{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T09:08:47Z","timestamp":1776157727692,"version":"3.50.1"},"reference-count":77,"publisher":"American Chemical Society (ACS)","issue":"14","license":[{"start":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T00:00:00Z","timestamp":1774569600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T00:00:00Z","timestamp":1774569600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T00:00:00Z","timestamp":1774569600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/501100012166","name":"Ministry of Science and Technology of the People's Republic of China","doi-asserted-by":"publisher","award":["2022YFC3702700"],"award-info":[{"award-number":["2022YFC3702700"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"name":"National Research Program for Key Issues in Air Pollution Control of China","award":["DQGG0401"],"award-info":[{"award-number":["DQGG0401"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China (NSFC)","doi-asserted-by":"crossref","award":["82025030"],"award-info":[{"award-number":["82025030"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China (NSFC)","doi-asserted-by":"crossref","award":["82241091"],"award-info":[{"award-number":["82241091"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Environ. Sci. Technol."],"published-print":{"date-parts":[[2026,4,14]]},"DOI":"10.1021\/acs.est.5c14653","type":"journal-article","created":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T15:37:01Z","timestamp":1774625821000},"page":"10500-10511","source":"Crossref","is-referenced-by-count":0,"title":["Longitudinal Internal Exposure to Methylsiloxanes among Healthy Elderly from the China BAPE Study: Plasma Levels, Intake Estimation, and Risk Assessment"],"prefix":"10.1021","volume":"60","author":[{"given":"Zhe","family":"Zhao","sequence":"first","affiliation":[{"name":"China CDC Key Laboratory of Environment and Population Health, National Institute of Environmental Health","place":["Beijing, China"]},{"name":"Chinese Center for Disease Control and Prevention","place":["Beijing, China"]},{"name":"School of Public Health","place":["Shenyang, China"]},{"name":"China Medical University","place":["Shenyang, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Runming","family":"He","sequence":"additional","affiliation":[{"name":"China CDC Key Laboratory of Environment and Population Health, National Institute of Environmental Health","place":["Beijing, China"]},{"name":"Chinese Center for Disease Control and Prevention","place":["Beijing, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ke","family":"Fang","sequence":"additional","affiliation":[{"name":"China CDC Key Laboratory of Environment and Population Health, National Institute of Environmental Health","place":["Beijing, China"]},{"name":"Chinese Center for Disease Control and Prevention","place":["Beijing, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yongjun","family":"Situ","sequence":"additional","affiliation":[{"name":"China CDC Key Laboratory of Environment and Population Health, National Institute of Environmental Health","place":["Beijing, China"]},{"name":"Chinese Center for Disease Control and Prevention","place":["Beijing, China"]},{"name":"School of Public Health","place":["Guangzhou, China"]},{"name":"Southern Medical University","place":["Guangzhou, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xinyue","family":"Bei","sequence":"additional","affiliation":[{"name":"China CDC Key Laboratory of Environment and Population Health, National Institute of Environmental Health","place":["Beijing, China"]},{"name":"Chinese Center for Disease Control and Prevention","place":["Beijing, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuling","family":"Duan","sequence":"additional","affiliation":[{"name":"China CDC Key Laboratory of Environment and Population Health, National Institute of