{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T19:37:57Z","timestamp":1789760277161,"version":"4.0.1"},"reference-count":49,"publisher":"American Chemical Society (ACS)","issue":"50","license":[{"start":{"date-parts":[[2025,12,11]],"date-time":"2025-12-11T00:00:00Z","timestamp":1765411200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003196","name":"Ministero della Salute","doi-asserted-by":"publisher","award":["Ricerca Corrente to IRCCS MultiMedica"],"award-info":[{"award-number":["Ricerca Corrente to IRCCS MultiMedica"]}],"id":[{"id":"10.13039\/501100003196","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100021856","name":"Ministero dell'Universit\u00e0 e della Ricerca","doi-asserted-by":"publisher","award":["2020LM8WNW"],"award-info":[{"award-number":["2020LM8WNW"]}],"id":[{"id":"10.13039\/501100021856","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Environ. Sci. Technol."],"published-print":{"date-parts":[[2025,12,23]]},"DOI":"10.1021\/acs.est.5c04941","type":"journal-article","created":{"date-parts":[[2025,12,12]],"date-time":"2025-12-12T00:41:17Z","timestamp":1765500077000},"page":"27044-27056","source":"Crossref","is-referenced-by-count":4,"title":["Detection and Proinflammatory Effects of BTEX within the Human Atherosclerotic Plaque"],"prefix":"10.1021","volume":"59","author":[{"given":"Raffaele","family":"Marfella","sequence":"first","affiliation":[{"name":"Department of Advanced Medical and Surgical Sciences, University of Campania \u201cLuigi Vanvitelli\u201d, Piazza Luigi Miraglia, 2, Naples 80138, Italy"},{"name":"Pollution and Cardiovascular Diseases Research Center","place":["Naples, Italy"]},{"name":"University of Campania \u201cLuigi Vanvitelli\u201d","place":["Naples, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Carreras","sequence":"additional","affiliation":[{"name":"IRCCS MultiMedica, Via Fantoli 16\/15, Milan 20138, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2959-2658","authenticated-orcid":true,"given":"Francesco","family":"Prattichizzo","sequence":"additional","affiliation":[{"name":"IRCCS MultiMedica, Via Fantoli 16\/15, Milan 20138, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosalba","family":"La Grotta","sequence":"additional","affiliation":[{"name":"IRCCS MultiMedica, Via Fantoli 16\/15, Milan 20138, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valeria","family":"Pellegrini","sequence":"additional","affiliation":[{"name":"IRCCS MultiMedica, Via Fantoli 16\/15, Milan 20138, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Celestino","family":"Sardu","sequence":"additional","affiliation":[{"name":"Department of Advanced Medical and Surgical Sciences, University of Campania \u201cLuigi Vanvitelli\u201d, Piazza Luigi Miraglia, 2, Naples 80138, Italy"},{"name":"Pollution and Cardiovascular Diseases Research Center","place":["Naples, Italy"]},{"name":"University of Campania \u201cLuigi Vanvitelli\u201d","place":["Naples, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nunzia","family":"D\u2019Onofrio","sequence":"additional","affiliation":[{"name":"Pollution and Cardiovascular Diseases Research Center","place":["Naples, Italy"]},{"name":"University of Campania \u201cLuigi Vanvitelli\u201d","place":["Naples, Italy"]},{"name":"Department of Precision Medicine","place":["Naples, Italy"]},{"name":"University of Campania \u201cLuigi Vanvitelli\u201d","place":["Naples, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelangela","family":"Barbieri","sequence":"additional","affiliation":[{"name":"Department of Advanced Medical and Surgical Sciences, University of Campania \u201cLuigi Vanvitelli\u201d, Piazza Luigi Miraglia, 2, Naples 80138, Italy"},{"name":"Pollution and Cardiovascular Diseases Research Center","place":["Naples, Italy"]},{"name":"University of Campania \u201cLuigi Vanvitelli\u201d","place":["Naples, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maurizio","family":"Municin\u00f2","sequence":"additional","affiliation":[{"name":"Department of Forensic, Evaluative and Necroscopic Medicine","place":["Naples, Italy"]},{"name":"ASL Napoli 2 NORD","place":["Naples, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mario","family":"Siniscalchi","sequence":"additional","affiliation":[{"name":"Department of Cardiology","place":["Naples, Italy"]},{"name":"Hospital Cardarelli","place":["Naples, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabio","family":"Spinetti","sequence":"additional","affiliation":[{"name":"Department