timestamp":1780434122135,"version":"3.54.1"},"reference-count":74,"publisher":"American Chemical Society (ACS)","issue":"27","license":[{"start":{"date-parts":[[2025,7,3]],"date-time":"2025-07-03T00:00:00Z","timestamp":1751500800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,7,3]],"date-time":"2025-07-03T00:00:00Z","timestamp":1751500800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,7,3]],"date-time":"2025-07-03T00:00:00Z","timestamp":1751500800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/501100002402","name":"Sun Yat-sen University","doi-asserted-by":"publisher","award":["51000-12240024, 51000-12255006"],"award-info":[{"award-number":["51000-12240024, 51000-12255006"]}],"id":[{"id":"10.13039\/501100002402","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Jinchuan Group companies","award":["JKZ, 2020-02"],"award-info":[{"award-number":["JKZ, 2020-02"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Environ. Sci. Technol."],"published-print":{"date-parts":[[2025,7,15]]},"DOI":"10.1021\/acs.est.5c00554","type":"journal-article","created":{"date-parts":[[2025,7,3]],"date-time":"2025-07-03T03:08:51Z","timestamp":1751512131000},"page":"13624-13637","source":"Crossref","is-referenced-by-count":2,"title":["The Potential Carcinogenicity of Long-Term Polymetallic Exposure on the Development of Primary Liver Cancer: Nested Case-Control Evidence from the Jinchang Cohort Study"],"prefix":"10.1021","volume":"59","author":[{"given":"Lizhen","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Medical Records","place":["Lanzhou, P. R. China"]},{"name":"The First Hospital of Lanzhou University","place":["Lanzhou, P. R. China"]},{"name":"Department of Epidemiology and Health Statistics, School of Public Health","place":["Lanzhou, P. R. China"]},{"name":"Lanzhou University","place":["Lanzhou, P. R. China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yana","family":"Bai","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Health Statistics, School of Public Health","place":["Lanzhou, P. R. China"]},{"name":"Lanzhou University","place":["Lanzhou, P. R. China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Cheng","sequence":"additional","affiliation":[{"name":"Gansu Provincial Center for Disease Control and Prevention","place":["Lanzhou, P. R. China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chun","family":"Yin","sequence":"additional","affiliation":[{"name":"Workers\u2019 Hospital of Jinchuan Group Co., Ltd.","place":["Jinchang, P. R. China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Occupational and Environmental Health, School of Public Health","place":["Lanzhou, P. R. China"]},{"name":"Lanzhou University","place":["Lanzhou, P. R. China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiangna","family":"Gao","sequence":"additional","affiliation":[{"name":"Gansu Provincial Center for Disease Control and Prevention","place":["Lanzhou, P. R. China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongbin","family":"Lu","sequence":"additional","affiliation":[{"name":"Center for Evidence-Based Medicine, School of Basic Medical Sciences","place":["Lanzhou, P. R. China"]},{"name":"Lanzhou University","place":["Lanzhou, P. R. China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhongge","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Health Statistics, School of Public Health","place":["Lanzhou, P. R. China"]},{"name":"Lanzhou University","place":["Lanzhou, P. R. China"]},{"name":"Department of Disease and Nosocomial Infection Control, Beijing Tsinghua Changgung Hospital, School of Clinical Medicine, Tsinghua Medicine","place":["Beijing, P. R. China"]},{"name":"Tsinghua University","place":["Beijing, P. R. China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Dou","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Health Statistics, School of Public Health","place":["Lanzhou, P. R. China"]},{"name":"Lanzhou University","place":["Lanzhou, P. R. China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junjun","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Science and Technology","place":["Lanzhou, P. R. China"]},{"name":"The First Hospital of Lanzhou