Environmental Health","place":["Beijing, China"]},{"name":"Chinese Center for Disease Control and Prevention","place":["Beijing, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan","family":"Liu","sequence":"additional","affiliation":[{"name":"China CDC Key Laboratory of Environment and Population Health, National Institute of Environmental Health","place":["Beijing, China"]},{"name":"Chinese Center for Disease Control and Prevention","place":["Beijing, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiao","family":"Ma","sequence":"additional","affiliation":[{"name":"China CDC Key Laboratory of Environment and Population Health, National Institute of Environmental Health","place":["Beijing, China"]},{"name":"Chinese Center for Disease Control and Prevention","place":["Beijing, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiankun","family":"Qian","sequence":"additional","affiliation":[{"name":"China CDC Key Laboratory of Environment and Population Health, National Institute of Environmental Health","place":["Beijing, China"]},{"name":"Chinese Center for Disease Control and Prevention","place":["Beijing, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuyao","family":"Chen","sequence":"additional","affiliation":[{"name":"China CDC Key Laboratory of Environment and Population Health, National Institute of Environmental Health","place":["Beijing, China"]},{"name":"Chinese Center for Disease Control and Prevention","place":["Beijing, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaojie","family":"Guo","sequence":"additional","affiliation":[{"name":"China CDC Key Laboratory of Environment and Population Health, National Institute of Environmental Health","place":["Beijing, China"]},{"name":"Chinese Center for Disease Control and Prevention","place":["Beijing, China"]},{"name":"Guangzhou Center for Disease Control and Prevention","place":["Guangzhou, China"]},{"name":"Guangzhou Health Supervision Institute","place":["Guangzhou, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yijing","family":"Zhang","sequence":"additional","affiliation":[{"name":"Beijing Advanced Innovation Center for Soft Matter Science and Engineering, College of Life Science and Technology","place":["Beijing, China"]},{"name":"Beijing University of Chemical Technology","place":["Beijing, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2563-8030","authenticated-orcid":true,"given":"Yifu","family":"Lu","sequence":"additional","affiliation":[{"name":"China CDC Key Laboratory of Environment and Population Health, National Institute of Environmental Health","place":["Beijing, China"]},{"name":"Chinese Center for Disease Control and Prevention","place":["Beijing, China"]},{"name":"Center for Global Health, School of Public Health","place":["Nanjing, China"]},{"name":"Nanjing Medical University","place":["Nanjing, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chao","family":"Wang","sequence":"additional","affiliation":[{"name":"China CDC Key Laboratory of Environment and Population Health, National Institute of Environmental Health","place":["Beijing, China"]},{"name":"Chinese Center for Disease Control and Prevention","place":["Beijing, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongyang","family":"Cui","sequence":"additional","affiliation":[{"name":"School of Environmental Science and Engineering","place":["Tianjin, China"]},{"name":"Tianjin University","place":["Tianjin, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0251-2355","authenticated-orcid":true,"given":"Zhaomin","family":"Dong","sequence":"additional","affiliation":[{"name":"Key Laboratory of Environmental Medicine Engineering, Ministry of Education, School of Public Health","place":["Nanjing, China"]},{"name":"Southeast University","place":["Nanjing, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lin","family":"Xu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences","place":["Beijing, China"]},{"name":"Chinese