{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T18:59:20Z","timestamp":1776279560330,"version":"3.50.1"},"reference-count":65,"publisher":"American Chemical Society (ACS)","issue":"47","license":[{"start":{"date-parts":[[2025,11,20]],"date-time":"2025-11-20T00:00:00Z","timestamp":1763596800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,11,20]],"date-time":"2025-11-20T00:00:00Z","timestamp":1763596800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,11,20]],"date-time":"2025-11-20T00:00:00Z","timestamp":1763596800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2024YFA0918900"],"award-info":[{"award-number":["2024YFA0918900"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["No. 22306003"],"award-info":[{"award-number":["No. 22306003"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["No. 22376032"],"award-info":[{"award-number":["No. 22376032"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["No. 22525602"],"award-info":[{"award-number":["No. 22525602"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002367","name":"Chinese Academy of Sciences","doi-asserted-by":"publisher","award":["XDB0750300"],"award-info":[{"award-number":["XDB0750300"]}],"id":[{"id":"10.13039\/501100002367","id-type":"DOI","asserted-by":"publisher"}]},{"name":"SEU Innovation Capability  Enhancement Plan for Doctoral Students","award":["CXJH_SEU 25226"],"award-info":[{"award-number":["CXJH_SEU 25226"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Environ. Sci. Technol."],"published-print":{"date-parts":[[2025,12,2]]},"DOI":"10.1021\/acs.est.5c11783","type":"journal-article","created":{"date-parts":[[2025,11,20]],"date-time":"2025-11-20T08:59:36Z","timestamp":1763629176000},"page":"25200-25213","source":"Crossref","is-referenced-by-count":1,"title":["ChemBioHepatox: Multimodal Integrating Chemical Structure and Biological Fingerprint for Robust and Interpretable Hepatotoxicity Prediction"],"prefix":"10.1021","volume":"59","author":[{"given":"Yingqing","family":"Shou","sequence":"first","affiliation":[{"name":"Key Laboratory of Environmental Medicine Engineering, Ministry of Education, School of Public Health","place":["Nanjing, China"]},{"name":"Southeast University","place":["Nanjing, China"]},{"name":"Department of Environmental Science and Engineering","place":["Shanghai, China"]},{"name":"Fudan University","place":["Shanghai, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yongbao","family":"Fang","sequence":"additional","affiliation":[{"name":"Department of Environmental Science and Engineering","place":["Shanghai, China"]},{"name":"Fudan University","place":["Shanghai, China"]},{"name":"Department of Gynecology and Obstetrics","place":["Hefei, China"]},{"name":"The Second Affiliated Hospital of Anhui Medical University","place":["Hefei, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Environmental Science and Engineering","place":["Shanghai, China"]},{"name":"Fudan University","place":["Shanghai, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuan","family":"Chi","sequence":"additional","affiliation":[{"name":"Department of Environmental Science and Engineering","place":["Shanghai, China"]},{"name":"Fudan University","place":["Shanghai, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9162-5425","authenticated-orcid":true,"given":"Jingzhi","family":"Yao","sequence":"additional","affiliation":[{"name":"Department of Environmental Science and Engineering","place":["Shanghai, China"]},{"name":"Fudan University","place":["Shanghai, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jie","family":"Xu","sequence":"additional","affiliation":[{"name":"Fudan University","place":["Shanghai, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"YongFeng","family":"Deng","sequence":"additional","affiliation":[{"name":"Key Laboratory of Environmental Medicine Engineering, Ministry of