{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T05:27:47Z","timestamp":1790227667889,"version":"4.1.0"},"reference-count":52,"publisher":"American Chemical Society (ACS)","issue":"46","license":[{"start":{"date-parts":[[2025,11,13]],"date-time":"2025-11-13T00:00:00Z","timestamp":1762992000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,11,13]],"date-time":"2025-11-13T00:00:00Z","timestamp":1762992000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,11,13]],"date-time":"2025-11-13T00:00:00Z","timestamp":1762992000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2022YFC27029044"],"award-info":[{"award-number":["2022YFC27029044"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100014980","name":"Wannan Medical College","doi-asserted-by":"publisher","award":["WYRCQD2025019"],"award-info":[{"award-number":["WYRCQD2025019"]}],"id":[{"id":"10.13039\/501100014980","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Excellent innovation team of Natural Science in Universities of Anhui Province","award":["2023AH010035"],"award-info":[{"award-number":["2023AH010035"]}]},{"name":"Research Funds of Center for Big Data and Population Health of IHM","award":["JKS2022016"],"award-info":[{"award-number":["JKS2022016"]}]},{"name":"Scientific Research and Innovation Team of School of Public Health of Anhui Medical University","award":["kctd200404"],"award-info":[{"award-number":["kctd200404"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Environ. Sci. Technol."],"published-print":{"date-parts":[[2025,11,25]]},"DOI":"10.1021\/acs.est.5c09190","type":"journal-article","created":{"date-parts":[[2025,11,13]],"date-time":"2025-11-13T15:45:14Z","timestamp":1763048714000},"page":"24728-24744","source":"Crossref","is-referenced-by-count":6,"title":["PPAR\u03b1 Activation-Mediated Testosterone Reduction as the Key Adverse Outcome Pathway for Cd-Induced Male Infertility: A Novel Integrated Approach"],"prefix":"10.1021","volume":"59","author":[{"given":"Zhi","family":"Yuan","sequence":"first","affiliation":[{"name":"Department of Toxicology, School of Public Health","place":["Hefei, China"]},{"name":"Anhui Medical University","place":["Hefei, China"]},{"name":"Key Laboratory of Environmental Toxicology of Anhui Higher Education Institutes","place":["Hefei, China"]},{"name":"(Anhui Medical University)","place":["Hefei, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Toxicology, School of Public Health","place":["Hefei, China"]},{"name":"Anhui Medical University","place":["Hefei, China"]},{"name":"Department of Preventive Medicine, School of Public Health","place":["Wuhu, China"]},{"name":"Wannan Medical College","place":["Wuhu, China"]},{"name":"Key Laboratory of Environmental Toxicology of Anhui Higher Education Institutes","place":["Hefei, China"]},{"name":"(Anhui Medical University)","place":["Hefei, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Toxicology, School of Public Health","place":["Hefei, China"]},{"name":"Anhui Medical University","place":["Hefei, China"]},{"name":"Key Laboratory of Environmental Toxicology of Anhui Higher Education Institutes","place":["Hefei, China"]},{"name":"(Anhui Medical University)","place":["Hefei, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Si-Ting","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Toxicology, School of Public Health","place":["Hefei, China"]},{"name":"Anhui Medical University","place":["Hefei, China"]},{"name":"Key Laboratory of Environmental Toxicology of Anhui Higher Education Institutes","place":["Hefei, China"]},{"name":"(Anhui Medical University)","place":["Hefei, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meng-Xue","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Toxicology, School of Public Health","place":["Hefei, China"]},{"name":"Anhui Medical University","place":["Hefei, China"]},{"name":"Key Laboratory of Environmental Toxicology of Anhui Higher Education Institutes","place":["Hefei, China"]},{"name":"(Anhui Medical University)","place":["Hefei, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin-Run","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Toxicology, School of Public Health","place":["Hefei, China"]},{"name":"Anhui Medical University","place":["Hefei, China"]},{"name":"Key Laboratory of Environmental Toxicology of Anhui Higher Education Institutes","place":["Hefei, China"]},{"name":"(Anhui Medical University)","place":["Hefei, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Chang","sequence":"additional","affiliation":[{"name":"Department of Toxicology, School of Public Health","place":["Hefei, China"]},{"name":"Anhui Medical University","place":["Hefei, China"]},{"name":"Key Laboratory of Environmental Toxicology of Anhui Higher Education Institutes","place":["Hefei, China"]},{"name":"(Anhui Medical University)","place":["Hefei, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin-Yi","family":"Cheng","sequence":"additional","affiliation":[{"name":"Department of Toxicology, School of Public Health","place":["Hefei, China"]},{"name":"Anhui Medical University","place":["Hefei, China"]},{"name":"Key Laboratory of Environmental Toxicology of Anhui Higher Education Institutes","place":["Hefei, China"]},{"name":"(Anhui Medical University)","place":["Hefei, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li-Yan","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Toxicology, School