of Vascular Surgery","place":["Naples, Italy"]},{"name":"\u201cOspedale del Mare\u201d ASL Napoli 1","place":["Naples, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gennaro","family":"Vigliotti","sequence":"additional","affiliation":[{"name":"Department of Vascular Surgery","place":["Naples, Italy"]},{"name":"\u201cOspedale del Mare\u201d ASL Napoli 1","place":["Naples, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmine","family":"Vecchione","sequence":"additional","affiliation":[{"name":"Department of Medicine, Surgery and Dentistry","place":["Salerno, Italy"]},{"name":"University of Salerno","place":["Salerno, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Albino","family":"Carrizzo","sequence":"additional","affiliation":[{"name":"Department of Medicine, Surgery and Dentistry","place":["Salerno, Italy"]},{"name":"University of Salerno","place":["Salerno, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giulio","family":"Accarino","sequence":"additional","affiliation":[{"name":"Department of Medicine, Surgery and Dentistry","place":["Salerno, Italy"]},{"name":"University of Salerno","place":["Salerno, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Squillante","sequence":"additional","affiliation":[{"name":"Department of Medicine, Surgery and Dentistry","place":["Salerno, Italy"]},{"name":"University of Salerno","place":["Salerno, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1906-5109","authenticated-orcid":true,"given":"Giuseppe","family":"Spaziano","sequence":"additional","affiliation":[{"name":"Pollution and Cardiovascular Diseases Research Center","place":["Naples, Italy"]},{"name":"University of Campania \u201cLuigi Vanvitelli\u201d","place":["Naples, Italy"]},{"name":"Department of Environmental, Biological and Pharmaceutical Sciences and Technologies","place":["Caserta, Italy"]},{"name":"University of Campania \u201cLuigi Vanvitelli\u201d","place":["Caserta, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Davida","family":"Mirra","sequence":"additional","affiliation":[{"name":"Pollution and Cardiovascular Diseases Research Center","place":["Naples, Italy"]},{"name":"University of Campania \u201cLuigi Vanvitelli\u201d","place":["Naples, Italy"]},{"name":"Department of Environmental, Biological and Pharmaceutical Sciences and Technologies","place":["Caserta, Italy"]},{"name":"University of Campania \u201cLuigi Vanvitelli\u201d","place":["Caserta, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renata","family":"Esposito","sequence":"additional","affiliation":[{"name":"Pollution and Cardiovascular Diseases Research Center","place":["Naples, Italy"]},{"name":"University of Campania \u201cLuigi Vanvitelli\u201d","place":["Naples, Italy"]},{"name":"Department of Environmental, Biological and Pharmaceutical Sciences and Technologies","place":["Caserta, Italy"]},{"name":"University of Campania \u201cLuigi Vanvitelli\u201d","place":["Caserta, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4679-7970","authenticated-orcid":true,"given":"Angelo","family":"Fenti","sequence":"additional","affiliation":[{"name":"Pollution and Cardiovascular Diseases Research Center","place":["Naples, Italy"]},{"name":"University of Campania \u201cLuigi Vanvitelli\u201d","place":["Naples, Italy"]},{"name":"Department of Engineering","place":["Aversa, Italy"]},{"name":"University of Campania \u201cLuigi Vanvitelli\u201d","place":["Aversa, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simona","family":"Galoppo","sequence":"additional","affiliation":[{"name":"Pollution and Cardiovascular Diseases Research Center","place":["Naples, Italy"]},{"name":"University of Campania \u201cLuigi Vanvitelli\u201d","place":["Naples, Italy"]},{"name":"Department of Engineering","place":["Aversa, Italy"]},{"name":"University of Campania \u201cLuigi Vanvitelli\u201d","place":["Aversa, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvana","family":"Canzano","sequence":"additional","affiliation":[{"name":"Pollution and Cardiovascular Diseases Research Center","place":["Naples, Italy"]},{"name":"University of Campania \u201cLuigi Vanvitelli\u201d","place":["Naples, Italy"]},{"name":"Environmental Technologies, University Spin-Off of University of Campania \u201cLuigi Vanvitelli\u201d","place":["Caserta, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ludovica Vittoria","family":"Marfella","sequence":"additional","affiliation":[{"name":"Department of Advanced Medical and Surgical Sciences, University of Campania \u201cLuigi Vanvitelli\u201d, Piazza Luigi Miraglia, 2, Naples 80138, Italy"},{"name":"Pollution and Cardiovascular Diseases Research Center","place":["Naples, Italy"]},{"name":"University of Campania \u201cLuigi Vanvitelli\u201d","place":["Naples, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni","family":"Falco","sequence":"additional","affiliation":[{"name":"Pollution and Cardiovascular Diseases Research Center","place":["Naples, Italy"]},{"name":"University of Campania \u201cLuigi Vanvitelli\u201d","place":["Naples, Italy"]},{"name":"Department of Environmental, Biological and Pharmaceutical Sciences and Technologies","place":["Caserta, Italy"]},{"name":"University of Campania \u201cLuigi Vanvitelli\u201d","place":["Caserta, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6001-1789","authenticated-orcid":true,"given":"Maria Luisa","family":"Balestrieri","sequence":"additional","affiliation":[{"name":"Pollution and Cardiovascular Diseases Research Center","place":["Naples, Italy"]},{"name":"University of Campania \u201cLuigi Vanvitelli\u201d","place":["Naples, Italy"]},{"name":"Department of Precision Medicine","place":["Naples, Italy"]},{"name":"University of Campania \u201cLuigi Vanvitelli\u201d","place":["Naples, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ciro","family":"Mauro","sequence":"additional","affiliation":[{"name":"Department of Cardiology","place":["Naples, Italy"]},{"name":"Hospital Cardarelli","place":["Naples, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Ceriello","sequence":"additional","affiliation":[{"name":"IRCCS MultiMedica, Via Fantoli 16\/15, Milan 20138, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip J","family":"Landrigan","sequence":"additional","affiliation":[{"name":"Boston College Global Observatory on Planetary Health","place":["Boston, United States"]},{"name":"Centre Scientifique de Monaco","place":["Monaco, Monaco"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruno","family":"D\u2019Agostino","sequence":"additional","affiliation":[{"name":"Pollution and Cardiovascular Diseases Research Center","place":["Naples, Italy"]},{"name":"University of Campania \u201cLuigi Vanvitelli\u201d","place":["Naples, Italy"]},{"name":"Department of Environmental, Biological and Pharmaceutical Sciences and Technologies","place":["Caserta, Italy"]},{"name":"University of Campania \u201cLuigi Vanvitelli\u201d","place":["Caserta, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pasquale","family":"Iovino","sequence":"additional","affiliation":[{"name":"Pollution and Cardiovascular Diseases Research Center","place":["Naples, Italy"]},{"name":"University of Campania \u201cLuigi Vanvitelli\u201d","place":["Naples, Italy"]},{"name":"Department of Environmental, Biological and Pharmaceutical Sciences and Technologies","place":["Caserta, Italy"]},{"name":"University of Campania \u201cLuigi Vanvitelli\u201d","place":["Caserta, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Paolisso","sequence":"additional","affiliation":[{"name":"Department of Advanced Medical and Surgical Sciences, University of Campania \u201cLuigi Vanvitelli\u201d, Piazza Luigi Miraglia, 2, Naples 80138, Italy"},{"name":"Pollution and Cardiovascular Diseases Research Center","place":["Naples, Italy"]},{"name":"University of Campania \u201cLuigi Vanvitelli\u201d","place":["Naples, Italy"]},{"name":"UniCamillus International Medical University","place":["Rome, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2025,12,11]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra2030281"},{"key":"ref2\/cit2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2018.07.099"},{"key":"ref3\/cit3","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhazmat.2025.137599"},{"key":"ref4\/cit4","doi-asserted-by":"publisher","DOI":"10.1016\/j.cej.2022.134825"},{"key":"ref5\/cit5","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhazmat.2025.137456"},{"key":"ref6\/cit6","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(17)30832-X"},{"key":"ref7\/cit7","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbi.2011.02.010"},{"key":"ref8\/cit8","doi-asserted-by":"publisher","DOI":"10.1016\/j.etap.2004.12.032"},{"key":"ref9\/cit9","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/bgr297"},{"key":"ref10\/cit10","doi-asserted-by":"publisher","DOI":"10.1016\/j.scitotenv.2024.170639"},{"key":"ref11\/cit11","doi-asserted-by":"publisher","DOI":"10.1136\/heartjnl-2014-307366"},{"key":"ref12\/cit12","doi-asserted-by