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Dynamic indoor and human physicologically based pharmacokinetic (PBPK) models of the distribution of nonionizing, organic chemical concentrations in indoor environments resulting in delivered tissue doses are developed, described and tested. The Indoor model successfully reproduced independently measured, reported time-dependent air concentrations of chloroform released during showering and of 2-butyoxyethanol following use of a volatile surface cleaner. The Indoor model predictions were also comparable to those from a higher tier consumer model (ConsExpo 4.1) for the surface cleaner scenario. The PBPK model successful reproduced observed chloroform exhaled air concentrations resulting from an inhalation exposure. Fugacity based modeling provided a seamless description of the partitioning, fluxes, accumulation and release of the chemical in indoor media and tissues of the exposed subject. This has the potential to assist in health risk assessments, provided that appropriate physical\/chemical property, usage characteristics, and toxicological information are available.<\/jats:p>","DOI":"10.1021\/acs.est.6b00895","type":"journal-article","created":{"date-parts":[[2016,7,19]],"date-time":"2016-07-19T15:15:15Z","timestamp":1468941315000},"page":"8697-8704","source":"Crossref","is-referenced-by-count":8,"title":["Modeling\nHuman Exposure to Indoor Contaminants: External\nSource to Body Tissues"],"prefix":"10.1021","volume":"50","author":[{"given":"Eva M.","family":"Webster","sequence":"first","affiliation":[{"name":"Carrousel Environmental Modelling Research , ,","place":["Peterborough, Ontario, Canada, K9H 0E2"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hua","family":"Qian","sequence":"additional","affiliation":[{"name":"ExxonMobil Biomedical Sciences, Inc. , , ,","place":["Annandale, New Jersey, United States, 08801"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donald","family":"Mackay","sequence":"additional","affiliation":[{"name":"Trent University , , ,","place":["Peterborough, Ontario, Canada, K9L 0G2"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecca D.","family":"Christensen","sequence":"additional","affiliation":[{"name":"Trent University , , ,","place":["Peterborough, Ontario, Canada, K9L 0G2"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Britta","family":"Tietjen","sequence":"additional","affiliation":[{"name":"Trent University , , ,","place":["Peterborough, Ontario, Canada, K9L 0G2"]},{"name":"Freie Universita\u0308t Berlin , , ,","place":["Berlin, Germany, D-14195"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosemary","family":"Zaleski","sequence":"additional","affiliation":[{"name":"ExxonMobil Biomedical Sciences, Inc. , , ,","place":["Annandale, New Jersey, United States, 08801"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2016,7,19]]},"reference":[{"key":"2026090303273549700_cit1","doi-asserted-by":"publisher","first-page":"2142","DOI":"10.1021\/es034287m","article-title":"Fugacity-based indoor\nresidential pesticide fate model","volume":"38","author":"Bennett","year":"2004","journal-title":"Environ. 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Ph.D. Dissertation, Rutgers UniversityNew Brunswick, NJ. 2002."},{"issue":"1","key":"2026090303273549700_cit48","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1111\/j.1539-6924.1993.tb00728.x","article-title":"A compartmental\nmodel for the prediction of breath\nconcentration and absorbed dose of chloroform after exposure while\nshowering","volume":"13","author":"Chinery","year":"1993","journal-title":"Risk Anal."},{"key":"2026090303273549700_cit49","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1016\/j.envint.2015.07.015","article-title":"Evaluation\nof 3D-human skin equivalents\nfor assessment of human dermal absorption of some brominated flame\nretardants","volume":"84","author":"Abdallah","year":"2015","journal-title":"Environ. 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