University","place":["Lanzhou, P. R. China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yufeng","family":"Wang","sequence":"additional","affiliation":[{"name":"Workers\u2019 Hospital of Jinchuan Group Co., Ltd.","place":["Jinchang, P. R. China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xijiang","family":"Wu","sequence":"additional","affiliation":[{"name":"Workers\u2019 Hospital of Jinchuan Group Co., Ltd.","place":["Jinchang, P. R. China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Desheng","family":"Zhang","sequence":"additional","affiliation":[{"name":"Workers\u2019 Hospital of Jinchuan Group Co., Ltd.","place":["Jinchang, P. R. China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4694-4843","authenticated-orcid":true,"given":"Zhiyuan","family":"Cheng","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, School of Public Health","place":["Guangzhou, P. R. China"]},{"name":"Sun Yat-sen University","place":["Guangzhou, P. R. China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2025,7,3]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"publisher","DOI":"10.1017\/S0007114520001208"},{"key":"ref2\/cit2","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21834"},{"key":"ref3\/cit3","doi-asserted-by":"publisher","DOI":"10.1002\/hep.27406"},{"key":"ref4\/cit4","doi-asserted-by":"publisher","DOI":"10.1016\/j.jncc.2024.01.006"},{"key":"ref5\/cit5","doi-asserted-by":"publisher","DOI":"10.1002\/hep.31288"},{"key":"ref6\/cit6","doi-asserted-by":"publisher","DOI":"10.1016\/j.canep.2023.102362"},{"key":"ref7\/cit7","doi-asserted-by":"publisher","DOI":"10.1016\/j.scitotenv.2016.06.166"},{"key":"ref8\/cit8","doi-asserted-by":"publisher","DOI":"10.1016\/j.envint.2019.01.067"},{"key":"ref9\/cit9","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.26234"},{"key":"ref10\/cit10","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph17113782"},{"key":"ref11\/cit11","doi-asserted-by":"publisher","DOI":"10.1007\/s11356-016-6333-x"},{"key":"ref12\/cit12","doi-asserted-by":"publisher","DOI":"10.3390\/ijms18051039"},{"key":"ref13\/cit13","doi-asserted-by":"publisher","DOI":"10.1111\/apt.15880"},{"key":"ref14\/cit14","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinorgbio.2019.03.013"},{"key":"ref15\/cit15","doi-asserted-by":"publisher","DOI":"10.1007\/s10661-023-11399-z"},{"key":"ref16\/cit16","doi-asserted-by":"publisher","DOI":"10.1038\/s41568-021-00417-2"},{"key":"ref17\/cit17","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtemb.2023.127128"},{"key":"ref18\/cit18","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.nutr.17.1.37"},{"key":"ref19\/cit19","doi-asserted-by":"publisher","DOI":"10.2903\/sp.efsa.2015.EN-478"},{"key":"ref20\/cit20","doi-asserted-by":"publisher","DOI":"10.1007\/s12011-020-02240-6"},{"key":"ref21\/cit21","doi-asserted-by":"publisher","DOI":"10.1016\/j.scitotenv.2023.168678"},{"key":"ref22\/cit22","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20190257"},{"key":"ref23\/cit23","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/dyw223"},{"key":"ref24\/cit24","doi-asserted-by":"publisher","DOI":"10.1007\/s10654-022-00875-4"},{"key":"ref25\/cit25","doi-asserted-by":"publisher","DOI":"10.1093\/biostatistics\/kxu058"},{"key":"ref26\/cit26","doi-asserted-by":"publisher","DOI":"10.17849\/insm-47-01-31-39.1"},{"key":"ref27\/cit27","doi-asserted-by":"publisher","DOI":"10.48550\/arXiv.1706.06060"},{"key":"ref28\/cit28","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1201\/9780203738535-7","volume-title":"Statistical Models in S","author":"Hastie T. J.","year":"2017"},{"key":"ref29\/cit29","doi-asserted-by":"publisher","DOI":"10.1016\/j.envres.2021.110998"},{"key":"ref30\/cit30","doi-asserted-by":"publisher","DOI":"10.1016\/j.taap.2011.01.011"},{"key":"ref31\/cit31","doi-asserted-by":"publisher","DOI":"10.3892\/or.2012.1897"},{"key":"ref32\/cit32","doi-asserted-by":"publisher","DOI":"10.1111\/febs.16208"},{"key":"ref33\/cit33","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2025.1583275"},{"key":"ref34\/cit34","doi-asserted-by":"publisher","DOI":"10.2147\/OTT.S139262"},{"key":"ref35\/cit35","doi-asserted-by":"publisher","DOI":"10.1016\/j.scitotenv.2019.135135"},{"key":"ref36\/cit36","doi-asserted-by":"publisher","DOI":"10