Education, School of Public Health","place":["Nanjing, China"]},{"name":"Southeast University","place":["Nanjing, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bo","family":"Peng","sequence":"additional","affiliation":[{"name":"SKL-ESPC and College of Environmental Sciences and Engineering, Center for Environment and Health","place":["Beijing, China"]},{"name":"Peking University","place":["Beijing, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2204-9783","authenticated-orcid":true,"given":"Mingliang","family":"Fang","sequence":"additional","affiliation":[{"name":"Department of Environmental Science and Engineering","place":["Shanghai, China"]},{"name":"Fudan University","place":["Shanghai, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"316","published-online":{"date-parts":[[2025,11,20]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"publisher","DOI":"10.1038\/s41573-019-0048-x"},{"key":"ref2\/cit2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(17)32345-0"},{"key":"ref3\/cit3","doi-asserted-by":"publisher","DOI":"10.1016\/j.cotox.2020.01.001"},{"key":"ref4\/cit4","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-019-1373-2"},{"key":"ref5\/cit5","doi-asserted-by":"publisher","DOI":"10.1177\/17562848231163410"},{"key":"ref6\/cit6","doi-asserted-by":"publisher","DOI":"10.1177\/0192623312468517"},{"key":"ref7\/cit7","doi-asserted-by":"publisher","DOI":"10.1201\/9780203647295.ch7"},{"key":"ref8\/cit8","doi-asserted-by":"publisher","DOI":"10.1007\/s11356-018-2665-z"},{"key":"ref9\/cit9","doi-asserted-by":"publisher","DOI":"10.14309\/01.ajg.0001037124.81921.b2"},{"key":"ref10\/cit10","doi-asserted-by":"publisher","DOI":"10.1006\/rtph.2000.1399"},{"key":"ref11\/cit11","doi-asserted-by":"publisher","DOI":"10.1007\/s00204-013-1078-5"},{"key":"ref12\/cit12","doi-asserted-by":"publisher","DOI":"10.1080\/17425255.2017.1341489"},{"key":"ref13\/cit13","unstructured":"FDA Announces\nPlan to Phase Out Animal Testing Requirement for Monoclonal Antibodies\nand Other Drugs. https:\/\/www.fda.gov\/news-events\/press-announcements\/fda-announces-plan-phase-out-animal-testing-requirement-monoclonal-antibodies-and-other-drugs (accessed May 23, 2025)."},{"key":"ref14\/cit14","doi-asserted-by":"publisher","DOI":"10.1007\/s00204-023-03666-2"},{"key":"ref15\/cit15","doi-asserted-by":"publisher","DOI":"10.1080\/17460441.2021.1918096"},{"key":"ref16\/cit16","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202413405"},{"key":"ref17\/cit17","doi-asserted-by":"publisher","DOI":"10.1093\/toxsci\/kfp059"},{"key":"ref18\/cit18","doi-asserted-by":"publisher","DOI":"10.1021\/tx900451r"},{"key":"ref19\/cit19","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrestox.9b00264"},{"key":"ref20\/cit20","doi-asserted-by":"publisher","DOI":"10.1016\/j.comtox.2024.100338"},{"key":"ref21\/cit21","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.adk6669"},{"key":"ref22\/cit22","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrestox.0c00374"},{"key":"ref23\/cit23","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrestox.3c00199"},{"key":"ref24\/cit24","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-030-28954-6_18"},{"key":"ref25\/cit25","doi-asserted-by":"publisher","DOI":"10.1038\/clpt.2011.58"},{"key":"ref26\/cit26","doi-asserted-by":"publisher","DOI":"10.2174\/092986709788803097"},{"key":"ref27\/cit27","doi-asserted-by":"publisher","DOI":"10.1097\/HEP.0000000000000628"},{"key":"ref28\/cit28","doi-asserted-by":"publisher","DOI":"10.1016\/j.yrtph.2017.09.020"},{"key":"ref29\/cit29","doi-asserted-by":"publisher","DOI":"10.1021\/tx400410s"},{"key":"ref30\/cit30","doi-asserted-by":"publisher","DOI":"10.1093\/toxsci\/kfaa005"},{"key":"ref31\/cit31","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrestox.1c00032"},{"key":"ref32\/cit32","doi-asserted-by":"publisher","DOI":"10.1016\/j.comtox.2021