{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T02:35:15Z","timestamp":1790822115047,"version":"4.1.0"},"reference-count":52,"publisher":"American Chemical Society (ACS)","issue":"1","license":[{"start":{"date-parts":[[2025,12,18]],"date-time":"2025-12-18T00:00:00Z","timestamp":1766016000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,12,18]],"date-time":"2025-12-18T00:00:00Z","timestamp":1766016000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,12,18]],"date-time":"2025-12-18T00:00:00Z","timestamp":1766016000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/501100007129","name":"Natural Science Foundation of Shandong Province","doi-asserted-by":"publisher","award":["ZR2023MH050"],"award-info":[{"award-number":["ZR2023MH050"]}],"id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China (NSFC)","doi-asserted-by":"crossref","award":["8247091353"],"award-info":[{"award-number":["8247091353"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Environ. Sci. Technol."],"published-print":{"date-parts":[[2026,1,13]]},"DOI":"10.1021\/acs.est.5c12267","type":"journal-article","created":{"date-parts":[[2025,12,18]],"date-time":"2025-12-18T05:42:27Z","timestamp":1766036547000},"page":"228-242","source":"Crossref","is-referenced-by-count":4,"title":["Unraveling the Mechanisms of Osteoporosis Triggered by Methylparaben and Monomethyl Phthalate through Integrated Mendelian Randomization, In Silico Simulations, and Experimental Validation"],"prefix":"10.1021","volume":"60","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-9952-7994","authenticated-orcid":true,"given":"Hailong","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Orthopedics","place":["Jinan, China"]},{"name":"Qilu Hospital of Shandong University","place":["Jinan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Orthopedics","place":["Jinan, China"]},{"name":"Qilu Hospital of Shandong University","place":["Jinan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Longzhuo","family":"Du","sequence":"additional","affiliation":[{"name":"Department of Orthopedics","place":["Jinan, China"]},{"name":"Qilu Hospital of Shandong University","place":["Jinan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wencan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Orthopedics","place":["Jinan, China"]},{"name":"Qilu Hospital of Shandong University","place":["Jinan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongyuan","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Orthopedics","place":["Jinan, China"]},{"name":"Qilu Hospital of Shandong University","place":["Jinan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fujian","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Orthopedics","place":["Jinan, China"]},{"name":"Qilu Hospital of Shandong University","place":["Jinan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Houyi","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Orthopedics","place":["Jinan, China"]},{"name":"Qilu Hospital of Shandong University","place":["Jinan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haipeng","family":"Si","sequence":"additional","affiliation":[{"name":"Department of Orthopedics","place":["Jinan, China"]},{"name":"Qilu Hospital of Shandong University","place":["Jinan, China"]},{"name":"Key Laboratory of Qingdao in Medicine and Engineering, Department of Orthopedics","place":["Qingdao, China"]},{"name":"Qilu Hospital (qingdao) of Shandong University","place":["Qingdao, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peilai","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Orthopedics","place":["Jinan, China"]},{"name":"Qilu Hospital of Shandong University","place":["Jinan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2025,12,18]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"publisher","DOI":"10.1093\/bmb\/ldaa005"},{"key":"ref2\/cit2","doi-asserted-by":"publisher","DOI":"10.1016\/s0140-6736(18)32112-3"},{"key":"ref3\/cit3","doi-asserted-by":"publisher","DOI":"10.1016\/j.envres.2023.117103"},{"key":"ref4\/cit4","doi-asserted-by":"publisher","DOI":"10.1210\/en.2012-1422"},{"key":"ref5\/cit5","doi-asserted-by":"publisher","DOI":"10.1007\/s10653-021-00946-7"},{"key":"ref6\/cit6","doi-asserted-by":"publisher","DOI":"10.3390\/jcm12093158"},{"key":"ref7\/cit7","doi-asserted-by":"publisher","DOI":"10.1016\/j.etap.2014.02.003"},{"key":"ref8\/cit8","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2022.115015"},{"key":"ref9\/cit9","doi-asserted-by":"publisher","DOI":"10.1038\/nrendo.2017.42"},{"key":"ref10\/cit10","