.1186\/1476-069X-10-50"},{"key":"ref37\/cit37","doi-asserted-by":"publisher","DOI":"10.1007\/s00128-013-0998-3"},{"key":"ref38\/cit38","doi-asserted-by":"publisher","DOI":"10.1016\/j.mrrev.2007.11.005"},{"key":"ref39\/cit39","doi-asserted-by":"publisher","DOI":"10.1080\/10408440701845401"},{"key":"ref40\/cit40","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2019.110748"},{"key":"ref41\/cit41","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxrep.2015.03.013"},{"key":"ref42\/cit42","doi-asserted-by":"publisher","DOI":"10.3390\/ijms18091877"},{"key":"ref43\/cit43","doi-asserted-by":"publisher","DOI":"10.1111\/jgh.12019"},{"key":"ref44\/cit44","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-18-0531"},{"key":"ref45\/cit45","doi-asserted-by":"publisher","DOI":"10.1002\/jat.3965"},{"key":"ref46\/cit46","doi-asserted-by":"publisher","DOI":"10.1002\/tox.20478"},{"key":"ref47\/cit47","doi-asserted-by":"publisher","DOI":"10.1002\/tox.20478"},{"key":"ref48\/cit48","doi-asserted-by":"publisher","DOI":"10.5604\/16652681.1184191"},{"key":"ref49\/cit49","doi-asserted-by":"publisher","DOI":"10.1016\/j.mrgentox.2011.12.009"},{"key":"ref50\/cit50","doi-asserted-by":"publisher","DOI":"10.1007\/s12011-022-03156-z"},{"key":"ref51\/cit51","doi-asserted-by":"publisher","DOI":"10.3390\/nu10121955"},{"key":"ref52\/cit52","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-4800(03)00097-2"},{"key":"ref53\/cit53","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtemb.2022.127061"},{"key":"ref54\/cit54","doi-asserted-by":"publisher","DOI":"10.17179\/excli2023-6335"},{"key":"ref55\/cit55","doi-asserted-by":"publisher","DOI":"10.1002\/jat.1263"},{"key":"ref56\/cit56","doi-asserted-by":"publisher","DOI":"10.1007\/s10552-013-0219-8"},{"key":"ref57\/cit57","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-021-89991-x"},{"key":"ref58\/cit58","doi-asserted-by":"publisher","DOI":"10.21037\/atm-21-4608"},{"key":"ref59\/cit59","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-14-0360"},{"key":"ref60\/cit60","doi-asserted-by":"publisher","DOI":"10.17795\/ijcp-5494"},{"key":"ref61\/cit61","doi-asserted-by":"publisher","DOI":"10.3892\/ijo.2019.4720"},{"key":"ref62\/cit62","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.can-20-1628"},{"key":"ref63\/cit63","doi-asserted-by":"publisher","DOI":"10.3390\/cancers12010164"},{"key":"ref64\/cit64","doi-asserted-by":"publisher","DOI":"10.3390\/nu15092221"},{"key":"ref65\/cit65","first-page":"1","volume-title":"Handbook on the Toxicology of Metals","author":"Yokel R. A.","year":"2022"},{"issue":"1","key":"ref66\/cit66","first-page":"1","volume":"7","author":"Gorgogietas V. A.","year":"2018","journal-title":"J. Mol. Biochem."},{"key":"ref67\/cit67","doi-asserted-by":"publisher","DOI":"10.21037\/tau-22-483"},{"key":"ref68\/cit68","doi-asserted-by":"publisher","DOI":"10.3390\/ijms232012213"},{"key":"ref69\/cit69","doi-asserted-by":"publisher","DOI":"10.2478\/intox-2019-0007"},{"key":"ref70\/cit70","doi-asserted-by":"publisher","DOI":"10.3390\/life13020537"},{"key":"ref71\/cit71","doi-asserted-by":"publisher","DOI":"10.1007\/s10517-020-05044-9"},{"key":"ref72\/cit72","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21031169"},{"key":"ref73\/cit73","doi-asserted-by":"publisher","DOI":"10.3390\/cancers15041095"},{"key":"ref74\/cit74","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2012.11.009"}],"container-title":["Environmental Science & Technology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acs.est.5c00554","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acs.est.5c00554","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,7,15]],"date-time":"2025-07-15T20:15:04Z","timestamp":1752610504000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/acs.est.5c00554"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7,3]]},"references-count":74,"journal-issue":{"issue":"27","published-print":{"date-parts":[[2025,7,15]]}},"alternative-id":["10.1021\/acs.est.5c00554"],"URL":"https:\/\/doi.org\/10.1021\/acs.est.5c00554","relation":{},"ISSN":["0013-936X","1520-5851"],"issn-type":[{"value":"0013-936X","type":"print"},{"value":"1520-5851","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,7,3]]}}}