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Environmental chemical exposures, particularly endocrine-disrupting chemicals (EDCs) from consumer products, may contribute to reproductive health challenges. We mailed wearable passive samplers (Fresh Air wristbands) to 132 female participants across 39 U.S. states and 24 of their male partners in the Pregnancy Study Online (PRESTO) to characterize exposure among couples trying to conceive between January and October 2021. Wristbands were analyzed using thermal desorption gas chromatography\u2013high-resolution mass spectrometry with targeted and nontargeted approaches. Nontargeted analysis revealed exposure to 491 chemicals, predominantly benzenoids (36.9%) and organoheterocyclic compounds (18.3%). Health hazard assessment identified 107 high-risk EDCs and 47 compounds predicted to have medium-to-high impacts on reproductive outcomes, including galaxolide, salicylates, and phthalates. Targeted analysis quantified 43 chemicals, revealing universal exposure to polycyclic aromatic hydrocarbons and phthalates. Lifestyle factors influenced exposures: frequent sunscreen users had up to 3.1 times higher ultraviolet filter exposures, while dog owners had 1.2\u20132.6 times higher exposure to fragrance compounds. Among cohabitating couples, few similarities were observed, despite shared environments. The findings demonstrate that consumer products contribute to complex exposure mixtures with reproductive health implications during preconception.<\/jats:p>","DOI":"10.1021\/acs.est.5c18677","type":"journal-article","created":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T00:34:42Z","timestamp":1784162082000},"page":"20197-20212","source":"Crossref","is-referenced-by-count":1,"title":["Contribution of\nConsumer Products to Emerging Chemical\nExposures in a Preconception Cohort Study"],"prefix":"10.1021","volume":"60","author":[{"given":"Jieqiong","family":"Zhou","sequence":"first","affiliation":[{"name":"Yale School of Public Health , , , ,","place":["New Haven, Connecticut, United States, 06520"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth Z.","family":"Lin","sequence":"additional","affiliation":[{"name":"Yale School of Public Health , , , ,","place":["New Haven, Connecticut, United States, 06520"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amelia K.","family":"Wesselink","sequence":"additional","affiliation":[{"name":"Boston University School of Public Health , , , ,","place":["Boston, Massachusetts, United States, 02118"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7845-3566","authenticated-orcid":true,"given":"Samantha","family":"Schildroth","sequence":"additional","affiliation":[{"name":"Boston University School of Public Health , , , ,","place":["Boston, Massachusetts, United States, 02118"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary D.","family":"Willis","sequence":"additional","affiliation":[{"name":"Boston University School of Public Health , , , ,","place":["Boston, Massachusetts, United States, 02118"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth E.","family":"Hatch","sequence":"additional","affiliation":[{"name":"Boston University School of Public Health , , , ,","place":["Boston, Massachusetts, United States, 02118"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lauren A.","family":"Wise","sequence":"additional","affiliation":[{"name":"Boston University School of Public Health , , , ,","place":["Boston, Massachusetts, United States, 02118"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7332-2228","authenticated-orcid":true,"given":"Krystal J.","family":"Godri Pollitt","sequence":"additional","affiliation":[{"name":"Yale School of Public Health , , , ,","place":["New Haven, Connecticut, United States, 06520"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,7,15]]},"reference":[{"issue":"202","key":"2026072809085979900_cit1","first-page":"1","article-title":"Infertility and Impaired Fecundity in Women and Men\nin the United States, 2015\u20132019","author":"Nugent","year":"2024","journal-title":"Natl.\nHealth Stat. 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RBE"},{"issue":"4","key":"2026072809085979900_cit5","doi-asserted-by":"publisher","first-page":"379","DOI":"10.1016\/j.ajog.2017.08.010","article-title":"Diet and Fertility: A Review","volume":"218","author":"Gaskins","year":"2018","journal-title":"Am. J. Obstet. Gynecol."},{"issue":"7","key":"2026072809085979900_cit6","doi-asserted-by":"publisher","first-page":"401","DOI":"10.1038\/nrurol.2015.145","article-title":"Adverse Effects\nof Common Medications on Male Fertility","volume":"12","author":"Samplaski","year":"2015","journal-title":"Nat.\nRev. Urol."},{"issue":"4","key":"2026072809085979900_cit7","doi-asserted-by":"publisher","first-page":"726","DOI":"10.1093\/humrep\/dead016","article-title":"for the Shanghai Birth Cohort Study. Paraben Exposure\nand Couple Fecundity: A Preconception Cohort Study","volume":"38","author":"Ao","year":"2023","journal-title":"Hum. 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