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Trifluoroacetic acid (TFA): Assessment\nfor classification\nin new hazard classes submitted German authorities classify TFA as\nreprotoxic, very persistent and very mobile; German Federal Institute for Risk Assessment, 2025. https:\/\/www.bfr.bund.de\/en\/press-release\/trifluoroacetic-acid-tfa-assessment-for-classification-in-new-hazard-classes-submitted\/(accessed Sept 30, 2025)."},{"key":"ref39\/cit39","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/0147-6513(77)90016-1","volume":"1","author":"Stephenson M. M. S.","year":"1977","journal-title":"Ecotoxicol. Environ. 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