Academy of Sciences","place":["Beijing, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wen","family":"Gu","sequence":"additional","affiliation":[{"name":"China CDC Key Laboratory of Environment and Population Health, National Institute of Environmental Health","place":["Beijing, China"]},{"name":"Chinese Center for Disease Control and Prevention","place":["Beijing, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3219-1422","authenticated-orcid":true,"given":"Song","family":"Tang","sequence":"additional","affiliation":[{"name":"China CDC Key Laboratory of Environment and Population Health, National Institute of Environmental Health","place":["Beijing, China"]},{"name":"Chinese Center for Disease Control and Prevention","place":["Beijing, China"]},{"name":"Center for Global Health, School of Public Health","place":["Nanjing, China"]},{"name":"Nanjing Medical University","place":["Nanjing, China"]},{"name":"National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases, National Institute of Environmental Health","place":["Beijing, China"]},{"name":"Chinese Center for Disease Control and Prevention","place":["Beijing, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7071-571X","authenticated-orcid":true,"given":"Xiaoming","family":"Shi","sequence":"additional","affiliation":[{"name":"China CDC Key Laboratory of Environment and Population Health, National Institute of Environmental Health","place":["Beijing, China"]},{"name":"Chinese Center for Disease Control and Prevention","place":["Beijing, China"]},{"name":"Center for Global Health, School of Public Health","place":["Nanjing, China"]},{"name":"Nanjing Medical University","place":["Nanjing, China"]},{"name":"National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases, National Institute of Environmental Health","place":["Beijing, China"]},{"name":"Chinese Center for Disease Control and Prevention","place":["Beijing, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"316","published-online":{"date-parts":[[2026,3,27]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chemosphere.2012.10.040"},{"key":"ref2\/cit2","doi-asserted-by":"publisher","DOI":"10.1016\/j.envres.2021.111513"},{"key":"ref3\/cit3","doi-asserted-by":"crossref","unstructured":"Horii, Y.; Kannan, K.\n                      Main Uses and Environmental Emissions of Volatile Methylsiloxanes\n                      ; Springer International Publishing, 2020; pp 33\u201370.","DOI":"10.1007\/698_2019_375"},{"key":"ref4\/cit4","unstructured":"European Chemicals, A.\n                      Annex XV Restriction Report: Proposal for a Restriction on Octamethylcyclotetrasiloxane (D4), Decamethylcyclopentasiloxane (D5) and Dodecamethylcyclohexasiloxane (D6)\n                      ; ECHA, Helsinki, Finland, 2019. (accessed 02 December 2025)."},{"key":"ref5\/cit5","doi-asserted-by":"publisher","DOI":"10.1021\/es101368n"},{"key":"ref6\/cit6","unstructured":"Silicones and Siloxanes Market:\nGlobal Industry Trends, Share, Size,\nGrowth, Opportunity and Forecast 2020\u20132025\n                      ; 2019. (accessed 22 September 2025)."},{"key":"ref7\/cit7","doi-asserted-by":"publisher","DOI":"10.1021\/acs.est.3c10752"},{"key":"ref8\/cit8","doi-asserted-by":"publisher","DOI":"10.1016\/j.chemosphere.2023.140779"},{"key":"ref9\/cit9","doi-asserted-by":"publisher","DOI":"10.1016\/j.scitotenv.2019.03.092"},{"key":"ref10\/cit10","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph192113869"},{"key":"ref11\/cit11","doi-asserted-by":"publisher","DOI":"10.1016\/j.envres.2023.117018"},{"key":"ref12\/cit12","doi-asserted-by":"publisher","DOI":"10.1016\/j.envpol.2018.03.017"},{"key":"ref13\/cit13","doi-asserted-by":"publisher","DOI":"10.1021\/acs.est.0c00056"},{"key":"ref14\/cit14","doi-asserted-by":"publisher","DOI":"10.1016\/j.chemosphere.2019.04.130"},{"key":"ref15\/cit15","doi-asserted-by":"publisher","DOI":"10.1016\/j.envint.2021.106471"},{"key":"ref16\/cit16","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxlet.2017.01.010"},{"key":"ref17\/cit17","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxlet.2017.08.016"},{"key":"ref18\/cit18","doi-asserted-by":"publisher","DOI":"10.1016\/j.envint.2020.105931"},{"key":"ref19\/cit19","unstructured":"Opinion