of Public Health","place":["Hefei, China"]},{"name":"Anhui Medical University","place":["Hefei, China"]},{"name":"Key Laboratory of Environmental Toxicology of Anhui Higher Education Institutes","place":["Hefei, China"]},{"name":"(Anhui Medical University)","place":["Hefei, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Toxicology, School of Public Health","place":["Hefei, China"]},{"name":"Anhui Medical University","place":["Hefei, China"]},{"name":"Key Laboratory of Environmental Toxicology of Anhui Higher Education Institutes","place":["Hefei, China"]},{"name":"(Anhui Medical University)","place":["Hefei, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lan-Lan","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Toxicology, School of Public Health","place":["Hefei, China"]},{"name":"Anhui Medical University","place":["Hefei, China"]},{"name":"Key Laboratory of Environmental Toxicology of Anhui Higher Education Institutes","place":["Hefei, China"]},{"name":"(Anhui Medical University)","place":["Hefei, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shen-Dong","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Toxicology, School of Public Health","place":["Hefei, China"]},{"name":"Anhui Medical University","place":["Hefei, China"]},{"name":"Key Laboratory of Environmental Toxicology of Anhui Higher Education Institutes","place":["Hefei, China"]},{"name":"(Anhui Medical University)","place":["Hefei, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Toxicology, School of Public Health","place":["Hefei, China"]},{"name":"Anhui Medical University","place":["Hefei, China"]},{"name":"Key Laboratory of Environmental Toxicology of Anhui Higher Education Institutes","place":["Hefei, China"]},{"name":"(Anhui Medical University)","place":["Hefei, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing-Wen","family":"Hong","sequence":"additional","affiliation":[{"name":"Department of Toxicology, School of Public Health","place":["Hefei, China"]},{"name":"Anhui Medical University","place":["Hefei, China"]},{"name":"Key Laboratory of Environmental Toxicology of Anhui Higher Education Institutes","place":["Hefei, China"]},{"name":"(Anhui Medical University)","place":["Hefei, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ye-Xin","family":"Luo","sequence":"additional","affiliation":[{"name":"Department of Toxicology, School of Public Health","place":["Hefei, China"]},{"name":"Anhui Medical University","place":["Hefei, China"]},{"name":"Key Laboratory of Environmental Toxicology of Anhui Higher Education Institutes","place":["Hefei, China"]},{"name":"(Anhui Medical University)","place":["Hefei, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xu-Dong","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Toxicology, School of Public Health","place":["Hefei, China"]},{"name":"Anhui Medical University","place":["Hefei, China"]},{"name":"Key Laboratory of Environmental Toxicology of Anhui Higher Education Institutes","place":["Hefei, China"]},{"name":"(Anhui Medical University)","place":["Hefei, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hua-Long","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Toxicology, School of Public Health","place":["Hefei, China"]},{"name":"Anhui Medical University","place":["Hefei, China"]},{"name":"Key Laboratory of Environmental Toxicology of Anhui Higher Education Institutes","place":["Hefei, China"]},{"name":"(Anhui Medical University)","place":["Hefei, China"]},{"name":"Key Laboratory of Population Health Across Life Cycle (Anhui Medical University)","place":["Hefei, China"]},{"name":"Ministry of Education of the People\u2019s Republic of China","place":["Hefei, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong-Wei","family":"Xiong","sequence":"additional","affiliation":[{"name":"Department of Toxicology, School of Public Health","place":["Hefei, China"]},{"name":"Anhui Medical University","place":["Hefei, China"]},{"name":"Key Laboratory of Environmental Toxicology of Anhui Higher Education Institutes","place":["Hefei, China"]},{"name":"(Anhui Medical University)","place":["Hefei, China"]},{"name":"Key Laboratory of Population Health Across Life Cycle (Anhui Medical University)","place":["Hefei, China"]},{"name":"Ministry of Education of the People\u2019s Republic of China","place":["Hefei, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0093-9275","authenticated-orcid":true,"given":"Hua","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Toxicology, School of Public Health","place":["Hefei, China"]},{"name":"Anhui Medical University","place":["Hefei, China"]},{"name":"Key Laboratory of Environmental Toxicology of Anhui Higher Education Institutes","place":["Hefei, China"]},{"name":"(Anhui Medical University)","place":["Hefei, China"]},{"name":"Key Laboratory of Population Health Across Life Cycle (Anhui Medical University)","place":["Hefei, China"]},{"name":"Ministry of Education of the People\u2019s Republic of China","place":["Hefei, China"]},{"name":"School of Public Health, Center for Big Data and Population Health of IHM","place":["Hefei, China"]},{"name":"Anhui Medical