{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T00:32:20Z","timestamp":1792456340332,"version":"4.5.0"},"reference-count":50,"publisher":"American Chemical Society (ACS)","issue":"46","license":[{"start":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T00:00:00Z","timestamp":1761004800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T00:00:00Z","timestamp":1761004800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T00:00:00Z","timestamp":1761004800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2022YFC3202101"],"award-info":[{"award-number":["2022YFC3202101"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007839","name":"Yunnan University","doi-asserted-by":"publisher","award":["CY22623101"],"award-info":[{"award-number":["CY22623101"]}],"id":[{"id":"10.13039\/501100007839","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007839","name":"Yunnan University","doi-asserted-by":"publisher","award":["CZ22623101"],"award-info":[{"award-number":["CZ22623101"]}],"id":[{"id":"10.13039\/501100007839","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Environ. Sci. Technol."],"published-print":{"date-parts":[[2025,11,25]]},"DOI":"10.1021\/acs.est.5c08571","type":"journal-article","created":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T15:05:26Z","timestamp":1761059126000},"page":"24717-24727","source":"Crossref","is-referenced-by-count":7,"title":["Water Environmental RNA Reveals Dose-Dependent Toxicant Responses in Fish"],"prefix":"10.1021","volume":"59","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2417-6919","authenticated-orcid":true,"given":"Xiao","family":"Gou","sequence":"first","affiliation":[{"name":"State Key Laboratory of Water Pollution Control and Green Resource Recycling, School of the Environment","place":["Nanjing, China"]},{"name":"Nanjing University","place":["Nanjing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6742-7768","authenticated-orcid":true,"given":"Xianglin","family":"Liu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Water Pollution Control and Green Resource Recycling, School of the Environment","place":["Nanjing, China"]},{"name":"Nanjing University","place":["Nanjing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinxin","family":"Su","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Water Pollution Control and Green Resource Recycling, School of the Environment","place":["Nanjing, China"]},{"name":"Nanjing University","place":["Nanjing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huimin","family":"Ji","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Water Pollution Control and Green Resource Recycling, School of the Environment","place":["Nanjing, China"]},{"name":"Nanjing University","place":["Nanjing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiong","family":"Wang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Water Pollution Control and Green Resource Recycling, School of the Environment","place":["Nanjing, China"]},{"name":"Nanjing University","place":["Nanjing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8974-9963","authenticated-orcid":true,"given":"Xiaowei","family":"Zhang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Water Pollution Control and Green Resource Recycling, School of the Environment","place":["Nanjing, China"]},{"name":"Nanjing University","place":["Nanjing, China"]},{"name":"School of Ecology and Environmental Sciences","place":["Kunming, China"]},{"name":"Yunnan University & Yunnan Key Laboratory for Plateau Mountain Ecology and Restoration of Degraded Environments","place":["Kunming, China"]},{"name":"State Key Laboratory of Vegetation Structure, Function and Construction (VegLab)","place":["Kunming, China"]},{"name":"Yunnan University","place":["Kunming, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2025,10,21]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"publisher","DOI":"10.1111\/gcb.16689"},{"key":"ref2\/cit2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1321082111"},{"key":"ref3\/cit3","doi-asserted-by":"publisher","DOI":"10.1002\/etc.4373"},{"key":"ref4\/cit4","doi-asserted-by":"publisher","DOI":"10.1016\/j.watres.2021.117341"},{"key":"ref5\/cit5","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1500232112"},{"key":"ref6\/cit6","doi-asserted-by":"publisher","DOI":"10.1021\/acs.est.7b06494"},{"key":"ref7\/cit7","doi-asserted-by":"publisher","DOI":"10.1021\/acs.est.1c00152"},{"key":"ref8\/cit8","volume-title":"Effect Based Monitoring in Water Safety Planning","author":"Pronk