on Cyclomethicone: Octamethylcyclotetrasiloxane\n(Cyclotetrasiloxane,\nD4) and Decamethylcyclopentasiloxane (Cyclopentasiloxane, D5)\n                      ; 2010. (accessed 16 July 2025)."},{"key":"ref20\/cit20","first-page":"103","volume":"31","author":"Biesemeier J. A.","year":"2011","journal-title":"Reprod. Toxicol."},{"key":"ref21\/cit21","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.toxlet.2016.04.016","volume":"253","author":"Montemurro N.","year":"2016","journal-title":"Toxicol. Lett."},{"key":"ref22\/cit22","doi-asserted-by":"publisher","DOI":"10.3390\/toxics11040302"},{"key":"ref23\/cit23","doi-asserted-by":"publisher","DOI":"10.1016\/j.chemosphere.2017.10.045"},{"key":"ref24\/cit24","doi-asserted-by":"publisher","DOI":"10.1021\/envhealth.4c00245"},{"key":"ref25\/cit25","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1016\/j.yrtph.2015.02.002","volume":"71","author":"Lee S.","year":"2015","journal-title":"Regul. Toxicol. Pharmacol."},{"key":"ref26\/cit26","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.envint.2016.10.024","volume":"98","author":"Lopez C. M.","year":"2017","journal-title":"Environ. Int."},{"key":"ref27\/cit27","doi-asserted-by":"publisher","DOI":"10.1016\/j.envint.2017.01.022"},{"key":"ref28\/cit28","doi-asserted-by":"publisher","DOI":"10.1016\/j.envint.2021.106672"},{"key":"ref29\/cit29","doi-asserted-by":"publisher","DOI":"10.1016\/j.scitotenv.2022.157379"},{"key":"ref30\/cit30","doi-asserted-by":"publisher","DOI":"10.1016\/j.envres.2024.120633"},{"key":"ref31\/cit31","doi-asserted-by":"publisher","DOI":"10.1016\/j.scitotenv.2025.179295"},{"key":"ref32\/cit32","doi-asserted-by":"publisher","DOI":"10.1016\/j.scitotenv.2022.154449"},{"key":"ref33\/cit33","first-page":"823","volume":"6","author":"Xu L.","year":"2019","journal-title":"Environ. Sci.: Nano"},{"key":"ref34\/cit34","doi-asserted-by":"publisher","DOI":"10.1289\/ehp.0800379"},{"key":"ref35\/cit35","doi-asserted-by":"publisher","DOI":"10.1016\/j.envint.2021.106913"},{"key":"ref36\/cit36","first-page":"516","volume":"92","author":"Capela D.","year":"2016","journal-title":"Environ. Int."},{"key":"ref37\/cit37","first-page":"135733","volume":"705","author":"Gao Y.","year":"2020","journal-title":"Sci. Total Environ."},{"key":"ref38\/cit38","first-page":"4272","volume":"47","author":"Wang D.-G.","year":"2013","journal-title":"Environ. Sci. Technol."},{"key":"ref39\/cit39","first-page":"1300","volume":"220","author":"Xu L.","year":"2017","journal-title":"Environ. Pollut."},{"key":"ref40\/cit40","doi-asserted-by":"crossref","unstructured":"Weiss, B.\n                      Aging and Vulnerability to Environmental Chemicals: Age-Related Disorders and Their Origins in Environmental Exposures\n                      ; Royal Society of Chemistry, 2013; pp 125\u2013150.","DOI":"10.1039\/9781849734660"},{"key":"ref41\/cit41","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2013.11.015"},{"key":"ref42\/cit42","doi-asserted-by":"publisher","DOI":"10.1016\/j.envint.2021.106866"},{"key":"ref43\/cit43","doi-asserted-by":"publisher","DOI":"10.1021\/es3023368"},{"key":"ref44\/cit44","doi-asserted-by":"publisher","DOI":"10.1016\/j.scitotenv.2024.172435"},{"key":"ref45\/cit45","doi-asserted-by":"publisher","DOI":"10.1289\/ehp13864"},{"key":"ref46\/cit46","volume-title":"Half Life","author":"Hallare J.","year":"2023"},{"key":"ref47\/cit47","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chas.5c00166"},{"key":"ref48\/cit48","doi-asserted-by":"publisher","DOI":"10.1504\/IJRAM.2017.082561"},{"key":"ref49\/cit49","first-page":"1","volume":"282","author":"EFSA","year":"2005","journal-title":"EFSA J."