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-8587(20)30129-7"},{"key":"ref11\/cit11","doi-asserted-by":"publisher","DOI":"10.1289\/ehp.1307909"},{"key":"ref12\/cit12","doi-asserted-by":"publisher","DOI":"10.1016\/j.envres.2023.117611"},{"key":"ref13\/cit13","doi-asserted-by":"publisher","DOI":"10.1016\/j.envpol.2018.04.108"},{"key":"ref14\/cit14","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2019-00576"},{"key":"ref15\/cit15","doi-asserted-by":"publisher","DOI":"10.1016\/j.beem.2021.101495"},{"key":"ref16\/cit16","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.0050177"},{"key":"ref17\/cit17","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwt084"},{"key":"ref18\/cit18","doi-asserted-by":"publisher","DOI":"10.1016\/j.envint.2023.108396"},{"key":"ref19\/cit19","doi-asserted-by":"publisher","DOI":"10.1007\/s00198-024-07249-4"},{"key":"ref20\/cit20","doi-asserted-by":"publisher","DOI":"10.1038\/ng.3949"},{"key":"ref21\/cit21","doi-asserted-by":"publisher","DOI":"10.1080\/15287390903212923"},{"key":"ref22\/cit22","doi-asserted-by":"publisher","DOI":"10.1016\/j.envres.2016.10.021"},{"key":"ref23\/cit23","doi-asserted-by":"publisher","DOI":"10.1289\/ehp.1409586"},{"key":"ref24\/cit24","doi-asserted-by":"publisher","DOI":"10.1016\/j.envint.2020.105865"},{"key":"ref25\/cit25","doi-asserted-by":"publisher","DOI":"10.1016\/j.taap.2017.05.019"},{"key":"ref26\/cit26","doi-asserted-by":"publisher","DOI":"10.3803\/EnM.2024.1963"},{"key":"ref27\/cit27","doi-asserted-by":"publisher","DOI":"10.1186\/s12940-022-00920-5"},{"key":"ref28\/cit28","doi-asserted-by":"publisher","DOI":"10.1210\/clinem\/dgab189"},{"key":"ref29\/cit29","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2014-2279"},{"key":"ref30\/cit30","doi-asserted-by":"publisher","DOI":"10.1021\/es202340b"},{"key":"ref31\/cit31","doi-asserted-by":"publisher","DOI":"10.1289\/ehp.1307996"},{"key":"ref32\/cit32","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2021.114521"},{"issue":"7","key":"ref33\/cit33","first-page":"587","volume":"21","author":"Cheng Z. N.","year":"2000","journal-title":"Acta Pharmacol Sin."},{"key":"ref34\/cit34","doi-asserted-by":"publisher","DOI":"10.1038\/clpt.2008.215"},{"key":"ref35\/cit35","doi-asserted-by":"publisher","DOI":"10.3803\/EnM.2021.1349"},{"key":"ref36\/cit36","doi-asserted-by":"publisher","DOI":"10.1038\/tpj.2017.15"},{"key":"ref37\/cit37","doi-asserted-by":"publisher","DOI":"10.1016\/j.gene.2017.03.005"},{"key":"ref38\/cit38","doi-asserted-by":"publisher","DOI":"10.1038\/embor.2011.34"},{"key":"ref39\/cit39","doi-asserted-by":"publisher","DOI":"10.1186\/s13287-020-02037-3"},{"key":"ref40\/cit40","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(04)00344-7"},{"key":"ref41\/cit41","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.21543"},{"key":"ref42\/cit42","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2017.12.008"},{"key":"ref43\/cit43","doi-asserted-by":"publisher","DOI":"10.1016\/j.yexcr.2021.112781"},{"key":"ref44\/cit44","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2025.1552150"},{"key":"ref45\/cit45","doi-asserted-by":"publisher","DOI":"10.1186\/s12979-019-0155-x"},{"key":"ref46\/cit46","doi-asserted-by":"publisher","DOI":"10.1186\/s13018-024-05014-1"},{"key":"ref47\/cit47","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2015.12.021"},{"key":"ref48\/cit48","doi-asserted-by":"publisher","DOI":"10.1007\/s12032-024-02301-z"},{"key":"ref49\/cit49","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2021.752546"},{"key":"ref50\/cit50","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24043772"},{"key":"ref51\/cit51","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2016.12.009"},{"key":"ref52\/cit52","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2023.1289976"}],"container-title":["Environmental Science &amp; Technology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acs.est.5c12267","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acs.est.5c12267","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T12:45:33Z","timestamp":1768567533000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/acs.est.5c12267"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,18]]},"references-count":52,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1,13]]}},"alternative-id":["10.1021\/acs.est.5c12267"],"URL":"https:\/\/doi.org\/10.1021\/acs.est.5c12267","relation":{},"ISSN":["0013-936X","1520-5851"],"issn-type":[{"value":"0013-936X","type":"print"},{"value":"1520-5851","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12,18]]}}}