G.","year":"2020"},{"key":"ref9\/cit9","doi-asserted-by":"publisher","DOI":"10.1126\/science.1127291"},{"key":"ref10\/cit10","doi-asserted-by":"publisher","DOI":"10.1126\/science.aat9219"},{"key":"ref11\/cit11","doi-asserted-by":"publisher","DOI":"10.1016\/j.envint.2019.104994"},{"key":"ref12\/cit12","doi-asserted-by":"publisher","DOI":"10.1016\/j.tree.2019.05.003"},{"key":"ref13\/cit13","doi-asserted-by":"publisher","DOI":"10.3389\/fmars.2019.00621"},{"key":"ref14\/cit14","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0187636"},{"key":"ref15\/cit15","doi-asserted-by":"publisher","DOI":"10.1111\/1755-0998.13857"},{"key":"ref16\/cit16","doi-asserted-by":"publisher","DOI":"10.1111\/mec.17152"},{"key":"ref17\/cit17","doi-asserted-by":"publisher","DOI":"10.1021\/acs.est.3c03737"},{"key":"ref18\/cit18","doi-asserted-by":"publisher","DOI":"10.1002\/edn3.169"},{"key":"ref19\/cit19","doi-asserted-by":"publisher","DOI":"10.1002\/edn3.70137"},{"key":"ref20\/cit20","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbpb.2024.111036"},{"key":"ref21\/cit21","doi-asserted-by":"publisher","DOI":"10.1016\/j.etap.2016.03.010"},{"key":"ref22\/cit22","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhazmat.2023.130958"},{"key":"ref23\/cit23","doi-asserted-by":"publisher","DOI":"10.1038\/s41893-025-01513-z"},{"key":"ref24\/cit24","doi-asserted-by":"publisher","DOI":"10.1186\/s13059-014-0550-8"},{"key":"ref25\/cit25","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/bti042"},{"key":"ref26\/cit26","unstructured":"Mullen, K. M.; Stokkum, I. H. M. v.; Mullen, K. The Lawson-Hanson Algorithm for Non-Negative Least Squares (NNLS) 2024 https:\/\/CRAN.R-project.org\/package=nnls. (accessed February 19, 2025)."},{"key":"ref27\/cit27","doi-asserted-by":"publisher","DOI":"10.1021\/acs.est.7b04073"},{"key":"ref28\/cit28","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkaf018"},{"key":"ref29\/cit29","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0146021"},{"key":"ref30\/cit30","doi-asserted-by":"publisher","DOI":"10.1002\/sim.6052"},{"key":"ref31\/cit31","unstructured":"Carlson, M. Genome Wide Annotation for Zebrafish 2024 https:\/\/bioconductor.org\/packages\/org.Dr.eg.db\/. (accessed March 20, 2025)."},{"key":"ref32\/cit32","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btw313"},{"key":"ref33\/cit33","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-025-56884-w"},{"key":"ref34\/cit34","doi-asserted-by":"publisher","DOI":"10.18637\/jss.v033.i01"},{"key":"ref35\/cit35","doi-asserted-by":"publisher","DOI":"10.18637\/jss.v039.i05"},{"key":"ref36\/cit36","unstructured":"Kolde, R.\n                      Pretty Heatmaps. R Package Version 1.0.12.\n                      , 2019 https:\/\/CRAN.R-project.org\/package=pheatmap. (accessed March 20, 2025)."},{"key":"ref37\/cit37","doi-asserted-by":"publisher","DOI":"10.1016\/j.scitotenv.2024.178182"},{"key":"ref38\/cit38","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygeno.2022.110477"},{"key":"ref39\/cit39","doi-asserted-by":"publisher","DOI":"10.1016\/j.isci.2021.103409"},{"key":"ref40\/cit40","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0702000104"},{"key":"ref41\/cit41","doi-asserted-by":"publisher","DOI":"10.1016\/j.tree.2021.03.001"},{"key":"ref42\/cit42","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-018-2987-5"},{"key":"ref43\/cit43","doi-asserted-by":"publisher","DOI":"10.1016\/j.aquatox.2010.10.006"},{"key":"ref44\/cit44","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2011.10.026"},{"key":"ref45\/cit45","doi-asserted-by":"publisher","DOI":"10.1038\/s41568-021-00378-6"},{"key":"ref46\/cit46","doi-asserted-by":"publisher","DOI":"10.1038\/nrm2745"},{"key":"ref47\/cit47","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2023.11.044"},{"key":"ref48\/cit48","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-021-82205-4"},{"key":"ref49\/cit49","doi-asserted-by":"publisher","DOI":"10.1007\/s00239-001-0027-8"},{"key":"ref50\/cit50","doi-asserted-by":"publisher","DOI":"10.1007\/s00360-006-0083-x"}],"container-title":["Environmental Science & Technology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acs.est.5c08571","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acs.est.5c08571","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,25]],"date-time":"2025-11-25T09:12:33Z","timestamp":1764061953000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/acs.est.5c08571"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10,21]]},"references-count":50,"journal-issue":{"issue":"46","published-print":{"date-parts":[[2025,11,25]]}},"alternative-id":["10.1021\/acs.est.5c08571"],"URL":"https:\/\/doi.org\/10.1021\/acs.est.5c08571","relation":{},"ISSN":["0013-936X","1520-5851"],"issn-type":[{"value":"0013-936X","type":"print"},{"value":"1520-5851","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,10,21]]}}}