},{"key":"ref50\/cit50","doi-asserted-by":"publisher","DOI":"10.4103\/0976-0105.177703"},{"key":"ref51\/cit51","doi-asserted-by":"publisher","DOI":"10.1021\/acs.est.9b05042"},{"key":"ref52\/cit52","unstructured":"Guidance for Data Quality Assessment: Practical\nMethods for Data\nAnalysis\n                      ; US Environmental Protection Agency, WA, 2000. (accessed\n02 December 2025)."},{"key":"ref53\/cit53","doi-asserted-by":"publisher","DOI":"10.1016\/j.envpol.2022.120423"},{"key":"ref54\/cit54","doi-asserted-by":"publisher","DOI":"10.1016\/j.envint.2016.03.016"},{"key":"ref55\/cit55","doi-asserted-by":"publisher","DOI":"10.1016\/j.envint.2013.10.002"},{"key":"ref56\/cit56","doi-asserted-by":"publisher","DOI":"10.1016\/j.envpol.2011.08.015"},{"key":"ref57\/cit57","doi-asserted-by":"publisher","DOI":"10.1021\/es502081j"},{"key":"ref58\/cit58","doi-asserted-by":"publisher","DOI":"10.1016\/j.yrtph.2016.11.016"},{"key":"ref59\/cit59","unstructured":"Environment, C.; Health, C.\n                      Screening Assessment for the Challenge: Octamethylcyclotetrasiloxane (D4)\n                      ; Government of Canada, 2008. (accessed 16 December 2025)."},{"key":"ref60\/cit60","doi-asserted-by":"publisher","DOI":"10.1016\/j.scitotenv.2014.10.039"},{"key":"ref61\/cit61","doi-asserted-by":"publisher","DOI":"10.1016\/j.envint.2012.10.008"},{"key":"ref62\/cit62","doi-asserted-by":"publisher","DOI":"10.1016\/j.atmosenv.2013.08.001"},{"key":"ref63\/cit63","doi-asserted-by":"publisher","DOI":"10.1377\/hlthaff.2010.1225"},{"key":"ref64\/cit64","doi-asserted-by":"publisher","DOI":"10.1289\/ehp.1104597"},{"key":"ref65\/cit65","doi-asserted-by":"publisher","DOI":"10.1016\/j.envres.2024.119411"},{"key":"ref66\/cit66","doi-asserted-by":"publisher","DOI":"10.1016\/j.envint.2007.10.004"},{"key":"ref67\/cit67","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0668.2010.00683.x"},{"key":"ref68\/cit68","doi-asserted-by":"publisher","DOI":"10.1038\/jes.2011.11"},{"key":"ref69\/cit69","doi-asserted-by":"publisher","DOI":"10.3109\/10408444.2012.756455"},{"key":"ref70\/cit70","doi-asserted-by":"publisher","DOI":"10.1016\/j.envint.2014.10.017"},{"key":"ref71\/cit71","unstructured":"Environment;\nClimate Change,\nC.; Health, C.\n                      Assessment\u2500Siloxanes Group\n                      ; Government of Canada, 2023. (accessed 16 December 2025)."},{"key":"ref72\/cit72","doi-asserted-by":"publisher","DOI":"10.1016\/j.scitotenv.2019.07.168"},{"key":"ref73\/cit73","doi-asserted-by":"publisher","DOI":"10.1289\/ehp10009"},{"key":"ref74\/cit74","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijheh.2015.08.004"},{"key":"ref75\/cit75","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijheh.2022.114052"},{"key":"ref76\/cit76","volume-title":"Siloxanes\u2500Consumption, Toxicity and Alternatives","year":"2005"},{"key":"ref77\/cit77","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhazmat.2025.137365"}],"container-title":["Environmental Science &amp; Technology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acs.est.5c14653","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acs.est.5c14653","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T08:17:02Z","timestamp":1776154622000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/acs.est.5c14653"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,27]]},"references-count":77,"journal-issue":{"issue":"14","published-print":{"date-parts":[[2026,4,14]]}},"alternative-id":["10.1021\/acs.est.5c14653"],"URL":"https:\/\/doi.org\/10.1021\/acs.est.5c14653","relation":{},"ISSN":["0013-936X","1520-5851"],"issn-type":[{"value":"0013-936X","type":"print"},{"value":"1520-5851","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3,27]]}}}