":"publisher","DOI":"10.1016\/j.envpol.2018.07.086"},{"key":"ref13\/cit13","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0183602"},{"key":"ref14\/cit14","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0100307"},{"key":"ref15\/cit15","doi-asserted-by":"publisher","DOI":"10.1097\/EDE.0000000000000607"},{"key":"ref16\/cit16","doi-asserted-by":"publisher","DOI":"10.1021\/acs.est.3c08937"},{"key":"ref17\/cit17","doi-asserted-by":"publisher","DOI":"10.1016\/j.envint.2020.106121"},{"key":"ref18\/cit18","doi-asserted-by":"publisher","DOI":"10.1016\/j.envres.2017.03.048"},{"key":"ref19\/cit19","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2023.06.971"},{"key":"ref20\/cit20","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-021-03392-8"},{"key":"ref21\/cit21","doi-asserted-by":"publisher","DOI":"10.3390\/cells13191662"},{"key":"ref22\/cit22","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehae552"},{"key":"ref23\/cit23","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2024.102405"},{"key":"ref24\/cit24","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.2c09299"},{"key":"ref25\/cit25","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2309822"},{"key":"ref26\/cit26","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.2013.177"},{"key":"ref27\/cit27","doi-asserted-by":"publisher","DOI":"10.1080\/13547500500382975"},{"key":"ref28\/cit28","doi-asserted-by":"publisher","DOI":"10.1021\/acs.est.2c07810"},{"key":"ref29\/cit29","doi-asserted-by":"publisher","DOI":"10.1002\/celc.201900541"},{"key":"ref30\/cit30","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2019.08.056"},{"key":"ref31\/cit31","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-022-04289-z"},{"key":"ref32\/cit32","doi-asserted-by":"publisher","DOI":"10.1016\/j.pcad.2008.09.001"},{"key":"ref33\/cit33","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2005.02.054"},{"key":"ref34\/cit34","doi-asserted-by":"publisher","DOI":"10.1038\/icb.2015.26"},{"key":"ref35\/cit35","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrep.2018.11.008"},{"key":"ref36\/cit36","doi-asserted-by":"publisher","DOI":"10.1038\/cddis.2013.78"},{"key":"ref37\/cit37","doi-asserted-by":"publisher","DOI":"10.1186\/s12891-025-08458-6"},{"key":"ref38\/cit38","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1707914"},{"key":"ref39\/cit39","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2023.e19496"},{"key":"ref40\/cit40","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehw294"},{"key":"ref41\/cit41","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0b013e3181dbece1"},{"key":"ref42\/cit42","doi-asserted-by":"crossref","unstructured":"Zelko, I. N., Malovichko, M. V., McFall, S. A., Taylor, B. S., Chen, H., Conklin, D. J.2025 Chronic Inhaled Benzene Exposure Exacerbates Atherosclerosis in LDL Receptor-Null Mice [Internet]. Available from: http:\/\/biorxiv.org\/lookup\/doi\/10.1101\/2025.01.29.635519","DOI":"10.1101\/2025.01.29.635519"},{"key":"ref43\/cit43","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehr195"},{"key":"ref44\/cit44","doi-asserted-by":"publisher","DOI":"10.1093\/toxsci\/kfl145"},{"key":"ref45\/cit45","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph16132284"},{"key":"ref46\/cit46","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMsa2300523"},{"key":"ref47\/cit47","doi-asserted-by":"publisher","DOI":"10.1203\/00006450-197607000-00013"},{"key":"ref48\/cit48","doi-asserted-by":"publisher","DOI":"10.1007\/BF02342512"},{"key":"ref49\/cit49","author":"World Health Organization Regional Office for Europe","year":"2010","journal-title":"SELECTED POLLUTANTS; WHO guidelines for indoor air quality: selected pollutants"}],"container-title":["Environmental Science & Technology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acs.est.5c04941","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acs.est.5c04941","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T12:20:13Z","timestamp":1768566013000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/acs.est.5c04941"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,11]]},"references-count":49,"journal-issue":{"issue":"50","published-print":{"date-parts":[[2025,12,23]]}},"alternative-id":["10.1021\/acs.est.5c04941"],"URL":"https:\/\/doi.org\/10.1021\/acs.est.5c04941","relation":{},"ISSN":["0013-936X","1520-5851"],"issn-type":[{"value":"0013-936X","type":"print"},{"value":"1520-5851","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12,11]]}}}