University","place":["Hefei, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2025,11,13]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"publisher","DOI":"10.1007\/s00204-024-03871-7"},{"key":"ref2\/cit2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ecoenv.2024.116095"},{"key":"ref3\/cit3","doi-asserted-by":"publisher","DOI":"10.1016\/j.tips.2011.01.001"},{"key":"ref4\/cit4","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkad128"},{"key":"ref5\/cit5","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhazmat.2019.121706"},{"key":"ref6\/cit6","doi-asserted-by":"publisher","DOI":"10.1021\/acs.est.2c04917"},{"key":"ref7\/cit7","doi-asserted-by":"publisher","DOI":"10.1007\/s00204-022-03351-w"},{"key":"ref8\/cit8","doi-asserted-by":"publisher","DOI":"10.1007\/s00204-023-03637-7"},{"key":"ref9\/cit9","doi-asserted-by":"publisher","DOI":"10.1016\/j.eehl.2024.08.002"},{"key":"ref10\/cit10","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhazmat.2023.131541"},{"key":"ref11\/cit11","doi-asserted-by":"publisher","DOI":"10.1016\/j.envint.2024.108952"},{"key":"ref12\/cit12","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-022-05364-w"},{"key":"ref13\/cit13","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhazmat.2024.134142"},{"key":"ref14\/cit14","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2021.09.028"},{"key":"ref15\/cit15","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202400389"},{"key":"ref16\/cit16","doi-asserted-by":"publisher","DOI":"10.1016\/j.envint.2024.108447"},{"key":"ref17\/cit17","doi-asserted-by":"publisher","DOI":"10.1186\/s12933-024-02251-w"},{"key":"ref18\/cit18","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhazmat.2024.134607"},{"key":"ref19\/cit19","doi-asserted-by":"publisher","DOI":"10.1016\/j.jss.2016.08.049"},{"key":"ref20\/cit20","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00322.2014"},{"key":"ref21\/cit21","doi-asserted-by":"publisher","DOI":"10.1016\/j.reprotox.2016.01.006"},{"key":"ref22\/cit22","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jcim.0c01390"},{"key":"ref23\/cit23","doi-asserted-by":"publisher","DOI":"10.1038\/s43587-024-00692-2"},{"key":"ref24\/cit24","doi-asserted-by":"publisher","DOI":"10.5534\/wjmh.180036"},{"key":"ref25\/cit25","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-024-45675-4"},{"key":"ref26\/cit26","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jcim.6b00407"},{"key":"ref27\/cit27","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2024.103312"},{"key":"ref28\/cit28","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202500924"},{"key":"ref29\/cit29","doi-asserted-by":"publisher","DOI":"10.1016\/j.envpol.2020.116241"},{"key":"ref30\/cit30","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhazmat.2020.123737"},{"key":"ref31\/cit31","doi-asserted-by":"publisher","DOI":"10.1016\/j.mce.2019.110675"},{"key":"ref32\/cit32","doi-asserted-by":"publisher","DOI":"10.1016\/j.envint.2023.108202"},{"key":"ref33\/cit33","doi-asserted-by":"publisher","DOI":"10.1016\/j.ecoenv.2024.116809"},{"key":"ref34\/cit34","doi-asserted-by":"publisher","DOI":"10.1007\/s40265-023-01853-0"},{"key":"ref35\/cit35","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2023.1184794"},{"key":"ref36\/cit36","doi-asserted-by":"publisher","DOI":"10.1016\/j.envint.2023.108138"},{"key":"ref37\/cit37","doi-asserted-by":"publisher","DOI":"10.1016\/j.ecoenv.2024.116216"},{"key":"ref38\/cit38","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhazmat.2023.133375"},{"key":"ref39\/cit39","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2021.0241"},{"key":"ref40\/cit40","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.pharmtox.43.100901.140223"},{"key":"ref41\/cit41","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2007.08.007"},{"key":"ref42\/cit42","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2017-01540"},{"key":"ref43\/cit43","doi-asserted-by":"publisher","DOI":"10.1007\/s10653-023-01719-0"},{"key":"ref44\/cit44","doi-asserted-by":"publisher","DOI":"10.1016\/j.scitotenv.2017.11.137"},{"key":"ref45\/cit45","doi-asserted-by":"publisher","DOI":"10.1016\/j.watres.2023.121076"},{"key":"ref46\/cit46","doi-asserted-by":"publisher","DOI":"10.5530\/ajbls.2024.13.91"},{"key":"ref47\/cit47","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/dmab036"},{"key":"ref48\/cit48","doi-asserted-by":"publisher","DOI":"10.1186\/s12958-022-00915-4"},{"key":"ref49\/cit49","doi-asserted-by":"publisher","DOI":"10.1186\/1477-7827-9-93"},{"key":"ref50\/cit50","doi-asserted-by":"publisher","DOI":"10.1038\/s41597-021-00962-3"},{"key":"ref51\/cit51","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkac833"},{"key":"ref52\/cit52","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkae883"}],"container-title":["Environmental Science &amp; Technology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acs.est.5c09190","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acs.est.5c09190","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,25]],"date-time":"2025-11-25T09:13:10Z","timestamp":1764061990000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/acs.est.5c09190"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,13]]},"references-count":52,"journal-issue":{"issue":"46","published-print":{"date-parts":[[2025,11,25]]}},"alternative-id":["10.1021\/acs.est.5c09190"],"URL":"https:\/\/doi.org\/10.1021\/acs.est.5c09190","relation":{},"ISSN":["0013-936X","1520-5851"],"issn-type":[{"value":"0013-936X","type":"print"},{"value":"1520-5851","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11,13]]}}}