.100171"},{"key":"ref33\/cit33","doi-asserted-by":"publisher","DOI":"10.1016\/j.drudis.2019.09.022"},{"key":"ref34\/cit34","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrestox.0c00374"},{"key":"ref35\/cit35","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jcim.5b00238"},{"key":"ref36\/cit36","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20081897"},{"key":"ref37\/cit37","doi-asserted-by":"publisher","DOI":"10.1007\/s10822-011-9468-3"},{"key":"ref38\/cit38","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrestox.0c00030"},{"key":"ref39\/cit39","doi-asserted-by":"publisher","DOI":"10.1093\/toxsci\/kfy121"},{"key":"ref40\/cit40","doi-asserted-by":"publisher","DOI":"10.1002\/hep.31999"},{"key":"ref41\/cit41","doi-asserted-by":"publisher","DOI":"10.48550\/arXiv.2010.09885"},{"key":"ref42\/cit42","volume-title":"LiverTox: Clinical and Research Information on Drug-Induced Liver Injury","year":"2012"},{"key":"ref43\/cit43","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.pharmtox.46.120604.141046"},{"key":"ref44\/cit44","doi-asserted-by":"publisher","DOI":"10.1155\/2010\/325183"},{"key":"ref45\/cit45","doi-asserted-by":"publisher","DOI":"10.1093\/toxsci\/65.2.299"},{"key":"ref46\/cit46","doi-asserted-by":"publisher","DOI":"10.1016\/j.taap.2006.12.013"},{"key":"ref47\/cit47","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkae298"},{"key":"ref48\/cit48","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkae236"},{"key":"ref49\/cit49","doi-asserted-by":"publisher","DOI":"10.1177\/02611929221090530"},{"key":"ref50\/cit50","doi-asserted-by":"publisher","DOI":"10.1016\/j.chemosphere.2020.125941"},{"key":"ref51\/cit51","doi-asserted-by":"publisher","DOI":"10.1007\/BF00213961"},{"key":"ref52\/cit52","doi-asserted-by":"publisher","DOI":"10.1093\/toxres\/tfae070"},{"key":"ref53\/cit53","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxrep.2017.12.022"},{"key":"ref54\/cit54","doi-asserted-by":"publisher","DOI":"10.15835\/buasvmcn-fst:2024.0005"},{"key":"ref55\/cit55","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2010.07.039"},{"key":"ref56\/cit56","doi-asserted-by":"publisher","DOI":"10.61919\/jhrr.v4i2.1159"},{"key":"ref57\/cit57","doi-asserted-by":"publisher","DOI":"10.1016\/j.nut.2017.08.010"},{"issue":"4","key":"ref58\/cit58","first-page":"525","volume":"4","author":"Tawfek N.","year":"2015","journal-title":"Current Science International"},{"key":"ref59\/cit59","doi-asserted-by":"publisher","DOI":"10.1186\/s13321-023-00708-w"},{"key":"ref60\/cit60","doi-asserted-by":"publisher","DOI":"10.1016\/j.taap.2022.116250"},{"key":"ref61\/cit61","doi-asserted-by":"publisher","DOI":"10.3389\/fbioe.2020.562677"},{"key":"ref62\/cit62","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2024.e29128"},{"key":"ref63\/cit63","doi-asserted-by":"publisher","DOI":"10.1016\/j.yrtph.2020.104592"},{"key":"ref64\/cit64","doi-asserted-by":"publisher","DOI":"10.1080\/10937404.2010.483176"},{"key":"ref65\/cit65","doi-asserted-by":"publisher","DOI":"10.1007\/s00204-020-02866-4"}],"container-title":["Environmental Science &amp; Technology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acs.est.5c11783","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acs.est.5c11783","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,2]],"date-time":"2025-12-02T09:11:09Z","timestamp":1764666669000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/acs.est.5c11783"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,20]]},"references-count":65,"journal-issue":{"issue":"47","published-print":{"date-parts":[[2025,12,2]]}},"alternative-id":["10.1021\/acs.est.5c11783"],"URL":"https:\/\/doi.org\/10.1021\/acs.est.5c11783","relation":{},"ISSN":["0013-936X","1520-5851"],"issn-type":[{"value":"0013-936X","type":"print"},{"value":"1520-5851","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11,20]]}}}